scholarly journals Comparative Hepatotoxicity of Aflatoxin B1 among Workers Exposed to Different Organic Dust with Emphasis on Polymorphism Role of Glutathione S-Transferase Gene

2016 ◽  
Vol 4 (2) ◽  
pp. 312-318 ◽  
Author(s):  
Amal Saad-Hussein ◽  
Eman M. Shahy ◽  
Weam Shaheen ◽  
Mona M. Taha ◽  
Heba Mahdy-Abdallah ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Aflatoxin B1 ◽  
Liver Enzymes ◽  
Dust Exposure ◽  
Organic Dust ◽  
Glutathione S Transferase ◽  
Exposed Workers ◽  
Sawmill Workers ◽  
Gst Polymorphism

AIM: The study aimed to investigate effects of organic dust exposure from different sources on aflatoxin B1-albumin adducts (AFB1/Alb), and role of glutathione S-transferase (GST) gene polymorphism in hepatotoxicity of (AFB1) among exposed workers. MATERIAL AND METHODS: Liver enzymes, AFB1/Alb, and GST polymorphism were estimated in 132 wheat flour dust and 87 woods sawmill workers, and 156 controls.RESULTS: Results revealed that AFB1/Alb and liver enzymes were significantly elevated in exposed workers compared to controls, and were significantly higher in sawmill workers compared to flour workers. AFB1/Alb in flour and sawmill workers with GSTT1 and GSTM1&GSTT1 null genotypes were significantly higher than controls, and in sawmill workers with GSTM1&GSTT1 null than flour workers. Liver enzymes (ALT and AST) in sawmill workers were significantly higher than flour workers and controls in all GST polymorphism; except in GSTT1 polymorphism, where these enzymes were significantly higher in the two exposed groups than controls.CONCLUSIONS: In conclusion, organic dust exposure may cause elevation in AFB1/Alb and liver enzymes of exposed workers, and GST gene polymorphism plays an important role in susceptibility to hepatic parenchymal cell injury; except in workers with GSTT1&GSTM1 null genotype, gene susceptibility seemed to have little role and the main role was for environmental exposures.

scholarly journals Role of Glutathione S Transferase M1 and T1 Gene Polymorphism in Hepatitis B Related Liver Diseases and Cryptogenic Cirrhosis

2018 ◽  
Vol 8 (2) ◽  
pp. 169-172 ◽  
Author(s):  
Siddharth Kapahtia ◽  
Rajib K. Hazam ◽  
Mohammad Asim ◽  
Vijay K. Karra ◽  
Soumya J. Chowdhury ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Gene Polymorphism ◽  
Liver Diseases ◽  
Glutathione S Transferase ◽  
Cryptogenic Cirrhosis ◽  
T1 Gene

Role of Glutathione S Transferase M1 and T1 Gene Polymorphism in Hepatitis B-Related Liver Diseases and Cryptogenic Cirrhosis

2017 ◽  
Vol 112 ◽  
pp. S575-S576 ◽  
Author(s):  
Siddharth Kapahtia ◽  
Rajib Hazam ◽  
Mohammad Asim ◽  
Vijay Karra ◽  
Soumya Chowdhury ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Gene Polymorphism ◽  
Liver Diseases ◽  
Glutathione S Transferase ◽  
Cryptogenic Cirrhosis ◽  
T1 Gene

scholarly journals Role of glutathione S-transferase P-1 (GSTP-1) gene polymorphism in COPD patients

2016 ◽  
Vol 65 (4) ◽  
pp. 739-744 ◽  
Author(s):  
Tarek F. El-Gazzar ◽  
Samy S. El-dahdouh ◽  
Ibrahim I. El-Mahalawy ◽  
Hisham E. Abd El-aty ◽  
Safaa I. Tayel
Keyword(s):  
Gene Polymorphism ◽  
Glutathione S Transferase ◽  
Copd Patients

scholarly journals Oxidative Role of Aflatoxin B1 on the Liver of Wheat Milling Workers

2014 ◽  
Vol 2 (1) ◽  
pp. 141-146 ◽  
Author(s):  
Amal Saad-Hussein ◽  
Mohgah Sh. Abdalla ◽  
Wafaa Gh. Shousha ◽  
Gehan Moubarz ◽  
Aya H. Mohamed
Keyword(s):  
Oxidative Stress ◽  
Statistical Analysis ◽  
Vitamin C ◽  
Aflatoxin B1 ◽  
Crucial Role ◽  
Case Control Study ◽  
Liver Enzymes ◽  
Case Control ◽  
Control Study

Aim: The study aimed to estimate oxidative role of aflatoxin B1 (AFB1) on the liver in wheat milling workers. Materials and Methods: Case-control study was conducted to compare between the levels of AFB1/albumin (AFB1/alb), liver enzymes (ALT, AST, GGT, and ALP), P53, MDA, GST, SOD, zinc and vitamin C in 35 wheat milling workers and 40 control subjects. Results: Statistical analysis revealed that ALT, AST, GGT, ALP, P53, MDA, GST and SOD in workers were significantly elevated compared to their controls. In the milling workers, there were significant correlations between MDA levels and the levels of AST, GGT, and P53, while, P53 was inversely correlated with GST and SOD activities. There were significant correlations between Zn levels and GGT, GST and SOD activities, between vitamin C and GST activities, and vitamin C inversely correlated with MDA. Conclusion: The present study concluded that the oxidative stress of AFB1 elevated the MDA and the liver enzymes in wheat milling workers. GST has a crucial role in the detoxification of aflatoxin and SOD as a scavenger antioxidant increased in the workers to overcome the oxidative toxic effects of AFB1 on the liver of the workers, and roles of Zn and vitamin C were significant in activation of these processes.

Role of glutathione S-transferase (GSTM1) gene polymorphism in development of uterine fibroids

2009 ◽  
Vol 91 (4) ◽  
pp. 1496-1498 ◽  
Author(s):  
Emerson de Oliveira ◽  
Rodrigo de Aquino Castro ◽  
Mariano Tamura Vieira Gomes ◽  
Ismael Dale Cotrim Guerreiro da Silva ◽  
Edmund Chada Baracat ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Uterine Fibroids ◽  
Glutathione S Transferase ◽  
Gstm1 Gene

Role of antioxidant supplementation in oxidant/antioxidant status and hepatotoxic effects due to aflatoxin B1 in wheat miller workers

2019 ◽  
Vol 16 (4) ◽  
Author(s):  
Amal Saad-Hussein ◽  
Gehan Moubarz ◽  
Sh. Abdalla Mohgah ◽  
Gh. Shousha Wafaa ◽  
H. Mohamed Aya
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Aflatoxin B1 ◽  
Antioxidant Status ◽  
Liver Enzymes ◽  
P53 Protein ◽  
Oral Supplementation ◽  
Group I ◽  
Ameliorative Effect

Abstract Background Aflatoxin B1 (AFB1) is classified as a Group I carcinogen. A Previous study found that oxidative stress from the metabolism of AFB1 induced hepatotoxic effects in wheat miller workers. Zinc and vitamin C may play a significant role in the activation of detoxification and overcoming the oxidative stress of AFB1. Objectives A prospective clinical trial was designed to evaluate the role of zinc and vitamin C oral supplementation on the oxidant-antioxidant status and the hepatotoxic effects of AFB1 in wheat miller workers. Methods Liver enzymes (ALT, AST, ALP, and GGT), P53 protein, malondialdehyde (MDA), glutathione S transferase (GST), Superoxide dismutase (SOD), zinc and vitamin C were estimated in 35 wheat miller workers before and after zinc and vitamin C supplementation for 1 month. Results The results revealed that zinc and vitamin C were significantly increased after the one-month supplementation, while liver enzymes (AST, ALP, and GGT), MDA, and GST of the workers were significantly decreased. SOD and P53 were also decreased but not to a significant level; SOD was decreased in 56% and P53 was decreased in 58% of the total workers. Conclusions Zinc and vitamin C oral supplementation for 1 month had an ameliorative effect on the hepatotoxicity of AFB1 in wheat miller workers, through decreasing MDA, SOD, and GST levels that in turn led to an improvement in their liver enzymes. Further study on a larger scale is needed to confirm these results.

Sign in / Sign up

Export Citation Format

Share Document