Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer

Pulmonary actinomycosis is a rare disease that is often misdiag-nosed as tuberculosis or lung cancer.Actinomyces graevenitziiis a relatively new recognizedActinomycesspecies isolated from various clinical samples. The authors report a case of pulmonary actinomycosis caused byA graevenitzii. A computed tomography examination revealed an excavated consolidation in the middle right lobe of a previously healthy young man who presented with a long history of moderate cough. Cultures of the bronchoalveolar lavage fluid confirmed the diagnosis of pulmonary abscess caused byA gravenitzii. At the three-month follow-up consultation and, after six weeks of high-dose amoxicillin, the pulmonary lesion had completely disappeared.

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Knockdown of IKKβ Inhibits Tumor Development in a Leptomeningeal Metastasis Mouse Model and Proliferation of Lung Cancer Cells

Cancer Management and Research ◽

10.2147/cmar.s252184 ◽

2020 ◽

Vol Volume 12 ◽

pp. 6007-6017

Author(s):

Yakun Liu ◽

Yuanyuan Li ◽

Zhongyao Li ◽

Chunyan Li ◽

Junying He ◽

...

Keyword(s):

Lung Cancer ◽

Mouse Model ◽

Cancer Cells ◽

Tumor Development ◽

Leptomeningeal Metastasis ◽

Lung Cancer Cells

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The Prognostic Value of Circulating VEGF-A Level in Patients With Hepatocellular Cancer

Technology in Cancer Research & Treatment ◽

10.1177/1533033820971677 ◽

2020 ◽

Vol 19 ◽

pp. 153303382097167

Author(s):

Sahin Lacin ◽

Suayib Yalcin

Keyword(s):

Tumor Size ◽

Tumor Development ◽

Biological Marker ◽

Hepatocellular Cancer ◽

Response To Treatment ◽

Vascular Endothelial ◽

B Virus ◽

Endothelial Growth Factor ◽

Turkish Patients

Background: Neovascularization plays a crucial pathogenic role in tumor development and vascular endothelial growth factor (VEGF-A) is a key signaling element that drives angiogenesis, thereby facilitating hepatocellular cancer (HCC) growth and metastasis. We aimed to define the relationship between serum VEGF-A levels and clinical outcomes in a cohort of Turkish patients with HCC. Methods: We enrolled and prospectively followed 84 patients with HCC in our study. Serum VEGF-A levels were measured and we assessed the association between VEGF-A levels and clinical features. Results: Forty-eight patients had cirrhosis while 35 patients were noncirrhotic. Serum VEGF-A levels were significantly lower in HCC patients with cirrhosis compared to non-cirrhotic HCC patients (p = 0.03).In terms of viral hepatitis subtype, 36 (%42.8) of patients were hepatitis B virus (HBV) positive and 8 (%9.5) of patients were hepatitis C virus (HCV) positive. Patients with serum VEGF-A levels ≥100 pg/mL had significantly lower OS rates than patients with serum VEGF-A level <100 pg/mL (p = 0.01). The OS rates were 5.8 and 14.2 months, respectively (p = 0.02). The median OS was 7.38 months (95% CI: 5.89-13.79 months). We observed a significant relationship between serum VEGF-A level and tumor size. Patients with tumor size ≤ 5cm had lower VEGF-A levels than patients with VEGF-A levels <5 cm. The VEGF-A levels were 132.7 and 342.1 pg/mL, respectively (p < 0.001). The median follow-up was 32 months. Conclusions: Serum VEGF-A level, a biological marker of angiogenesis, is an independent predictor of survival in patients with HCC. Serum VEGF-A levels may be utilized to predict response to treatment targeting serum VEGF-A in patients with HCC.

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Contralateral Maxillary Sinus Lesions in Patients with Nasal Cavity and/or Paranasal Sinus Carcinoma: Analysis of Computed Tomography Findings

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348940811701208 ◽

2008 ◽

Vol 117 (12) ◽

pp. 909-913 ◽

Cited By ~ 2

Author(s):

Jong Hwan Wang ◽

Jeong Hyun Lee ◽

Ju Hee Han ◽

Bong-Jae Lee ◽

Yong Ju Jang

Keyword(s):

Computed Tomography ◽

Nasal Cavity ◽

Maxillary Sinus ◽

Paranasal Sinus ◽

Tumor Development ◽

Second Primary ◽

Ct Analysis ◽

Paranasal Sinus Carcinoma ◽

Age Range

Objectives: The incidence of bilateral maxillary sinus carcinoma is very low in patients with primary maxillary sinus carcinoma. However, surgeons should perform careful diagnosis of any contralateral maxillary sinus lesions to avoid missing a second primary maxillary sinus carcinoma. We therefore investigated the computed tomography (CT) findings of the contralateral maxillary sinus in patients with nasal cavity and/or paranasal sinus carcinoma. Methods: Between August 1994 and September 2006, 66 patients (41 male, 25 female; age range, 22 to 85 years; mean age, 56.9 years) with nasal and/or paranasal sinus carcinoma were treated. Preoperative and follow-up CT scans of their contralateral maxillary sinuses were retrospectively reviewed. Results: Of the 66 patients, 26 (39.4%) had rhinosinusitis, 6 (9.1%) had retention cysts, and 33 (50.0%) showed normal findings on CT. One patient (1.5%) had bilateral enhanced mass-like lesions. Both masses were diagnosed histologically as poorly differentiated squamous cell carcinoma. The rhinosinusitis findings included mucoperiosteal thickening, sclerotic bone thickening, hyperdense secretion, and an air-fluid level, in order of decreasing frequency. Twenty-three of the 32 patients with benign lesions were included in the follow-up CT analysis, ranging from 24 to 108 months (mean, 45 months). On the final CT scan, rhinosinusitis was aggravated in 5 of 19 cases and improved in 14 cases, and the size of the retention cyst decreased in 4 cases. During the follow-up period, no definite abnormality suggesting tumor development in the contralateral maxillary sinus was detected. Conclusions: Even though most contralateral maxillary sinus lesions are benign and the incidence of bilateral maxillary sinus carcinoma is very low, second primary maxillary sinus carcinoma should be kept in mind in the differential diagnosis of contralateral maxillary sinus lesions in patients with nasal cavity and/or paranasal sinus carcinoma.

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