scholarly journals Electric Field-controlled Directed Migration of Neural Progenitor Cells in 2D and 3D Environments

10.3791/3453 ◽  
2012 ◽  
Author(s):  
Xiaoting Meng ◽  
Wenfei Li ◽  
Fraser Young ◽  
Runchi Gao ◽  
Laura Chalmers ◽  
...  
Keyword(s):  
Electric Field ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Directed Migration ◽  
3D Environments ◽  
2D And 3D

Electric field stimulation induced neuronal differentiation of filum terminale derived neural progenitor cells

2017 ◽  
Vol 651 ◽  
pp. 109-115 ◽  
Author(s):  
Zhi-yong Dong ◽  
Zhe Pei ◽  
Zhe Li ◽  
Yan-ling Wang ◽  
Amber Khan ◽  
...  
Keyword(s):  
Electric Field ◽  
Progenitor Cells ◽  
Neuronal Differentiation ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Field Stimulation ◽  
Filum Terminale ◽  
Electric Field Stimulation

scholarly journals Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells from human induced pluripotent stem cells

2017 ◽  
Vol 25 ◽  
pp. 139-151 ◽  
Author(s):  
Abinaya Chandrasekaran ◽  
Hasan X. Avci ◽  
Anna Ochalek ◽  
Lone N. Rösingh ◽  
Kinga Molnár ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Progenitor Cells ◽  
Pluripotent Stem Cells ◽  
Neural Progenitor Cells ◽  
Neural Induction ◽  
Neural Progenitor ◽  
Induced Pluripotent ◽  
2D And 3D

scholarly journals Controlling properties of human neural progenitor cells using 2D and 3D conductive polymer scaffolds

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Shang Song ◽  
Danielle Amores ◽  
Cheng Chen ◽  
Kelly McConnell ◽  
Byeongtaek Oh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cell ◽  
Electrical Stimulation ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neurological Diseases ◽  
Conductive Polymer ◽  
Physical Nature ◽  
Neural Progenitor ◽  
2D And 3D

AbstractHuman induced pluripotent stem cell-derived neural progenitor cells (hNPCs) are a promising cell source for stem cell transplantation to treat neurological diseases such as stroke and peripheral nerve injuries. However, there have been limited studies investigating how the dimensionality of the physical and electrical microenvironment affects hNPC function. In this study, we report the fabrication of two- and three-dimensional (2D and 3D respectively) constructs composed of a conductive polymer to compare the effect of electrical stimulation of hydrogel-immobilized hNPCs. The physical dimension (2D vs 3D) of stimulating platforms alone changed the hNPCs gene expression related to cell proliferation and metabolic pathways. The addition of electrical stimulation was critical in upregulating gene expression of neurotrophic factors that are important in regulating cell survival, synaptic remodeling, and nerve regeneration. This study demonstrates that the applied electrical field controls hNPC properties depending on the physical nature of stimulating platforms and cellular metabolic states. The ability to control hNPC functions can be beneficial in understanding mechanistic changes related to electrical modulation and devising novel treatment methods for neurological diseases.

Chemokine-directed migration of tumor-inhibitory neural progenitor cells towards an intracranially growing glioma

2006 ◽  
Vol 312 (8) ◽  
pp. 1265-1276 ◽  
Author(s):  
G HONETH ◽  
K STAFLIN ◽  
S KALLIOMAKI ◽  
M LINDVALL ◽  
C KJELLMAN
Keyword(s):  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Directed Migration
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