scholarly journals Oxidative Stress and Reproductive Damage Induced by Lead Acetate in Female Guinea Pig (Cavia porcellus): Curative Effects of Hydroethanolic Extract of Spirulina platensis

2019 ◽  
Vol 14 (1) ◽  
pp. 69-77
Author(s):  
Deutcheu Nienga Sorelle ◽  
Ngoula Ferdinand ◽  
Manfo Tsague Faustin Pascal ◽  
Ngouateu Kenfack Omer Bebe ◽  
Mabou Nguemo Jasmine Laura ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Guinea Pig ◽  
Spirulina Platensis ◽  
Lead Acetate ◽  
Cavia Porcellus ◽  
Hydroethanolic Extract

scholarly journals Protective Effect of Ethanolic Extract of Spirulina platensis on Reproductive Characteristic and Biochemical Profile in Female Guinea Pig (Cavia porcellus) Exposed to Lead Acetate

2020 ◽  
pp. 37-46
Author(s):  
Deutcheu Nienga Sorelle ◽  
Ngoula Ferdinand ◽  
Tchoffo Herve ◽  
Mabou Nguemo Jeasmine Laura ◽  
Vemo Bertin Narcisse ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Guinea Pig ◽  
Spirulina Platensis ◽  
Guinea Pigs ◽  
Lead Acetate ◽  
Reproductive Function ◽  
Ethanolic Extract ◽  
Mature Female ◽  
Reproductive Characteristic ◽  
Reproductive Characteristics

The effect of ethanolic extract of Spirulina platensis (EESP) on reproductive function of female guinea pigs exposed to oxidative stress induced by lead acetate was explored. 60 mature female guinea pigs were used. They were divided into 6 groups of 10 guinea pigs each. For 3 months, pigs in Groups 1 were orally given distilled water daily; Group 2 were treated with lead; Group 3: received lead acetate and Vitamin C while Groups 4,5 and 6 were given lead acetate with 50, 100 and 200 mg of EESP/kg.bw respectively by gavage. At the end of trial (90 days), 6 female pigs per group were sacrificed and some reproductive characteristics, oxidative stress and hepatic toxicity markers were evaluated. Results revealed that, exposure to Lead acetate induced a significant decrease (p < 0.05) of fertility index, reproductive organs and hormone concentrations. It equally led to a significant (p < 0.05) decline of serum content in superoxide dismutase, catalase and total peroxidase activities. The reverse effect was noted in malondialdehyde concentration, hepatic and renal toxicity biomarkers. Histological examination of the ovaries of lead treated females revealed lesions and severe degenerative changes in the structures of the ovaries. However, the administration of ethanolic extract of Spirulina platensis to treated females alleviated the toxicity of reproductive function and oxidative damage induced by lead acetate. In conclusion, the exposure of animals to lead acetate had negative effects on guinea pig reproductive characteristics. The co-exposition to lead acetate and ethanolic extract of Spirulina platensis however, reestablishes normal reproductive characteristic values.

scholarly journals Effects of ethanol extract of Bersama engleriana leaves on oxidative stress and reproductive parameters in male Guinea pig (Cavia porcellus) exposed to cypermethrin

2018 ◽  
Vol 11 (5) ◽  
pp. 2243
Author(s):  
Bertin Narcisse Vemo ◽  
Augustave Kenfack ◽  
Ferdinand Ngoula ◽  
Edouard Akono Nantia ◽  
Norbert Kodjio ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Guinea Pig ◽  
Ethanol Extract ◽  
Cavia Porcellus ◽  
Reproductive Parameters

Design‐based stereological study of the guinea‐pig ( Cavia porcellus ) cerebellum

2021 ◽  
Author(s):  
Margherita De Silva ◽  
Javad Sadeghinezhad ◽  
Jens R. Nyengaard ◽  
Mahdi Aghabalazadeh Asl ◽  
Ava Saeidi ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Cavia Porcellus

Source and stability of attractive components in guinea pig (Cavia porcellus) urine

1973 ◽  
Vol 9 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Gary K. Beauchamp ◽  
Josef Berüter
Keyword(s):  
Guinea Pig ◽  
Cavia Porcellus

Facial reconstructive surgery after tumour removal in a guinea pig (Cavia porcellus)

2021 ◽  
Vol 26 (1) ◽  
pp. 1-4
Author(s):  
Anna Linda Nógrádi ◽  
Judit Kojer ◽  
Dóra Csatári ◽  
Iain Cope ◽  
Tibor Németh
Keyword(s):  
Guinea Pig ◽  
Reconstructive Surgery ◽  
Skin Flap ◽  
Advancement Flap ◽  
Cavia Porcellus ◽  
Post Surgery ◽  
Tumour Removal ◽  
Nerve Sheath ◽  
Peripheral Nerve Sheath Tumour ◽  
Made In

A 2-year-old male guinea pig (Cavia porcellus) presented with a pea-sized swelling on his right labium. The tumour was excised and reconstructive surgery was performed using a single pedicle advancement flap, leaving the bottom of the lip intact on account of it being essential for food apprehension and manipulation. Two parallel skin incisions were made in the rostrocaudal direction for almost half the length of the head and the resulting skin flap was carefully undermined, to avoid damaging the follicles and the muscles of the whiskers. The flap was carefully sutured over the excisional defect and at 1.5 months post-surgery, only a small residual scar remains. The lips are intact, the surgical site is covered with fur and many of the whiskers have regrown. Histopathology showed the excised mass to be a grade 1 soft tissue sarcoma, most likely a malignant peripheral nerve sheath tumour.

Effect of Vernonia cognata on oxidative damage induced by ethanol in rats

2010 ◽  
Vol 30 (7) ◽  
pp. 675-684 ◽  
Author(s):  
CS Mota ◽  
RB Freitas ◽  
ML Athayde ◽  
AA Boligon ◽  
PR Augusti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Performance ◽  
Tissue Injury ◽  
Antioxidant Effect ◽  
Gastric Tissue ◽  
Thiol Groups ◽  
Protein Thiol ◽  
Stress Markers ◽  
Hydroethanolic Extract ◽  
And Oxidative Stress

Free radicals production and oxidative stress play a central role in injuries caused by ethanol (EtOH) on gastric mucosal. Thus, strategies to counteract EtOH toxicity are highly desirable. This study was aimed at evaluating whether Vernonia cognata extract would reduce EtOH effects in rats. Rats received Vernonia cognata extract (0, 1 and 2 g/kg bw, by gavage) 1 hour after EtOH had been administered (0 or 70%, 0.5 mL/100 g bw, by gavage) and were killed 1 hour after Vernonia cognata extract administration. The stomach was removed for macroscopic and histopathological evaluation, as well as, oxidative stress markers such as lipoperoxidation (LPO) and non-protein thiol groups (NPSH) levels and catalase (CAT) activity. EtOH acute exposure increased LPO and decreased NPSH levels and CAT activity along with macroscopic and microscopic lesions in gastric tissue, confirming the involvement of oxidative stress in EtOH toxicity. Vernonia cognata extract attenuated oxidative and histopathological features induced by EtOH at all evaluated doses. Moreover, both studied doses of Vernonia cognata extract caused an increase in NPSH levels per se. However, only the dose of 2 g/kg reverted all macroscopic changes caused by EtOH toxicity. The protective effect of the extract could be attributed to antioxidant molecules present in the extract, such as flavonoids and phenolic acids, which were quantified by high performance liquid chromatography (HPLC). Thus, an antioxidant effect of the extract leads to a protection on gastric tissue. Our results indicate that Vernonia cognata hydroethanolic extract could have a beneficial role against EtOH toxicity by preventing oxidative stress and gastric tissue injury.

Control of the estrous cycle in guinea-pig (Cavia porcellus)

2012 ◽  
Vol 78 (4) ◽  
pp. 842-847 ◽  
Author(s):  
A. Grégoire ◽  
A. Allard ◽  
E. Huamán ◽  
S. León ◽  
R.M. Silva ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Estrous Cycle ◽  
Cavia Porcellus

Acute lead exposure induces renal haeme oxygenase-1 and decreases urinary Na excretion

2003 ◽  
Vol 22 (5) ◽  
pp. 237-244 ◽  
Author(s):  
Hilda Vargas ◽  
Carlos Castillo ◽  
Francisco Posadas ◽  
Bruno Escalante
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Renal Function ◽  
Lead Exposure ◽  
Lead Acetate ◽  
Single Injection ◽  
Rat Kidney ◽  
Kidney Cortex ◽  
Tin Protoporphyrin ◽  
Pb Exposure

The effects of acute lead exposure on renal function, lipid peroxidation and the expression of haeme oxygenase (HO) in rat kidney were determined. A single injection of lead acetate (50 mg Pb/kg) was given to rats. Changes in renal function, characterized by a significant reduction in the Na excretion was observed six hours after Pb exposure; this effect persisted for 24 hours. TBARS levels increased in kidney cortex 24 hours after Pb administration. In kidney cortex, Pb exposure affected the expression of HO-1, a renal protein associated with oxidative stress. HO-1 mRNA increased 2.3-fold, three hours after Pb administration and remained increased for six, 12 and 24 hours. HO enzymatic activity and HO-1 protein increased six and three hours after Pb administration, respectively, and remained increased at 24 hours. HO inhibition by tin-protoporphyrin, potentiated Pb-induced increase in TBARS and prevented the Pb-induced reduction in Na excretion. Our data suggest that Pb may be acting through the generation of oxidant products and induction of HO.

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