Nasopharyngeal and oropharyngeal rinses with neutral electrolyzed water prevents COVID‑19 in front‑line health professionals: A randomized, open‑label, controlled trial in a general hospital in Mexico City

Abstract Background: The COVID-19 pandemic, caused by the SARS-COV-2 virus, has destabilized society all around the world and is predicted to take a long time to be overcome. The worldwide efforts that healthcare professionals are making is well known, and the high risk of illness and death that front-line staff experience on a daily basis is a reality as well. Despite well-defined protocols for the use of personal protective equipment, many nurses and doctors are still getting sick and dying. It is well known that vaccination is still faraway to be achieved worldwide and that new variants are emerging, so additional protective measures must be explored. This study investigated the effectivity of a neutral electrolyzed water (SES) to reduce the risk of COVID-19 disease in front-line medical staff, when it was used for nasopharyngeal and oropharyngeal rinses (prophylactic protocol).Methods: A prospective open-label, randomized controlled clinical trial was performed in front-line medical staff from the general hospital Enrique Cabrera in México City. One hundred and seventy volunteers were enrolled and equally divided in control group and SES group. All members of the trial wore the adequate personal protection equipment at all times while performing their duties, as required by standard COVID-19 safety protocols. Additionally, the SES group participants followed a prophylactic protocol with SES (oral and nasal rinses, three times a day for 4 weeks). All participants were monitored for COVID-19 symptoms and disease in a time-frame of 4 weeks and the incidence of illness per group was registered. The relative risk of disease, associated with each treatment was calculated. Results: The presence of COVID-19 positive cases, in the group that received the nasal and oral rinses with SES was 1.2%, while in the group that did not do the SES rinses (control group), it was 12.7% (p= 0.0039 and RR= 0.09405; 95%, CI of 0.01231-0.7183). The prophylactic protocol was demonstrated as a protective factor for developing the disease. Conclusions: Nasal and oral rinses with SES may be an efficient alternative to reinforce the protective measures against COVID-19 disease and should be further investigated. Trial registration: RPCEC00000357. Retrospectively registered, March, 16, 2021. https://rpcec.sld.cu/en/trials/RPCEC00000357-En/revisions/5137/view

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Effectiveness of Homeopathic Medicines as Add-on to Institutional Management Protocol for Acute Encephalitis Syndrome in Children: an Open-Label Randomized Placebo-Controlled Trial

10.1055/s-0040-1702077 ◽

2020 ◽

Author(s):

Praveen Oberai ◽

Roja Varanasi ◽

Maya Padmanabhan ◽

Alok Upadhyaya ◽

Supriya Singh ◽

...

Keyword(s):

Controlled Trial ◽

Open Label ◽

Institutional Management ◽

Acute Encephalitis Syndrome ◽

Acute Encephalitis ◽

Management Protocol

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Impact of Temperature on Injection-Related Pain Caused by Subcutaneous Administration of Ustekinumab: A Three-arm Crossover Open-label Randomized Controlled Trial

SKIN The Journal of Cutaneous Medicine ◽

10.25251/skin.1.3.2 ◽

2017 ◽

Vol 1 (3) ◽

pp. 117-127

Author(s):

Yasaman Mansouri ◽

Yasmin Amir ◽

Michelle Min ◽

Raveena Khanna ◽

Ruiqi Huang ◽

...

Keyword(s):

Controlled Trial ◽

Subcutaneous Administration ◽

Open Label ◽

Post Dose ◽

Subcutaneous Injections ◽

Pain Scores ◽

Observational Cohort ◽

Vas Scores ◽

Pre Treatment ◽

To Receive

Background: Adherence to subcutaneous biologic agents for the treatment of psoriasis can be negatively influenced by injection pain.Objective: To explore the differences in injection site pain when patients are pre-treated with heat or cold, versus no pre-treatment prior to administration of a subcutaneous biologic agent.Methods: In an observational cohort study, patients receiving subcutaneous injections of ustekinumab were randomly assigned to receive pretreatment with ice, heat, or no intervention over three visits. Post-dose, patients rated pain on a 100 mm visual analogue scale (VAS).Results: There was an increase in the VAS score for both heat (2.51, P=0.30) and ice (3.33, P=0.16), compared to no intervention. No differences were found between the two intervention groups (-0.83, P=0.73). On average, females had the same VAS scores with ice compared to that of no intervention (-0.12, P=0.97) and a non–significant decrease of 3.29 points (P=0.38) with heat. Males had increased pain scores by 5.65 points (P=0.07) with ice and by 6.39 points (P=0.04) with heat.Limitations: Pain is a subjective measurement and objective quantification is difficult.Conclusions: On average, neither heat nor cold application reliably reduced pain. Our results do not support the application of heat or cold prior to ustekinumab injection.

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Taking Open Label Placebo Further: Randomized Controlled Trial of Imaginary Pills in Test Anxiety

Case Medical Research ◽

10.31525/ct1-nct04250571 ◽

2020 ◽

Author(s):

Keyword(s):

Randomized Controlled Trial ◽

Test Anxiety ◽

Controlled Trial ◽

Open Label ◽

Randomized Controlled

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Experiences in physical activity promotion in health care settings for primary prevention in the UK

Swiss Sports & Exercise Medicine ◽

10.34045/ssem/2014/11 ◽

2014 ◽

Vol 62 (2) ◽

Keyword(s):

Physical Activity ◽

Primary Care ◽

Health Professionals ◽

Controlled Trial ◽

Full Range ◽

Tertiary Care ◽

Physical Activity Promotion ◽

Community Based ◽

Activity Promotion ◽

Randomised Controlled

In addition to the delivery of primary care services, recent changes to the NHS in the United Kingdom have placed increasing responsibility on GPs for the commissioning of the full range of health services from prevention through to clinical interventions and rehabilitation. Whilst historically there has always been an expectation that primary care professionals were ideally placed to provide support for prevention as well as treatment, their active engagement in the promotion of physical activity has remained largely superficial. With notable exceptions where individuals have a personal interest or commitment, the majority of health professionals tend to limit themselves to peremptory non-specific advice at best, or frequently don’t broach the subject at all. There are a number of reasons for this including increasing time pressures, a general lack of knowledge, limited evidence and concerns about litigation in the event of an adverse exercise induced event. However in the 1990s there was a surge of interest in the emerging “Exercise on Prescription” model where patients could be referred to community based exercise instructors for a structured “prescription” of exercise in community leisure centres. Despite the continuing popularity of the model there remain problems particularly in getting the active support of health professionals who generally cite the same barriers as previously identified. In an attempt to overcome some of these problems Wales established a national exercise referral scheme with an associated randomised controlled trial. The scheme evaluated well and had subsequently evolved with new developments including integration with secondary and tertiary care pathways, accredited training for exercise instructors and exit routes into alternative community based exercise opportunities.

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