scholarly journals Extracorporeal Shock Wave Therapy Improves the Impaired Neovascularization in Diabetic Wound Healing via Altering the Expression of Angiopoietin-1 and Angiopoietin-2

2012 ◽  
Vol 11 (17) ◽  
pp. 3160-3168
Author(s):  
Xiaoyu Yan ◽  
Guang Yang ◽  
Xiangguo Cheng ◽  
Cheng Liang ◽  
Yimin Chai ◽  
...  
Keyword(s):  
Shock Wave ◽  
Wound Healing ◽  
Extracorporeal Shock Wave Therapy ◽  
Diabetic Wound ◽  
Shock Wave Therapy ◽  
Extracorporeal Shock Wave ◽  
Diabetic Wound Healing ◽  
Angiopoietin 2 ◽  
Angiopoietin 1

Extracorporeal shock wave therapy (ESWT) for wound healing: Technology, mechanisms, and clinical efficacy

2012 ◽  
pp. n/a-n/a ◽  
Author(s):  
Rainer Mittermayr ◽  
Vlado Antonic ◽  
Joachim Hartinger ◽  
Hanna Kaufmann ◽  
Heinz Redl ◽  
...  
Keyword(s):  
Shock Wave ◽  
Wound Healing ◽  
Clinical Efficacy ◽  
Extracorporeal Shock Wave Therapy ◽  
Shock Wave Therapy ◽  
Extracorporeal Shock Wave

scholarly journals Proteomic Analysis of Peri-Wounding Tissue Expressions in Extracorporeal Shock Wave Enhanced Diabetic Wound Healing in a Streptozotocin-Induced Diabetes Model

2020 ◽  
Vol 21 (15) ◽  
pp. 5445 ◽  
Author(s):  
Rong-Fu Chen ◽  
Ming-Yu Yang ◽  
Ching-Jen Wang ◽  
Chun-Ting Wang ◽  
Yur-Ren Kuo
Keyword(s):  
Shock Wave ◽  
Wound Healing ◽  
Real Time ◽  
Proteomic Analysis ◽  
Mapk Signaling ◽  
Diabetic Rats ◽  
Diabetic Wound ◽  
Rt Pcr ◽  
Extracorporeal Shock Wave ◽  
Diabetic Wound Healing

Our former studies have demonstrated that extracorporeal shock wave therapy (ESWT) could enhance diabetic wound healing but the bio-mechanisms remain elusive. This study investigated the changes of topical peri-wounding tissue expressions after ESWT in a rodent streptozotocin-induced diabetic wounding model by using the proteomic analysis and elucidated the molecular mechanism. Diabetic rats receiving ESWT, normal control, and diabetic rats receiving no therapy were analyzed. The spots of interest in proteome analysis were subjected to mass spectrometry to elucidate the peptide mass fingerprints. Protein expression was validated using immunohistochemical staining and related expression of genes were analyzed using real-time RT-PCR. The proteomic data showed a significantly higher abundance of hemopexin at day 3 of therapy but down-regulation at day 10 as compared to diabetic control. In contrast, the level of serine proteinase inhibitor (serpin) A3N expression was significantly decreased at day 3 therapy but expression was upregulated at day 10. Using real-time RT-PCR revealed that serpin-related EGFR-MAPK pathway was involved in ESWT enhanced diabetic wound healing. In summary, proteome analyses demonstrated the expression change of hemopexin and serpin with related MAPK signaling involved in ESWT-enhanced diabetic wound healing. Modulation of hemopexin and serpin related pathways are good strategies to promote wound healing.

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