scholarly journals Comparison of Quantiferon-TB Gold and TST tests in the diagnosis of latent tuberculosis infection among HIV infected patients in Hamadan, west of Iran

2020 ◽  
Vol 14 (04) ◽  
pp. 360-365
Author(s):  
Fariba Keramat ◽  
Benyamin Bagheri Delavar ◽  
Alireza Zamani ◽  
Jalal Poorolajal ◽  
Elham Lajevardi ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Latent Tuberculosis Infection ◽  
Demographic Data ◽  
Clinical Manifestations ◽  
Latent Tuberculosis ◽  
Cd4 Count ◽  
Tuberculosis Infection ◽  
Percent Agreement ◽  
Immunodeficiency Virus ◽  
The Mean

Introduction: Human immunodeficiency virus (HIV) infection increases the susceptibility of patients for latent tuberculosis infection (LTBI) and reactivtion tuberculosis. This study aimed to compare the Quantiferon-TB gold-in tube test (QFT) with tuberculin skin test (TST) in the diagnosis of LTBI in HIV infected patients. Methodology: This comparative study of 89 patients with HIV in the Behavioral Diseases Counseling Center in Hamadan was carried out from July 2015 to November 2016. After obtaining consent from the patients, all demographic data, clinical manifestations, and laboratory results (CD4 count, TST and QFT) were entered into the questionnaires. The CD4 count is usually routinely performed using flow cytometry at the Behavioral Counselling Center. Quantiferon-TB test was done by using Qiagen – Quantiferon-2 plate kit ELISA. Results: Totally, 89 HIV infected patients with the mean age of 39.55 ± 10.31 years old were enrolled in the study. Sixty patients (67.42%) were male. The mean duration of HIV infection was 4.44 ± 3.88 years and the mean of CD4 count was 388.65 ± 260.66 cells/µL . Twenty patients had LTBI based on TST. Considering the QFT intermediate results as a positive test, the percent agreement of QFT and TST was 59.55%, which was not statistically significant (P = 0.2387). Conclusions: According to the results, there was no significant percent agreement between QFT and TST for detecting LTBI in HIV infected patients. However, by decreasing CD4 counts, there was a significant relation between TST positive and LTBI in HIV patients.

scholarly journals Higher Levels of Alcohol Use Are Associated With Latent Tuberculosis Infection in Adults Living With Human Immunodeficiency Virus

2020 ◽  
Author(s):  
Sarah B Puryear ◽  
Robin Fatch ◽  
Brian Beesiga ◽  
Allen Kekibiina ◽  
Sara Lodi ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Alcohol Use ◽  
Latent Tuberculosis Infection ◽  
Multivariable Analysis ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Hazardous Alcohol Use ◽  
Immunodeficiency Virus ◽  
Hazardous Alcohol ◽  
Very High

Abstract We assessed associations between hazardous alcohol use and latent tuberculosis infection (LTBI) among adults living with human immunodeficiency virus (HIV) in Uganda. We compared tuberculin skin test positivity across medium, high, and very-high alcohol use levels, classified by AUDIT-C scores. In multivariable analysis, very high use was associated with LTBI (adjusted odds ratio 1.61, 95% confidence interval: 1.03–2.50).

Cost-effectiveness of testing for latent tuberculosis infection in people living with human immunodeficiency virus

AIDS ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Peter E. Auguste ◽  
Hema Mistry ◽  
Noel D. McCarthy ◽  
Paul A. Sutcliffe ◽  
Aileen E. Clarke
Keyword(s):  
Human Immunodeficiency Virus ◽  
Cost Effectiveness ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Immunodeficiency Virus

Tuberculosis in healthcare workers, Scotland

2017 ◽  
Vol 62 (3) ◽  
pp. 101-103 ◽  
Author(s):  
Kevin G Pollock ◽  
Eisin McDonald ◽  
Alison Smith-Palmer ◽  
Fiona Johnston ◽  
Syed Ahmed
Keyword(s):  
Incidence Rate ◽  
Healthcare Workers ◽  
Latent Tuberculosis Infection ◽  
Screening Programme ◽  
Latent Tuberculosis ◽  
Mycobacterial Infection ◽  
Population Based ◽  
Tuberculosis Infection ◽  
The Mean ◽  
The Uk

In an attempt to explore healthcare worker acquisition of tuberculosis infection, we conducted population-based surveillance of all cases recorded as healthcare workers reported to Enhanced Surveillance of Mycobacterial Infection from 2000 to 2015. Over the study period, the mean incidence rate of tuberculosis among all healthcare workers was 15.4 per 100,000 healthcare workers. However, the incidence rate of tuberculosis amongst those healthcare workers born outside the UK was 164.8 per 100,000 compared with 5.0 per 100,000 UK-born healthcare workers. Fifty-seven per cent of all non-UK-born healthcare workers were diagnosed within five years of their arrival in the UK and would have been new entrants to the NHS. An effective new entrant occupational health screening programme for latent tuberculosis infection may have prevented some of these active cases of infection.

scholarly journals Prevalence of latent tuberculosis infection and risk of infection in patients with chronic kidney disease undergoing hemodialysis in a referral center in Brazil

2013 ◽  
Vol 39 (2) ◽  
pp. 214-220 ◽  
Author(s):  
Jane Corrêa Fonseca ◽  
Waleska Teixeira Caiaffa ◽  
Mery Natali Silva Abreu ◽  
Katia de Paula Farah ◽  
Wânia da Silva Carvalho ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Skin Tests ◽  
Risk Of Infection ◽  
The Mean ◽  
Annual Risk ◽  
Booster Effect

OBJECTIVE: To determine the prevalence of latent tuberculosis infection (LTBI) and the risk of infection in patients with chronic kidney disease treated at a hemodialysis center. METHODS: We included 307 patients with chronic kidney disease undergoing hemodialysis at the Mineiro Institute of Nephrology, located in the city of Belo Horizonte, Brazil. All of the patients were submitted to tuberculin skin tests (TSTs). We investigated the booster effect and TST conversion. If the initial TST (TST1) was negative, a second TST (TST2) was performed 1-3 weeks later in order to investigate the booster effect. If TST2 was also negative, a third TST (TST3) was performed one year after TST2 in order to determine whether there was TST conversion. RESULTS: When we adopted a cut-off induration of 5 mm, the prevalence of LTBI was 22.2% on TST1, increasing by 11.2% on TST2. When we adopted a cut-off induration of 10 mm, the prevalence of LTBI was 28.5% on TST1, increasing by 9.4% on TST2. The prevalence of LTBI increased significantly from TST1 to TST2 (booster effect), as well as from TST2 to TST3 (p < 0.01 for both). In our sample, the mean annual risk of infection was 1.19%. CONCLUSIONS: In the population studied, the prevalence of LTBI was high, and the mean annual risk of infection was similar to that reported for the general population of Brazil, which suggests recent infection.

scholarly journals Prevalence of Latent Tuberculosis Infection (LTBI) among Health Care Workers at Al-Thawrah Modern General Hospital, Sana’a-Yemen 2016

2019 ◽  
pp. 1-5
Author(s):  
Askar Faiza ◽  
Alaghbari Khaled ◽  
Bamashmus Mohammed ◽  
Alselwi Abdalhafed
Keyword(s):  
Health Care ◽  
General Hospital ◽  
Health Care Workers ◽  
Latent Tuberculosis Infection ◽  
Health Workers ◽  
Demographic Data ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Mantoux Test ◽  
Care Workers

Objective: To determine the prevalence of latent tuberculosis infection among Healthcare Workers (HCWs) in Al- Thawra Modern General Hospital. Methods: We carried out cross sectional study to determine the prevalence of Latent Tuberculosis Infection (LTBI) among HCW. Two-steps Tuberculin Skin Test (TST) was performed among health care workers (HCWs) in Al -Thawra Modern General Hospital (TMGH) Sana'a- Yemen during the year 2016. We included all health care workers in the hospital. Out of 466 total HCWs 426 were fulfilled the inclusion criteria. Questionnaire was distributed to HCWs and information related to demographic data, profession, and duration of work, individual and in the family history of Tuberculosis (TB) was recorded. TST was done by a single investigator using the standard Mantoux test. The reaction was read 48 to 72 hours after injection, and the widest axis of indurations was measured by a standardized palpation method. Those with negative result were advised to come, after1- 2 weeks for second step TST. Results: The total number of health workers in the hospital were 466, Eligible cases who fulfilled the including criteria were 426. The remaining either excluded or not present at the time of study. Of them 232 (54.5%) were males and 194 (45.5 %), were females with a ratio of 1.2:1.269 (70%) were positive for TST. The positive result was highest among radiology assistant and laboratory worker represented 91%, 80% respectively, while 76% of doctors found positive for TST. There was an increase in TST reactivity with an older age, and there is a positive correlation between work duration and TST reaction. Conclusion: Latent tuberculosis infection is prominent among HCW who work in high-risk departments. This suggests that some TBI develops via in-hospital infection

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