scholarly journals Active Component in Green Tea Catechins and Effective Intake Period for Prevention of Age-related Brain Dysfunction

2011 ◽  
Vol 8 (6) ◽  
pp. 75-81 ◽  
Author(s):  
Keiko Unno ◽  
Hiroyuki Yamamoto ◽  
Toshiya Ohtaki ◽  
Yuichi Ishikawa ◽  
Shigenori Noda ◽  
...  
Keyword(s):  
Green Tea ◽  
Active Component ◽  
Brain Dysfunction ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Age Related

scholarly journals Green Tea Catechins Trigger Immediate-Early Genes in the Hippocampus and Prevent Cognitive Decline and Lifespan Shortening

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1484 ◽  
Author(s):  
Keiko Unno ◽  
Monira Pervin ◽  
Kyoko Taguchi ◽  
Tomokazu Konishi ◽  
Yoriyuki Nakamura
Keyword(s):  
Cognitive Decline ◽  
Green Tea ◽  
Brain Function ◽  
Immediate Early Genes ◽  
Immediate Early ◽  
Memory Retention ◽  
Tea Catechins ◽  
Early Genes ◽  
Green Tea Catechins ◽  
Age Related

Senescence-accelerated mouse prone 10 (SAMP10) mice, after ingesting green tea catechins (GT-catechin, 60 mg/kg), were found to have suppressed aging-related decline in brain function. The dose dependence of brain function on GT-catechin indicated that intake of 1 mg/kg or more suppressed cognitive decline and a shortened lifespan. Mice that ingested 1 mg/kg GT-catechin had the longest median survival, but the dose was less effective at suppressing cognitive decline. The optimal dose for improving memory acquisition was 60 mg/kg, and memory retention was higher in mice that ingested 30 mg/kg or more. To elucidate the mechanism by which cognitive decline is suppressed by GT-catechin, changes in gene expression in the hippocampus of SAMP10 mice one month after ingesting GT-catechin were analyzed. The results show that the expression of immediate-early genes such as nuclear receptor subfamily 4 (Nr4a), FBJ osteosarcoma oncogene (Fos), early growth response 1 (Egr1), neuronal PAS domain protein 4 (Npas4), and cysteine-rich protein 61 (Cyr61) was significantly increased. These results suggest that GT-catechin suppresses age-related cognitive decline via increased expression of immediate-early genes that are involved in long-term changes in plasticity of synapses and neuronal circuits.

Daily ingestion of green tea catechins from adulthood suppressed brain dysfunction in aged mice

BioFactors ◽  
2008 ◽  
Vol 34 (4) ◽  
pp. 263-271 ◽  
Author(s):  
Keiko Unno ◽  
Yuichi Ishikawa ◽  
Fumiyo Takabayashi ◽  
Toru Sasaki ◽  
Nina Takamori ◽  
...  
Keyword(s):  
Green Tea ◽  
Brain Dysfunction ◽  
Tea Catechins ◽  
Aged Mice ◽  
Green Tea Catechins ◽  
Daily Ingestion

Role of green tea catechins in prevention of age‐related cognitive decline: Pharmacological targets and clinical perspective

2018 ◽  
Vol 234 (3) ◽  
pp. 2447-2459 ◽  
Author(s):  
Mohammad Hosein Farzaei ◽  
Roodabeh Bahramsoltani ◽  
Zahra Abbasabadi ◽  
Nady Braidy ◽  
Seyed Mohammad Nabavi
Keyword(s):  
Cognitive Decline ◽  
Green Tea ◽  
Clinical Perspective ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Age Related ◽  
Pharmacological Targets ◽  
Age Related Cognitive Decline

Green tea catechins attenuate high-fat diet effects related to obesity and diabetes without effect hypothalamic expression of TLR4 pathway or serotoninergic 1B and 2C receptors

2013 ◽  
Author(s):  
Marcos Hiromu Okuda ◽  
de Santana Aline Alves ◽  
Mayara Franzoi Moreno ◽  
Ana Claudia Hachul ◽  
Nelson Inacio Neto ◽  
...  
Keyword(s):  
Green Tea ◽  
High Fat Diet ◽  
High Fat ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Obesity And Diabetes

The Protective Effects of Green Tea Catechins in the Management of Neurodegenerative Diseases: A Review

2019 ◽  
Vol 16 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Tahereh Farkhondeh ◽  
Hanieh Shaterzadeh Yazdi ◽  
Saeed Samarghandian
Keyword(s):  
Neurodegenerative Diseases ◽  
Signaling Pathways ◽  
Green Tea ◽  
Molecular Mechanisms ◽  
Main Role ◽  
Related Factor ◽  
Protective Effects ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
And Control

Background: The therapeutic strategies to manage neurodegenerative diseases remain limited and it is necessary to discover new agents for their prevention and control. Oxidative stress and inflammation play a main role in the pathogenesis of neurodegenerative diseases. The aim of this study is to review the effects of green tea catechins against the Neurodegenerative Diseases. Methods: In this study, we extensively reviewed all articles on the terms of Green tea, catechins, CNS disorders, and different diseases in PubMed, Science Direct, Scopus, and Google Scholar databases between the years 1990 and 2017. Results: The present study found that catechins, the major flavonoids in green tea, are powerful antioxidants and radical scavengers which possess the potential roles in the management of neurodegenerative diseases. Catechins modulate the cellular and molecular mechanisms through the inflammation-related NF-&amp;#954;B and the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways. Conclusion: The findings of the present review shows catechins could be effective against neurodegenerative diseases due to their antioxidation and anti-inflammation effects and the involved biochemical pathways including Nrf2 and NF-kB signaling pathways.<P&gt;

Neuroprotection of green tea catechins on surgical menopause-induced overactive bladder in a rat model

2012 ◽  
Vol 19 (3) ◽  
pp. 346-354 ◽  
Author(s):  
Yung-Shun Juan ◽  
Shu-Mien Chuang ◽  
Cheng-Yu Long ◽  
Chung-Hwan Chen ◽  
Robert M. Levin ◽  
...  
Keyword(s):  
Overactive Bladder ◽  
Green Tea ◽  
Rat Model ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Surgical Menopause

scholarly journals Anti-Influenza with Green Tea Catechins: A Systematic Review and Meta-Analysis

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4014
Author(s):  
Anchalee Rawangkan ◽  
Kirati Kengkla ◽  
Sukrit Kanchanasurakit ◽  
Acharaporn Duangjai ◽  
Surasak Saokaew
Keyword(s):  
Systematic Review ◽  
Green Tea ◽  
Viral Infections ◽  
Influenza Infection ◽  
Meta Analysis ◽  
Influenza Virus Infection ◽  
Control Group ◽  
Tea Consumption ◽  
Tea Catechins ◽  
Green Tea Catechins

Influenza is one of the most serious respiratory viral infections worldwide. Although several studies have reported that green tea catechins (GTCs) might prevent influenza virus infection, this remains controversial. We performed a systematic review and meta-analysis of eight studies with 5,048 participants that examined the effect of GTC administration on influenza prevention. In a random-effects meta-analysis of five RCTs, 884 participants treated with GTCs showed statistically significant effects on the prevention of influenza infection compared to the control group (risk ratio (RR) 0.67, 95%CIs 0.51–0.89, P = 0.005) without evidence of heterogeneity (I2= 0%, P = 0.629). Similarly, in three cohort studies with 2,223 participants treated with GTCs, there were also statistically significant effects (RR 0.52, 95%CIs 0.35–0.77, P = 0.001) with very low evidence of heterogeneity (I2 = 3%, P = 0.358). Additionally, the overall effect in the subgroup analysis of gargling and orally ingested items (taking capsules and drinking) showed a pooled RR of 0.62 (95% CIs 0.49–0.77, P = 0.003) without heterogeneity (I2= 0%, P = 0.554). There were no obvious publication biases (Egger’s test (P = 0.138) and Begg’s test (P = 0.103)). Our analysis suggests that green tea consumption is effective in the prophylaxis of influenza infections. To confirm the findings before implementation, longitudinal clinical trials with specific doses of green tea consumption are warranted.

Inhibition of adenovirus infection and adenain by green tea catechins

2003 ◽  
Vol 58 (2) ◽  
pp. 167-173 ◽  
Author(s):  
Joseph M Weber ◽  
Angelique Ruzindana-Umunyana ◽  
Lise Imbeault ◽  
Sucheta Sircar
Keyword(s):  
Green Tea ◽  
Adenovirus Infection ◽  
Tea Catechins ◽  
Green Tea Catechins
Sign in / Sign up

Export Citation Format

Share Document