scholarly journals Comparative expression of matrix metalloproteinases in low‑grade mucoepidermoid carcinoma and typical lung cancer

2011 ◽  
Author(s):  
Ge-Ning Jiang
Keyword(s):  
Lung Cancer ◽  
Matrix Metalloproteinases ◽  
Mucoepidermoid Carcinoma ◽  
Low Grade

scholarly journals Comparative expression of matrix metalloproteinases in low-grade mucoepidermoid carcinoma and typical lung cancer

2011 ◽  
Vol 2 (6) ◽  
pp. 1269-1273 ◽  
Author(s):  
JIANG FAN ◽  
FENG-YING WU ◽  
LEI WANG ◽  
GE-NING JIANG ◽  
WEN GAO
Keyword(s):  
Lung Cancer ◽  
Matrix Metalloproteinases ◽  
Mucoepidermoid Carcinoma ◽  
Low Grade

scholarly journals Mucoepidermoid Carcinoma of the Lung: A Case Report and Literature Review

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
S. Alsidawi ◽  
J. C. Morris ◽  
K. A. Wikenheiser-Brokamp ◽  
S. L. Starnes ◽  
N. A. Karim
Keyword(s):  
Lung Cancer ◽  
Surgical Resection ◽  
Mucoepidermoid Carcinoma ◽  
Primary Treatment ◽  
Pathological Examination ◽  
Low Grade ◽  
High Grade ◽  
Lobe Bronchus ◽  
Rare Type ◽  
The Right

Introduction. Mucoepidermoid carcinoma (MEC) of the lung is a rare form of lung cancer that is classified into low grade and high grade based on histological features. Surgical resection is the primary treatment for low-grade MEC with excellent outcomes, while high-grade MEC is a more aggressive form of malignancy.Clinical Case. We report a case of a 46-year-old woman who presented with dyspnea on exertion. Imaging studies revealed a mass involving the right upper lobe bronchus. Bronchoscopy, surgical resection, and pathological examination revealed a low-grade MEC with tumor-free margins. No adjuvant treatment was given.Discussion. Primary pulmonary MEC is a rare type of lung cancer with only few reported cases. This patient illustrates a typical presentation for low-grade MEC wherein surgical resection is considered curative. In contrast, high-grade MEC is a more aggressive malignancy with a poorer outcome. The role of targeted therapy directed against EGFR or a novel CRTC1-MAML2 fusion protein expressed in some high-grade tumors is yet to be determined.

Hosszú túléléssel járó malignus tumor miatti tüdőmegtartó centrális főhörgőplasztikáink

2013 ◽  
Vol 66 (6) ◽  
pp. 338-347
Author(s):  
László István Kecskés ◽  
Győző Bátor ◽  
Árpád Füredi ◽  
Pál Gehér ◽  
Béla Kiss ◽  
...  
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Low Grade ◽  
Karnofsky Index

AbsztraktBevezetés:A daganatos haláloki statisztikát vezető malignus hörgőtumorok eseteiben hosszú túlélésre csak a radikálisan operált betegek számíthatnak. Mégis, jól lokalizált, centrális és low grade malignomák kezelésében a tüdőmegtartó centrális bronchusplasztikáknak is helye lehet.Célkitűzés:A parenchymakonzerváló műtétek az egyik oldali teljes tüdő eltávolításának vagy az inoperabilitásnak a pozitív alternatívái lehetnek. Értékét a mortalitás, a szövődmények és a túlélés alapján lehet megítélni.Beteganyag és módszer:1985–2012 között 7130 hörgőcarcinomás beteget operáltunk. 80 centrális bronchoplasztikai műtétből7 esetben a jobb vagy bal főhörgő izolált vagy az egész bifurcatiós carina resectiója és a tüdő autotranszplantációja révén teljes tüdőmegtartást értünk el.A 4 nő és 3 férfi átlagéletkora 28,5 (14–58) év volt. 4 beteg carcinoid, 1 laphámrák, 1 mucoepidermoid carcinoma miatt, 1 beteg kissejtes tüdőrák (SCLC) miatti kemo-radioterápia (KRT) után került műtétre. 1 esetben izolált carina-, 1 betegnél balfőhörgő-, 5 betegnél jobbfőhörgő-resectio történt. Az anastomosist csomós PDS öltésekkel a műtéti területen át bevezetett steril tubus (6 beteg), illetve jet-katéter (1 beteg) felett varrtuk. A betegeket műtét után extubáltuk.Eredmények:Műtéti mortalitás nem volt. A korai posztoperatív szakban ismételt bronchoscopos leszívásokat alkalmaztunk. A SCLC miatt operált betegnél subacut anastomosisstenosis miatt kétoldali ideiglenes stentimplantációt alkalmaztunk. 174 hónapja él, Karnofsky-index 90%. 5 másik beteg is tumorrecidíva, metastasis nélkül él. A laphámrák miatti izolált jobbfőhörgő-resecált beteg 83 hónap után bal oldali disseminált kissejtes tüdőrák miatt exitált.Átlagos túlélés: 118 hónap (7–233).Következtetések:Fiatal betegeknél, lokalizált centrális főhörgő rosszindulatú daganatok szelektált eseteiben, izolált carina-főhörgő resectióval nemcsak teljes tüdőmegtartás, hanem hosszú túlélés is elérhető. Az irodalomban vannak hasonlóan sikeres, kisebb szériák és esetbemutatások (összes esetszám 200 alatt), de hosszú távú eredményekről kevés az adat. Hazánkban ez a legnagyobb széria, eredményeink nemzetközi kitekintéssel mérve is helytállóak.

Different effects of bronchoscopic interventions on children and adults with tracheobronchial mucoepidermoid carcinoma

2021 ◽  
pp. 030089162199589
Author(s):  
Zhang Jieli ◽  
Zhou Yunzhi ◽  
Zhang Nan ◽  
Zou Heng ◽  
Wang Hongwu ◽  
...  
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Argon Plasma Coagulation ◽  
Survival Rates ◽  
Argon Plasma ◽  
Rigid Bronchoscopy ◽  
Low Grade ◽  
High Grade ◽  
Adult Group ◽  
Histologic Grading ◽  
Comprehensive Therapy

Aims: To investigate the efficacy and safety of minimally invasive bronchoscopic interventions for patients with tracheobronchial mucoepidermoid carcinoma (MEC). Methods: Patients with tracheobronchial MEC were included in this retrospective study, and the clinical features, histologic grading, treatments, and cumulative survival rates were calculated. Patients were categorized into child (n = 16) and adult (n = 19) group according to their ages. Histologic grading, treatments, and survival status were compared between the two groups. Results: In pathology, high-grade MEC counts for 6.77% and 42.10% in the child and adult group, respectively. As tumor growth pattern was concerned, 93.33% and 21.05% tumors in the child and adult group present intratracheal type. Multiple bronchoscopic interventions were conducted, including rigid bronchoscopy, argon plasma coagulation (APC), dioxide carbon cryotherapy, and electric loop. Tumors could be removed by multiple bronchoscopic interventions. Bronchoscopy-associated complications were rare, including an oral mucosa injury and a glottis edema. In the child group, one patient underwent left upper lung lobectomy. In the adult group, lobectomy and/or chemotherapy and/or radiotherapy were conducted in seven patients. The 5-year survival rate was 100% and 68.90% in the child and the adult group, respectively. Conclusions: Almost all children have low-grade and intratracheal MEC; 2/5 adults have invasive high-grade MEC. Multiple bronchoscopic interventions are effective in erasing low-grade intratracheal MEC without severe complications. For high-grade invasive MEC, aggressive and comprehensive therapy should be considered.

Salivary Gland Mucoepidermoid Carcinoma, Low Grade: Diagnostic Pearls Among Pitfalls

2018 ◽  
Vol 7 (5) ◽  
pp. S18
Author(s):  
Ameer Hamza ◽  
Ahmed Alrajjal ◽  
Zhifei Zhang ◽  
Basim Al-Khafaji
Keyword(s):  
Salivary Gland ◽  
Mucoepidermoid Carcinoma ◽  
Low Grade

Diagnosis and management of cold agglutinin disease associated with low-grade B-cell lymphoma in a patient receiving pembrolizumab for lung cancer

2021 ◽  
Vol 14 (8) ◽  
pp. e243751
Author(s):  
Nabin Raj Karki ◽  
Peyton McElhone ◽  
Natasha Savage ◽  
Nagla Abdel Karim
Keyword(s):  
Lung Cancer ◽  
B Cell ◽  
Marginal Zone ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
High Titre ◽  
Cold Agglutinin ◽  
Low Grade ◽  
Cold Agglutinin Disease ◽  
Cold Room

A 65-year-old with non-small cell lung cancer developed autoimmune haemolytic anaemia while receiving pembrolizumab containing chemoimmunotherapy. Initially thought to be due to pembrolizumab induced haemolysis, he was treated with steroids, and pembrolizumab was held. Haemolysis was refractory to steroids and blood was observed to agglutinate in cold room temperatures. Cold agglutinins in high titre and monoclonal serum IgM kappa protein were detected. Bone marrow biopsy showed marginal zone lymphoma confirming low grade B-cell lymphoma causing cold agglutinin disease. B-cell depletion by rituximab stopped haemolysis, and pembrolizumab was safely continued for lung cancer.

scholarly journals Anaplastic Lymphoma Kinase-Positive Lung Cancer with Mucoepidermoid Carcinoma Differentiation: A Case Report

2020 ◽  
Vol 13 (2) ◽  
pp. 1037-1041
Author(s):  
Toshio Sakatani ◽  
Yoshio Masuda ◽  
Teppei Morikawa ◽  
Kazuhiro Usui
Keyword(s):  
Lung Cancer ◽  
Anaplastic Lymphoma Kinase ◽  
Mucoepidermoid Carcinoma ◽  
Fusion Gene ◽  
Clinical Stage ◽  
Lower Lobe ◽  
Egfr Mutations ◽  
Rare Tumor ◽  
Genetic Characteristics ◽  
Anaplastic Lymphoma

Mucoepidermoid carcinoma (MEC) of the lung is an extremely rare tumor, and a standard chemotherapy has not been established. Furthermore, little work has been conducted on the genetic characteristics of MEC. We herein report the case of a 42-year-old nonsmoking male patient who was referred to our hospital due to cough. Chest computed tomography demonstrated infiltration and atelectasis in the right lower lobe. He was eventually diagnosed with non-small cell lung cancer (NSCLC) with MEC differentiation corresponding to clinical stage IVA (cT4N2M1a[PLE]). Genetic testing for EGFR mutations was negative, but positive for anaplastic lymphoma kinase (ALK) fusion gene. After 2 weeks of first-line treatment with alectinib, the tumor decreased in size and his symptoms improved. Advanced MEC is a rare tumor, and reports on the treatment of ALK-positive NSCLC with MEC differentiation are rare.

LOW-GRADE MUCOEPIDERMOID CARCINOMA OF LOWER LIP MIMICKING MUCOCELE

2020 ◽  
Vol 130 (3) ◽  
pp. e202
Author(s):  
RICARDO NATã FONSECA SILVA ◽  
SEBASTIãO SILVéRIO DE SOUSA-NETO ◽  
JéSSICA SILVA BUSO ◽  
ROBSON RODRIGUES GARCIA ◽  
ENEIDA FRANCO VÊNCIO ◽  
...  
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Low Grade ◽  
Lower Lip
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