scholarly journals The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes

2014 ◽  
Vol 29 (5) ◽  
pp. 620 ◽  
Author(s):  
Ohk-Hyun Ryu ◽  
Wankyo Chung ◽  
Sungwha Lee ◽  
Kyung-Soon Hong ◽  
Moon-Gi Choi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Arterial Stiffness ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
High Dose Vitamin

scholarly journals The effects of vitamin D supplementation on adiponectin level and insulin resistance in first-degree relatives of subjects with type 2 diabetes: a randomized double-blinded controlled trial

10.19082/2849 ◽  
2016 ◽  
Vol 8 (9) ◽  
pp. 2849-2854 ◽  
Author(s):  
Seyed Mohammad Mohammadi ◽  
Seyed Ahmad Eghbali ◽  
Sedighah Soheilikhah ◽  
Saeedeh Jam Ashkezari ◽  
Maryam Salami ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Adiponectin Level ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
First Degree Relatives ◽  
Double Blinded

scholarly journals High-Dose versus Low-Dose Vitamin D Supplementation and Arterial Stiffness among Individuals with Prehypertension and Vitamin D Deficiency

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Amanda Zaleski ◽  
Gregory Panza ◽  
Heather Swales ◽  
Pankaj Arora ◽  
Christopher Newton-Cheh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Vitamin D Deficiency ◽  
Wave Velocity ◽  
Low Dose ◽  
Pulse Wave ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
High Dose Vitamin

Introduction. Vitamin D deficiency is associated with the onset and progression of hypertension and cardiovascular disease (CVD). However, mechanisms underlying vitamin D deficiency-mediated increased risk of CVD remain unknown. We sought to examine the differential effect of high-dose versus low-dose vitamin D supplementation on markers of arterial stiffness among ~40 vitamin D deficient adults with prehypertension.Methods. Participants were randomized to high-dose (4000 IU/d) versus low-dose (400 IU/d) oral vitamin D3 for 6 months. 24 hr ambulatory blood pressure (BP), carotid-femoral pulse wave velocity, and pulse wave analyses were obtained at baseline and after 6 months of vitamin D supplementation.Results. There were no changes in resting BP or pulse wave velocity over 6 mo regardless of vitamin D dose (allp>0.202). High-dose vitamin D decreased augmentation index and pressure by 12.3 ± 5.3% (p=0.047) and 4.0 ± 1.5 mmHg (p=0.02), respectively. However, these decreases in arterial stiffness were not associated with increases in serum 25-hydroxyvitamin D over 6 mo (p=0.425).Conclusion. High-dose vitamin D supplementation appears to lower surrogate measures of arterial stiffness but not indices of central pulse wave velocity.Clinical Trial Registration. This trial is registered with www.clinicaltrials.gov (Unique Identifier:NCT01240512).

scholarly journals Vitamin D Supplementation and Cognition in People with Type 2 Diabetes: A Randomized Control Trial

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Mary A. Byrn ◽  
William Adams ◽  
Sue Penckofer ◽  
Mary Ann Emanuele
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Cognitive Function ◽  
Randomized Control Trial ◽  
Low Dose ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
Significant Finding ◽  
Randomized Control

Aim. Type 2 diabetes increases the risk of cognitive decline which adversely impacts self-management of the disease. Evidence also supports a relationship between low serum 25(OH)D levels and poor cognition. The purpose of this trial was to assess vitamin D supplementation on cognitive executive functioning in persons living with type 2 diabetes. Methods. This was a double-blinded RCT where participants were randomized to receive either weekly vitamin D3 supplementation (50,000 IUs) or a matching comparator (5,000 IUs) for three months. The primary outcome was a battery of neuropsychological tests. Serum 25(OH)D was measured by liquid chromatography/tandem mass spectrometry. Repeated assessments of cognitive measures were collected over 12 weeks using alternative testing forms to minimize practice effects. Results. Thirty participants were randomized to either the low-dose allocation (n=15) or the high-dose allocation (n=15). Most participants were female (83%) and identified as Black (57%). For all cognition measures, there was no statistically significant finding between participants who received high-dose vitamin D supplementation and those who received low-dose supplementation. However, when assessing cognitive function in both groups over time, minimal improvement on the Symbol-Digits, the Stroop Interference Test, and the Trail Making Test Part B was observed. Conclusions. To our knowledge, this is the first randomized control trial to examine the effects of vitamin D supplementation on cognitive function in people with type 2 diabetes. However, no significant differences in cognitive outcomes between participants who received high-dose therapy and those who received low dose were found.

A randomised controlled trial of high dose vitamin D in recent-onset type 2 diabetes

2014 ◽  
Vol 106 (3) ◽  
pp. 576-582 ◽  
Author(s):  
Shirley Elkassaby ◽  
Leonard C. Harrison ◽  
Namita Mazzitelli ◽  
John M. Wentworth ◽  
Peter G. Colman ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
High Dose ◽  
Recent Onset ◽  
Onset Type ◽  
Randomised Controlled ◽  
High Dose Vitamin

Vitamin D and new insights into pathophysiology of type 2 diabetes

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Karel Vondra ◽  
Richard Hampl
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Inflammatory Cytokines ◽  
Vitamin D Supplementation ◽  
Low Grade ◽  
Peripheral Tissues ◽  
Functional Inactivation

Abstract Deficiency in vitamin D plays a role in the onset and development of insulin resistance (IR) and type 2 diabetes (T2DM). A normal level of vitamin D is able to reduce low grade inflammation, which is a major process in inducing insulin resistance. It is also engaged in maintaining low resting levels of reactive species and radicals, normal Ca2+ signaling, a low expression of pro-inflammatory cytokines but increased formation of anti-inflammatory cytokines. Vitamin D is also able to prevent hypermethylation (of DNA) and consequent functional inactivation of many genes, as well as other epigenetic alterations in β cells and in other insulin-sensitive peripheral tissues, mainly liver, adipose tissue and muscle. Vitamin D deficiency thus belongs to key factors accelerating the development of IR and consequently T2DM as well. However, vitamin D supplementation aimed at the control of glucose homeostasis in humans showed controversial effects. As a result, further studies are running to gain more detailed data needed for the full clinical utilization of vitamin D supplementation in the prevention and treatment of T2DM. Until new results are published, supplementation with high doses of vitamin D deficiency is not recommended. However, prevention of vitamin D deficiency and its correction are highly desired.

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