Risk Factors for Wound Infection in Colorectal Cancer Surgery

Purpose: The impact of postoperative complications on long-term oncologic outcome after radical colorectal cancer surgery is controversial. The aim of this study was to examine the risk factors and oncologic outcomes of surgery-related postoperative complication groups.Methods: From January 2010 to December 2010, 310 patients experienced surgery-related postoperative complications after radical colorectal cancer surgery. These stage I–III patients were classified into 2 subgroups, minor (grades I, II) and major (grades III, IV) complication groups, according to extended Clavien-Dindo classification system criteria. Clinicopathologic differences between the 2 groups were analyzed to identify risk factors for major complications. The diseasefree survival rates of surgery-related postoperative complication groups were also compared.Results: Minor and major complication groups were stratified with 194 patients (62.6%) and 116 patients (37.4%), respectively. The risk factors influencing the major complication group were pathologic N category and operative method. The prognostic factors associated with disease-free survival were preoperative perforation, perineural invasion, tumor budding, and receiving neoadjuvant therapy. With a median follow-up period of 72.2 months, the 5-year disease-free survival rates were 84.4% in the minor group and 78.5% in the major group, but there was no statistical significance between the minor and major groups (P = 0.392).Conclusion: Advanced cancer and open surgery were identified as risk factors for increased surgery-related major complications after radical colorectal cancer surgery. However, severity of postoperative complications did not affect disease-free survival from colorectal cancer.

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Chylous ascites after colorectal cancer surgery: risk factors and impact on short-term and long-term outcomes

Langenbeck s Archives of Surgery ◽

10.1007/s00423-016-1500-6 ◽

2016 ◽

Vol 401 (8) ◽

pp. 1171-1177 ◽

Cited By ~ 1

Author(s):

Soo Young Lee ◽

Chang Hyun Kim ◽

Young Jin Kim ◽

Hyeong Rok Kim

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Chylous Ascites ◽

Cancer Surgery ◽

Long Term Outcomes ◽

Short Term ◽

Colorectal Cancer Surgery

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Risk factors for postoperative ileus after colorectal cancer surgery: methodological issues

Colorectal Disease ◽

10.1111/codi.14043 ◽

2018 ◽

Vol 20 (4) ◽

pp. 351-352

Author(s):

J. Weng ◽

H. Wu ◽

Z. Wang

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Postoperative Ileus ◽

Cancer Surgery ◽

Methodological Issues ◽

Colorectal Cancer Surgery

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Morbidity and mortality after colorectal cancer surgery in patients with cirrhosis: A critical review of the literature.

Journal of Clinical Oncology ◽

10.1200/jco.2014.32.3_suppl.608 ◽

2014 ◽

Vol 32 (3_suppl) ◽

pp. 608-608

Author(s):

Tarek Boussaha ◽

Jean François Cadranel ◽

Allaoua Smail ◽

Hortensia Lison ◽

Armand Garioud ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Colorectal Surgery ◽

Postoperative Morbidity ◽

Cancer Surgery ◽

Morbidity And Mortality ◽

Colorectal Cancer Surgery ◽

Increased Risk ◽

Cirrhotic Patients ◽

Independent Risk Factors

608 Background: Cirrhotic patients with localized colorectal cancer are potential candidates for tumor resection. The aim of this review was to evaluate the morbi-mortality after colorectal surgery. Methods: Comprehensive search was conducted using PUBMED, EMBASE, and the COCHRANE Library. Prospective and retrospective studies were selected. The study population included cirrhotic patients who underwent colorectal resection for non-metastatic colorectal cancer and patients with benign and other malignant disease. The postoperative morbi-mortality and independent risk factors were analysed. Results: Eight studies were identified. Among these, four studies compared the risk of colorectal surgery in patients with and without liver cirrhosis. The number of patients varied from 41 to 6,120. The severity of cirrhosis in most of the studies was classified with the Child-Pugh score. Class B and C were observed in 20% to 60% of the patients. Sepsis represented the main postoperative complication and occurred in 48% to 77% of patients. Mortality varied according to the Child-Pugh score, ranging from 11% to 41%, and was significantly higher for patients with cirrhosis in Child-Pugh Class C. Urgent surgical procedure had a negative impact on prognosis. The average length of hospital stay ranged from 9 to 18 days. Cirrhosis was associated with a 2-3 time and a 4-10 time increased risk of postoperative mortality in the absence and presence of portal hypertension, respectively compared with non-cirrhotic patients. The independent risk factors for postoperative morbidity and mortality were encephalopathy, ascites, low haemoglobin, prolonged prothrombin time, elevated bilirubin, hypoalbuminemia, postoperative infection, total colectomy, elective or non-elective surgery, the presence of co-morbidities and MELD score ≥ 15. Conclusions: Colorectal cancer surgery is associated with an increased risk of postoperative morbidity and mortality in cirrhosis patients. Studies evaluating exclusively the operative risk for colorectal cancer surgery in this patient’s population are rare. Prospective controlled trials to optimize the perioperative management of those patients are needed.

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