Biomarkers for Comorbidities in Psoriasis: A Report from the Grappa 2011 Annual Meeting

Biomarkers are being recognized that will help identify patients with psoriasis who may be destined to develop psoriatic arthritis (PsA). Recent genome-wide association studies have identified genes that are common to both psoriasis and PsA, as well as differentially expressed in the 2 conditions. Further, biomarkers of inflammation and cartilage can differentiate between patients with PsA and those with psoriasis without arthritis. An overview of these biomarkers was presented at the 2011 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis. Additionally, a report was presented from the current database of the International Psoriasis and Psoriatic Arthritis Research Team, a group of dermatologists and rheumatologists with the objective to improve the lives of patients with psoriasis and PsA.

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Current Challenges in the Genetics of Psoriatic Arthritis: A Report from the GRAPPA 2009 Annual Meeting

The Journal of Rheumatology ◽

10.3899/jrheum.101123 ◽

2011 ◽

Vol 38 (3) ◽

pp. 564-566 ◽

Cited By ~ 2

Author(s):

PROTON RAHMAN

Keyword(s):

Psoriatic Arthritis ◽

Annual Meeting ◽

Association Studies ◽

Environment Interaction ◽

Genome Wide Association Studies ◽

Novel Genes ◽

Gene Environment Interaction ◽

Gene Environment ◽

Genome Wide

Psoriasis and psoriatic arthritis (PsA) are heterogeneous diseases. While both have a strong genetic basis, it is strongest for PsA, where fewer investigators are studying its genetics. Over the last year the number of independent genetic loci associated with psoriasis has substantially increased, mostly due to completion of multiple genome-wide association studies (GWAS) in psoriasis. At least 2 GWAS efforts are now under way in PsA to identify novel genes in this disease; a metaanalysis of genome-wide scans and further studies must follow to examine the genetics of disease expression, epistatic interaction, and gene-environment interaction. In the long term, it is anticipated that genome-wide sequencing is likely to generate another wave of novel genes in PsA. At the annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) in Stockholm, Sweden, in 2009, members discussed issues and challenges regarding the advancement of the genetics of PsA; results of those discussions are summarized here.

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Genome-Wide Association Studies and Transcriptome Changes during Acclimation and Deacclimation in Divergent Brassica napus Varieties

International Journal of Molecular Sciences ◽

10.3390/ijms21239148 ◽

2020 ◽

Vol 21 (23) ◽

pp. 9148 ◽

Cited By ~ 1

Author(s):

David P. Horvath ◽

Jiaping Zhang ◽

Wun S. Chao ◽

Ashok Mandal ◽

Mukhlesur Rahman ◽

...

Keyword(s):

Oxidative Stress ◽

Cold Acclimation ◽

Candidate Genes ◽

Calcium Binding ◽

Association Studies ◽

Differentially Expressed ◽

Genome Wide Association ◽

Genome Wide Association Studies ◽

Genome Wide ◽

A Genome

Information concerning genes and signals regulating cold acclimation processes in plants is abundant; however, less is known about genes and signals regulating the deacclimation process. A population of primarily winter B. napus varieties was used to conduct a genome-wide association study and to compare the transcriptomes from two winter B. napus varieties showing time-dependent differences in response to cold acclimation and deacclimation treatments. These studies helped to identify loci, candidate genes, and signaling processes impacting deacclimation in B. napus. GWAS identified polymorphisms at five different loci associated with freezing tolerance following deacclimation. Local linkage decay rates near these polymorphisms identified 38 possible candidate genes. Several of these genes have been reported as differentially regulated by cold stress in arabidopsis (Arabidopsis thaliana), including a calcium-binding EF-hand family protein (encoded by BnaCnng10250D) that was also differentially expressed during deacclimation in this study. Thousands of other genes differentially expressed during the acclimation and deacclimation treatments implicated processes involving oxidative stress, photosynthesis, light-regulated diurnal responses, and growth regulation. Generally, responses observed during acclimation were reversed within one week of deacclimation. The primary differences between the two winter B. napus varieties with differential deacclimation responses involved protection from oxidative stress and the ability to maintain photosynthesis.

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