scholarly journals Metastatic Papillary Thyroid Carcinoma Arising in a Neglected Goiter: A Case Report

2020 ◽  
Vol 8 (C) ◽  
pp. 55-59
Author(s):  
Mohd Zulhilmie Mohd Nasir ◽  
Alan Basil Peter ◽  
Awla Mohd Azraai ◽  
Khasnur Abd Malek
Keyword(s):  
Thyroid Cancer ◽  
Case Report ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Lung Metastases ◽  
Histopathological Examination ◽  
Papillary Thyroid ◽  
Surgical Specimen ◽  
Ablation Therapy ◽  
Diffuse Goiter

BACKGROUND: Periodical clinical surveillance for early thyroid cancer detection among patients with diffuse goiter is a common scenario managed in the primary care setting. However, clinical palpation alone is neither sensitive nor specific in detecting the presence of nodules within a goiter. Hence, further investigation with ultrasound is key to effective surveillance for early detection of thyroid cancer. CASE REPORT: We present a case of a stable diffuse goiter in a 51-year-old woman diagnosed 30 years ago who refused further imaging investigation. Based solely on clinical palpation, the presence of nodules within the goiter was missed. This resulted in transformation into papillary thyroid carcinoma with lung metastases. She presented with progressive hoarseness of voice and cough for 3 months. An ultrasound of the thyroid gland revealed a large heterogeneous nodule in the left lower pole with coarse calcification and internal vascularity. Further imaging with contrast-enhanced computed tomography of the neck and thorax revealed an enhancing nodule in the left thyroid lobe which extends inferiorly to the left retroclavicular region which compresses the trachea causing narrowing of its lumen at T1 and T2 vertebral levels. There were multiple lung nodules in both lungs suggestive of metastases. CONCLUSION: A total thyroidectomy followed by radioactive iodine thyroid ablation therapy was performed. The histopathological examination revealed the surgical specimen to be papillary thyroid carcinoma.

scholarly journals Warthin-Like Papillary Carcinoma of the Thyroid Gland: Case Report and Review of the Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Panagiotis Paliogiannis ◽  
Federico Attene ◽  
Federica Trogu ◽  
Mario Trignano
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Gland ◽  
Thyroid Carcinoma ◽  
Papillary Carcinoma ◽  
Histopathological Examination ◽  
Lymph Node Involvement ◽  
Papillary Thyroid ◽  
Review Of The Literature

We present a case of Warthin-like papillary thyroid carcinoma in a 22-year-old woman and a review of the literature on the topic. The patient had the occasional discovery of a hypoechoic thyroid nodule of approximately 18 mm, characterized by irregular margins, hyperechoic spots, rich intra- and perilesional vascularization, and a suspicious enlarged right laterocervical lymph node. Fine-needle aspiration was performed for both lesions and the diagnosis of papillary thyroid carcinoma without lymph node involvement was made. The patient underwent thyroidectomy and central neck lymphadenectomy without complications. Histopathological examination suggested a Warthin-like papillary carcinoma of the thyroid gland, with all the removed lymph nodes being free of disease. The patient subsequently underwent iodine ablative therapy and she remains free of disease one year after surgery. Warthin-like papillary thyroid carcinoma is a recently described variant of papillary thyroid cancer that is frequently associated with lymphocytic thyroiditis. Morphologically, it resembles Warthin tumors of the salivary glands, with T and B lymphocytes infiltrating the stalks of papillae lined with oncocytic cells. Surgical and postoperative management is identical to that of classic differentiated thyroid cancer, while prognosis seems to be favourable.

scholarly journals When you hear hoof beats, it may also be a Zebra: a case report in a malignancy glottis

2020 ◽  
Vol 6 (4) ◽  
pp. 796
Author(s):  
Mohamed Abdul Kathar M. ◽  
Kapila Manikantan ◽  
Rajeev Sharan ◽  
Arun Pattatheyil
Keyword(s):  
Thyroid Cancer ◽  
Case Report ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Lymph Nodes ◽  
Laryngeal Carcinoma ◽  
Causes Of Death ◽  
Medical Center ◽  
Papillary Thyroid ◽  
Laryngeal Carcinomas

<p>Laryngeal cancer is one of the leading causes of death in Indian males. Papillary thyroid carcinoma is the most common subtype of thyroid cancer in 80% of cases and has a tendency to metastasize to lymph nodes. Patients with laryngeal cancers undergoing laryngectomy might have other occult primaries including thyroid carcinoma especially in patients with recurrent laryngeal carcinomas. We report a case of recurrent laryngeal carcinoma with incidental carcinomas. This study was conducted at TATA medical center, Kolkata.</p>

Assessment Of Plasma B-Catenin Concentration As Biomarker Of Thyroid Cancer*

2015 ◽  
Vol 87 (7) ◽  
Author(s):  
Michał Bełdowski
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Histopathological Examination ◽  
Nodular Goiter ◽  
Diagnostic Methods ◽  
Control Group ◽  
Papillary Thyroid ◽  
It Use ◽  
Cellular Expression

AbstractNew diagnostic methods for thyroid diseases are still being searched for. Immunohistochemical diagnosis is expanded by the introduction of new biomarkers including ß-catenin (B-Cat). Associations are indicated between the cellular expression of this biomarker and tumor stage, nodal metastases and the degree of tumor cell differentiation. Reports are scarce regarding the plasma level of this biomarker in malignant neoplastic diseases.was to analyze the plasma B-Cat concentration and the possibility of it use in the diagnostics of patients with nodular goiter and papillary thyroid carcinoma.Plasma B-Cat concentration was determined in 64 patients with goiter and 15 healthy volunteers. The final histopathological examination revealed 41 cases of papillary thyroid carcinoma (PTC) and 13 cases of nodular goiter (NG).A significant increase in B-Cat (p <0.05) in both groups compared to the control group. No differences in the concentrations of biomarker was demonstrated between the PTC and NG groups. After determining the AUC for the tested biomarker, the B-Cat ratio of the area value 0.721 was the strong diagnostic test.Changes in the plasma B-Cat concentration can be the biomarker of thyroid cancer but it cannot be used for the detection of papillary thyroid carcinoma becouse of concomitant tumor-like lesions in the thyroid gland.

scholarly journals Prevalence of papillary thyroid cancer in subacute thyroiditis patients may be higher than it is presumed: retrospective analysis of 137 patients

2018 ◽  
Vol 52 (3) ◽  
pp. 257-262 ◽  
Author(s):  
Nurdan Gül ◽  
Ayşe Kubat Üzüm ◽  
Özlem Soyluk Selçukbiricik ◽  
Gülçin Yegen ◽  
Refik Tanakol ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Differentiated Thyroid Cancer ◽  
Histopathological Examination ◽  
Needle Aspiration ◽  
Subacute Thyroiditis ◽  
Papillary Thyroid ◽  
Small Series ◽  
Male Patients

Abstract Background The association of subacute thyroiditis (SAT) and papillary thyroid carcinoma is a rare finding. In this study, we aimed to investigate the prevalence of differentiated thyroid cancer in a cohort of patients followed with the diagnosis of SAT. Patients and methods We retrospectively screened medical records of Endocrinology and Metabolism outpatient clinic in the past 20 years for patients with SAT. Patients with nodules and suspicious ultrasonography findings who underwent fine needle aspiration biopsy (FNAB) and operated due to malignancy risk were identified. Results We identified 137 (100 females, 37 males) patients with reliable records to confirm the diagnosis of SAT. The mean age of female patients was 41.1 ± 9.1 (range, 20–64) and of male patients was 43.0 ± 9.3 (range, 20–65). One or more FNAB was performed in 23 of the patients (16.8%) at the beginning and/or during the follow-up period when needed. Seven patients with suspicious FNAB findings were operated, and histopathological examination of the nodules confirmed the diagnosis of papillary thyroid carcinoma in 6 patients (4.4%). Conclusions Our observations suggesting a relatively higher prevalence of thyroid cancer in a small series of SAT patients warrant further studies to identify the real frequency of differentiated thyroid cancer and its association with inflammatory pathogenesis of SAT. This finding is compatible with the trend of increased thyroid cancer incidence all over the world. A repeat ultrasonography after resolution of clinical and inflammatory findings, and FNAB should be recommended to all patients with suspicious nodules.

scholarly journals Brain Metastases in a Patient With Papillary Thyroid Carcinoma. Clinical Case Report

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A883-A884
Author(s):  
Andrés Felipe García Ramos ◽  
Jose Leonel Zambrano Urbano ◽  
Víctor Manuel Blanco Pico ◽  
Franco Alejandro Vallejo García ◽  
Marcela Patiño Arboleda ◽  
...  
Keyword(s):  
Case Report ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Brain Metastases ◽  
Clinical Case ◽  
Lung Metastases ◽  
Brain Mri ◽  
Braf V600e ◽  
Papillary Thyroid ◽  
Promising Alternative

Abstract Introduction: Papillary thyroid carcinoma (PTC) is the most common neoplasm of the endocrine system and the least aggressive, representing between 70% and 80% of thyroid neoplasms. This is characterized by slow growth and a low risk of progression to metastasis. Brain Metastases (BM) associated with PTC occur with a incidence rate of 0.15%. Tyrosine kinase inhibitors (TKI) are a very promising alternative for managing these patients. Here is described the case of a patient with PTC with brain and lung metastases, her respective management and evolution. Clinical Case Report: A 64-year-old patient with a history of controlled hypothyroidism, who was recently diagnosed with high cell variant PTC, positive for BRAF V600E mutation. Neck CT revealed a thyroid mass extending to the superior mediastinum, with associated lung metastases. We started by suppressing TSH with levothyroxine. Brain MRI was done due to persistent and as safety precaution before starting thyrotropin alfa This showed multiple intra-parenchymal lesions compatible with BM. Patient received management with gamma Knife radiosurgery for BM and with lenvatinib 24mg day. The patient presented a decrease in tumor size by more than 50% in the neck, with disappearance of the majority of BM at 90 days. After 18 months of treatment, she was still alive. Discussion and Conclusion: PTC associated with BM has a very poor life expectancy, and there are not guidelines for its management and the treatment is based on case reports and expert opinions. Radiosurgery plus ITK combined therapy could provide better outcomes to these patients

A case report: co-occurence of medullary thyroid carcinoma and papillary thyroid carcinoma

2017 ◽  
Author(s):  
Beliz Camur ◽  
Mehmet Celik ◽  
Buket Yilmaz Bulbul ◽  
Semra Ayturk ◽  
Ebru Tastekin ◽  
...  
Keyword(s):  
Case Report ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Medullary Thyroid
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