scholarly journals ASSESSMENT OF EFFICIENCY OF COMBINED PHARMACOTHERAPY FOR IMPERATIVE AND MIXED URINARY DISORDERS IN WOMEN WITH THE INTERVAL SCALE

2021 ◽  
pp. 22-30
Author(s):  
V. V. Danilov ◽  
E. V. Eliseeva ◽  
V. V. Danilov ◽  
I. Yu. Vol'nyh ◽  
V. V. Danilov ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Therapeutic Effect ◽  
Rating Scale ◽  
Clinical Effectiveness ◽  
Interval Scale ◽  
Regulatory Processes ◽  
Urinary Tract Symptoms ◽  
The Difference ◽  
Symptom Rating

Introduction. The search for effective drug combinations for treating continental disorders in women is still relevant. The interval scale for assessing lower urinary tract symptoms in women is a simple and convenient tool for monitoring pharmacotherapy. Objective: to evaluate the effectiveness of treatment of imperative and mixed urination disorders in women with alpha1-blockers in combination with nootropic drugs using an interval symptom rating scale.Materials and methods. Under observation there were 31 patients aged 40 to 73 years who applied to the Center “Urination Pathology” with mixed and imperative disorders of the continent and urinary incontinence. Conservative therapy was carried out with the appointment of alpha1-adrenoblockers, nootropic and metabolic drugs for an average of 5.8 months. The therapeutic effect is recorded using the interval symptom score scale.Results. After discontinuation of drugs, the overall score on the symptom rating scale decreased by 40.2%, imperative symptoms – by 29.5-50%, and quality of life increased by 19%. In the group of women aged 40-49, with comparable dynamics of symptoms with patients older than 50 years, therapy lasted less. The difference averaged 4.1 months and was associated with a higher frequency in the older age group of vascular, metabolic and neurological disorders that slow down the regulatory processes of urination recovery.Conclusion. Alpha1-blockers and nootropics are pathogenetically substantiated for the treatment of imperative disorders of urination and urinary incontinence. Evaluation using the interval scale reliably demonstrates their high clinical effectiveness, persistence of the therapeutic effect and the feasibility of application at the stage of selection for surgical treatment.

scholarly journals A Rasch-Based Validation of ELT Certificate-LORT

2020 ◽  
Vol 13 (9) ◽  
pp. 94
Author(s):  
Xin Qu
Keyword(s):  
Teacher Candidates ◽  
Rating Scales ◽  
Rating Scale ◽  
Qualitative Interviews ◽  
Structured Interviews ◽  
High Stakes ◽  
Efl Teacher ◽  
The Difference ◽  
Group Interviews

The present study was executed with the purpose of validating ELT Certificate Lesson Observation and Report Task (ELTC-LORT), which was developed by China Language Assessment to certify China’s EFL teachers by performance-based testing. The ELT Certificate has high-stakes considering its impacts on candidates’ recruitment, ELT in China and quality of education, so it is crucially important for its validation so as to guarantee fairness and justice. The validity of task construct and rating rubric went through a process suited for many-facet Rasch measurement supplemented with qualitative interviews. Participants (N = 40) were provided with a video excerpt from a real EFL lesson, and required to deliver a report on the teacher’s performance. Two raters graded the records of the candidates’ reports using rating scales developed to measure EFL teacher candidates’ oral English proficiency and ability to analyze and evaluate teaching. Many-facet Rasch analysis demonstrated a successful estimation, with a noticeable spread among the participants and their traits, proving the task functioned well in measuring candidates’ performance and reflecting the difference of their ability. The raters were found to have good internal self-consistency, but not the same leniency. The rating scales worked well, with the average measures advancing largely in line with Rasch expectations. Semi-structured interviews as well as focus group interviews were executed to provide knowledge regarding the raters’ performance levels and the functionalities of the rating scale items. The findings provide implications for further research and practice of the Certificate.

Double-Blind Evaluation of Domperidone in Acute Vomiting and Dyspeptic Disorders

1981 ◽  
Vol 9 (2) ◽  
pp. 143-147 ◽  
Author(s):  
I Agorastos ◽  
N P Zissis ◽  
I Kaprinis ◽  
G Goulis
Keyword(s):  
Side Effects ◽  
Rating Scale ◽  
Second Phase ◽  
Double Blind Trial ◽  
Duration Of Treatment ◽  
Double Blind ◽  
Blind Trial ◽  
Therapeutic Results ◽  
The Difference ◽  
Symptom Rating

The anti-emetic effects of domperidone were evaluated under double-blind conditions in twenty-four patients with acute vomiting randomly assigned to treatment either with 10 mg i.m. domperidone (six females, five males) or with placebo (seven females, six males). The therapeutic results were better with domperidone and the differences from placebo were statistically significant (p < 0.02). In a second randomized, crossover, double-blind trial, domperidone (10 mg t.i.d.) evaluated according to a nine-symptom rating scale, in eighteen dyspeptic patients, proved significantly more effective than placebo. The duration of treatment was 6 weeks and the drugs were crossed-over after 3 weeks. The difference between the two groups was most marked during the second phase of the trial. No side-effects were reported.

scholarly journals Prune intake ameliorates chronic constipation symptoms and causes little discomfort from diarrhea and loose stools: A randomized placebo-controlled trial

2022 ◽  
Author(s):  
Taishi Koyama ◽  
Naoyoshi Nagata ◽  
Kengo Nishiura ◽  
Naoki Miura ◽  
Takashi Kawai ◽  
...  
Keyword(s):  
Chronic Constipation ◽  
Rating Scale ◽  
Controlled Trial ◽  
Double Blind ◽  
Gastrointestinal Symptom Rating Scale ◽  
Long Time ◽  
Stool Form ◽  
Natural Foods ◽  
Symptom Rating

Aim: Little data is available regarding the effectiveness of natural foods in treating chronic constipation. We aimed to identify whether prune ameliorates chronic constipation and can be used safely for a relatively long time. Methods: In this double-blind, randomized, placebo-controlled trial, 84 subjects with chronic constipation, presenting more than 6 months before and persisting for more than 3 months, were randomized to prune (n=42) or placebo (n=42) intake for 8 weeks. We assessed daily Bristol stool form scale (BSFS) scores and stool frequencies and administered the gastrointestinal symptom rating scale (GSRS) questionnaire, as primary outcomes for constipation improvement. Results: The prune group showed significantly decreased rates of hard stool (BSFS1 or 2) and increased rates of normal stool (BSFS 3 or 4) after 1 week, which were more evident after 7 weeks between the two groups. Prune significantly increased stool frequency immediately after 1 week. Furthermore, GSRS of hard stools, flatulence, and incomplete evacuation significantly improved after 4-8 weeks of prune intake, of which constipation and hard stools were significantly reduced compared to the placebo group. In contrast, prune intake did not cause diarrhea, loose stools, or urgent need for defecation during 8 weeks evaluated by GSRS score. We found no abnormal laboratory tests of liver function, renal function, inflammation, or urinalysis after prune intake. Conclusions: Daily prune intake ameliorates chronic constipation, improving quality of life, and causes few diarrhea-related symptoms or side effects. Our results emphasize a new, useful, and easy strategy for chronic constipation. (UMIN ID:000041384)

scholarly journals Quality of life in schizophrenia and bipolar disorder: The impact of symptomatic remission and resilience

2017 ◽  
Vol 46 ◽  
pp. 42-47 ◽  
Author(s):  
A. Hofer ◽  
Y. Mizuno ◽  
F. Wartelsteiner ◽  
W. Wolfgang Fleischhacker ◽  
B. Frajo-Apor ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rating Scale ◽  
Young Mania ◽  
Cross Sectional ◽  
Control Subjects ◽  
The Difference ◽  
Lower Hrqol ◽  
Symptomatic Remission ◽  
The Impact

AbstractBackground:Health-related quality of life (HRQOL) is significantly affected in individuals with schizophrenia or bipolar I disorder (BD-I). The current study investigated whether symptomatic remission and resilience might differently impact HRQOL in these patients.Methods:Fifty-two patients with schizophrenia and 60 patients suffering from BD-I from outpatient mental health services as well as 77 healthy control subjects from the general community were included into a cross-sectional study. HRQOL and resilience were assessed using the WHOQOL-BREF and the Resilience Scale. In patients, psychopathology was quantified by the Positive and Negative Syndrome Scale or the Montgomery Asberg Depression Rating Scale and the Young Mania Rating Scale, respectively.Results:Notably, both patient groups showed lower HRQOL and resilience compared to control subjects, non-remitted patients indicated lower HRQOL than remitted ones. The effect of remission on HRQOL was significantly larger in patients with BD-I than in those with schizophrenia but did not explain the difference in HRQOL between groups. Resilience predicted HRQOL in all three groups. When accounting for the effect of resilience among remitted patients, only the difference in HRQOL between schizophrenia patients and control subjects was significant.Conclusion:These findings demonstrate the impact of symptomatic remission and resilience on HRQOL of both patients suffering from schizophrenia and BD-I and indicate that these factors are especially relevant for HRQOL of patients with BD-I.

scholarly journals Assessing the stigma content of urinary incontinence intervention outcome measures

2017 ◽  
Vol 4 ◽  
pp. 205566831773894 ◽  
Author(s):  
Kenneth Southall ◽  
Joshua R Tuazon ◽  
Abdul H Djokhdem ◽  
Eleanor A van den Heuvel ◽  
Walter Wittich ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Rating Scale ◽  
Outcome Measurement ◽  
Cochrane Library ◽  
Inclusion Criteria ◽  
Health Care Interventions ◽  
Measurement Tools ◽  
Representative Model ◽  
Therapy Treatment

The goal of this narrative review is to evaluate the efficacy of available questionnaires for assessing the outcomes of “continence difficulty” interventions and to assess the selected questionnaires concerning aspects of stigmatization. The literature was searched for research related to urinary incontinence, as well as questionnaires and rating scale outcome measurement tools. The following sources were searched: Cochrane Library, EMBASE, Medline, and PubMed. The following keywords were used separately or in combination: “Urinary incontinence,” “therapy,” ”treatment outcome,” “patient satisfaction,” “quality of life,” “systematic reviews,” “aged 65+ years,” and “questionnaire.” The search yielded 194 references, of which 11 questionnaires fit the inclusion criteria; 6 of the 11 questionnaires did not have any stigma content and the content regarding stigma that was identified in the other five was very limited. A representative model of how stigma impacts continence difficulty interventions was proposed. While the 11 incontinence specific measurement tools that were assessed were well researched and designed specifically to measure the outcomes of incontinence interventions, they have not been used consistently or extensively and none of the measures thoroughly assess stigma. Further studies are required to examine how the stigma associated with continence difficulty impacts upon health care interventions.

scholarly journals Investigation of the Necessity of Urodynamic Test in Patients with Urinary Stress Incontinence for TOT Surgery

2020 ◽  
Vol 7 (1) ◽  
pp. 40-43
Author(s):  
Tahereh Poordast ◽  
Elham Askari ◽  
Fatemeh Sadat Najib ◽  
Shaghayegh Moradialamdarloo ◽  
Najmeh Naghizadeh
Keyword(s):  
Quality Of Life ◽  
Urinary Incontinence ◽  
Stress Incontinence ◽  
Transobturator Tape ◽  
Urinary Stress Incontinence ◽  
Additional Information ◽  
Urinary Tract Symptoms ◽  
The Mean ◽  
Lower Urinary

Background and aims: Stress urinary incontinence is one of the most common diseases which can reduce the quality of life in women. Urodynamic test is a common method of diagnosis of this disease. This study is designed for investigating the necessity of urodynamic test in patients with urinary stress incontinency before transobturator tape (TOT) surgery. Urodynamic test before surgery can affect the quality of life in patients. Methods: This study was a randomized clinical trial. The sample size was 48 patients divided into two groups of 24 women in January 2018. Women with urinary incontinence complaints were randomly divided into two groups. For the first group, the urodynamic test was done. Both groups were evaluated one month and six months after TOT surgery based on the results of the I-QOL questionnaire. Results: The mean I-QOL score was 83.9±3.3 in questionnaire group and 81.6±4.6 in urodynamic group one month after surgery with no statistically significant (P=0.052) difference. The quality of life score after 6 months was 87.2±4 in the questionnaire group and 85.4±3 in the urodynamic group with no statistically significant differences with each other (P=0.084). Conclusion: In this study, the urodynamic test only had additional information related to lower urinary tract symptoms and it did not have effects on improving the outcome of the surgery. The test only imposes economic burden. Therefore, the urodynamic test is not required before surgery in patients with urinary stress incontinence

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