The Effect of Local Pharmacological Agents in Acceleration of Orthodontic Tooth Movement: A Systematic Review

AIM: Acceleration of orthodontic tooth movement has gained a massive interest to decrease the total treatment time. Local pharmacological agents might be used for that purpose as a practical, effective and inexpensive alternative. A systematic review was achieved to evaluate the evidence in that topic. METHODS: A search was conducted on electronic databases including PubMed, Lilacs, Web of Science (Thompson Reuters), EMBASE (OvidSP), and Cochrane Database of Systematic Reviews (Wiley) in addition to hand searching of relevant journals till June 2018. Only studies written in English were utilised. Publications were selected, assessed systematically and graded by two observers according to Bondemark grading system. RESULTS: Only two human studies were found investigating the effect of Relaxin and Prostaglandins in the rate of orthodontic tooth movement. No obvious side effects were reported. Relaxin showed no increase in the rate of tooth movement while prostaglandin showed a marked increase in the rate of orthodontic tooth movement. CONCLUSION: There is below moderate evidence showing no effect of relaxin on orthodontic tooth movement, while inconclusive evidence was found regarding Prostaglandin in the acceleration of orthodontic tooth movement. More prospective well-conducted clinical trials are needed to reach a proper conclusion regarding the local pharmacological agents which can be safely used to accelerate orthodontic tooth movement.

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Surgical Methods for Accelerating Orthodontic Tooth Movement

Orthodontic Update ◽

10.12968/ortu.2020.13.4.170 ◽

2020 ◽

Vol 13 (4) ◽

pp. 170-179

Author(s):

Aman Ulhaq ◽

Emma McCrory ◽

Eleni Besi

Keyword(s):

Tooth Movement ◽

Treatment Time ◽

Orthodontic Tooth Movement ◽

Adverse Outcomes ◽

Current Evidence ◽

Surgical Interventions ◽

Future Studies ◽

Total Treatment Time ◽

Surgical Methods ◽

Total Treatment

The ability to consistently reduce orthodontic treatment time without adverse outcomes would be an attractive prospect. Several surgical interventions have been described aimed at accelerating orthodontic tooth movement. The aim of this review is to identify and evaluate the current evidence available for surgically-assisted orthodontic tooth movement (OTM). The current evidence suggests that surgical procedures may increase the rate of tooth movement, however, this effect is short lived. Further reporting on total treatment time, and patient centred outcomes, would be beneficial in future studies. CPD/Clinical Relevance: To explain surgical methods for accelerating orthodontic tooth movement.

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Surgery-first Approach

World Journal of Dentistry ◽

10.5005/jp-journals-10015-1462 ◽

2017 ◽

Vol 8 (4) ◽

pp. 343-350

Author(s):

Yash A Shah ◽

Shailesh V Deshmukh ◽

Amol S Patil

Keyword(s):

Orthognathic Surgery ◽

Tooth Movement ◽

Treatment Time ◽

Orthodontic Tooth Movement ◽

Conventional Approach ◽

Treatment Protocols ◽

Orthodontic Therapy ◽

Total Treatment Time ◽

Total Treatment ◽

Surgery First

ABSTRACT Aim This article is intended to provide an overview of the Surgery First Approach (SFA) mainly including case selection, diagnosis, treatment protocols, success rate and the potential problems encountered. Background The most important indication of the need for orthognathic surgery is usually the psychosocial effect resulting from the unaesthetic appearance of a dentofacial deformity. The conventional approach in treatment of such deformities till today has been an orthodontics-first approach. Review Results Available evidence suggest that both the SFA and the conventional approach had similar outcomes in dentofacial relationships however the relapse tendency was greater with the SFA but the total treatment duration was substantially shorter. Conclusion SFA treats facial aesthetics (and the skeletal malrelation) first and then occlusion, i.e. orthognathic surgery antecedes the orthodontic therapy. The concept of this technique is to utilize orthognathic surgery to eliminate the displeasing pre-surgical facial profile and promptly accomplish facial aesthetic enhancement that is usually the patient's chief complaint at the beginning of the treatment. SFA also facilitates accelerated orthodontic tooth movement thus reducing the length of post-surgical orthodontic therapy. Clinical Significance The optimal esthetic and functional results, significant reduction in total treatment time and high patient satisfaction led us to the postulation that SFA may represent a reasonable, cost-effective method to manage skeletal malocclusions in selected cases and that it has the potential to become a standard approach to orthognathic surgery in the future. How to cite this article Shah YA, Deshmukh SV, Patil AS. Surgery-first Approach. World J Dent 2017;8(4):343-350.

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Impact of Vibration on the Levels of Biomarkers: A Systematic Review

The Journal of Indian Orthodontic Society ◽

10.1177/03015742211019520 ◽

2021 ◽

pp. 030157422110195

Author(s):

Ashish Agrawal ◽

TM Chou

Keyword(s):

Systematic Review ◽

Web Of Science ◽

Tooth Movement ◽

Orthodontic Tooth Movement ◽

Cochrane Collaboration ◽

Risk Of Bias ◽

Cochrane Library ◽

Inclusion Criteria ◽

Electronic Search ◽

Proquest Dissertation

Introduction: The objective of this systematic review is to assess the effect of vibrational force on biomarkers for orthodontic tooth movement. Methods: An electronic search was conducted for relevant studies (up to December 31, 2020) on the following databases: Pubmed, Google scholar, Web of Science, Cochrane Library, Wiley Library, and ProQuest Dissertation Abstracts and Thesis database. Hand searching of selected orthodontic journals was also undertaken. The selected studies were assessed for the risk of bias in Cochrane collaboration risk of bias tool. The “traffic plot” and “weighted plot” risk of bias distribution are designed in the RoB 2 tool. The 2 authors extracted the data and analyzed it. Results: Six studies fulfilled the inclusion criteria. The risks of biases were high for 4, low and some concern for other 2 studies. The biomarkers, medium, device, frequency and duration of device, as well as other data were extracted. The outcomes of the studies were found to be heterogenous. Conclusion: One study showed highly statistically significant levels of IL-1 beta with <.001. Rate of tooth movement was correlated with levels of released biomarkers under the influence of vibrational force in 3 studies, but it was found to be significant only in 1 study. It was further observed that vibration does not have any significant reduction in pain and discomfort.

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Micro-osteoperforations and Its Effect on the Rate of Tooth Movement: A Systematic Review

European Journal of Dentistry ◽

10.1055/s-0040-1713955 ◽

2020 ◽

Author(s):

Khalifa S. Al-Khalifa ◽

Hosam A. Baeshen

Keyword(s):

Minimally Invasive ◽

Cortical Bone ◽

Web Of Science ◽

Tooth Movement ◽

Treatment Time ◽

Orthodontic Tooth Movement ◽

Inclusion Criteria ◽

Electronic Search ◽

Invasive Method ◽

Regional Acceleratory Phenomenon

AbstractProlonged orthodontic treatments have inconvenienced patients and clinicians alike. Surgically assisted techniques for accelerating orthodontic tooth movement have shown promising results in the literature over the years. The minimally invasive nature of micro-osteoperforations (MOPs), however, for enhanced orthodontic tooth movement has recently gained momentum, with many clinical trials conducted on both animals and humans. An electronic search was performed to extract papers using PubMed, Google Scholar, Scopus, and Web of Science. The keywords that were used included “MOP,” “accelerating tooth movement,” “orthodontic tooth movement,” and “regional acceleratory phenomenon.” The studies that met our inclusion criteria were extracted and evaluated in this review. MOPs have been proven time and again, in animal and human studies alike, to increase the rate of orthodontic tooth movement. The application of perforations to cortical bone present in the pathway of teeth, which are specifically to be moved creates transient osteopenia. This reduces the density of the cortical bone, hence speeding up the rate of orthodontic tooth movement. Many techniques have been implemented and perfected to enhance orthodontic tooth movement and shorten the treatment time in the literature. MOPs have proven to be a universally applied, nontechnical, repeatable, and minimally invasive method of accelerating tooth movement, with extremely minimal consequences.

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Effectiveness and Safety of Minimally Invasive Orthodontic Tooth Movement Acceleration: A Systematic Review and Meta-analysis

Journal of Dental Research ◽

10.1177/0022034519878412 ◽

2019 ◽

Vol 98 (13) ◽

pp. 1469-1479 ◽

Cited By ~ 7

Author(s):

T. Fu ◽

S. Liu ◽

H. Zhao ◽

M. Cao ◽

R. Zhang

Keyword(s):

Systematic Review ◽

Minimally Invasive Surgery ◽

Adverse Effects ◽

Minimally Invasive ◽

Invasive Surgery ◽

Tooth Movement ◽

Treatment Time ◽

Meta Analysis ◽

Orthodontic Tooth Movement ◽

Sufficient Evidence

Doctors and patients attempt to accelerate orthodontic tooth movement with a minimally invasive surgery approach. The purpose of this systematic review was to evaluate the evidence of accelerated tooth movement in minimally invasive surgery and the adverse effects from it. A systematic search of the literature was performed in the electronic databases of PubMed, CENTRAL (Cochrane Central Register of Controlled Trials), Embase, Scopus, Web of Science, Science Direct, and Medline and was complemented by a manual search until February 2019. The inclusion criteria were prospective clinical studies of patients treated with a fixed appliance, and the intervention was accelerated orthodontic treatment with minimally invasive surgery. Nineteen articles (538 participants) were included in the review: 9 studies assessed the rate of upper canine movement; 5 considered the treatment time; 1 evaluated the en masse retraction time; and 4 studied adverse effects. We performed a meta-analysis for the rate of canine movement and treatment time and described the results for the adverse effects in a systematic review. The results of the subgroup analysis according to micro-osteoperforation and piezocision were included in the study. No accelerated tooth movement was found in the micro-osteoperforation group. After flapless corticotomy procedures, increased tooth movement rates were identified by weighted mean differences of 0.63 (95%CI = 0.22, 1.03, P = 0.003) and 0.64 (95% CI, −25 to 1.53; P = 0.16) for 1 and 2 mo, respectively. The mean treatment time was 68.42 d (95% CI, −113.19 to −23.65; P = 0.003) less that than for minimally invasive surgery. Moreover, no significant adverse effect was found. Because of the high heterogeneity of the meta-analysis, the results must be validated by additional large-sample multicenter clinical trials. There is not sufficient evidence to support that the single use of micro-osteoperforation could accelerate tooth movement, and there is only low-quality evidence to prove that flapless corticotomy could accelerate tooth movement.

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Relationship between the polymorphism in the interleukin 1-β and the treatment time of patients subjected to a modified piezocision technique

Colombia Medica ◽

10.25100/cm.v51i1.4141 ◽

2020 ◽

pp. 1-14

Author(s):

Juan Fernando Aristizabal ◽

Hector Rios ◽

Diego Rey ◽

Maria Antonia Alvarez ◽

Beatriz Parra ◽

...

Keyword(s):

Tooth Movement ◽

Treatment Time ◽

Interleukin 1 ◽

Orthodontic Tooth Movement ◽

Collagen Matrix ◽

Control Group ◽

Controlled Clinical Trial ◽

Protein Levels ◽

Total Treatment Time ◽

3D Collagen

Aim: We aimed to evaluate the correlation between the polymorphism of the interleukin 1-Beta (IL1-β, +3954 C>T) and tooth movement, in a group of Colombian patients undergoing surgically accelerated orthodontic tooth movement. Methods: The study was nested to a controlled clinical trial. Blood samples were taken from 11 women and 29 healthy Colombian male volunteers between 18 and 40 years old, after 1 year of starting orthodontic treatment. The patients presented malocclusion class I, with grade II or III. To detect the genetic polymorphism of the nucleotide +3954 C to T in the IL-1β gene, we used a real-time PCR assay. Results: Eleven individuals presented the allele 2 (T) heterozygous with the allele 1 (T/C) and 19 individuals were homozygous for the allele 1 (C/C). When analyzing the presence of the SNP, no significant differences were found in any of the variables. The best treatment was reflected in Group 3 (selective upper and lower alveolar decortication and 3D collagen matrix) and Group 4 (only selective alveolar decortication in the upper arch, with 3D collagen matrix), with 27% and 35% more speed respectively than in the control group. Conclusions: Our analyses indicated that a reduction in the total treatment time can be mostly potentiated by using decortication and collagen matrices and not for the presence of the allele 2 in the IL-1β. Nevertheless, it is important that further studies investigate if the polymorphism could be associated with the speed of tooth movement and analyze the baseline protein levels.

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Nonextraction Treatment of Severe Crowding with the Aid of Corticotomy-Assisted Orthodontics

Case Reports in Dentistry ◽

10.1155/2012/694527 ◽

2012 ◽

Vol 2012 ◽

pp. 1-8

Author(s):

Ali S. Aljhani ◽

Khalid H. Zawawi

Keyword(s):

Tooth Movement ◽

Treatment Time ◽

Orthodontic Appliances ◽

Duration Of Treatment ◽

Orthodontic Therapy ◽

Total Treatment Time ◽

Fixed Orthodontic Appliances ◽

Total Treatment ◽

Maxilla And Mandible ◽

Augmentation Procedure

This paper illustrates the combined nonextraction orthodontic treatment with the corticotomy technique in an adult patient (age: 25 years and 3 months) with severely crowded arches to accelerate tooth movement and shorten the treatment time. Both her upper lateral incisors were congenitally absent and both upper central incisors’ roots were short. Initial fixed orthodontic appliances (bidimensional) were bonded and one week later buccal and lingual corticotomy with alveolar augmentation procedure in the maxilla and mandible was performed. Orthodontic activation to level and align and unravel the crowding was performed every two weeks. The total treatment time was 8 months with no adverse effects observed at the end of active treatment. The addition of the decortication procedure to the conventional orthodontic therapy decreased the duration of treatment significantly. Successful alignment of both arches with ideal overbite and overjet as well as adequate occlusion was achieved.

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Vital Tooth Whitening Techniques. A literature Review

Current Dentistry ◽

10.2174/2542579x02999200812130854 ◽

2020 ◽

Vol 02 ◽

Author(s):

Pia Chatterjee Kirk

Keyword(s):

Soft Tissues ◽

Treatment Time ◽

Tooth Bleaching ◽

Tooth Whitening ◽

Easy Method ◽

Tooth Structure ◽

Dental Esthetics ◽

Total Treatment Time ◽

Restorative Materials ◽

Total Treatment

Background: Vital tooth whitening has become an integral part of esthetic dentistry and remains one of the safest and most economic options today to improve dental esthetics without removing tooth structure. The tooth whitening materials have evolved into three categories: dentist-prescribed/dispensed (in office and patient home-use), and over-thecounter purchased and applied by patients. Objective: This review outlines the latest advances in dentist prescribed vital teeth whitening techniques, effects on tooth structure, soft tissues, and dental restoratives. Areas requiring additional research are also discussed. Methods: Electronic and manual literature search was conducted for key words such as tooth bleaching, and dental bleaching techniques using PubMed/MEDLINE, followed by manual selection of the studies that included whitening procedures in vital teeth. Results: The two main whitening agents are carbamide peroxide (CP) and hydrogen peroxide (HP or H2O2) whose concentration, duration of contact, and total treatment time can alter results. In addition, factors including the type of stain, and age of patient can affect results. Although whitening agents can affect tooth structure, restorative materials, and gingival tissues, the changes are temporary or can be treated using minimally invasive techniques. Conclusion: Areas requiring further research include the actual mechanism of whitening, its effect on tooth structure and restorative materials, and the development of an easy method to quantitate the degree of whitening in the dental office.

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