scholarly journals Luteinizing hormone facilitates angiogenesis in ovarian epithelial tumor cells and metformin inhibits the effect through the mTOR signaling pathway

2012 ◽  
Author(s):  
Youji Feng
Keyword(s):  
Luteinizing Hormone ◽  
Signaling Pathway ◽  
Tumor Cells ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Epithelial Tumor ◽  
Ovarian Epithelial Tumor ◽  
Epithelial Tumor Cells

Secretion of a 97 kilodalton glycoprotein by primary cultures of human ovarian epithelial tumor cells

1986 ◽  
Vol 33 (3) ◽  
pp. 325-332 ◽  
Author(s):  
G. Subba Rao ◽  
P. Hanjani
Keyword(s):  
Tumor Cells ◽  
Primary Cultures ◽  
Epithelial Tumor ◽  
Ovarian Epithelial Tumor ◽  
Epithelial Tumor Cells

scholarly journals Implications of cell division cycle associated 4 on the Wilm’s tumor cells viability via AKT/mTOR signaling pathway

Renal Failure ◽  
2021 ◽  
Vol 43 (1) ◽  
pp. 1470-1478
Author(s):  
Suqing Li ◽  
Cong Qin ◽  
Yike Chen ◽  
Dan Wei ◽  
Zhijun Tan ◽  
...  
Keyword(s):  
Cell Division ◽  
Signaling Pathway ◽  
Tumor Cells ◽  
Cell Division Cycle ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Wilm's Tumor ◽  
Wilm’S Tumor

scholarly journals Metformin inhibits the proliferation of canine mammary gland tumor cells through the AMPK/AKT/mTOR signaling pathway in vitro

2021 ◽  
Vol 22 (6) ◽  
Author(s):  
Yuying Fan ◽  
Xiaoli Ren ◽  
Yingxue Wang ◽  
Enshuang Xu ◽  
Shuang Wang ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Signaling Pathway ◽  
Tumor Cells ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Mammary Gland Tumor ◽  
Gland Tumor ◽  
Canine Mammary Gland

scholarly journals CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway

2015 ◽  
Vol 55 (11) ◽  
pp. 1688-1699 ◽  
Author(s):  
Qi Wang ◽  
Yong Tang ◽  
Hongjing Yu ◽  
Qiaoyun Yin ◽  
Mengdi Li ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Signaling Pathway ◽  
Tumor Cells ◽  
Cancer Metastasis ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway

Shedding of 97-kDa glycoprotein (97k-GP) by human ovarian epithelial tumor cells

1986 ◽  
Vol 23 (2) ◽  
pp. 264
Author(s):  
P. Hanjani ◽  
G.Subba Rao
Keyword(s):  
Tumor Cells ◽  
Epithelial Tumor ◽  
Ovarian Epithelial Tumor ◽  
Epithelial Tumor Cells

598 POSTER Analysis of the mTOR signaling pathway versus proliferative response of tumor cells to the mTOR inhibitor RAD001 (everolimus)

2006 ◽  
Vol 4 (12) ◽  
pp. 181
Author(s):  
M. Breuleux ◽  
S. Zumstein-Mecker ◽  
T. O'Reilly ◽  
F. Natt ◽  
M. Maira ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Tumor Cells ◽  
Proliferative Response ◽  
Mtor Inhibitor ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway

Lupron Retards Proliferation of Ovarian Epithelial Tumor Cells Cultured in Serum-Free Medium

1991 ◽  
Vol 72 (5) ◽  
pp. 1036-1041 ◽  
Author(s):  
MARGARET A. THOMPSON ◽  
MARK D. ADELSON ◽  
LYDIA M. KAUFMAN
Keyword(s):  
Tumor Cells ◽  
Serum Free Medium ◽  
Free Medium ◽  
Epithelial Tumor ◽  
Serum Free ◽  
Ovarian Epithelial Tumor ◽  
Epithelial Tumor Cells ◽  
Cells Cultured

Hederacolchiside A1 suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway

2018 ◽  
Vol 10 (2) ◽  
pp. 215-222
Author(s):  
Yan-Er Wang ◽  
Kun Xu ◽  
Wen-Hua Yue ◽  
Qiong-Ming Xu ◽  
Ben-Gang You ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Tumor Cells ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway

scholarly journals High Sensitivity of Circulating Tumor Cells Derived from a Colorectal Cancer Patient for Dual Inhibition with AKT and mTOR Inhibitors

Cells ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 2129
Author(s):  
Daniel J. Smit ◽  
Laure Cayrefourcq ◽  
Marie-Therese Haider ◽  
Nico Hinz ◽  
Klaus Pantel ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Signaling Pathway ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Mapk Pathway ◽  
Synergistic Effects ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Mtor Inhibition

Circulating tumor cells (CTCs) are cells shed from the primary tumor into the bloodstream. While many studies on solid tumor cells exist, data on CTCs are scarce. The mortality of cancer is mostly associated with metastasis and recent research identified CTCs as initiators of metastasis. The PI3K/AKT/mTOR signaling pathway is an intracellular pathway that regulates essential functions including protein biosynthesis, cell growth, cell cycle control, survival and migration. Importantly, activating oncogenic mutations and amplifications in this pathway are frequently observed in a wide variety of cancer entities, underlining the significance of this signaling pathway. In this study, we analyzed the functional role of the PI3K/AKT/mTOR signaling pathway in the CTC-MCC-41 line, derived from a patient with metastatic colorectal cancer. One striking finding in our study was the strong sensitivity of this CTC line against AKT inhibition using MK2206 and mTOR inhibition using RAD001 within the nanomolar range. This suggests that therapies targeting AKT and mTOR could have been beneficial for the patient from which the CTC line was isolated. Additionally, a dual targeting approach of AKT/mTOR inside the PI3K/AKT/mTOR signaling pathway in the colorectal CTCs showed synergistic effects in vitro. Depending on the phenotypical behavior of CTC-MCC-41 in cell culture (adherent vs. suspension), we identified altered phosphorylation levels inside the PI3K/AKT/mTOR pathway. We observed a downregulation of the PI3K/AKT/mTOR signaling pathway, but not of the RAS/RAF/MAPK pathway, in CTCs growing in suspension in comparison to adherent CTCs. Our results highlight distinct functions of AKT isoforms in CTC-MCC-41 cells with respect to cell proliferation. Knockdown of AKT1 and AKT2 leads to significantly impaired proliferation of CTC-MCC-41 cells in vitro. Therefore, our data demonstrate that the PI3K/AKT/mTOR signaling pathway plays a key role in the proliferation of CTC-MCC-41.

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