Organotypic Slice Cultures as Preclinical Models of Tumor Microenvironment in Primary Pancreatic Cancer and Metastasis

10.3791/62541 ◽  
2021 ◽  
Author(s):  
Rüdiger Braun ◽  
Olha Lapshyna ◽  
Susanne Eckelmann ◽  
Kim Honselmann ◽  
Louisa Bolm ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Microenvironment ◽  
Preclinical Models ◽  
Organotypic Slice Cultures

Abstract 1502: KRAS RNAi therapy in preclinical models of pancreatic cancer sensitizes tumors to checkpoint blockade by affecting the tumor microenvironment

2019 ◽  
Author(s):  
Shanthi Ganesh ◽  
Serena Shui ◽  
Kevin Craig ◽  
Weimin Wang ◽  
Bob D. Brown ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Microenvironment ◽  
Checkpoint Blockade ◽  
Preclinical Models ◽  
Rnai Therapy

Abstract 1502: KRAS RNAi therapy in preclinical models of pancreatic cancer sensitizes tumors to checkpoint blockade by affecting the tumor microenvironment

2019 ◽  
Author(s):  
Shanthi Ganesh ◽  
Serena Shui ◽  
Kevin Craig ◽  
Weimin Wang ◽  
Bob D. Brown ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Microenvironment ◽  
Checkpoint Blockade ◽  
Preclinical Models ◽  
Rnai Therapy

Combined blockade of TGf-β1 and GM-CSF improves chemotherapeutic effects for pancreatic cancer by modulating tumor microenvironment

2020 ◽  
Vol 69 (8) ◽  
pp. 1477-1492 ◽  
Author(s):  
Qiaofei Liu ◽  
Huanwen Wu ◽  
Yuan Li ◽  
Ronghua Zhang ◽  
Jorg Kleeff ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Microenvironment ◽  
Gm Csf ◽  
Tgf Β1

scholarly journals Cross-talk within the tumor microenvironment mediates Th2-type inflammation in pancreatic cancer

2012 ◽  
Vol 1 (1) ◽  
pp. 89-91 ◽  
Author(s):  
Maria Pia Protti ◽  
Lucia De Monte
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Microenvironment ◽  
Cross Talk

Role of Tumor Microenvironment on Gene Expression in Pancreatic Cancer Tumor Models

2011 ◽  
Vol 171 (1) ◽  
pp. 136-142 ◽  
Author(s):  
Soeren Torge Mees ◽  
Wolf Arif Mardin ◽  
Christina Schleicher ◽  
Mario Colombo-Benkmann ◽  
Norbert Senninger ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pancreatic Cancer ◽  
Tumor Microenvironment ◽  
Tumor Models ◽  
Cancer Tumor

scholarly journals The immunological impact of preoperative chemoradiotherapy on the tumor microenvironment of pancreatic cancer

2021 ◽  
Author(s):  
Satoshi Okubo ◽  
Toshihiro Suzuki ◽  
Masayoshi Hioki ◽  
Yasuhiro Shimizu ◽  
Hirochika Toyama ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Microenvironment ◽  
Preoperative Chemoradiotherapy

scholarly journals CXCL12 and Its Isoforms: Different Roles in Pancreatic Cancer?

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Alessandra Righetti ◽  
Matteo Giulietti ◽  
Berina Šabanović ◽  
Giulia Occhipinti ◽  
Giovanni Principato ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Microenvironment ◽  
Stromal Cells ◽  
Tumor Invasion ◽  
Epithelial To Mesenchymal Transition ◽  
Current Knowledge ◽  
Tumor Development ◽  
Physiological Role ◽  
Mesenchymal Transition ◽  
Splicing Isoforms

CXCL12 is a chemokine that acts through CXCR4 and ACKR3 receptors and plays a physiological role in embryogenesis and haematopoiesis. It has an important role also in tumor development, since it is released by stromal cells of tumor microenvironment and alters the behavior of cancer cells. Many studies investigated the roles of CXCL12 in order to understand if it has an anti- or protumor role. In particular, it seems to promote tumor invasion, proliferation, angiogenesis, epithelial to mesenchymal transition (EMT), and metastasis in pancreatic cancer. Nevertheless, some evidence shows opposite functions; therefore research on CXCL12 is still ongoing. These discrepancies could be due to the presence of at least six CXCL12 splicing isoforms, each with different roles. Interestingly, three out of six variants have the highest levels of expression in the pancreas. Here, we report the current knowledge about the functions of this chemokine and then focus on pancreatic cancer. Moreover, we discuss the methods applied in recent studies in order to understand if they took into account the existence of the CXCL12 isoforms.

B Cells in the Gastrointestinal Tumor Microenvironment with a Focus on Pancreatic Cancer: Opportunities for Precision Medicine?

2020 ◽  
pp. 175-195
Author(s):  
Dário Ligeiro ◽  
Martin Rao ◽  
Andreia Maia ◽  
Mireia Castillo ◽  
Antonio Beltran ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
B Cells ◽  
Tumor Microenvironment ◽  
Precision Medicine ◽  
Gastrointestinal Tumor
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