Comprehensive analysis of competitive endogenous RNAs networks reveals potential prognostic biomarkers associated with epithelial ovarian cancer

IntroductionEpithelial ovarian cancer (EOC) is the deadliest gynecologic malignancy worldwide. Reliable predictive biomarkers are urgently needed to estimate the risk of relapse and to improve treatment management. Soluble immune-checkpoints in EOC are promising molecules serving as prognostic biomarkers accessible via liquid biopsy. We thus, aimed at elucidating the role of sB7-H4 in EOC.Material and MethodsWe analyzed soluble serum B7-H4 (sB7-H4) using ELISA and circulating tumor cells (CTCs) in blood applying the AdnaTest OvarianCancer in 85 patients suffering from advanced EOC. Findings were correlated with clinical parameters as well as survival data.ResultssB7-H4 was detectable in 14.1% patients, CTCs in 32.9% patients and simultaneous presence of CTCs and sB7-H4 was found in 7% patients, respectively. Although no association between sB7-H4 and CTC could be documented, each of them served as independent predictive factors for overall survival (OS).ConclusionsB7-H4 and CTCs are independent prognostic biomarkers for impaired survival in EOC. As they are easily accessible via liquid biopsy, they may be of potential benefit for the prediction of therapy response and survival for EOC patients.

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Comprehensive Analysis of Conditioned Media from Ovarian Cancer Cell Lines Identifies Novel Candidate Markers of Epithelial Ovarian Cancer

Journal of Proteome Research ◽

10.1021/pr900411g ◽

2009 ◽

Vol 8 (10) ◽

pp. 4705-4713 ◽

Cited By ~ 60

Author(s):

C. Geeth Gunawardana ◽

Cynthia Kuk ◽

Chris R. Smith ◽

Ihor Batruch ◽

Antoninus Soosaipillai ◽

...

Keyword(s):

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Cell Lines ◽

Cancer Cell ◽

Ovarian Cancer Cell ◽

Cancer Cell Lines ◽

Comprehensive Analysis ◽

Conditioned Media ◽

Ovarian Cancer Cell Lines

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Cytokines as Prognostic Biomarkers of Epithelial Ovarian Cancer (EOC): A Systematic Review and Meta-Analysis

Asian Pacific Journal of Cancer Prevention ◽

10.31557/apjcp.2021.22.2.315 ◽

2021 ◽

Vol 22 (2) ◽

pp. 315-323

Author(s):

Moh Fahmi ◽

Heru Pradjatmo ◽

Indwiani Astuti ◽

Ricvan Nindrea

Keyword(s):

Systematic Review ◽

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Meta Analysis ◽

Prognostic Biomarkers

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Abstract 5703: Immunoscore as prognostic biomarkers in patients with epithelial ovarian cancer

10.1158/1538-7445.am2018-5703 ◽

2018 ◽

Author(s):

Shin-Wha Lee ◽

Min-Je Kim ◽

Ju-hyun Kim ◽

Young-Jae Lee ◽

Yong-Man Kim ◽

...

Keyword(s):

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Prognostic Biomarkers

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Circular RNA profiling reveals circEXOC6B and circN4BP2L2 as novel prognostic biomarkers in epithelial ovarian cancer

International Journal of Oncology ◽

10.3892/ijo.2018.4566 ◽

2018 ◽

Cited By ~ 8

Author(s):

Li Ning ◽

Bo Long ◽

Wen Zhang ◽

Mei Yu ◽

Shu Wang ◽

...

Keyword(s):

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Circular Rna ◽

Prognostic Biomarkers ◽

Rna Profiling

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High Expression of MYL9 Indicates Poor Clinical Prognosis of Epithelial Ovarian Cancer

Recent Patents on Anti-Cancer Drug Discovery ◽

10.2174/1574891x16666210706153740 ◽

2021 ◽

Vol 16 ◽

Author(s):

Yuao Deng ◽

Longyang Liu ◽

Weifeng Feng ◽

Zhongqiu Lin ◽

Yingxia Ning ◽

...

Keyword(s):

Ovarian Cancer ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Epithelial Ovarian Cancer ◽

Expression Patterns ◽

Prognostic Biomarkers ◽

Survival Prediction ◽

Clinical Prognosis ◽

Cancer Tissues ◽

Medical University

Background: The prognosis of epithelial ovarian cancer (EOC) is poor, but the prognostic biomarkers are neither sensitive nor specific. Therefore, it is very important to search novel prognostic biomarkers for EOC. Objectives: The present study aimed to investigate myosin light chain 9(MYL9) expression in epithelial ovarian cancer (EOC) tissues (including paraffin-embedded and fresh tissue samples) and its relationship with clinicopathological characteristics, as well as its potential prognostic value in patients with EOC. Methods: Between March 2009 and December 2018, all of 184 paraffin-embedded cancer tissues from patients with EOC and 41 paratumor tissues, pathologically confirmed at the Memorial Hospital of Sun Yat-sen University and Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, were collected for the present study and were assessed for MYL9 protein expression patterns using immunohistochemistry (IHC). Furthermore, from August 2013 to November 2019, 16 fresh EOC tissues and their paired paratumor tissues, pathologically confirmed at the Integrated Hospital of Traditional Chinese Medicine, Southern Medical University were analyzed using reverse-transcription quantitative PCR (RT-qPCR) to detect MYL9 mRNA expression levels. Results: The results showed that MYL9 expression was higher in cancer tissues compared with that in paratumor tissues, and MYL9 overexpression was associated with shorter recurrence free survival (RFS) and overall survival (OS) of EOC patients. Furthermore, multivariate Cox model analysis indicated that MYL9 overexpression was an independent poor survival prediction in patients with EOC. Conclusion: MYL9 is upregulated in EOC and may serve as a useful patent of prognostic biomarker in EOC, and it may demonstrate an important value for the clinical treatment and supervision of patients with EOC.

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