Correlative Study of Bone-Related Biochemicals and Endocrine Changes in Perimenopausal Women in Enugu, Nigeria.

2020 ◽  
Vol 23 ◽  
Author(s):  
Chinwe Ifeoma Ikegwuonu ◽  
Ikenna Kingsley Uchendu ◽  
Chukwudi Ignatius Maduka
Keyword(s):  
Inorganic Phosphate ◽  
Premenopausal Women ◽  
Positive Association ◽  
Biochemical Changes ◽  
Health Conditions ◽  
Hormonal Changes ◽  
Negatively Associated ◽  
Perimenopausal Women ◽  
Endocrine Parameters ◽  
Apparently Healthy

Background and Objective: Perimenopause is a physiological occurrence in women, and is characterized by endocrine and biochemical changes. During perimenopause phase, many derangements or abnormal health conditions start developing as a result of hormonal changes. These derangements in health conditions and biochemical changes lead to higher incidence of metabolic syndrome (MetS) occurrence with or without bone involvement. There is scarcity of information on MetS in Enugu, Southern Nigeria and there is no available data on the correlation of selected bone-related biochemicals with endocrine parameters and MetS in perimenopausal women from the region. Material and Methods: We consecutively sampled 200 apparently healthy women, and categorized them into 120 perimenopausal women (age ( Results: Calcium was predominantly high in the three criteria (p<0.05). LH and FSH showed positive correlation with FPG while E2 was negatively associated with FPG. Similarly LH showed positive association with inorganic phosphate while E2 was negatively associated with alkaline phosphatase (p<0.05). Conclusion: Perimenopausal women are at higher risk for developing osteoporosis than premenopausal women. This emphasizes the need for timely diagnosis of osteoporosis in perimenopausal women.

Comparative Studies on Hormonal Changes and Metabolic Syndrome in Perimenopausal and Premenopausal Igbo Women in Enugu Metropolis Nigeria: A Cross-sectional Study

2019 ◽  
Vol 15 (4) ◽  
pp. 284-294
Author(s):  
Chinwe Ifeoma Ikegwuonu ◽  
Uchendu Kingsley Ikenna ◽  
Okonkwo Innocent Nwabueze ◽  
Mba Chika Betina ◽  
Maduka Ignatius Chukwudi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
International Diabetes Federation ◽  
Premenopausal Women ◽  
World Health ◽  
Categorical Variables ◽  
Hormonal Changes ◽  
Cross Sectional ◽  
Perimenopausal Women

Background and Objective: Few studies have focused on the epidemiology of perimenopausal syndrome, and its prevalence in African women is concerningly high. This study investigated selected biochemical parameters, hormonal changes, and possible metabolic syndrome (MetS) in perimenopausal and premenopausal women among Igbo women in Enugu, Southeast of Nigeria. Methods: This study was conducted between March 2018 and November 2018. A total of 200 apparently healthy women, comprising 120 perimenopausal women (mean age 50 years) and 80 premenopausal women (mean age 35 years), living in Enugu, were randomly recruited for this study. Anthropometric indices (blood pressure, waist circumference, weight, and height) of these women were measured. Fasting blood samples were collected and used for measurement of luteinizing hormone (LH), estradiol (E2), follicle stimulating hormone (FSH), fasting plasma glucose (FPG), and lipid profile using standard methods. MetS in the perimenopausal and premenopausal women was observed using three different criteria: the National Cholesterol Education Program- Adult Treatment Panel 111 (NCEP-ATP 111), the World Health Organization (WHO), and International Diabetes Federation (IDF). Student’s t-test and Chi-square were used to compare continuous and categorical variables. Results: There were significantly (p<0.05) higher values of blood pressure (systolic and diastolic), FPG, waist circumference, LH, FSH, total cholesterol, and LDL-C, but significantly (p<0.05) lower values of estradiol in perimenopausal women as compared to premenopausal women. The incidence of MetS was higher in perimenopausal women as compared to premenopausal women in all the three criteria studied. Interpretation and Conclusion: Perimenopausal women have a higher risk for the development of metabolic syndrome-associated diseases than premenopausal women.

Cardiovascular Risk in Perimenopausal Women

2019 ◽  
Vol 17 (6) ◽  
pp. 591-594 ◽  
Author(s):  
John C. Stevenson ◽  
Sophia Tsiligiannis ◽  
Nick Panay
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Ovarian Function ◽  
Density Lipoprotein ◽  
Premenopausal Women ◽  
Therapeutic Interventions ◽  
Additional Risk Factor ◽  
Chd Risk ◽  
Perimenopausal Women ◽  
Chd Risk Factors

Cardiovascular disease, and particularly coronary heart disease (CHD), has a low incidence in premenopausal women. Loss of ovarian hormones during the perimenopause and menopause leads to a sharp increase in incidence. Although most CHD risk factors are common to both men and women, the menopause is a unique additional risk factor for women. Sex steroids have profound effects on many CHD risk factors. Their loss leads to adverse changes in lipids and lipoproteins, with increases being seen in low density lipoprotein (LDL) cholesterol and triglycerides, and decreases in high density lipoprotein (HDL) cholesterol. There is a reduction in insulin secretion and elimination, but increases in insulin resistance eventually result in increasing circulating insulin levels. There are changes in body fat distribution with accumulation in central and visceral fat which links to the other adverse metabolic changes. There is an increase in the incidence of hypertension and of type 2 diabetes mellitus, both major risk factors for CHD. Oestrogens have potent effects on blood vessels and their loss leads to dysfunction of the vascular endothelium. All of these changes result from loss of ovarian function contributing to the increased development of CHD. Risk factor assessment in perimenopausal women is recommended, thereby permitting the timely introduction of lifestyle, hormonal and therapeutic interventions to modify or reverse these adverse changes.

Association between dietary patterns and risk of breast cancer in Chinese female population: a latent class analysis

2020 ◽  
pp. 1-24
Author(s):  
Shang Cao ◽  
Shurong Lu ◽  
Jinyi Zhou ◽  
Zheng Zhu ◽  
Wei Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Latent Class Analysis ◽  
Dietary Patterns ◽  
Latent Class ◽  
Chinese Women ◽  
Premenopausal Women ◽  
Positive Association ◽  
Class Analysis ◽  
Female Population ◽  
Soy Foods

ABSTRACT Objective: To determine if specific dietary patterns are associated with breast cancer risk in Chinese women. Design: Latent class analysis (LCA) was performed to identify generic dietary patterns based on daily food-frequency data. Setting: The Chinese Wuxi Exposure and Breast Cancer Study (2013-2014). Participants: A population-based case-control study (695 cases, 804 controls). Results: Four dietary patterns were identified, Prudent, Chinese traditional, Western, and Picky, the proportion in the controls and cases were 0.30/0.32/0.16/0.23 and 0.29/0.26/0.11/0.33, respectively. Women in Picky class were characterized by higher extreme probabilities of non-consumption on specific foods, the highest probabilities of consumption of pickled foods, and the lowest probabilities of consumption of cereals, soy foods, and nuts. Compared with Prudent class, Picky class was associated with a higher risk (OR=1.42, 95%CI=1.06, 1.90), while the relevant association was only in post- (OR=1.44, 95%CI=1.01, 2.05) but not premenopausal women. The Western class characterized by high-protein, -fat, and -sugar foods, the Chinese traditional class characterized by typical consumption of soy foods and white meat over red meat, both of them showed no difference in BC risk compared with Prudent class did. Conclusions: LCA capture the heterogeneity of individuals embedded in the population, could be a useful approach in the study of dietary pattern and disease. Our results indicated that the Picky class might have a positive association with the risk of breast cancer.

scholarly journals A Dyadic Perspective on Coping and its Effects on Relationship Quality and Psychological Distress in Couples Living with Chronic Pain: A Longitudinal Study

Pain Medicine ◽  
2019 ◽  
Vol 21 (2) ◽  
pp. e102-e113 ◽  
Author(s):  
Manasi M Mittinty ◽  
Sara Kindt ◽  
Murthy N Mittinty ◽  
Sonia Bernardes ◽  
Annmarie Cano ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Relationship Quality ◽  
Positive Association ◽  
Psychological Outcomes ◽  
Dyadic Coping ◽  
Negatively Associated ◽  
Curve Model ◽  
The Relationship ◽  
Over Time

Abstract Objective Dyadic coping is a process of coping within couples that is intended not only to support the patient with chronic pain but also to maintain equilibrium in the relationship. This study aims to investigate the effect of patient-perceived and spouse-reported dyadic coping on both the patient and their partner’s relationship quality and anxiety, stress, and depression over time. Methods One hundred thirty-nine couples, with one partner experiencing chronic pain, participated in this study. Spanning three measurements over six months, couples reported on their anxiety, stress, depression, relationship quality, and dyadic coping. Results Patient-perceived supportive dyadic coping was positively associated with both partners’ relationship quality but was negatively associated with spouses’ stress over time. Patient-perceived negative dyadic coping was negatively associated with both partners’ relationship quality and positively associated with patients’ depression and spouses’ depression and stress over time. Spouse-reported supportive dyadic coping showed a positive association with their own relationship quality and a negative association with spouses’ depression at baseline and patients’ depression at three-month follow-up. Spouse-reported negative dyadic coping was negatively associated with their relationship quality at baseline and positively associated with their partner’s anxiety and stress at six-month and three-month follow-up, respectively. Similar inference was observed from the findings of growth curve model. Conclusions As compared with spouse report, patient perception of dyadic coping is a better predictor of both partners’ relationship quality and psychological outcomes over time. Both partners may benefit from early psychosocial intervention to improve their dyadic coping, relationship quality, and psychological outcomes.

scholarly journals Height, weight, weight change and risk of breast cancer in Rio de Janeiro, Brazil

2001 ◽  
Vol 119 (2) ◽  
pp. 62-66 ◽  
Author(s):  
Anelise Bezerra de Vasconcelos ◽  
Gulnar Azevedo e Silva Mendonça ◽  
Rosely Sichieri
Keyword(s):  
Breast Cancer ◽  
Weight Loss ◽  
Rio De Janeiro ◽  
Menopausal Status ◽  
Premenopausal Women ◽  
Positive Association ◽  
State University ◽  
Weight Changes ◽  
Potential Risk Factors ◽  
Incident Cases

CONTEXT: The relationship between body size and breast cancer still remains controversial in considering menopausal status. OBJECTIVE: To evaluate the association of height, weight and weight changes with breast cancer in the city of Rio de Janeiro, Brazil. DESIGN: Case-control study. SETTING: National Cancer Institute (INCA), Rio de Janeiro, Brazil, and State University of Rio de Janeiro (UERJ). SAMPLE: 177 incident cases of invasive breast cancer admitted to the main hospital of INCA between May 1995 and February 1996, and 377 controls recruited from among female visitors to the same hospital. MAIN MEASUREMENTS: Height and weight were measured and information on maximum weight, weight at ages 18 and 30 years, and potential risk factors were ascertained by interview at the hospital. RESULTS: Height was not related to risk of breast cancer among both pre and postmenopausal women. Nevertheless, women in this study were shorter than in studies that have found a positive association. Premenopausal women in the upper quartile of recent body mass index (BMI) and maximum BMI showed a reduced risk of breast cancer (P for trend <= 0.03). Weight loss between ages 18 and 30 years and from 18 years to present was also associated with breast cancer among premenopausal women. CONCLUSIONS: These findings may merely indicate the known association between leanness and breast cancer. Further studies should explore the role of weight loss on breast cancer risk.

scholarly journals Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort

BMC Medicine ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Mathilde His ◽  
Vivian Viallon ◽  
Laure Dossus ◽  
Julie A. Schmidt ◽  
Ruth C. Travis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lower Risk ◽  
Positive Association ◽  
Blood Collection ◽  
Linear Regression Models ◽  
Case Control Studies ◽  
Cross Sectional ◽  
Blood Concentrations ◽  
Exogenous Hormones ◽  
Negatively Associated

Abstract Background Metabolomics is a promising molecular tool for identifying novel etiological pathways leading to cancer. In an earlier prospective study among pre- and postmenopausal women not using exogenous hormones, we observed a higher risk of breast cancer associated with higher blood concentrations of one metabolite (acetylcarnitine) and a lower risk associated with higher blood concentrations of seven others (arginine, asparagine, phosphatidylcholines (PCs) aa C36:3, ae C34:2, ae C36:2, ae C36:3, and ae C38:2). Methods To identify determinants of these breast cancer-related metabolites, we conducted a cross-sectional analysis to identify their lifestyle and anthropometric correlates in 2358 women, who were previously included as controls in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition cohort and not using exogenous hormones at blood collection. Associations of each metabolite concentration with 42 variables were assessed using linear regression models in a discovery set of 1572 participants. Significant associations were evaluated in a validation set (n = 786). Results For the metabolites previously associated with a lower risk of breast cancer, concentrations of PCs ae C34:2, C36:2, C36:3, and C38:2 were negatively associated with adiposity and positively associated with total and saturated fat intakes. PC ae C36:2 was also negatively associated with alcohol consumption and positively associated with two scores reflecting adherence to a healthy lifestyle. Asparagine concentration was negatively associated with adiposity. Arginine and PC aa C36:3 concentrations were not associated to any of the factors examined. For the metabolite previously associated with a higher risk of breast cancer, acetylcarnitine, a positive association with age was observed. Conclusions These associations may indicate possible mechanisms underlying associations between lifestyle and anthropometric factors, and risk of breast cancer. Further research is needed to identify potential non-lifestyle correlates of the metabolites investigated.

scholarly journals Combined Exposure to Multiple Endocrine Disruptors and Uterine Leiomyomata and Endometriosis in US Women

2021 ◽  
Vol 12 ◽  
Author(s):  
Yuqing Zhang ◽  
Yingying Lu ◽  
Huiyuan Ma ◽  
Qing Xu ◽  
Xiaoli Wu
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Premenopausal Women ◽  
Positive Association ◽  
Multivariable Logistic Regression Model ◽  
Significant Positive Association ◽  
Uterine Leiomyomata ◽  
Endocrine Disrupting ◽  
Complete Measurement ◽  
Single Chemical ◽  
Potential Factors

BackgroundUterine leiomyomata (UL) and endometriosis (EM) are common gynecological diseases damaging the reproductive health of fertile women. Among all the potential factors, environmental endocrine-disrupting chemicals are insufficiently addressed considering the multiple pollutants and mixture exposure.MethodsWomen aged 20 to 54 years old in the National Health and Nutrition Examination Survey (NHANES) 2001-2006, having a complete measurement of ten commonly exposed endocrine-disrupting chemicals (including urinary phthalate metabolites, equol, and whole blood heavy metals) and answered questions about UL and EM were included (N=1204). Multivariable logistic regression model, weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR) models were implemented to analyze the combined effect of chemicals on the overall association with UL and EM.ResultsIn single chemical analysis, equol (OR: 1.90, 95% CI: 1.11, 3.27) and mercury (Hg) (OR: 1.91, 95% CI: 1.14, 3.25) were found positively associated with UL in tertile 3 vs. tertile 1. In WQS regression and BKMR models, the significant positive association between WQS index and UL (OR: 2.54, 95% CI: 1.52, 4.29) was identified and the positive relationship between equol and Hg exposure and UL were further verified. Besides, the mixture evaluation models (WQS and BKMR) also found MEHP negatively associated with UL. Although none of the single chemicals in tertile 3 were significantly associated with EM, the WQS index had a marginally positive association with EM (OR: 2.01, 95% CI: 0.98, 4.15), and a significant positive association was identified in subanalysis with participants restricted to premenopausal women (OR: 2.18, 95% CI: 1.03, 4.70). MIBP and MBzP weighted high in model of EM and MEHP weighted the lowest.ConclusionComparing results from these three statistical models, the associations between equol, Hg, and MEHP exposure with UL as well as the associations of MIBP, MBzP, and MEHP exposure with EM warrant further research.

scholarly journals Follicle-Stimulating Hormone Positively Associates with Metabolic Factors in Perimenopausal Women

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Chen Zhang ◽  
Meng Zhao ◽  
Zhengyang Li ◽  
Yongfeng Song
Keyword(s):  
Metabolic Syndrome ◽  
Central Obesity ◽  
Follicle Stimulating Hormone ◽  
Premenopausal Women ◽  
Single Center ◽  
Metabolic Factors ◽  
Cross Sectional ◽  
Increased Risk ◽  
Perimenopausal Women ◽  
Cv Disease

Objective. Menopause is associated with the increased risk of metabolic syndrome (MetS) and cardiovascular (CV) disease. Most studies have focused the postmenopausal women and the relationships among estrogen, androgen, and Mets risk. The main aim of the study was to investigate the Mets risk in perimenopausal women and whether the variation of FSH is associated with metabolic factors. Methods. A single-center cross-sectional retrospective analysis including 154 premenopausal women and 124 perimenopausal women was performed. Results. The prevalence of Mets in the perimenopausal group was much higher than the premenopausal group (49.19% vs. 35.71%, p = 0.023 ). The prevalence of central obesity and NAFLD also increased in the perimenopausal group than in the premenopausal group. We grouped the population by FSH tertiles; compared with women in the lowest tertile, women in the highest tertile had higher age, WC, serum TC, LDL-C, AST, ALT, and creatine levels. The prevalence of hypertriglyceridemia, raised BP and Mets also increased in the highest tertile group. Further, we subdivided the perimenopausal women according to FSH tertiles. Compared with perimenopausal women in the lowest tertile, the prevalence of raised BP significantly increased in the highest tertile. Conclusions. The risk of Mets increased in perimenopausal females than in premenopausal women. And a higher FSH level was associated with higher WC, TG, BPs, and the risk of Mets in perimenopausal women. Elevated FSH level appears to be a risk factor of MetS biomarkers in perimenopausal women.

Anti-Müllerian Hormone Concentrations Are Inversely Associated With Subclinical Atherosclerosis in Premenopausal Women

Angiology ◽  
2020 ◽  
Vol 71 (6) ◽  
pp. 552-558 ◽  
Author(s):  
Irene Lambrinoudaki ◽  
Stefanos Stergiotis ◽  
Panagiota Chatzivasileiou ◽  
Areti Augoulea ◽  
Panagiotis Anagnostis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ovarian Reserve ◽  
Augmentation Index ◽  
Subclinical Atherosclerosis ◽  
Premenopausal Women ◽  
Reproductive Age ◽  
Inverse Association ◽  
Cross Sectional ◽  
Carotid Imt ◽  
Negatively Associated

Anti-Müllerian hormone (AMH), which is secreted by granulosa cells of late preantral and small antral follicles, is a marker of ovarian reserve. The association of ovarian reserve with subclinical atherosclerosis in women of reproductive age is currently unknown. We primary investigated whether AMH levels are associated with markers of subclinical atherosclerosis in healthy, normally menstruating women. In this cross-sectional study, vascular structure and function were assessed by measurement of carotid and femoral intima–media thickness (IMT), flow-mediated dilation, carotid–femoral pulse wave velocity and augmentation index. Lipid profile and serum AMH concentrations were also measured. Seventy premenopausal women, aged 32.7 ± 6.5 years, were included. Mean AMH levels were lower in smokers than in non-smokers and negatively associated with total cholesterol (TC) levels. An inverse association between mean AMH concentrations and femoral and carotid IMT in all segments was observed. No correlation with other markers of subclinical atherosclerosis or established cardiovascular (CV) risk factors was found. After multivariable adjustment, the association between AMH concentrations and combined carotid IMT or carotid bulb IMT remained significant. In conclusion, in healthy, normally ovulating women, AMH concentrations are negatively associated with subclinical atherosclerosis indices and TC levels, independently of established CV risk factors.

Mining possible associations of faecal A. muciniphila colonisation patterns with host adiposity and cardiometabolic markers in an adult population

2019 ◽  
Vol 10 (7) ◽  
pp. 741-749 ◽  
Author(s):  
E.K. Mitsou ◽  
M. Detopoulou ◽  
A. Kakali ◽  
E. Fragopoulou ◽  
T. Nomikos ◽  
...  
Keyword(s):  
Human Subjects ◽  
Adult Population ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Positive Association ◽  
Interleukin 10 ◽  
Normal Weight ◽  
Lipoprotein Cholesterol ◽  
Negatively Associated ◽  
Cardiometabolic Markers

We aimed to evaluate colonisation patterns of Akkermansia muciniphila in a Greek adult population and to investigate model-adjusted associations of A. muciniphila with host adiposity and cardiometabolic markers. Participants (n=125) underwent anthropometric, dietary, physical activity and lifestyle evaluation. Blood sampling for determination of blood lipid indices, glucose metabolism, adiponectin, lipoprotein-associated phospholipase A2 (Lp-PLA2), inflammation and oxidative stress parameters was also performed. Stool A. muciniphila presence and levels were determined by quantitative PCR and subjects were grouped based on bimodal distribution of levels (Low vs High). A. muciniphila was detected in 88.6% of participants. Overweight/obese (OW/OB) subjects were more prone in low bimodal levels of A. muciniphila compared to normal-weight (NW) individuals (58.75 vs 27.59%, P=0.004), with a 4-time greater likelihood after multi-adjusted logistic regression analysis (P=0.016). Levels of A. muciniphila were negatively associated with total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C) ratio (log10:-0.009±0.004, P=0.033), whereas detection of this bacterium was negatively associated with both TC/HDL-C ratio (log10: -0.049±0.023, P=0.036) and low-density lipoprotein cholesterol/HDL-C ratio (-0.407±0.176, P=0.023). Furthermore, low bimodal levels of A. muciniphila were positively associated with fasting blood glucose (log10: 0.018±0.009, P=0.037). In terms of inflammation markers, levels of A. muciniphila were positively associated with soluble cluster of differentiation-14 (sCD14) (log10: 0.012±0.004, P=0.003) and faecal detection of this bacterium had a positive association with anti-inflammatory interleukin 10 levels (log10: 0.325±0.131, P=0.015). In addition, A. muciniphila levels were positively associated with total adiponectin (log10: 0.046±0.015, P=0.002), whereas low bimodal levels of A. muciniphila had an inverse relationship with this blood marker (log10: -0.131±0.053, P=0.016). In conclusion, we confirmed the previously reported association of A. muciniphila with metabolic health for the first time in a Greek urban population; furthermore, we shed some light to novel atherosclerotic risk markers with rather unexplored connections with A. muciniphila colonisation patterns in human subjects.

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