scholarly journals Effect of Avocado Leaf Extract on the Decrease of Fasting Blood Glucose Level of White Rats

2019 ◽  
Vol 12 (2) ◽  
pp. 287-292
Author(s):  
Nurdin Rahman ◽  
Sri Mulyani Sabang ◽  
Nikmah Utami Dewi ◽  
Bohari .
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Leaf Extract ◽  
Fasting Blood Glucose ◽  
Fasting Blood Glucose Level ◽  
White Rats

scholarly journals Effect of Mangkokan (Polyscias scutellaria) Leaf Extract on Blood Sugar Levels in Alloxan-Induced Male White Rats

2021 ◽  
Vol 53 (3) ◽  
pp. 132-137
Author(s):  
Sri Lestari Ramadhani Nasution ◽  
◽  
Awanis ◽  
Stiven Elsafarindo
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Blood Sugar ◽  
Glucose Level ◽  
Leaf Extract ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
P Value ◽  
Standard Group ◽  
White Rats

Type 2 diabetes is a metabolic disorder caused by insulin resistance and is associated with oxidative stress. In Indonesia, the mean prevalence of diabetes ranges from 1.4% to 1.6%; however, some areas have a much higher diabetes prevalence such as Pekajangan (2.3%) and in Manado (6%). The 2013 Indonesian Basic Health Research (IBHR) stated that the number of people with DM in Indonesia has reached an alarming rate. This study aimed to determine the antidiabetic effect of Polyscias scutellaria on alloxan-induced male Wistar. This was an experimental study conducted in July 2020 in the Faculty of Medicine, Prima Indonesia University. This study used 25 rats that were grouped into 5 treatment groups: control group (Na-CMC), standard (Metformin), and 3 extract groups with different doses (125 mg/kg BW, 250 mg/kg BW, and 500 mg/kg BW). Mangkokan leaf extract was obtained through the maceration method. All ratswere induced intraperitoneally using alloxan monohydrate 10% at a dose of 175 mg/kg BW. The parameters used in this study were fasting blood glucose level before induction, after induction, and after treatment and body weight before treatment. It was observed that there was a significant change in blood glucose level between the extract groups. The blood sugar level in the 125 mg/kg BW group was 495.00 mg/dl while in the 250 mg/kg BW and 500 mg/kg BW, the blood glucose levels were 317.00 mg/dl and 126.00 mg/dl, respectively, with the 500 mg/Kg BW dose as the most effective dose (P-value = 0.001). Thus, mangkokan leaves have the potential to reduce blood glucose level but are not as good as the standard group.

scholarly journals PRE-CLINICAL STUDIES ON DIABETES MELLITUS USING PARTIAL PANCREATECTOMY IN SWISS ALBINO MICE

2018 ◽  
Vol 10 (1) ◽  
pp. 71
Author(s):  
Shibu Narayan Jana ◽  
Papiya Mitra Mazumder
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Cholesterol Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Fasting Blood Glucose Level ◽  
Β Cells ◽  
Partial Pancreatectomy ◽  
Swiss Albino Mice ◽  
Diabetes Status

Objective: The present study was aimed at the development of partial pancreatectomy in a murine model for diabetes.Methods: Diabetes model was successfully developed by partial pancreatectomy method. In this study, cyclosporine was used for influenced the glycaemic status. Diabetes status was evaluated by fasting blood glucose level (FBG), lipid profile (by estimation of total cholesterol level and HDL-level), serum amylase and biochemical assay like glutathione estimation.Results: We report here the restoration of euglycaemic status in cyclosporine-induced diabetic in swiss albino mice after 30% pancreatectomy. In this study, Pancreatectomised (partial) group of animals showed a rapid elevation of glycaemic status, starting from 15th post observational d, but the level of significance decreased gradually from 15th (P<0.01) to 60th (P<0.05) d. This was probably due to nesidioblastotic activity which shifted the fasting blood glucose level towards normoglycaemic status with β-cells regeneration. Cyclosporine treated a group of mice showed normoglycaemic status throughout the whole experimental period, but the cholesterol level remained significant (P<0.001) till the end of the experimental d. Gradually decrements in glycaemia of the diabetic pancreatectomised animals demonstrate islets neogenesis occurring after the operative activity, leading to normoglycaemic condition, probably attributed to β-cells proliferation.Conclusion: The biochemical and histopathological evaluations suggest that there is the development of the diabetic model in the pancreatectomized group and diabetes status induced by pancreatectomy is curable to a certain extent due to the regeneration of β-cells.

Time Course Effect of Selected Carbonated Soft Drinks on Human Fasting Blood Glucose Level

2018 ◽  
Vol 3 (1) ◽  
pp. 22
Author(s):  
Osasenaga Ighodaro ◽  
Abiola Adeosun ◽  
Oyindamola FuyiWilliams ◽  
Francis Ojiko ◽  
Abeeb Akorede
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Time Course ◽  
Fasting Blood Glucose ◽  
Soft Drinks ◽  
Fasting Blood Glucose Level ◽  
Carbonated Soft Drinks

The evaluation of the agreement between fasting glycemia at the first prenatal visit and the results of the glucose tolerance test in diagnostics of gestational diabetes mellitus

2014 ◽  
Vol 60 (5) ◽  
pp. 9-14 ◽  
Author(s):  
P V Popova ◽  
A V Dronova ◽  
E R Sadikova ◽  
M P Parkkinen ◽  
M V Bol’shakova ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Glucose Tolerance Test ◽  
Fasting Blood Glucose ◽  
Tolerance Test ◽  
Fasting Blood Glucose Level ◽  
Prenatal Visit ◽  
Fasting Glycemia ◽  
The Mean

Objective. To evaluate the importance of determining fasting glycemia at the first prenatal visit for timely diagnostics of gesta- tional diabetes mellitus (GDM). Material and methods. The study included 577 pregnant women examined with the use of the oral glucose tolerance test (OGTT) during weeks 24-28 of pregnancy. The results of the test were compared with the fasting glucose level at the first prenatal visit. Results. The mean fasting blood glucose level at the first prenatal visit was 4.70±0.61 mmol/l. In 25% of the patients, fasting glycemia at this time was 5.1 mmol/l or higher. Only in 36% of the women (52 of the145 ones) with the fasting blood glucose level ≥5.1 and <7 mmol/l at the first prenatal visit, the results of OGTT were consistent with the criteria for GDM. The mean fasting blood glucose level at the first prenatal visit (up to week 16) was significantly higher than on weeks 24-28 (4.71±0.61 and 4.53±0.69 mmol/l respectively, p<0.001). The ROC analysis failed to reveal the fasting blood glucose level that could be used to predict the development of gestational diabetes with a reliable sensitivity and specific- ity. Conclusion. Further population-based investigations are needed to elucidate the relationship between fasting glycemia in the first trimester of pregnancy and its unfavourable outcome.

scholarly journals Gambaran Elektrolit dan Gula Darah Pasien Kejang Demam yang Dirawat di Bangsal Anak RSUP Dr. M. Djamil Periode Januari 2010 - Desember 2012

2013 ◽  
Vol 2 (3) ◽  
pp. 127
Author(s):  
Khairunnisa Imaduddin ◽  
Iskandar Syarif ◽  
Rahmatini Rahmatini
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Serum Sodium ◽  
Serum Potassium ◽  
Febrile Seizure ◽  
Fasting Blood Glucose ◽  
Febrile Seizures ◽  
Normal Serum ◽  
Fasting Blood Glucose Level

AbstrakKejang demam merupakan kelainan neurologik yang paling sering dijumpai pada anak. Kejang demam merupakan bangkitan kejang yang terjadi pada saat anak demam akibat proses ekstrakranial. Kejang demam terjadi pada suhu rektal >38 C. Penelitian ini bertujuan untuk mengetahui gambaran elektrolit dan gula darah pada pasien kejang demam yang dirawat di bangsal anak RSUP Dr. M. Djamil. Penelitian ini merupakan penelitian deskriptif menggunakan metode retrospektif dengan mengambil data dari bagian rekam medis RSUP Dr. M.Djamil. Sampel penelitian adalah seluruh pasien kejang demam yang dirawat di bangsal anak RSUP Dr. M. Djamil periode Januari 2010 - Desember 2012 yang memenuhi kriteria inklusi. Dari 173 kasus kejang demam, terdapat 51 kasus yang memenuhi kriteria sampel penelitian. Sebagian besar sampel merupakan kejang demam pertama (76,5%). Kejang demam kompleks didapatkan sebesar 64,7%. Kasus kejang demam terbanyak terjadi pada kelompok usia ≥6 bulan < 2 tahun yaitu sebesar 51%. Kejang demam lebih sering terjadi pada laki-laki daripada perempuan dengan perbandingan 1,4:1. Penelitian menunjukkan penurunan nilai natrium serum (n=46, 80,4%), dan kalsium serum (n=30, 63,3%), nilai kalium serum normal (n=46, 76,1%), dan peningkatan nilai gula darah sewaktu (n=45, 57,8%). Pada pasien kejang demam ditemukan penurunan nilai natrium dan kalsium serum, nilai kalium serum normal, dan peningkatan nilai gula darah sewaktu. Diharapkan penelitian yang akan datang memiliki jumlah sampel yang lebih besar untuk mengetahui gambaran elektrolit dan gula darah pada pasien kejang demam.Kata kunci: kejang demam, natrium serum, kalium serum, kalsium serum, gula darah sewaktuAbstractFebrile seizure is the most common neurological disorder found in children. Febrile seizure is seizure that occurs while the children have fever caused by extracranial process. It occurs in rectal temperature >38 C. This research aim to describe the electrolytes and blood glucose in patients with febrile seizure who were treated at the pediatric's ward of Dr. M. Djamil general hospital. From 173 cases of febrile seizures, there are 51 cases that meet the criterias of the research sample. Most of the research samples are first febrile seizure (76.5%). Complex febrile seizure occurred in 64.7%. Most cases of febrile seizures occurred in the age group ≥ 6 months - <2 years, about 51%. Febrile seizures are more common in males than females with the ratio 1.4:1. The research shows decrease serum sodium (n = 46, 80.4%), and serum calcium (n = 30, 63.3%), normal serum potassium (n = 46, 76.1%), and increase non-fasting blood glucose level (n = 45, 57.8%). The patients with febrile seizure show decrease serum sodium and calcium, normal serum potassium, and increase non-fasting blood glucose level. Expected future studies have a lot of samples in determining the electrolytes and blood glucose in patients with febrile seizure.Keywords: febrile seizures, serum sodium, serum potassium, serum calcium, non-fasting blood glucose level

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