scholarly journals 17β‑estradiol‑induced mitochondrial dysfunction and Warburg effect in cervical cancer cells allow cell survival under metabolic stress

2019 ◽  
Author(s):  
Annie Riera Leal ◽  
Pablo Ortiz‑Lazareno ◽  
Luis Jave‑Su�rez ◽  
Adri�n Ram�rez De Arellano ◽  
Adriana Aguilar‑Lemarroy ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Mitochondrial Dysfunction ◽  
Cell Survival ◽  
Cancer Cells ◽  
Warburg Effect ◽  
Metabolic Stress ◽  
Cervical Cancer Cells ◽  
17Β Estradiol

scholarly journals High expression of prolactin receptor is associated with cell survival of cervical cancer cells

2013 ◽  
Vol 4 ◽  
Author(s):  
L�pez Pulido Edgar ◽  
Mu�oz Valle Jos� ◽  
Pereira Su�rez Ana ◽  
Del Toro Arreola Susana ◽  
Ascencio Cedillo Rafael ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Survival ◽  
Cancer Cells ◽  
Prolactin Receptor ◽  
High Expression ◽  
Cervical Cancer Cells

scholarly journals The nuclear export of TR3 mediated gambogic acid-induced apoptosis in cervical cancer cells through mitochondrial dysfunction

RSC Advances ◽  
2019 ◽  
Vol 9 (21) ◽  
pp. 11855-11864
Author(s):  
Chunhong Zhang ◽  
Jia Liu ◽  
Fengxing Tao ◽  
Yiyi Lu ◽  
Qin He ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Nuclear Export ◽  
Gambogic Acid ◽  
Cervical Cancer Cells ◽  
Induced Apoptosis

The crosstalk of TR3 and p53 mediates GA-induced apoptosis of cervical cancer cells.

scholarly journals FoxO1, a Potential Therapeutic Target, Regulates Mitochondrial Dysfunction and Pyroptosis in LPS-Induced Human Cervical Cancer Cells

2020 ◽  
Author(s):  
Huizhi Wang ◽  
Zhi Ma ◽  
Fanshu Gao ◽  
Wei Jiang ◽  
Yang Li ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Therapeutic Target ◽  
Mitochondrial Morphology ◽  
Potential Therapeutic Target ◽  
Cervical Cancer Cells ◽  
Foxo1 Gene ◽  
Human Cervical Cancer Cells ◽  
Human Cervical Cancer

Abstract Background: Chronic inflammation plays an important role in the development of cervical cancer. Studies have demonstrated that transcription factors forkhead box protein O1 (FoxO1) have been reported to play important roles in various cancers. Aim: The purpose of this study was to investigate the effect of FoxO1 gene on lipopolysaccharide (LPS)-induced inflammation and intracellular pyroptosis in the development and progression of human cervical cancer cells (SiHa).Methods: In this study, FoxO1 expression was examined using real-time polymerase chain reaction (PCR), western blotting and immunohistochemical staining. SiHa cells migration and proliferation was detected using the transwell assay and 3H‑TdR assay. Mitochondrial function was assessed based on reactive oxygen species (ROS) generation and changes in the mitochondrial membrane potential (ΔΨm). Results: Our study demonstrated that LPS inhibited FoxO1 gene expression, and the silence of FoxO1 gene caused the accumulation of ROS, decreases in the ΔΨm and mitochondrial morphology change). However, either overexpression of FoxO1 or metformin could reverse the LPS-induced mitochondrial dysfunction, cell pyroptosis, migration and proliferation.Conclusions: Our study indicated that FoxO1 as a potential therapeutic target to cure against LPS-induced human cervical cancer in a mitochondria-dependent manner.

scholarly journals Retraction: The nuclear export of TR3 mediated gambogic acid-induced apoptosis in cervical cancer cells through mitochondrial dysfunction

RSC Advances ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 4443-4443
Author(s):  
Laura Fisher
Keyword(s):  
Cervical Cancer ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Nuclear Export ◽  
Gambogic Acid ◽  
Cervical Cancer Cells ◽  
Induced Apoptosis

Retraction of ‘The nuclear export of TR3 mediated gambogic acid-induced apoptosis in cervical cancer cells through mitochondrial dysfunction’ by Chunhong Zhang et al., RSC Adv., 2019, 9, 11855–11864, DOI: 10.1039/C8RA10542A.

Eriodictyol Suppresses Survival of Cervical Cancer Cells Through Mediation of PTEN/Akt Signaling Pathway

2019 ◽  
Vol 18 (2) ◽  
pp. 196-200
Author(s):  
Yu Lixiao ◽  
Liu Xiaoyun
Keyword(s):  
Cell Cycle ◽  
Cervical Cancer ◽  
Cell Survival ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Hela Cells ◽  
Akt Signaling ◽  
Dependent Manner ◽  
Akt Signaling Pathway ◽  
Cervical Cancer Cells

Cervical cancer is one of the most malignant cancers of the female reproductive system with high morbidity and mortality. In the current study, we have examined the effect of eriodictyol on cell survival including cell growth, cell cycle and apoptosis of cervical cancer cells and also explored the underlying mechanism(s). To this end, CCK-8 assay, flow cytometry and western blotting assays were performed in cervical cancer HeLa cells. Eriodictyol significantly inhibited cell survival including impeding the cell viability, arresting the cell cycle at the G1 phase and potentiating cell apoptosis in a concentration-dependent manner. Also, ERI activated PTEN, P21, cleaved caspase-3/-9 expression and downregulated P-Akt and cyclin D1 expression in a dose-dependent manner. In conclusion, ERI can inhibit cervical cancer HeLa cells viability via impeding cell cycle and inducing apoptosis by regulating PTEN/Akt signaling pathway.

scholarly journals LncRNA OIP5-AS1 Regulates the Warburg Effect Through miR-124-5p/IDH2/HIF-1α Pathway in Cervical Cancer

2021 ◽  
Vol 9 ◽  
Author(s):  
Li Li ◽  
Yan Ma ◽  
Kamalibaike Maerkeya ◽  
Davuti Reyanguly ◽  
Lili Han
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Warburg Effect ◽  
Hypoxia Inducible Factor ◽  
Hypoxic Condition ◽  
Cervical Cancer Cells ◽  
The Warburg Effect

Hypoxia reprogrammed glucose metabolism affects the Warburg effect of tumor cells, but the mechanism is still unclear. Long-chain non-coding RNA (lncRNA) has been found by many studies to be involved in the Warburg effect of tumor cells under hypoxic condition. Herein, we find that lncRNA OIP5-AS1 is up-regulated in cervical cancer tissues and predicts poor 5-years overall survival in cervical cancer patients, and it promotes cell proliferation of cervical cancer cells in vitro and in vivo. Moreover, OIP5-AS1 is a hypoxia-responsive lncRNA and is essential for hypoxia-enhanced glycolysis which is IDH2 or hypoxia inducible factor-1α (HIF-1α) dependent. In cervical cancer cells, OIP5-AS1 promotes IDH2 expression by inhibiting miR-124-5p, and IDH2 promotes the Warburg effect of cervical under hypoxic condition through regulating HIF-1α expression. In conclusion, hypoxia induced OIP5-AS1 promotes the Warburg effect through miR-124-5p/IDH2/HIF-1α pathway in cervical cancer.

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