scholarly journals Relationship between the polymorphism in the interleukin 1-β and the treatment time of patients subjected to a modified piezocision technique

2020 ◽  
pp. 1-14
Author(s):  
Juan Fernando Aristizabal ◽  
Hector Rios ◽  
Diego Rey ◽  
Maria Antonia Alvarez ◽  
Beatriz Parra ◽  
...  
Keyword(s):  
Tooth Movement ◽  
Treatment Time ◽  
Interleukin 1 ◽  
Orthodontic Tooth Movement ◽  
Collagen Matrix ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Protein Levels ◽  
Total Treatment Time ◽  
3D Collagen

Aim: We aimed to evaluate the correlation between the polymorphism of the interleukin 1-Beta (IL1-β, +3954 C>T) and tooth movement, in a group of Colombian patients undergoing surgically accelerated orthodontic tooth movement. Methods: The study was nested to a controlled clinical trial. Blood samples were taken from 11 women and 29 healthy Colombian male volunteers between 18 and 40 years old, after 1 year of starting orthodontic treatment. The patients presented malocclusion class I, with grade II or III. To detect the genetic polymorphism of the nucleotide +3954 C to T in the IL-1β gene, we used a real-time PCR assay. Results: Eleven individuals presented the allele 2 (T) heterozygous with the allele 1 (T/C) and 19 individuals were homozygous for the allele 1 (C/C). When analyzing the presence of the SNP, no significant differences were found in any of the variables. The best treatment was reflected in Group 3 (selective upper and lower alveolar decortication and 3D collagen matrix) and Group 4 (only selective alveolar decortication in the upper arch, with 3D collagen matrix), with 27% and 35% more speed respectively than in the control group. Conclusions: Our analyses indicated that a reduction in the total treatment time can be mostly potentiated by using decortication and collagen matrices and not for the presence of the allele 2 in the IL-1β. Nevertheless, it is important that further studies investigate if the polymorphism could be associated with the speed of tooth movement and analyze the baseline protein levels.

scholarly journals The Effect of Local Pharmacological Agents in Acceleration of Orthodontic Tooth Movement: A Systematic Review

2019 ◽  
Vol 7 (5) ◽  
pp. 882-886 ◽  
Author(s):  
Ahmed Eltimamy ◽  
Fouad Aly El-Sharaby ◽  
Faten Hussien Eid ◽  
Amr Emad El-Dakrory
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Tooth Movement ◽  
Treatment Time ◽  
Orthodontic Tooth Movement ◽  
Grading System ◽  
Pharmacological Agents ◽  
Total Treatment Time ◽  
Cochrane Database ◽  
Total Treatment

AIM: Acceleration of orthodontic tooth movement has gained a massive interest to decrease the total treatment time. Local pharmacological agents might be used for that purpose as a practical, effective and inexpensive alternative. A systematic review was achieved to evaluate the evidence in that topic. METHODS: A search was conducted on electronic databases including PubMed, Lilacs, Web of Science (Thompson Reuters), EMBASE (OvidSP), and Cochrane Database of Systematic Reviews (Wiley) in addition to hand searching of relevant journals till June 2018. Only studies written in English were utilised. Publications were selected, assessed systematically and graded by two observers according to Bondemark grading system. RESULTS: Only two human studies were found investigating the effect of Relaxin and Prostaglandins in the rate of orthodontic tooth movement. No obvious side effects were reported. Relaxin showed no increase in the rate of tooth movement while prostaglandin showed a marked increase in the rate of orthodontic tooth movement. CONCLUSION: There is below moderate evidence showing no effect of relaxin on orthodontic tooth movement, while inconclusive evidence was found regarding Prostaglandin in the acceleration of orthodontic tooth movement. More prospective well-conducted clinical trials are needed to reach a proper conclusion regarding the local pharmacological agents which can be safely used to accelerate orthodontic tooth movement.  

Collagen Matrix in Decompressive Hemicraniectomy

2008 ◽  
Vol 63 (suppl_1) ◽  
pp. ONS176-ONS181 ◽  
Author(s):  
Jorn A. Horaczek ◽  
Jan Zierski ◽  
Alexander Graewe
Keyword(s):  
Cerebrospinal Fluid ◽  
Time Course ◽  
Treatment Time ◽  
Randomized Study ◽  
Operating Time ◽  
Collagen Matrix ◽  
Control Group ◽  
Dural Defect ◽  
Decompressive Hemicraniectomy ◽  
Total Treatment Time

Abstract Objective: Decompressive hemicraniectomy is an accepted treatment for otherwise untreatable intracranial hypertension. The aim of this prospective randomized study is to evaluate the benefit of application of collagen matrix as an onlay graft to reduce operating time during hemicraniectomy and to facilitate dural dissection during secondstage cranioplasty. Methods: Thirty-four consecutive patients were randomized to receive collagen matrix during hemicraniectomy or to undergo the conventional procedure. Specific time points were recorded during hemicraniectomy and cranioplasty. Intra- and postoperative complications, time course of Glasgow Coma Scale, Barthel's, and Early Rehabilitation Indices were monitored. The surgeon had to rate the convenience of the procedure if collagen matrix was used. Cost implications are discussed. Results: The use of collagen matrix during hemicraniectomy resulted in a reduction of combined operating time for hemicraniectomy and cranioplasty by an average of 19.7%. The rate of cerebrospinal fluid effusion during cranioplasty was 13% when collagen was used and 58% in the control group. None of the patients who received collagen developed cerebrospinal fluid effusion persisting longer than 1 week, compared with 33% of patients in the control group. A total of 85% of the surgeons rated the use of collagen matrix as being easier than usual; the rest did not see a difference. Conclusion: The use of collagen matrix to cover the dural defect during hemicraniectomy reduces operating time in hemicraniectomy and cranioplasty. The complication rate (cerebrospinal fluid effusion), total treatment time, and time on intensive care unit can be reduced, giving a potential for cost reduction. There was no difference in the rehabilitative outcome.

Surgical Methods for Accelerating Orthodontic Tooth Movement

2020 ◽  
Vol 13 (4) ◽  
pp. 170-179
Author(s):  
Aman Ulhaq ◽  
Emma McCrory ◽  
Eleni Besi
Keyword(s):  
Tooth Movement ◽  
Treatment Time ◽  
Orthodontic Tooth Movement ◽  
Adverse Outcomes ◽  
Current Evidence ◽  
Surgical Interventions ◽  
Future Studies ◽  
Total Treatment Time ◽  
Surgical Methods ◽  
Total Treatment

The ability to consistently reduce orthodontic treatment time without adverse outcomes would be an attractive prospect. Several surgical interventions have been described aimed at accelerating orthodontic tooth movement. The aim of this review is to identify and evaluate the current evidence available for surgically-assisted orthodontic tooth movement (OTM). The current evidence suggests that surgical procedures may increase the rate of tooth movement, however, this effect is short lived. Further reporting on total treatment time, and patient centred outcomes, would be beneficial in future studies. CPD/Clinical Relevance: To explain surgical methods for accelerating orthodontic tooth movement.

scholarly journals Surgery-first Approach

2017 ◽  
Vol 8 (4) ◽  
pp. 343-350
Author(s):  
Yash A Shah ◽  
Shailesh V Deshmukh ◽  
Amol S Patil
Keyword(s):  
Orthognathic Surgery ◽  
Tooth Movement ◽  
Treatment Time ◽  
Orthodontic Tooth Movement ◽  
Conventional Approach ◽  
Treatment Protocols ◽  
Orthodontic Therapy ◽  
Total Treatment Time ◽  
Total Treatment ◽  
Surgery First

ABSTRACT Aim This article is intended to provide an overview of the Surgery First Approach (SFA) mainly including case selection, diagnosis, treatment protocols, success rate and the potential problems encountered. Background The most important indication of the need for orthognathic surgery is usually the psychosocial effect resulting from the unaesthetic appearance of a dentofacial deformity. The conventional approach in treatment of such deformities till today has been an orthodontics-first approach. Review Results Available evidence suggest that both the SFA and the conventional approach had similar outcomes in dentofacial relationships however the relapse tendency was greater with the SFA but the total treatment duration was substantially shorter. Conclusion SFA treats facial aesthetics (and the skeletal malrelation) first and then occlusion, i.e. orthognathic surgery antecedes the orthodontic therapy. The concept of this technique is to utilize orthognathic surgery to eliminate the displeasing pre-surgical facial profile and promptly accomplish facial aesthetic enhancement that is usually the patient's chief complaint at the beginning of the treatment. SFA also facilitates accelerated orthodontic tooth movement thus reducing the length of post-surgical orthodontic therapy. Clinical Significance The optimal esthetic and functional results, significant reduction in total treatment time and high patient satisfaction led us to the postulation that SFA may represent a reasonable, cost-effective method to manage skeletal malocclusions in selected cases and that it has the potential to become a standard approach to orthognathic surgery in the future. How to cite this article Shah YA, Deshmukh SV, Patil AS. Surgery-first Approach. World J Dent 2017;8(4):343-350.

The Comparison of Ostecyte in the Pressure area and Tension area on Tooth Movement Because of Hyperbaric Oxygen Therapy

DENTA ◽  
2018 ◽  
Vol 12 (1) ◽  
pp. 34
Author(s):  
Arya Barahmanta ◽  
Muhammad Faizal Winaris ◽  
Pambudi Raharjo
Keyword(s):  
Hyperbaric Oxygen ◽  
Oxygen Therapy ◽  
Tooth Movement ◽  
Bone Remodelling ◽  
Orthodontic Tooth Movement ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Pressure Area

<p><strong><em>Background:</em></strong><em> Orthodontic tooth movement is a </em><em>interaction prosess</em><em> of resorption and deposition of bone remodeling. Orthodontic tooth movement by mechanical strength causes changes in alveolar bone. Osteocyte is an essential cell to respond bone remodelling. Hyperbaric Oxygen Therapy affects production of osteocyte because it can release Reactive Oxygen Species (ROS) and Nitrid Oxide (NO).  <strong>Purpose: </strong>To determine the difference number  of osteocyte in pressure and tension area during tooth movement by adjuvant of Hyperbaric Oxygen 2,4 ATA during 7 days starting on day 8 to day 14. <strong>Materials and Methods</strong>: This research used Completery Randomized Control Group Post Test Only Design. 36 cavia cobaya (male)  were divided into 3 groups randomly : the negative control groups, positive control group, and treatment group. Preparat staining used Hematoxylin Eosin (HE) and calculated on microscop 1000x with 20 field of view. Data analyses used one way ANOVA and LSD test then compared each area by using paired T test. <strong>Result:</strong> The data showed that the treatment group (P=10,67) tension area has the highest number of osteocyte than  negative control group (K-=3,67), positive control (K+=7,42). In the pressure area showed that negative control group (K-=5,00) has the highest  than positive control group (K+=3,83) and treatment (P=3,25). <strong>Conclusion: </strong>Therapy HBO 2,4 ATA 7 days starting on day 8 to day 14 is could increase osteocyte in the tissue to stimulate process of bone remodelling.</em></p><pre><strong> </strong></pre><p><strong><em>Keywords:</em></strong><em> Hyperbaric Oxygen, Tooth movement, Bone remodeling, </em><em>Osteocyte</em><em></em></p><p><em> </em></p><p><strong><em>Correspondence:</em></strong><em> </em><em>Arya Brahmanta</em><em>, Department of Orthodonty, Faculty of Dentistry, Hang Tuah University, Arif Rahman Hakim 150, Surabaya, Phone 031-5945864, Email:</em><em> </em><a href="mailto:[email protected]"><em>arya.brahmanta</em><em>@</em><em>hangtuah.ac.id</em></a></p>

scholarly journals Curcumin nanomicelle versus curcumin improves lipid profile, stress oxidative factors and inflammatory markers in patients undergoing coronary elective angioplasty; A Randomized Clinical Trial

2019 ◽  
Author(s):  
Bijan Helli ◽  
Hadis Gerami ◽  
Maria Kavianpour ◽  
Habib Heybar ◽  
Seyed Kianoosh Hosseini ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Lipid Profile ◽  
Inflammatory Markers ◽  
Interleukin 1 ◽  
Stress Index ◽  
Inflammatory Factors ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Stress Oxidative

Abstract Background: Curcumin exhibited antioxidant and anti-inflammatory effects. The aim of this study, assess and compare curcumin and nano- curcumin effects on lipid profile, oxidative stress index and inflammatory factors of heart patients.Methods: This Randomized, Double-Blind, Placebo-Controlled Clinical Trial conducted on 90 patients undergoing coronary elective angioplasty. Patients were randomly divided into 3 groups. The first group received a 500 mg capsule of curcumin daily. The second group received an 80 mg capsule of nano- curcumin daily. The placebo group also received capsules similar to curcumin for 8 weeks. Lipid profile, stress oxidative factors and inflammatory markers measured in baseline and end of the investigation.Results: At the end of study, statistically significant changes was seen in the total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL) in the intervention groups to the control group (p<0.05). These changes in the nano-curcumin group were greater than the curcumin group. Curcumin and nano-curcumin supplementation also caused a statistically significant improvement in plasma levels of total antioxidant capacity (TAC), malondialdehyde (MDA), Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), high-sensitivity C-reactive protein (hs-CRP), Interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) in comparison to the placebo (p<0.05).Conclusion: Complementary therapy of cardiovascular patients with curcumin and nano-curcumin supplements, could improve lipid profile, stress oxidative index and, inflammatory factors. The effects of curcumin on nano formula may be better for cardiac patients due to high bioavailability. However, further investigation is suggested in this regard.

The Effect of Apis mellifera Propolis on RUNX-2 and ALP during Remodeling of Orthodontic Tooth movement

2021 ◽  
pp. 2363-2366
Author(s):  
Budi Handayani ◽  
Mieke Sylvia Margaretha A R ◽  
Rini Devijanti Ridwan ◽  
Mohammed Aljunaid
Keyword(s):  
Apis Mellifera ◽  
Immunohistochemical Staining ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Laboratory Research ◽  
Control Group ◽  
Propolis Extract ◽  
Treatment Groups ◽  
Experimental Laboratory ◽  
Group 2

Herbal medicine is interesting including treatments that use propolis. Propolis collected by Apis mellifera bees has a very useful composition whose active ingredients are flavonoids, CAPE and saponin. This research aims to analyze the effect of Apis mellifera propolis on RUNX-2 and ALP during the remodeling period caused by the orthodontic tooth movement in Cavia cobaya. It constitutes an experimental laboratory study and a random sampling method. The method used experimental laboratory research on 28 Cavia cobaya, which were divided into four groups consisting of two control groups and two treatment groups which have been given 3% and 5% propolis extract respectively. RUNX-2 and ALP expression were evaluated using immunohistochemical staining. Materials and Methods: Propolis is a resin substance produced by bees. Cavia cobaya with orthodontic tooth movement by separator rubber. The control group (Group 1) included clinically healthy Cavia cobaya (n=7), (Group 2) included Cavia cobaya with orthodontic tooth movement (n=7). A treatment group (Group P1) Cavia cobaya have been treated with orthodontic tooth movement and propolis 3%, (Group P2) Cavia cobaya have been treated with orthodontic tooth movement and propolis 5% and observed for 17 days. Samples of maxilla were taken from the subjects for analysis on day 17. RUNX-2 and ALP expression were evaluated using immunohistochemical staining. Results: showed that RUNX-2 and ALP expression were found to increase in the tension side. Conclusion: Propolis extract at 5% concentration had ability in bone remodeling by increasing RUNX-2 and ALP expression in the tension area during orthodontic tooth movement.

scholarly journals The effect of autologous leukocyte platelet rich fibrin on the rate of orthodontic tooth movement: A prospective randomized clinical trial

2018 ◽  
Vol 12 (03) ◽  
pp. 350-357 ◽  
Author(s):  
Azita Tehranchi ◽  
Hossein Behnia ◽  
Fereydoun Pourdanesh ◽  
Parsa Behnia ◽  
Nelson Pinto ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Tooth Movement ◽  
Random Effect ◽  
Random Effect Model ◽  
Orthodontic Tooth Movement ◽  
Control Group ◽  
Extraction Socket ◽  
Effect Model ◽  
Significant Difference ◽  
And Control

ABSTRACT Objective: The aim of this study was to evaluate the effect of LPRF, placed in extraction sockets, on orthodontic tooth movement (OTM). Materials and Methods: Thirty extraction sockets from eight patients (five males, three females, with a mean age of 17.37 years; range 12–25 years) requiring extraction of first premolars based on their orthodontic treatment plan participated in this split-mouth clinical trial. In one randomly selected quadrant of each jaw, the extraction socket was preserved as the experimental group by immediate placement of LPRF in the extraction socket. The other quadrant served as the control group for secondary healing. Immediately, the teeth adjacent to the defects were pulled together by a NiTi closed-coil spring with constant force. A piece of 0.016 × 0.022-inch stainless steel wire was used as the main arch wire. The amount of OTM was measured on the study casts at eight time points with 2-week intervals for 3 months. Analysis of random effect model was performed for the purpose of comparison between the experimental and control groups. Results: According to the random effect model, a statistically significant difference was found between the experimental and control group in rate of OTM (P = 0.006). Conclusion: According to the results, application of LPRF, as an interdisciplinary approach combining orthodontics and surgery, may accelerate OTM, particularly in extraction cases.

scholarly journals The Administration of 4-Hexylresorcinol Accelerates Orthodontic Tooth Movement and Increases the Expression Level of Bone Turnover Markers in Ovariectomized Rats

2020 ◽  
Vol 21 (4) ◽  
pp. 1526 ◽  
Author(s):  
Kwang-Hyo Choi ◽  
Dae-Won Kim ◽  
Suk Keun Lee ◽  
Seong-Gon Kim ◽  
Tae-Woo Kim
Keyword(s):  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Ovariectomized Rats ◽  
Control Group ◽  
Tartrate Resistant Acid Phosphatase ◽  
Sprague Dawley ◽  
Osteogenic Markers ◽  
Surgical Methods ◽  
Elevated Expression ◽  
Turnover Markers

Surgical methods for accelerating orthodontic tooth movement are limited by possible damage to the tooth root and patient discomfort. 4-Hexylresorcinol (4HR) has been shown to increase bone remodeling and may potentially facilitate tooth movement. This study investigated the (1) effect of 4HR administration on osteoblast-like cells and (2) effect of 4HR administration on tooth movement in ovariectomized rats. Saos-2 cells were treated with either 4HR or solvent (control). Protein expression levels were investigated 2, 8, and 24 h after treatment. Thirty ovariectomized Sprague-Dawley rats were divided into two experimental groups (A and B) and one control group. After installation of an orthodontic tooth movement device, groups A and B received subcutaneous weekly injections of 4HR (1.28 and 128 mg/kg). Micro-computerized tomography and histological analyses were performed after 2 weeks of tooth movement. The application of 4HR elevated expression of osteogenic markers in Saos-2 cells. Movement of the first molars was significantly greater in rats administered 4HR. Furthermore, the expression of bone morphogenic protein-2, receptor activator of nuclear factor kappa-B ligand, osteocalcin, and tartrate-resistant acid phosphatase were increased after 4HR administration. 4HR application demonstrated increased expression of osteogenic markers in Saos-2 cells and accelerated orthodontic tooth movement in rats.

scholarly journals Bone dehiscence formation during orthodontic tooth movement through atrophic alveolar ridges

2019 ◽  
Vol 90 (3) ◽  
pp. 321-329
Author(s):  
Adilson Luiz Ramos ◽  
Monique Cimão dos Santos ◽  
Márcio Rodrigues de Almeida ◽  
Carlos Flores Mir
Keyword(s):  
Null Hypothesis ◽  
Alveolar Bone ◽  
Tooth Movement ◽  
Linear Regression Analysis ◽  
Orthodontic Tooth Movement ◽  
Wilcoxon Test ◽  
Control Group ◽  
Multivariate Linear Regression Analysis ◽  
Alveolar Ridge ◽  
Bone Height

ABSTRACT Objectives To test the null hypothesis that there is no difference in bone dehiscence formation before and after orthodontic tooth movement through an atrophic alveolar ridge. Material and Methods This longitudinal retrospective study evaluated pretreatment and posttreatment cone-beam computed tomography imaging of 15 adult patients. Twenty-five teeth were moved through the atrophic alveolar bone, whereas 25 teeth not subjected to translational movement were considered controls. The distances between the cementoenamel junction and the alveolar bone crest were assessed at the mesial, distal, buccal, and lingual surfaces of all of these teeth. Data were compared using the Wilcoxon test. The Spearman correlation test and multivariate linear regression analysis were also performed. Results In general, crestal bone height was reduced around 0.5 mm in all groups in every direction. Median buccal dehiscence increased significantly (+2.25 mm) (P &lt; .05) in teeth moved through the atrophic ridge. Control teeth also had buccal crest loss (+0.83 mm), but this was not statistically different from that of the experimental teeth. Lingual dehiscence increased significantly for the experimental (+0.17 mm) and control (+0.65 mm) groups. Mesial bone height decreased more in the control group (–0.44mm) than in the experimental group (–0.14mm). There was moderate correlation between amount of tooth movement and alveolar bone loss. Conclusions The null hypothesis was rejected as dehiscence increased after tooth movement through an atrophic alveolar ridge, mainly in the buccal plate.

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