scholarly journals Implications of cleaved caspase 3 and AIF expression in colorectal cancer based on patient age

2012 ◽  
Author(s):  
Aur�lie Perraud
Keyword(s):  
Colorectal Cancer ◽  
Caspase 3 ◽  
Patient Age ◽  
Patient Âgé

scholarly journals Colorectal cancer surgery remains effective with rising patient age

2014 ◽  
Vol 29 (8) ◽  
pp. 971-979 ◽  
Author(s):  
Ulrich Nitsche ◽  
Christoph Späth ◽  
Tara C. Müller ◽  
Matthias Maak ◽  
Klaus-Peter Janssen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Surgery ◽  
Patient Age ◽  
Colorectal Cancer Surgery ◽  
Patient Âgé

Implications of Familial Colorectal Cancer Risk Profiles and Microsatellite Instability Status

2009 ◽  
Vol 27 (13) ◽  
pp. 2238-2244 ◽  
Author(s):  
Steven J. Lubbe ◽  
Emily L. Webb ◽  
Ian P. Chandler ◽  
Richard S. Houlston
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Familial Aggregation ◽  
Absolute Risk ◽  
Familial Risk ◽  
Risk Groups ◽  
Familial Colorectal Cancer ◽  
Patient Age ◽  
Screening Programs ◽  
Patient Âgé

Purpose Estimating familial colorectal cancer (CRC) risk is clinically important in being able to discriminate between high- and low-risk groups. To quantify familial CRC risks associated with mismatch repair (MMR) deficient and microsatellite stable (MSS) tumors, we analyzed 2,941 population-based cases of CRC. Patients and Methods MMR status in CRCs was established by testing for microsatellite instability (MSI). MUTYH status was assigned by screening for Y165C and G382D variants. Age-specific relative and absolute CRC risks in first-degree relatives (FDRs) were calculated, and the most likely genetic models of familial aggregation were derived. Results CRC risks in FDRs were strongly associated with MSI status (MSI, standardized incidence ratio [SIR] = 4.28, 95% CI, 3.51 to 5.17; MSS, SIR = 1.91, 95% CI, 1.73 to 2.11), early-onset disease (MSI patient age < 55 years, SIR = 10.96, 95% CI, 8.32 to 14.17; MSS patient age < 55 years, SIR = 2.3, 95% CI, 1.88 to 2.85), and having more than one affected FDR (MSI, SIR = 10.00, 95% CI, 7.74 to 12.72; MSS, SIR = 2.78, 95% CI, 2.18 to 3.48). The familial aggregation of CRC associated with MSI cancer was parsimonious with dominant model conferring a high CRC risk at early ages. Approximately 69% of the excess familial risk in FDRs can be ascribed to MSS CRC, and although the pattern of familial risk supports recessive susceptibility in addition to MUTYH, the absolute risk of CRC is at best modest. Conclusion The results from this analysis should enable an individual's risk of CRC to be more accurately estimated, thus maximizing the value of screening programs. Results also have utility in the design of genetic analyses to identify novel disease alleles.

scholarly journals Demographic And Histopathological Characteristics Of Colorectal Polyps: A Descriptive Study Based On Samples Obtained From Symptomatic Patients

2016 ◽  
Vol 55 (2) ◽  
pp. 118-123
Author(s):  
Genta Cekodhima ◽  
Altin Cekodhima ◽  
Arben Beqiri ◽  
Mehdi Alimehmeti ◽  
Gerhard Sulo
Keyword(s):  
Colorectal Cancer ◽  
Histopathological Examination ◽  
Colorectal Polyps ◽  
Medium Size ◽  
Polyp Size ◽  
Patient Age ◽  
Patient Âgé ◽  
Potentially Malignant ◽  
Study Population ◽  
And Gender

Abstract Background Colorectal polyps (CP) are common among individuals older than 50 years. Some polyp types can precede colorectal cancer (CRC). This study aimed at describing histopathological characteristics of colorectal polyps in relation to age and gender among symptomatic patients referred for a colonoscopy examination during 2011-2014 in Tirana, Albania. Methods Study population included 267 individuals aged ≥ 20 years and diagnosed with ≥ 1 polyp during a colonoscopy examination. A total of 346 polyps were identified, excised and measured, and underwent histopathological examination. Results Adenomas accounted for 79.8% of all polyps and tubular type was the most frequent one (74.4%). The majority of polyps (42.5%) were small (<1 cm), 38.7% of a medium size (1-2 cm) and 18.8% large (>2 cm). Adenomas were larger than non-adenomatous polyps (p<0.01) There was no gender difference with regard to patient age (p=0.22) or polyp size (p=0.84) Adenomas were more frequent among men compared to women (p=0.02). Age was strongly related to polyp characteristics. The proportion of adenomas increased significantly with age (p<0.01). Within adenomas, the proportion of villous types - a precursor of colorectal cancer - increased remarkably with age (p=0.01). Older age was positively associated with potentially malignant adenomas (defined as adenomas > 1 cm and showing high-grade dysplasia) (p<0.01). Conclusion Adenomas accounted for the majority of polyps. Their morphology, size and malignant potential were related to patient age.

scholarly journals The methylation of SDC2 and TFPI2 defined three methylator phenotypes of colorectal cancer

2021 ◽  
Author(s):  
Lei Ruixue ◽  
Zhao Yanteng ◽  
Huang Kai ◽  
Wan Kangkang ◽  
Li Tingting ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Cpg Island ◽  
Methylation Status ◽  
Tumor Location ◽  
Functional Enrichment ◽  
Superior Performance ◽  
Regulation Of Transcription ◽  
Patient Age ◽  
Patient Âgé

Methylation-based noninvasive molecular diagnostics are easy and feasible tools for the early detection of colorectal cancer (CRC). However, many of them have the limitation of low sensitivity with some CRCs detection failed in clinical practice. In this study, the clinical and pathological characteristics, as well as molecular features of three methylator-groups, defined by the promoter methylation status of SDC2 and TFPI2, were investigated in order to improve the performance of CRC detection. The Illumina Infinium 450k Human DNA methylation data and clinical information of CRCs were collected from The Cancer Genome Atlas (TCGA) project and Gene Expression Omnibus (GEO) database. CRC samples were divided into three groups, HH (dual-positive), HL (single positive) and LL (dual-negative) according to the methylation status of SDC2 and TFPI2 promoters. Differences in age, tumor location, microsatellite instable status and differentially expressed genes (DEGs) were evaluated among the three groups and these findings were then confirmed in our inner CRC dataset. The combination of methylated SDC2 and TFPI2 showed a superior performance of distinguishing CRCs from normal controls than each alone. Samples of HL group were more often originated from left-side CRCs whereas very few of them were from right-side (P < 0.05). HH grouped CRCs showed a higher level of microsatellite instability and mutation load than other two groups (mean nonsynonymous mutations for HH/HL/LL: 10.55/3.91/7.02, P = 0.0055). All mutations of BRAF, one of the five typical CpG island methylator phenotype (CIMP) related genes, were found in HH group (HH/HL/LL: 51/0/0, P = 0.018). Also there was a significantly older patient age at the diagnosis in HH group. Gene expression analysis identified 37, 84 and 22 group-specific DEGs for HH, HL and LL, respectively. Functional enrichment analysis suggested that HH specific DEGs were mainly related to the regulation of transcription and other processes, while LL specific DEGs were enriched in the biological processes of extracellular matrix interaction and cell migration. The three defined mathylator groups showed great difference in tumor location, patient age, MSI and ECM biological process, which could facilitate the development of more effective biomarkers for CRC detection.

Impact of patient age on quality of care in the treatment of colorectal cancer: Results from the Florida Initiative for Quality Cancer Care (FIQCC)

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 6548-6548
Author(s):  
E. Siegel ◽  
D. Shibata ◽  
M. Malaga ◽  
W. Fulp ◽  
J. Lee ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Quality Of Care ◽  
Quality Indicators ◽  
Quality Care ◽  
Age Groups ◽  
Quality Improvement Effort ◽  
Patient Age ◽  
Age Related ◽  
Patient Âgé

6548 Background: The quality of colorectal cancer (CRC) treatment has been suggested to vary by age, with older patients receiving poorer quality care. As part of a state-wide quality improvement effort, the FIQCC developed and implemented methods to assess the quality of care of several cancers among practices across the state of Florida. The current report focuses on the variability of adherence to CRC quality indicators for treatment and surveillance by patient age. Methods: Medical chart reviews were conducted of all patients first seen by a medical oncologist for CRC in 2006 at one of the 10 FIQCC sites (2 academic/8 community). Abstractors were trained and periodically monitored. Abstraction focused on assessing adherence to quality indicators consistent with evidence-, consensus-, and regulatory-based guidelines. Variability in adherence across age quartiles was evaluated using a Fisher's exact test. Of the 475 patients whose charts were reviewed, 53% were male, 80% were diagnosed with colon cancer and the median age was 65 years (range 27 to 92 years). Results: Adherence was consistently (p values>.05) high across all age quartiles for presence of chemotherapy flow sheets (85%-93%), assessment of body-surface area (98%-100%) and performance of complete colon evaluation within 12 months of surgery (87%-89%). Moderate-to-low adherence was consistent by age for performance of CEA test before (74%-84%) or in the 6 months after (75%-82%) surgery/chemotherapy, and documentation of planned chemotherapy dose (51%-59%). Adherence decreased with increasing age for documentation of discussion/referral for chemotherapy in non-metastatic CRC cases (100%, 99%, 93%, and 89%; p = 0.001), but was consistently adhered to for all ages among metastatic cases (100%). The documentation of consent for patients treated with chemotherapy also varied by age-quartile (63%. 57%, 79%, and 73%; p = 0.02). Conclusions: Overall quality of CRC treatment was not consistent across the broad spectrum of patient age. Our data suggest age related disparity in the recommendation for adjuvant chemotherapy. Efforts should be made to understand the reasons for these differences and to improve and standardize the quality of CRC care for patients across all age groups. No significant financial relationships to disclose.

scholarly journals K-ras mutation in colorectal cancer: relations to patient age, sex and tumour location

1994 ◽  
Vol 69 (2) ◽  
pp. 367-371 ◽  
Author(s):  
J Breivik ◽  
GI Meling ◽  
A Spurkland ◽  
TO Rognum ◽  
G Gaudernack
Keyword(s):  
Colorectal Cancer ◽  
Patient Age ◽  
Ras Mutation ◽  
Patient Âgé ◽  
Tumour Location

Number of Lymph Nodes Examined and Associated Clinicopathologic Factors in Colorectal Carcinoma

2009 ◽  
Vol 133 (5) ◽  
pp. 781-786 ◽  
Author(s):  
Steven S. Shen ◽  
Bisong X. Haupt ◽  
Jae Y. Ro ◽  
Jijiang Zhu ◽  
H. Randoph Bailey ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colorectal Carcinoma ◽  
Lymph Nodes ◽  
Medical Center ◽  
Tumor Location ◽  
Patient Age ◽  
Bowel Segment ◽  
Patient Âgé ◽  
Clinicopathologic Factors ◽  
Resected Bowel

Abstract Context.—Nodal metastasis is one of the most important prognostic factors in colorectal carcinoma. The number of lymph nodes recovered and examined in resection specimens has been recently shown to be critical for proper staging and is associated with survival. Objective.—To assess the clinicopathologic factors that may be associated with the number of lymph nodes harvested from surgical resections. Design.—Clinicopathologic factors of 434 consecutive cases of colorectal cancers treated by surgical resection from a single tertiary medical center were retrospectively reviewed and correlated with number of lymph nodes recovered. Results.—Our data show that patient age, tumor location, and length of resected bowel segment were associated with number of lymph nodes harvested in surgical resections of colorectal cancer. The average number of lymph nodes was 18.2 and 17.8 for patients younger than 50 years and aged 50 through 60 years, respectively, whereas it was 14.4, 15.1, and 14.9 for patients aged 61 through 70 years, 71 through 80 years, and 80 years and older, respectively. More lymph nodes were present in resection specimens of cecum/ascending colon and descending colon cancers than in those of transverse colon, sigmoid colon, and rectal cancers. There was a linear increase in number of lymph nodes examined with increasing length of bowel resection specimens. In multivariate regression analysis, the factors that remained independent predictors of removal of 12 or more lymph nodes from resection specimens were tumor location and length of resected bowel segment. Conclusions.—The number of lymph nodes obtained in resection specimens for colorectal cancer was significantly associated with the length of resected segments of bowel, patient age, and location of the tumor.

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