Expression of human telomerase reverse transcriptase splice variants is well correlated with low telomerase activity in osteosarcoma cell lines

2005 ◽  
Author(s):  
Hitomi Fujiwara-Akita ◽  
Chihaya Maesawa ◽  
Takehisa Honda ◽  
Seiichiro Kobayashi ◽  
Tomoyuki Masuda
Keyword(s):  
Reverse Transcriptase ◽  
Cell Lines ◽  
Splice Variants ◽  
Telomerase Activity ◽  
Telomerase Reverse Transcriptase ◽  
Osteosarcoma Cell ◽  
Human Telomerase Reverse Transcriptase ◽  
Human Telomerase

scholarly journals Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 526
Author(s):  
Anna A. Plyasova ◽  
Dmitry D. Zhdanov
Keyword(s):  
Alternative Splicing ◽  
Reverse Transcriptase ◽  
Splice Variants ◽  
Biological Activities ◽  
Telomerase Activity ◽  
Telomerase Reverse Transcriptase ◽  
Human Telomerase Reverse Transcriptase ◽  
Independent Manner ◽  
A Cell ◽  
Human Telomerase

Alternative splicing (AS) of human telomerase catalytic subunit (hTERT, human telomerase reverse transcriptase) pre-mRNA strongly regulates telomerase activity. Several proteins can regulate AS in a cell type-specific manner and determine the functions of cells. In addition to being involved in telomerase activity regulation, AS provides cells with different splice variants that may have alternative biological activities. The modulation of telomerase activity through the induction of hTERT AS is involved in the development of different cancer types and embryos, and the differentiation of stem cells. Regulatory T cells may suppress the proliferation of target human and murine T and B lymphocytes and NK cells in a contact-independent manner involving activation of TERT AS. This review focuses on the mechanism of regulation of hTERT pre-mRNA AS and the involvement of splice variants in physiological and pathological processes.

scholarly journals Telomerase Activity Reconstitutedin Vitrowith Purified Human Telomerase Reverse Transcriptase and Human Telomerase RNA Component

2000 ◽  
Vol 275 (29) ◽  
pp. 22568-22573 ◽  
Author(s):  
Kenkichi Masutomi ◽  
Shuichi Kaneko ◽  
Naoyuki Hayashi ◽  
Tatsuya Yamashita ◽  
Yukihiro Shirota ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Telomerase Activity ◽  
Telomerase Reverse Transcriptase ◽  
Telomerase Rna ◽  
Human Telomerase Reverse Transcriptase ◽  
Human Telomerase

scholarly journals Characterization of human telomerase reverse transcriptase immortalized anterior cruciate ligament cell lines

2019 ◽  
Vol 42 (6) ◽  
pp. 371-380 ◽  
Author(s):  
Patrick Prager ◽  
Matthias Schieker ◽  
Franz Jakob ◽  
Denitsa Docheva ◽  
Christian Konrads ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Reverse Transcriptase ◽  
Cell Lines ◽  
Cruciate Ligament ◽  
Telomerase Reverse Transcriptase ◽  
Human Telomerase Reverse Transcriptase ◽  
Anterior Cruciate ◽  
Human Telomerase
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