Investigation of angiogenetic axis Angiopoietin-1 and -2/Tie-2 in fibrotic lung diseases: A bronchoalveolar lavage study

Progressive fibrosing interstitial lung disease (PF-ILD) describes a phenotypic subset of interstitial lung diseases characterized by progressive, intractable lung fibrosis. PF-ILD is separate from, but has radiographic, histopathologic, and clinical similarities to idiopathic pulmonary fibrosis. Two antifibrotic medications, nintedanib and pirfenidone, have been approved for use in patients with idiopathic pulmonary fibrosis. Recently completed randomized controlled trials have demonstrated the clinical efficacy of antifibrotic therapy in patients with PF-ILD. The validation of efficacy of antifibrotic therapy in PF-ILD has changed the treatment landscape for all of the fibrotic lung diseases, providing a new treatment pathway and opening the door for combined antifibrotic and immunosuppressant drug therapy to address both the fibrotic and inflammatory components of ILD characterized by mixed pathophysiologic pathways.

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Bronchoalveolar Lavage Fluid and Serum Canine Surfactant Protein A Concentrations in Dogs with Chronic Cough by Bronchial and Interstitial Lung Diseases

Journal of Veterinary Medical Science ◽

10.1292/jvms.13-0428 ◽

2014 ◽

Vol 76 (4) ◽

pp. 593-596 ◽

Cited By ~ 1

Author(s):

Yoshiki YAMAYA ◽

Kazuyuki SUZUKI ◽

Toshihiro WATARI ◽

Ryuji ASANO

Keyword(s):

Bronchoalveolar Lavage ◽

Chronic Cough ◽

Lung Diseases ◽

Bronchoalveolar Lavage Fluid ◽

Protein A ◽

Lavage Fluid ◽

Surfactant Protein ◽

Interstitial Lung Diseases ◽

Surfactant Protein A

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Eosinophilic lung disease as a sequela of MSSA pneumonia

BMJ Case Reports ◽

10.1136/bcr-2020-239304 ◽

2021 ◽

Vol 14 (3) ◽

pp. e239304

Author(s):

Syed Muhammad Zubair ◽

Muhammad Zaid Hamid Hussain ◽

Ali Bin Sarwar Zubairi

Keyword(s):

Emergency Department ◽

Staphylococcus Aureus ◽

Bronchoalveolar Lavage ◽

Complete Resolution ◽

Lung Diseases ◽

Disease Process ◽

High Grade ◽

Shortness Of Breath ◽

High Grade Fever ◽

Rare Group

Eosinophilic lung diseases are a rare group of lung disorders with multiple known and unknown aetiologies and the diagnosis is often challenging. We present a case of a young man who was admitted with pneumonia due to methicillin-sensitive Staphylococcus aureus and was discharged on antibiotics. He presented to the emergency department approximately 2 weeks after discharge with high-grade fever, cough and shortness of breath associated with serum and bronchoalveolar lavage eosinophilia. He was then treated with steroids with complete resolution of disease process.

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Proteome analysis of bronchoalveolar lavage in lung diseases

PROTEOMICS ◽

10.1002/pmic.200600303 ◽

2006 ◽

Vol 6 (23) ◽

pp. 6354-6369 ◽

Cited By ~ 87

Author(s):

Barbara Magi ◽

Elena Bargagli ◽

Luca Bini ◽

Paola Rottoli

Keyword(s):

Bronchoalveolar Lavage ◽

Lung Diseases ◽

Proteome Analysis

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Concordance of Bronchoalveolar Lavage Cytology with Transbronchial Lung Biopsies in Non-neoplastic Pulmonary Diseases

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/48003.14971 ◽

2021 ◽

Author(s):

Nischita Jayaraj ◽

Kusuma Venkatesh

Keyword(s):

Bronchoalveolar Lavage ◽

Interstitial Pneumonia ◽

Lung Diseases ◽

Correct Diagnosis ◽

Usual Interstitial Pneumonia ◽

Granulomatous Inflammation ◽

Pulmonary Diseases ◽

Differential Count ◽

Flexible Bronchoscope ◽

Cell Counts

Introduction: In many pulmonary diseases, despite radiological & clinical investigations, laboratory tests and function studies, the diagnosis becomes difficult. Bronchoalveolar Lavage (BAL) is a minimally invasive method in which cells are collected from bronchial and alveolar spaces for cytology. This is facilitated by using a flexible bronchoscope with which a biopsy is taken following BAL. Bronchoscopy with BAL when used appropriately can offer correct diagnosis which in turn aids in proper management of the patient. Aim: To find the concordance of BAL findings with the histopathological features of Transbronchial Lung Biopsy (TBLB) in non-neoplastic lung diseases. Materials and Methods: It was a retrospective study conducted in Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka. A total of 40 patients presenting with clinico-radiological findings, suggesting a non-neoplastic lung disease in the year 2019, undergoing bronchoscopy with BAL and concurrent TBLB were chosen. The BAL fluid was processed and differential count of cells was done to classify according to the American Thoracic Society Guidelines. Concordance was checked between the diagnoses made on TBLB and BAL analysis. Results: In the present study, a total of 40 cases were included of which 13 (32.5%) cases showed neutrophilic, 16 (40%) cases showed lymphocytic, 5 (12.5%) cases showed eosinophilic and 6 (15%) cases showed normal cellular distribution on BAL cytology. Diagnoses on studying TBLB included nine cases of Nonspecific Interstitial Pneumonia, seven cases of Usual Interstitial Pneumonia, six cases of Bronchiolitis Obliterans Organising Pneumonia, three cases of Bronchiolitis, two cases each of pulmonary tuberculosis and granulomatous inflammation. There was one case each of actinomycosis, sarcoidosis, lung abscess and mucor mycosis. Normal histology was noted in seven cases. The sensitivity of BAL fluid analysis was found to be 84.84% and the concordance was 80%. The Kappa value obtained was 0.71 indicating good agreement/concordance between BAL cytology and TBLB. Conclusion: The data from the current study suggest that differential cell counts in BAL provide diagnostic information of fundamental importance in frequently occurring non-neoplastic lung diseases in the community.

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