scholarly journals Overexpression of monocarboxylate transporter 4 promotes the migration and invasion of non‑carcinogenic L929 fibroblast cells

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiangru Li ◽  
Xiaoju Zhou ◽  
Ying Liu ◽  
Jingjing Fan ◽  
Hongjing  Huo ◽  
...  
Keyword(s):  
Monocarboxylate Transporter ◽  
Migration And Invasion ◽  
Fibroblast Cells ◽  
L929 Fibroblast ◽  
Monocarboxylate Transporter 4

scholarly journals Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments

2019 ◽  
Vol 294 (52) ◽  
pp. 20135-20147 ◽  
Author(s):  
Yasna Contreras-Baeza ◽  
Pamela Y. Sandoval ◽  
Romina Alarcón ◽  
Alex Galaz ◽  
Francisca Cortés-Molina ◽  
...  
Keyword(s):  
Monocarboxylate Transporter ◽  
High Affinity ◽  
High Lactate ◽  
Monocarboxylate Transporter 4

Cytocompatibility property evaluation of gas pressure sintered SiAlON–SiC composites with L929 fibroblast cells and Saos-2 osteoblast-like cells

2012 ◽  
Vol 32 (3) ◽  
pp. 464-469 ◽  
Author(s):  
Alok Kumar ◽  
Awadesh Kumar Mallik ◽  
Nurcan Calis Acikbas ◽  
Merve Yaygıngol ◽  
Ferhat Kara ◽  
...  
Keyword(s):  
Gas Pressure ◽  
Fibroblast Cells ◽  
Property Evaluation ◽  
L929 Fibroblast ◽  
Sic Composites

Cytotoxicity of HC Orange NO. 1 to L929 fibroblast cells

2008 ◽  
Vol 26 (3) ◽  
pp. 309-314 ◽  
Author(s):  
Hongling Liu ◽  
Jiangning Chen ◽  
Jie Jiang ◽  
John P. Giesy ◽  
Hongxia Yu ◽  
...  
Keyword(s):  
Fibroblast Cells ◽  
L929 Fibroblast

scholarly journals AMP-activated protein kinase regulates the expression of monocarboxylate transporter 4 in skeletal muscle

Life Sciences ◽  
2011 ◽  
Vol 88 (3-4) ◽  
pp. 163-168 ◽  
Author(s):  
Ayako Furugen ◽  
Masaki Kobayashi ◽  
Katsuya Narumi ◽  
Meguho Watanabe ◽  
Sho Otake ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Protein Kinase ◽  
Monocarboxylate Transporter ◽  
Amp Activated Protein Kinase ◽  
Monocarboxylate Transporter 4

scholarly journals Identification of a selective inhibitor of human monocarboxylate transporter 4

2018 ◽  
Vol 495 (1) ◽  
pp. 427-432 ◽  
Author(s):  
Yuya Futagi ◽  
Masaki Kobayashi ◽  
Katsuya Narumi ◽  
Ayako Furugen ◽  
Ken Iseki
Keyword(s):  
Selective Inhibitor ◽  
Monocarboxylate Transporter ◽  
Monocarboxylate Transporter 4

scholarly journals MicroRNAs miR-1 and miR-206 Regulate Monocarboxylate Transporter-4 and Vascular Endothelial Growth Factor Gene Expression in Colorectal Cancer

2020 ◽  
pp. 141-152
Author(s):  
Anas Khaleel ◽  
Rowan AlEjielat ◽  
Cristina I. Batarseh ◽  
Abdallah Ahmed Elbakkoush ◽  
Amneh Tarkhan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Target Genes ◽  
Monocarboxylate Transporter ◽  
Cancer Type ◽  
Vascular Endothelial ◽  
Web Tool ◽  
Endothelial Growth Factor ◽  
Monocarboxylate Transporter 4

Background: Colorectal cancer (CRC) is currently the third most common cancer type in males and the second most occurring in females. The role of microRNA (miRNA) in the development of colorectal cancer is not fully elucidated. Therefore, understanding the mechanistic interaction between miRNA and their target oncogenes may hold great importance as a possible target for interventional anticancer therapy. Aims: To identify miRNAs that are part of the regulating pathway of Monocarboxylate Transporter-4 (MCT4) and Vascular Endothelial Growth Factor (VEGF) oncogenes. Study Design: We used publicly available prediction tools (e.g. TargetScan, MicroCosm, PicTar, and DIANA-microT-CDS) to identify the possible miRNA that target the two oncogenes. Methodology: We used the GeneMania database to visualize the network and verify gene names and remove ambiguity and duplications.  Furthermore, we used miRTarBase database to identify experimentally validated targets which we used to further confirm miRNA-oncogene relationships.  Finally, we utilized miR-Mfold web-tool to further visualize the circular structures and the simulated miR-1 and miR-206 targeting arrangements. Results: We found two putative miRNA (miR-1 and miR-206) that may downregulate MCT4 coded by SLC16A3 gene and VEGF which is coded by VEGF gene. We found relationships between the validated target genes of miR-1 and miR-206 through GeneMania which we extracted from the literature. And we elucidated the proposed structure of these two miRNAs through miR-Mfold web-tool. Conclusion: Our results elucidated a novel regulation pathway in CRC cells and may suggest a potential therapeutic approach for CRC therapy. MiR-1 and miR-206 may help cells go to apoptosis and inhibit the angiogenesis of colorectal cancer cells by down-regulation of MCT4 and VEGF proteins in tumor tissues.

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