Revised central nervous system neuropenetration-effectiveness score is associated with cognitive disorders in HIV-infected patients with controlled plasma viraemia

2013 ◽  
Vol 18 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Nicoletta Ciccarelli ◽  
Massimiliano Fabbiani ◽  
Manuela Colafigli ◽  
Enrico Maria Trecarichi ◽  
Maria Caterina Silveri ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cognitive Disorders ◽  
Plasma Viraemia

Homocysteine and cognitive disorders of postmenopausal women measured by a battery of computer tests—central nervous system vital signs

2015 ◽  
Vol 18 (4) ◽  
pp. 623-630 ◽  
Author(s):  
Grzegorz Raszewski ◽  
Małgorzata Loroch ◽  
Alfred Owoc ◽  
Krzysztof Łukawski ◽  
Rafał Filip ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Postmenopausal Women ◽  
Vital Signs ◽  
Cognitive Disorders

Hypothyroidism and Cognitive Disorders during Development and Adulthood: Implications in the Central Nervous System

2018 ◽  
Vol 56 (4) ◽  
pp. 2952-2963 ◽  
Author(s):  
Paulina Salazar ◽  
Pedro Cisternas ◽  
Milka Martinez ◽  
Nibaldo C. Inestrosa
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cognitive Disorders ◽  
The Central Nervous System

CLINICAL PARALLELS IN INFECTIOUS DISEASES OF THE CENTRAL NERVOUS SYSTEM IN PATIENTS WITH HIV

2020 ◽  
pp. 83-87
Author(s):  
K. Yu. Lytvyn ◽  
L. R. Shostakovych-Koretska ◽  
Z. O. Chykarenko ◽  
O. A. Kushnierova ◽  
I. V. Budaeva ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Hiv Infection ◽  
Cranial Nerve ◽  
Opportunistic Infections ◽  
Cranial Nerves ◽  
Clinical Manifestations ◽  
Cognitive Disorders ◽  
Speech Disorders ◽  
The Central Nervous System

A retrospective analysis of medical records of 451 patients with HIV infection showed that the most common clinical manifestations of cerebral tuberculosis are as follows: headache, fever ≥ 38.0 °C, meningeal symptoms; in toxoplasmosis encephalitis these are headache, paresis of cranial nerves and extremities, incoordination, cognitive disorders, dysarthria, fever ≥ 38.0 °C and convulsions; in mycotic lesions of the CNS they are headache, coordination disorders, positive meningeal symptoms, disturbances of consciousness, cognitive disorders, visual disorders, cranial nerve deficiency, convulsions and dysarthria. The clinical picture of bacterial (exacted) meningitis was dominated by positive meningeal symptoms, headache, fever, impaired consciousness. At the same time, in such neurological manifestations of central nervous system lesions as cranial nerve paresis, mono− and hemiparesis, visual, coordination and speech disorders, which mostly accompany cerebral toxoplasmosis, cerebrovascular diseases, brain tumors, encephalitis of unspecified etiology. Thus, the analysis suggests that the clinical manifestations of various etiologies of lesions of the central nervous system are often nonspecific and probably are stipulated with common morphological changes in brain tissue, which may be associated with the neuropathological effects of HIV, as well as a large impact co−infection. Key words: HIV infection, opportunistic infections, central nervous system, main symptoms.

scholarly journals The role of acetylcholine neurotransmission in the pharmacotherapy of cognitive dysfunction

2018 ◽  
pp. 90-96 ◽  
Author(s):  
D. V. Zaharov ◽  
V. A. Mihailov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Cortex ◽  
Clinical Studies ◽  
Cholinergic System ◽  
Cognitive Disorders ◽  
Cognitive Disorder ◽  
The Central Nervous System ◽  
Organic Lesions

Microangiopathy and deficit in cholinergic system innervating cerebral cortex and controlling the plasticity of neuronal structuresplay an important role in the formation of cognitive disorders. The main approaches to the therapy of dementia and organic lesions followed by cognitive disorder are based on the hypothesis of replenishment of acetylcholine. Choline alfoscerate takes a special place among the precursors of choline due to its proven effectiveness in the treatment of ischemic and neurodegenerative lesions of the central nervous system. The article presents the materials of experimental and clinical studies of the drug choline alfostserat (Gliatilin).

scholarly journals THE POLYPEPTIDE STIMULATOR APPLICATION IN COMPLEX TREATMENT OF COGNITIVE DISORDERS IN CHILDREN WITH DISEASES OF THE CENTRAL NERVOUS SYSTEM

2012 ◽  
Vol 9 (5) ◽  
pp. 80 ◽  
Author(s):  
S. A. Nemkova ◽  
O. I. Maslova ◽  
G. A. Karkashadze ◽  
Y. N. Kurbatov ◽  
I. V. Podkorytova
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cognitive Disorders ◽  
Complex Treatment ◽  
The Central Nervous System

scholarly journals Multiple Sclerosis and Evaluation of Vitamin D Effect

2019 ◽  
pp. 1-15
Author(s):  
Zahra Eslamifar ◽  
Behnaz Deihim ◽  
Reza Ghaffaripour
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Vitamin D ◽  
Nervous System ◽  
Common Ground ◽  
Inflammatory Diseases ◽  
Cognitive Disorders ◽  
Definitive Treatment ◽  
Disease Modifying Drugs ◽  
The Central Nervous System

Multiple sclerosis is an autoimmune disease of the central nervous system with symptoms of neurodegenerative diseases. The symptoms vary depending on damage location. Some of the symptoms include cognitive disorders, anxiety and depression, visual impairment, respiratory, speech and swallowing disorders, muscle spasm and fatigue. Due to the lack of a definitive treatment method, various therapeutic approaches are proposed to control the disease. Drugs are classified into attack control drugs, complication control drugs and disease-modifying drugs. Vitamin D is a hormone-like steroidal compound with immune modulatory and anti-inflammatory properties. Vitamin D deficiency is associated with a variety of inflammatory, neurologic and autoimmune diseases. Many studies on patients as well as experimental autoimmune encephalomyelitis studies have shown that the administration of vitamin D reduces inflammation in inflammatory diseases of the central nervous system. As argued, vitamin D level was significantly lower in MS compared to healthy subjects as controls.  Also, a higher level of vitamin D is reported in relapsing-remitting MS patients compared to patients with progressive MS. It is observed that higher serum levels of vitamin D can reduce the severity of symptoms, progress, and also delays the relapses. Few studies considered vitamin D to be ineffective in stopping or inhibition the disease. Despite the controversies concerning the role of vitamin D in MS progress, there is a lot of interest in further research in this regard with the hope of reaching a common ground. Therefore, frequent reviews of past and recent studies are essential to achieve the same results.

Neurotropic enteroviruses co-opt “fair-weather-friend” commensal gut microbiota to drive host infection and central nervous system disturbances

2019 ◽  
Vol 42 ◽  
Author(s):  
Kevin B. Clark
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gut Bacteria ◽  
Infection Cycle ◽  
Fair Weather ◽  
Host Health ◽  
Microbe Interactions ◽  
Animal Hosts ◽  
Host Infection ◽  
Neuropsychiatric Conditions

Abstract Some neurotropic enteroviruses hijack Trojan horse/raft commensal gut bacteria to render devastating biomimicking cryptic attacks on human/animal hosts. Such virus-microbe interactions manipulate hosts’ gut-brain axes with accompanying infection-cycle-optimizing central nervous system (CNS) disturbances, including severe neurodevelopmental, neuromotor, and neuropsychiatric conditions. Co-opted bacteria thus indirectly influence host health, development, behavior, and mind as possible “fair-weather-friend” symbionts, switching from commensal to context-dependent pathogen-like strategies benefiting gut-bacteria fitness.

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