scholarly journals Association between Fine-needle Aspiration Cytological Features and CD4 Level in Human Immunodeficiency Virus-Associated Tuberculous Lymphadenitis Patients Admitted to Haji Adam Malik Hospital in 2017

2019 ◽  
Vol 7 (20) ◽  
pp. 3475-3477
Author(s):  
Delyuzar Delyuzar ◽  
Agri Borneos Sinulingga ◽  
Dedy Suryadi
Keyword(s):  
Fine Needle Aspiration ◽  
Extrapulmonary Tuberculosis ◽  
Needle Aspiration ◽  
World Health ◽  
P Value ◽  
Tuberculous Lymphadenitis ◽  
Cross Sectional ◽  
Fine Needle ◽  
Cytological Features ◽  
Health Organization

BACKGROUND: World Health Organization stated that one-third of the world's population has tuberculosis with one infected person in every second. In 2015 there were 330,910 tuberculosis cases in Indonesia. This number increased compared to 2014, which amounted to 324,539 cases. HIV-positive patients with extrapulmonary tuberculosis accounted for 50% of TB cases, of which 35% were lymphadenitis. Lymph node fine-needle aspiration (FNA) is considered effective in determining the early diagnosis of lymphadenopathy. AIM: This study aims to evaluate the association between cytological features and CD4 level in HIV-associated tuberculous lymphadenitis patients in Haji Adam Malik Hospital in 2017. METHODS: This is an analytical study with a cross-sectional approach involving 42 samples. Cytological features were obtained by slide reviewed and CD4 level were obtained from the medical record. RESULTS: Analysis of the association of cytological features with CD4 level association revealed p-value of 0.353. CONCLUSION: This indicates that there is no significant association between FNA cytological features and CD4 level in HIV-associated tuberculous lymphadenitis patients.

scholarly journals Gallbladder carcinoma: An attempt of WHO histological classification on fine needle aspiration material

CytoJournal ◽  
2013 ◽  
Vol 10 ◽  
pp. 12 ◽  
Author(s):  
Rajni Yadav ◽  
Deepali Jain ◽  
Sandeep R. Mathur ◽  
Atul Sharma ◽  
Venkateswaran K. Iyer
Keyword(s):  
Fine Needle Aspiration ◽  
Who Classification ◽  
Giant Cells ◽  
Needle Aspiration ◽  
Undifferentiated Carcinoma ◽  
World Health ◽  
Fine Needle ◽  
Signet Ring ◽  
Needle Aspiration Cytology ◽  
Health Organization

Background: Carcinoma of the gallbladder (CaGB) is common in India and its prognosis depends primarily on the extent of the disease and histological type. We aim to study the role of guided fine needle aspiration cytology (FNAC) for diagnosis of CaGB and to evaluate the feasibility of applying world health organization (WHO) classification on fine needle aspiration (FNA) material to predict the outcome of the tumor. Materials and Methods: Retrospective cytomorphologic analysis was performed in all cases of CaGB diagnosed by ultrasound (US) guided FNAC over a period of 2 years. A specific subtype was assigned according to WHO classification based on characteristic cytologic features. These included papillary or acinar arrangement, intra and extracellular mucin, keratin, rosettes and columnar, signet ring, atypical squamous, small, clear, spindle and giant cells. Correlation with histopathology was performed when available. Results: A total of 541 aspirations with clinical or radiological suspicion of primary CaGB were studied. Of these, 54 aspirates were unsatisfactory. Fifty cases were negative for malignancy. Remaining 437 aspirates were positive for carcinoma. Histopathologic diagnosis was available in 32 cases. Adenocarcinoma was the most frequent diagnosis in 86.7% of cases. Mucinous, signet ring, adenosquamous, squamous, small cell, mixed adenoneuroendocrine and undifferentiated carcinoma including spindle and giant cell subtypes were diagnosed identifying specific features on FNAC. Correlation with histopathology was present in all, but one case giving rise to sensitivity of 96.8%. No post-FNA complications were recorded. Conclusions: US guided FNAC is a safe and effective method to diagnose CaGB. Although, rare, clinically and prognostically significant variants described in WHO classification can be detected on cytology.

scholarly journals Grading of pancreatic neuroendocrine tumors on endoscopic ultrasound-guided fine-needle aspiration using Ki-67 index and 2017 World Health Organization criteria: An analysis of 32 cases

CytoJournal ◽  
2020 ◽  
Vol 17 ◽  
pp. 21
Author(s):  
Sweety Kalantri ◽  
Pooja Bakshi ◽  
Kusum Verma
Keyword(s):  
World Health Organization ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
World Health ◽  
Pancreatic Neuroendocrine Tumors ◽  
Ultrasound Guided ◽  
Ki 67 ◽  
Fine Needle ◽  
Grade 3 ◽  
Health Organization

Objectives: Biological behavior of pancreatic neuroendocrine tumors (Pan NETs) is difficult to predict on morphology alone. The assessment of proliferation by the Ki-67 proliferation index (PI) is considered to be an important prognostic parameter in these tumors and has been endorsed by the 2017 World Health Organization (WHO) grading system for Pan NETs. Although widely accepted on surgical specimens, there is varied opinion on grading of these tumors on cytology samples. This study aimed at classification and grading of Pan NETs on endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) using the recent 2017 WHO criteria and assess the reliability of Ki-67 grading by comparing it with histology samples wherever available. Material and Methods: Search of cytopathology lab records over a 3-year period (June 2015–May 2018) revealed 33 cases of pancreatic NETs diagnosed on EUS-FNA specimens. Using the guidelines of 2017 WHO classification and grading of Pan NETs, retrospective grading of these Pan NETs was done. They were graded as Grades 1, 2, and 3 well differentiated Pan NETs and poorly differentiated Grade 3 neoplasms based on Ki-67 PI and cytomorphology. Cytomorphological features were compared across the three grades. The cytological grading was then compared with the histological grading where available. Results: Ki-67 grading on cytology was done in 32 cases (22 on cell block and 10 on smears), of which 19 (59.4%) were Grade 1, 8 (25%) were Grade 2, and 5 (15.6%) were Grade 3 tumors. The most common cytomorphological features observed in Grade 1 tumors were small round uniform cells with granular chromatin and prominent plasmacytoid morphology. As the grade increased, tumor cells showed increased pleomorphism, angulated nuclei, and less frequent plasmacytoid cells. Histopathology (biopsy/resected specimens) was available in 11 of the 32 cases. Comparison of grading on cytology and histology showed concordance in ten of the 11 cases (k value = 0.862). Conclusion: Our data suggest that grading of Pan NETs by assessing Ki-67 PI on cytology samples collected by EUS-FNA shows good agreement with that measured on histology samples.

scholarly journals Huge pelvic parachordoma: fine needle aspiration cytology and histological differential diagnosis

Rare Tumors ◽  
2012 ◽  
Vol 4 (4) ◽  
pp. 172-174 ◽  
Author(s):  
Rehab M. Samaka ◽  
Mona A. Kandil
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Soft Tissues ◽  
Pelvic Mass ◽  
Needle Aspiration ◽  
World Health ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Health Organization

Parachordoma is an extremely rare soft tissue tumor of unknown lineage. Parachordoma develops most often on the extremities. Only 2 cases have been reported as pelvic parachordoma. A 46-year old Egyptian woman with a huge painful pelvic mass was found to have a parachordoma with ectopic pelvic right kidney. There is only one report in the literature of fine needle aspiration cytology in this setting. The microscopic picture of parachordoma is not new to pathologists but the gross picture of this rare tumor has not previously been published; not even in the World Health Organization classification of soft tissues tumors. Diagnosis was confirmed by immunohistochemistry. The patient is in good clinical condition without any evidence of recurrence or metastasis after 84 months of follow up.

Role of Fine-Needle Aspiration in the Surgical Management of Pancreatic Neuroendocrine Tumors: Utility and Limitations in Light of the New World Health Organization Classification

2014 ◽  
Vol 138 (7) ◽  
pp. 896-902 ◽  
Author(s):  
Terence N. Moyana ◽  
Wayne S. Kendal ◽  
Avijit Chatterjee ◽  
Derek J. Jonker ◽  
Jean A. Maroun ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Fine Needle Aspiration ◽  
New World ◽  
Preoperative Evaluation ◽  
Needle Aspiration ◽  
World Health ◽  
Pancreatic Neuroendocrine Tumors ◽  
World Health Organization Classification ◽  
Fine Needle ◽  
Health Organization

Context.—Pancreatic neuroendocrine tumors (Panc-NETs) are rare and tend to get overshadowed by their more prevalent and aggressive ductal adenocarcinoma counterparts. The biological behavior of PancNETs is unpredictable, and thus management is controversial. However, the new World Health Organization classification has significantly contributed to the prognostic stratification of these patients. Concurrently, there have been advances in surgical techniques for benign or low-grade pancreatic tumors. These procedures include minimally invasive and parenchyma-sparing operations such as laparoscopy and enucleation. Objective.—To report on the utility and limitations of fine-needle aspiration in the preoperative evaluation and management of PancNETs. Design.—This was a retrospective review of our institutional tumor database from 2002 to 2012. There were 25 cases of PancNETs that were localized and staged by medical imaging and diagnosed by fine-needle aspiration. Results.—Fourteen patients underwent laparotomy, with some requiring only limited surgery; 4 had laparoscopic resections; 4 were serially observed without surgical intervention; and another 3 were inoperable. After a mean follow-up of 37 months, more than half of the patients had no evidence of disease, including most of those who underwent minimally invasive surgery. Conclusions.—Fine-needle aspiration is a useful diagnostic adjunct to medical imaging in the preoperative evaluation and management of PancNETs. However, there are limitations with regard to grading PancNETs using this technique.

scholarly journals Classification of Breast Cancer Malignancy Using Cytological Images of Fine Needle Aspiration Biopsies

2008 ◽  
Vol 18 (1) ◽  
pp. 75-83 ◽  
Author(s):  
Łukasz Jeleń ◽  
Thomas Fevens ◽  
Adam Krzyżak
Keyword(s):  
Breast Cancer ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
World Health ◽  
Support Vector ◽  
Fine Needle ◽  
Malignancy Grade ◽  
Precise Diagnosis ◽  
Health Organization

Classification of Breast Cancer Malignancy Using Cytological Images of Fine Needle Aspiration BiopsiesAccording to the World Health Organization (WHO), breast cancer (BC) is one of the most deadly cancers diagnosed among middle-aged women. Precise diagnosis and prognosis are crucial to reduce the high death rate. In this paper we present a framework for automatic malignancy grading of fine needle aspiration biopsy tissue. The malignancy grade is one of the most important factors taken into consideration during the prediction of cancer behavior after the treatment. Our framework is based on a classification using Support Vector Machines (SVM). The SVMs presented here are able to assign a malignancy grade based on preextracted features with the accuracy up to 94.24%. We also show that SVMs performed best out of four tested classifiers.

HUBUNGAN TINGKAT STRES DENGAN SIKLUS MENSTRUASI PADA MAHASISWA KEBIDANAN TINGKAT I DI STIKES KUNINGAN TAHUN 2019

2020 ◽  
Vol 1 (1) ◽  
pp. 8
Author(s):  
Fera Riswidautami Herwandar ◽  
Russiska Russiska ◽  
Intan Maharani Fakhrudin
Keyword(s):  
World Health Organization ◽  
World Health ◽  
P Value ◽  
Cross Sectional ◽  
Health Organization

Permasalahan kesehatan pada remaja yang menduduki persentasi terbesar dibanding yang lainnya adalah gangguan menstruasi. Gangguan pada siklus menstruasi (durasi perdarahan yang lebih lama dan ketidakteraturan siklus) disebabkan oleh beberapa faktor, salah satunya ialah stres. Stres diketahui sebagai faktor-faktor penyebab (etiologi) terjadinya gangguan siklus menstruasi. Stres akan memicu pelepasan hormon kortisol dimana hormon kortisol ini dijadikan tolak ukur untuk melihat derajat stres seseorang. Hormon kortisol diatur oleh hipotalamus otak dan kelenjar pituitari, dengan dimulainya aktivitas hipotalamus, hipofisis mengeluarkan FSH dan proses stimulus ovarium akan menghasilkan estrogen. Penelitian yang dilakukan oleh Pelayanan Kesehatan Peduli Remaja (PKPR) dibawah naungan World Health Organization (WHO) menyebutkan bahwa permasalahan remaja di Indonesia adalah seputar permasalahan yang mengenai gangguan menstruasi. Tujuan penelitian ini adalah untuk mengetahui hubungan tingkat stres dengan siklus menstruasi pada mahasiswa kebidanan tingkat I di STIKES Kuningan tahun 2019. Penelitian ini menggunakan desain penelitian kuantitatif dengan pendekatan Cross Sectional. Populasi dalam penelitian ini adalah mahasiswa kebidanan tingkat I di STIKES Kuningan tahun 2019 sebanyak 41 responden. Analisis yang digunakan analisis univariat dan bivariat dengan menggunakan uji Rank Spearman. Hasil penelitian menunjukkan adanya hubungan tingkat stres dengan siklus menstruasi pada mahasiswa kebidanan tingkat I di STIKES Kuningan, dari 41 responden terdapat 18 (44%) responden yang mengalami stres sedang, pada siklus menstruasi yang tidak teratur terdapat 25 (61%) responden. Hasil uji rank spearman,  yakni p value = 0,01 (<0,05) yang ada hubungan antara tingkat stres dengan siklus menstruasi. Berdasarkan hasil penelitian penulis dapat menyimpulkan bahwa terdapat hubungan yang signifikan antara tingkat stres dengan siklus menstruasi pada mahasiswa kebidanan tingkat I di STIKES Kuningan tahun 2019. Bagi institusi Pendidikan khususnya Program Studi Diploma III Kebidanan diharapkan dapat membuat sebuah program edukasi mengenai manajemen stres pada remaja yang bisa dilakukan secara rutin di luar jadwal perkuliahan.  

HUBUNGAN ANTARA PENDIDIKAN DAN SOSIAL EKONOMI KELUARGA DENGAN STATUS GIZI BALITA DI PUSKESMAS KERAMASAN PALEMBANG TAHUN 2012

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Dini Kesumah Dini Kesumah
Keyword(s):  
Nutritional Status ◽  
World Health Organization ◽  
Health Center ◽  
World Health ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Highly Educated ◽  
Health Organization ◽  
Nutritional Status Of Children

ABSTRACT According to World Health Organization Health Organization (WHO) in 2005 showed 49% of deaths occur in children under five in developing countries. Nutritional problems can not be done with the medical and health care approach alone. Causes related to malnutrition that maternal education, socioeconomic families, poor environmental sanitation, and lack of food supplies. This study aims to determine the relationship between education and socioeconomic status of families with nutrition survey using a cross sectional analytic approach, with a population of all mothers of children under five who visited the health center in Palembang Keramasan Accidental sampling Sampling the number of samples obtained 35 respondents. Variables include the study independent and dependent variables and univariate analysis using Chi-Square test statistic with a significance level α = 0.05. The results from 35 respondents indicate that highly educated mothers earned as many as 16 people (45.7%), and middle and upper income families as many as 12 people (34.3%) and bivariate test results show that highly educated respondents toddler nutritional status good for 81.3% (13 people) is larger than the less educated respondents balitanya good nutritional status 26.3% (5 persons) as well as respondents who have middle and upper socioeconomic families with good nutritional status of children at 91.7% ( 11 people) is larger when compared to respondents who have family socioeconomic medium with good nutritional status of children at 30.4% (7 people). Statistical tests show that education has a significant relationship with nutritional status of children P value = 0.004 and socioeconomic families have a meaningful relationship with nutritional status of children P value = 0.002. Based on the results of the study suggested the health professionals in the health center should further improve the education, information about the importance of nutrition to the development of the child in the mothers through the selection and processing of good food and a good diet through health centers and integrated health.   ABSTRAK  Menurut badan kesehatan World Health Organization (WHO) tahun 2005 menunjukkan 49% kematian yang terjadi pada anak dibawah umur lima tahun di negara berkembang. Masalah gizi ini tidak dapat dilakukan dengan pendekatan medis dan pelayanan kesehatan saja. Penyebab yang berhubungan dengan kurang gizi yaitu pendidikan ibu, sosial ekonomi keluarga, sanitasi lingkungan yang kurang baik,dan kurangnya persediaan pangan. Penelitian ini bertujuan untuk mengetahui hubungan antara pendidikan dan sosial ekonomi keluarga dengan status gizi balita dengan menggunakan metode survei analitik pendekatan secara Cross Sectional, dengan populasi semua ibu yang memiliki anak balita yang berkunjung ke Puskesmas Keramasan Palembang dengan pengambilan sampel secara Accidental Sampling diperoleh jumlah sampel 35 responden. Variabel penelitian meliputi variabel independen dan dependen serta analisis univariat menggunakan uji statistik Chi-Square dengan tingkat kemaknaan α = 0,05. Hasil penelitian ini menunjukkan dari 35 responden didapatkan ibu yang berpendidikan tinggi sebanyak 16 orang  (45,7%), dan keluarga yang berpenghasilan menengah keatas sebanyak 12 orang (34,3%) dan hasil uji bivariat menunjukkan bahwa responden yang berpendidikan tinggi status gizi balitanya baik sebesar 81,3% (13 orang) lebih besar bila dibanding responden yang berpendidikan rendah status gizi balitanya baik 26,3% (5 orang) serta responden yang mempunyai sosial ekonomi keluarga menengah keatas dengan status gizi balita baik sebesar 91,7% (11 orang) lebih besar bila dibanding responden yang mempunyai sosial ekonomi keluarga menengah kebawah dengan status gizi balita baik sebesar 30,4% (7 orang). Uji statistik menunjukkan bahwa pendidikan mempunyai hubungan yang bermakna dengan status gizi balita P value = 0,004 dan sosial ekonomi keluarga mempunyai hubungan yang bermakna dengan status gizi balita P value = 0,002. Berdasarkan hasil penelitian disarankan pada petugas kesehatan di Puskesmas hendaknya lebih meningkatkan penyuluhan-penyuluhan tentang pentingnya gizi terhadap tumbuh kembang anak pada ibu-ibu melalui cara pemilihan dan pengolahan bahan makanan yang baik serta pola makanan yang baik melalui kegiatan Puskesmas dan Posyandu.

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