Background and Objective:
Perimenopause is a physiological occurrence in women, and is characterized by endocrine and biochemical changes. During perimenopause phase, many derangements or abnormal health conditions start developing as a result of hormonal changes. These derangements in health conditions and biochemical changes lead to higher
incidence of metabolic syndrome (MetS) occurrence with or without bone involvement. There is scarcity of information on
MetS in Enugu, Southern Nigeria and there is no available data on the correlation of selected bone-related biochemicals with
endocrine parameters and MetS in perimenopausal women from the region.
Material and Methods:
We consecutively sampled 200 apparently healthy women, and categorized them into 120 perimenopausal women (age (
Results:
Calcium was predominantly high in the three criteria (p<0.05). LH and FSH showed positive correlation with FPG
while E2 was negatively associated with FPG. Similarly LH showed positive association with inorganic phosphate while E2
was negatively associated with alkaline phosphatase (p<0.05).
Conclusion:
Perimenopausal women are at higher risk for developing osteoporosis than premenopausal women. This emphasizes the need for timely diagnosis of osteoporosis in perimenopausal women.
