scholarly journals CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway

2015 ◽  
Vol 55 (11) ◽  
pp. 1688-1699 ◽  
Author(s):  
Qi Wang ◽  
Yong Tang ◽  
Hongjing Yu ◽  
Qiaoyun Yin ◽  
Mengdi Li ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Signaling Pathway ◽  
Tumor Cells ◽  
Cancer Metastasis ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway

MiR-206 inhibits epithelial ovarian cancer cells growth and invasion via blocking c-Met/AKT/mTOR signaling pathway

2018 ◽  
Vol 104 ◽  
pp. 763-770 ◽  
Author(s):  
Chunxiu Dai ◽  
Yongyong Xie ◽  
Xiaoping Zhuang ◽  
Zhengzhong Yuan
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Mtor Signaling ◽  
Ovarian Cancer Cells ◽  
Mtor Signaling Pathway

Activation of mTOR signaling pathway associated with adverse prognostic factors of epithelial ovarian cancer

2011 ◽  
Vol 121 (1) ◽  
pp. 8-12 ◽  
Author(s):  
Jae Hong No ◽  
Yong-Tark Jeon ◽  
In-Ae Park ◽  
Yong-Beom Kim ◽  
Jae Weon Kim ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Prognostic Factors ◽  
Epithelial Ovarian Cancer ◽  
Signaling Pathway ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway

scholarly journals Implications of cell division cycle associated 4 on the Wilm’s tumor cells viability via AKT/mTOR signaling pathway

Renal Failure ◽  
2021 ◽  
Vol 43 (1) ◽  
pp. 1470-1478
Author(s):  
Suqing Li ◽  
Cong Qin ◽  
Yike Chen ◽  
Dan Wei ◽  
Zhijun Tan ◽  
...  
Keyword(s):  
Cell Division ◽  
Signaling Pathway ◽  
Tumor Cells ◽  
Cell Division Cycle ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Wilm's Tumor ◽  
Wilm’S Tumor

scholarly journals Metformin inhibits the proliferation of canine mammary gland tumor cells through the AMPK/AKT/mTOR signaling pathway in vitro

2021 ◽  
Vol 22 (6) ◽  
Author(s):  
Yuying Fan ◽  
Xiaoli Ren ◽  
Yingxue Wang ◽  
Enshuang Xu ◽  
Shuang Wang ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Signaling Pathway ◽  
Tumor Cells ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Mammary Gland Tumor ◽  
Gland Tumor ◽  
Canine Mammary Gland

scholarly journals MicroRNA-1271-5p inhibits the tumorigenesis of ovarian cancer through targeting E2F5 and negatively regulates the mTOR signaling pathway

2020 ◽  
Author(s):  
Qin Li ◽  
Junyu Shi ◽  
Xiaoli Xu
Keyword(s):  
Ovarian Cancer ◽  
Signaling Pathway ◽  
Poor Prognosis ◽  
Mtor Signaling ◽  
Luciferase Assay ◽  
Migration And Invasion ◽  
Mtor Signaling Pathway ◽  
Direct Target ◽  
The Relationship

Abstract Background: MicroRNA-1271-5p (miR-1271-5p) has been reported to participate in the progression of many human cancers. However, the role of miR-1271-5p still remains unclear in ovarian cancer (OC). Therefore, we explored the effect of miR-1271-5p on the development of OC in present study. Methods: We measured the miR-1271-5p expression via the qRT-PCR assay. Then the function of miR-1271-5p was analyzed through MTT and Transwell assays. The relationship among miR-1271-5p and E2F5 was verified by dual luciferase assay. The protein expression levels were examined through western blot.Results: MiR-1271-5p was downregulated in OC tissues which predicted poor prognosis of OC patients. Moreover, E2F5 was a direct target of miR-1271-5p in OC. And miR-1271-5p suppressed cell proliferation, migration and invasion in OC through targeting E2F5. Furthermore, E2F5 was upregulated in OC tissues which predicted poor prognosis of OC patients. Besides that, miR-1271-5p suppressed EMT and mTOR pathway in OC. Conclusion: MiR-1271-5p inhibited the tumorigenesis of OC through targeting E2F5 and negatively regulated the mTOR signaling pathway.

MicroRNA-1271-5p inhibits the tumorigenesis of ovarian cancer through targeting E2F5 and negatively regulates the mTOR signaling pathway

2020 ◽  
Author(s):  
Qin Li ◽  
Junyu Shi ◽  
Xiaoli Xu
Keyword(s):  
Ovarian Cancer ◽  
Western Blot ◽  
Signaling Pathway ◽  
Blot Analysis ◽  
Mtor Signaling ◽  
Migration And Invasion ◽  
Mtor Signaling Pathway ◽  
Pcr Assay ◽  
Qrt Pcr ◽  
Worse Prognosis

Abstract Background: MicroRNA-1271-5p (miR-1271-5p) has been reported to participate in the progression of many malignancies. However, the molecular mechanism of miR-1271-5p still remains vague in ovarian cancer (OC). Therefore, we explored the effect of miR-1271-5p in the development of OC in present study.Methods: We measured the miR-1271-5p expression via qRT-PCR assay. Western blot analysis was employed to examine protein expression. Then, the functional mechanism of miR-1271-5p was analyzed by MTT, Transwell and dual luciferase assays.Results: Downregulation of miR-1271-5p was found in OC, which can predict worse prognosis in OC patients. Further, miR-1271-5p directly targets E2F5 in OC. And miR-1271-5p restrained the proliferation, migration and invasion of OC cells via targeting E2F5. Additionally, upregulation of E2F5 was observed in OC, which predicted unfavorable prognosis in OC patients. Besides that, miR-1271-5p suppressed EMT and mTOR pathway in OC.Conclusion: MiR-1271-5p inhibited the tumorigenesis of OC through targeting E2F5 and negatively regulated the mTOR signaling pathway.

The lncRNA SNHG15/miR‐18a‐5p axis promotes cell proliferation in ovarian cancer through activating Akt/mTOR signaling pathway

2020 ◽  
Vol 121 (12) ◽  
pp. 4699-4710
Author(s):  
Jingru Zhang ◽  
Ling Wang ◽  
Jing Jiang ◽  
Zhiwei Qiao
Keyword(s):  
Ovarian Cancer ◽  
Cell Proliferation ◽  
Signaling Pathway ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway

scholarly journals 313 Modulation of Ca125 expression by htert in ovarian cancer: possible implication of PI3K/Akt/mTOR signaling pathway

2019 ◽  
Author(s):  
D Atallah ◽  
S Antoun ◽  
M Moubarak ◽  
N El Kassis ◽  
G Chahine Chahine ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Signaling Pathway ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway
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