Influence of HLA-B*5703 and HLA-B*1403 on Susceptibility to Spondyloarthropathies in the Zambian Population

ObjectiveTo analyze the distribution of HLA-B alleles and to investigate their contribution in the susceptibility to spondyloarthropathies (SpA) in a sample population from Zambia, in order to determine a relationship between some HLA-B alleles and development of ankylosing spondylitis (AS), reactive arthritis (ReA), or undifferentiated SpA (uSpA).MethodsWe selected 72 patients with SpA and found that 46 had uSpA, 23 ReA, and 3AS.We also selected 92 matched controls; 55 of these had human immunodeficiency virus type I (HIV-I) infection.ResultsWe found a significant increase in the rate of uSpA and ReA with features of Reiter’s syndrome (RS) in HIV-positive individuals who carried the HLA-B*5703 allele (pc < 0.0001 and pc < 0.001, respectively). Among the significant new findings identified were the presence of B*1403 in 2 of the 3 AS patients (pc < 0.05, OR 47), confirming previous data in the Togolese population.ConclusionThe presence of B*5703 and HIV infection may not affect susceptibility to AS and ReA, but they do show an important influence in uSpA and RS. Our findings confirm that HLA-B* 1403 is the only factor to increase the risk of AS in a sub-Saharan African population, whereas HLA-B27 was virtually absent in patients with AS.

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Gestational trophoblastic syndrome and human immunodeficiency virus (HIV) infection: A retrospective analysis

International Journal of Gynecological Cancer ◽

10.1136/ijgc-00009577-200311000-00021 ◽

2003 ◽

Vol 13 (6) ◽

pp. 875-878 ◽

Cited By ~ 1

Author(s):

M. Moodley ◽

J. Moodley

Keyword(s):

Human Immunodeficiency Virus ◽

Hiv Infection ◽

Case Reports ◽

Hiv Positive ◽

Risk Category ◽

Immunodeficiency Virus ◽

The Subject ◽

The Mean ◽

Sub Saharan

The appropriate management of gynecological malignancies in association with human immunodeficiency virus (HIV) infection is not established. To date the reported literature on the subject consists mainly of case reports. Due to the increasing prevalence of HIV infection, especially in sub-Saharan countries, the chances of finding both conditions in the same patient has produced management and ethical dilemmas. This retrospective study describes the management of 12 HIV-infected patients and compares their outcome with 29 non HIV-infected patients. The mean age of the non HIV-infected patients was 30 years (range 16–56 years), while the mean age of the HIV-infected patients was 32 years (range 20–47 years). In terms of risk factors, there were 72% of non HIV-infected women in the high-risk category compared to 50% of HIV-infected women (P = 0.468). All patients who received treatment had CD4 counts greater than 200 cells/μl. Two HIV-infected women who did not receive any form of chemotherapy due to low CD4 counts (41 cells/μl and 84 cells/μl) demised of their disease. The majority of women (86% non HIV-infected & 90% HIV-infected) received lfewer than 10 cycles of chemotherapy to attain cure. Most side effects were minor. None of the HIV-infected patients who received chemotherapy demised of their disease. In total, irrespective of risk category, there were 38 patients (93%) who were cured of their disease by chemotherapy including 10 HIV-positive patients. All patients were alive and free of disease at their last follow-up visit. Although the numbers are small, it is proposed that HIV-infected patients with choriocarcinoma and a reasonable degree of CD4 counts (>200cells/μl) should receive standard therapy.

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Outcomes of patients with Kaposi's sarcoma who start antiretroviral therapy under routine programme conditions in Malawi

Tropical Doctor ◽

10.1258/td.2007.060023 ◽

2008 ◽

Vol 38 (1) ◽

pp. 5-7 ◽

Cited By ~ 20

Author(s):

Simon D Makombe ◽

Anthony D Harries ◽

Joseph Kwong-Leung Yu ◽

Mindy Hochgesang ◽

Eustice Mhango ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Antiretroviral Therapy ◽

Treatment Outcomes ◽

Kaposi's Sarcoma ◽

Kaposi’S Sarcoma ◽

Sub Saharan Africa ◽

Hiv Positive ◽

Immunodeficiency Virus ◽

Unfavourable Prognosis ◽

Sub Saharan

AIDS-associated Kaposi's sarcoma (KS) is the most common AIDS-related malignancy in sub-Saharan Africa, with a generally unfavourable prognosis. We report on six-month and 12-month cohort treatment outcomes of human immunodeficiency virus (HIV)-positive KS patients and HIV-positive non-KS patients treated with antiretroviral therapy (ART) in public sector facilities in Malawi. Data were collected from standardized antiretroviral (ARV) patient master cards and ARV patient registers. Between July and September 2005, 7905 patients started ART-488 (6%) with a diagnosis of KS and 7417 with a non-KS diagnosis. Between January and March 2005, 4580 patients started ART-326 (7%) with a diagnosis of KS and 4254 with a non-KS diagnosis. At six-months and 12-months, significantly fewer KS patients were alive and significantly more had died or defaulted compared to non-KS patients. HIV-positive KS patients on ART in Malawi have worse outcomes than other patients on ART. Methods designed to improve these outcomes must be found.

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Infants born to HIV-positive women—Zaire and France Perinatal transmision of the human immunodeficiency virus Type I to infants of seropositive women in Zaire. Ryder R, Nsa W, Hassig S, et al. 320:1637, 1989; A prospective study of infants born to women seropositive for human immunodeficiency virus Type I. Blanche S, Rouzioux C, Moscato M, et al. 320:1643, 1989

Journal of Nurse-Midwifery ◽

10.1016/0091-2182(90)90175-5 ◽

1990 ◽

Vol 35 (3) ◽

pp. 175

Keyword(s):

Human Immunodeficiency Virus ◽

Prospective Study ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Hiv Positive ◽

Type I ◽

Hiv Positive Women ◽

Immunodeficiency Virus ◽

A Prospective Study

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Targeting the Assembly of the Human Immunodeficiency Virus Type I

Current Pharmaceutical Design ◽

10.2174/1381612043382701 ◽

2004 ◽

Vol 10 (30) ◽

pp. 3725-3739 ◽

Cited By ~ 17

Author(s):

D. Muriaux ◽

J. Darlix ◽

A. Cimarelli

Keyword(s):

Human Immunodeficiency Virus ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Type I ◽

Immunodeficiency Virus

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FRI0435 THE CLINICAL SIGNIFICANCE OF SERUM AUTOANTIBODIES AND HLA-B27 MOLECULE TESTING IN UYGUR PATIENTS WITH HUMAN IMMUNODEFICIENCY VIRUS INFECTION

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.5155 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 815.3-815

Author(s):

X. Chen ◽

L. Wu ◽

X. Wu ◽

C. N. Luo ◽

Y. M. Shi

Keyword(s):

Human Immunodeficiency Virus ◽

Hiv Infection ◽

Highly Active Antiretroviral Therapy ◽

Molecular Mimicry ◽

Molecular Testing ◽

Hla B27 ◽

Clinical Value ◽

Rheumatic Manifestations ◽

Immunodeficiency Virus ◽

Positive Rate

Background:AIDS is a deadly infectious disease caused by the HIV. When HIV infects a host, it may induce production of autoantibodies due to the structural antigen similarity between viral proteins and selfantigens.The molecular mimicry between HIV protein and self-antigens could cause antibody cross-reactions and lead to development of autoimmune disease.Objectives:To explore the clinical value of serum autoantibodies and human leukocyte antigen (HLA-B27) molecular testing in Uygur patients with human immunodeficiency virus (HIV) infection.Methods:A total of 727 HIV-infected Uygur patients who visited Kuche Infectious Diseases Hospital during May 2016 to March 2017 were include in this study. The other 390 healthy people were enrolled as controls. Serum antinuclear antibodies (ANA) and ANA Profile, anti-cyclic citrullinated peptide (CCP) antibody, and HLA-B27 molecule were tested.Results:Among 727 HIV-infected Uygur patients, 317 were males and 410 were females with mean age (35.52±13.44) years old. The mean duration of disease was (6.34±3.05)years. There were 697(95.87%) patients receiving Highly active antiretroviral therapy (HAART) with mean duration of treatment (6.34±3.05)years. Rheumatic manifestations were recorded in 238 (32.74%) HIV-infected Uygur patients, mainly with dry mouth and dry eye (15.41%), alopecia (9.90%), arthralgia (8.94%), ect. Compared with the health controls, positive ANA was more common in HIV infected Uygur patients (33.42%vs.17.43%,P< 0.001) with low titers (ANA titer:1:100). HIV-infected Uygur patients had higher positive anti-u1-RNP antibodies positive rate (1.10%), but lower anti-SSA antibodies positive rate (0.14%) and anti-CCP antibodies positive rate (0.28%). Patients with positive ANA in HAART group were significantly less than that in non-treatment group (38.72%vs.50.00%,P=0.049).Only one female patient was HLA-B27 positive (0.14%), which was significantly lower than that in healthy controls (3.08%) (P<0.001). Also, only one patient was diagnosed with rheumatoid arthritis (RA).Conclusion:Rheumatic manifestations are common in HIV-infected Uygur patients. Several autoantibodies are positive, but the coincidence of rheumatic diseases is rare. It’s noted that patients with Rheumatic manifestations and low titre positive ANA should be considered as a differential diagnosis of HIV infection.Disclosure of Interests:None declared

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Influence of boarding secondary school environment on HIV positive students in South Western Uganda

BMC Public Health ◽

10.1186/s12889-021-10380-0 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Raymond Bernard Kihumuro ◽

David Jolly Muganzi ◽

Elton George Wandira ◽

Racheal Alinaiswe ◽

Jovitah Joselyne Nanyunja ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Secondary School ◽

Secondary Schools ◽

School Environment ◽

Coping Mechanisms ◽

Hiv Positive ◽

Key Informants ◽

Immunodeficiency Virus ◽

Negative Coping ◽

Depth Interviews

Abstract Background The number of human immunodeficiency virus (HIV) positive adolescents in secondary school has increased over the years. Little is known on how the students cope to the pressures and demands of their academic and health lives in the boarding secondary schools. This study explored the factors surrounding their anti-retroviral therapy adherence as well as their experiences. Methods We did a qualitative study that employed in-depth interviews amongst purposively selected 19 HIV positive adolescent students in boarding secondary school and seven key informants. Key informants were members of boarding secondary school staff directly taking care of the adolescents living with human immune virus and had spent at least two academic terms in that school. The study participants were recruited from four health facilities in Bushenyi district, southwestern Uganda, and key informants from five boarding secondary schools in Bushenyi. These were engaged in in-depth interviews using an interview guide. Data was transcribed, coded and the content analyzed thematically. Results Adolescents living with human immunodeficiency virus in boarding secondary school face challenges similar to adolescents outside boarding school settings. However, some challenges are unique to them. Students faced numerous barriers which made it difficult to adhere to their medication. Stigmatization in its different forms was also a major challenge amongst students. Willingness disclosure of serostatus was beneficial to the students since it guaranteed support while at school; facilitating adherence and better living. However, students were uneasy to disclose their status. Some students adopted negative coping mechanisms such as telling lies, escaping from school, and class to access medication. Conclusions Adolescents in boarding secondary schools face similar challenges as compared to their counterparts with some being unique to them. Few school mechanisms help these students to cope while at school. Limited disclosure has proven useful but some adolescents have opted not to disclose their status and hence used negative coping mechanisms. These challenges need to be addressed and a safe environment to encourage limited disclosure should be made.

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Combined Genotypes of CCR5, CCR2, SDF1, and HLA Genes Can Predict the Long-Term Nonprogressor Status in Human Immunodeficiency Virus-1–Infected Individuals

Blood ◽

10.1182/blood.v93.3.936 ◽

1999 ◽

Vol 93 (3) ◽

pp. 936-941 ◽

Cited By ~ 151

Author(s):

Magdalena Magierowska ◽

Ioannis Theodorou ◽

Patrice Debré ◽

Françoise Sanson ◽

Brigitte Autran ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Chemokine Receptor ◽

Multivariate Logistic Regression Model ◽

Hla B27 ◽

Hla Alleles ◽

Immunodeficiency Virus ◽

Combined Genotypes ◽

Hiv 1

Abstract Human immunodeficiency virus (HIV)-1–infected long-term nonprogressors (LT-NP) represent less than 5% of HIV-1–infected patients. In this work, we tried to understand whether combined genotypes of CCR5-▵32, CCR2-64I, SDF1-3′A and HLA alleles can predict the LT-NP status. Among the chemokine receptor genotypes, only the frequency of the CCR5-▵32 allele was significantly higher in LT-NP compared with the group of standard progressors. The predominant HLA alleles in LT-NP were HLA-A3, HLA-B14, HLA-B17, HLA-B27, HLA-DR6, and HLA-DR7. A combination of both HLA and chemokine receptor genotypes integrated in a multivariate logistic regression model showed that if a subject is heterozygous for CCR5-▵32 and homozygous for SDF1 wild type, his odds of being LT-NP are increased by 16-fold, by 47-fold when a HLA-B27 allele is present with HLA-DR6 absent, and by 47-fold also if at least three of the following alleles are present: HLA-A3, HLA-B14, HLA-B17, HLA-DR7. This model allowed a correct classification of 70% of LT-NPs and 81% of progressors, suggesting that the host’s genetic background plays an important role in the evolution of HIV-1. The chemokine receptor and chemokine genes along with the HLA genotype can serve as predictors of HIV-1 outcome for classification of HIV-1–infected subjects as LT-NPs or progressors.

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Arthritis and Foodborne Bacteria

Journal of Food Protection ◽

10.4315/0362-028x-57.10.935 ◽

1994 ◽

Vol 57 (10) ◽

pp. 935-941 ◽

Cited By ~ 11

Author(s):

JAMES L. SMITH

Keyword(s):

T Cells ◽

Ankylosing Spondylitis ◽

Reactive Arthritis ◽

Molecular Mimicry ◽

Food Poisoning ◽

Cell Subset ◽

Bacterial Cells ◽

Hla B27 ◽

Reiter's Syndrome ◽

Reiter’S Syndrome

Diarrheic episodes caused by the foodborne pathogens Campylobacter, Salmonella, Shigella or Yersinia may lead to a sterile arthritis such as reactive arthritis, Reiter's syndrome or ankylosing spondylitis. Reiter's syndrome and reactive arthritis have been shown to be sequelae in a few well-studied bacterial food poisoning outbreaks. Reactive arthritis, Reiter's syndrome and ankylosing spondylitis show strong familial association related to the gene for HLA-B27 (HLA = human leucocyte antigen) antigen. Why HLA-B27-positive individuals are more susceptible to arthritis is not known, but molecular mimicry between the HLA-B27 antigen and antigens of triggering bacteria has been demonstrated and this mimicry has been proposed as a mechanism involved in etiology of the arthritides. Antigens from bacteria that triggered the arthritis are present in arthritic joints but bacterial cells are not found. Antibodies and T-cells specific for the triggering bacteria have been demonstrated in arthritic patients. T-cells present in synovial joints respond specifically to the particular arthritic triggering pathogen. The cells that respond to bacterial antigens belong to the T-cell subset TH1 that secrete a limited number of cytokines but it is not known if cytokines are involved in arthritis. A few studies have demonstrated that T-cells from the joints of arthritic patients respond to both bacterial and human heat shock proteins indicating that autoimmunity may be involved in causation of arthritis. While only about 2% of a population exposed to a triggering infection will acquire arthritis, these individuals undergo pain and suffering as well as economic hardships as a result of their disease.

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