Phytochemical Properties and Hypoglycemic Activity of the Aqueous and Fractionated Portions of Acacia nilotica (Fabaceae) Pod Extracts on Blood Glucose Level in Normoglycemic Wistar Albino Rats

2013 ◽  
Vol 13 (2) ◽  
pp. 111-117 ◽  
Author(s):  
Mohammed Shaibu Auwal ◽  
Sanni Saka ◽  
Abdullahi Shuaibu ◽  
Ismail Alhaji Mairiga ◽  
Kyari Abba Sanda ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Hypoglycemic Activity ◽  
Acacia Nilotica ◽  
Albino Rats ◽  
Wistar Albino Rats

scholarly journals Hypoglycemic Activity of Ethanol Extract of Jasminum Grandiflorum Flowers in Vivo and Cytotoxicity of Its Chloroform Isolate in Vitro

2018 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Ethanol Extract ◽  
Diabetic Rats ◽  
Hypoglycemic Activity ◽  
Albino Rats ◽  
Chloroform Fraction ◽  
Dependent Manner ◽  
Flower Extract

Ethno pharmacological relevance: Traditionally different parts of Jasminum grandiflorum have been used to treat various ailments, including diabetes. However, antidiabetic potential of Jasminum grandiflorum on animal models of diabetes have not been evaluated. Aim of the study: The objective of this study was to determine antidiabetic potential of ethanol extract of leaves and flowers of Jasminum grandiflorum, and different fractions of the flower extract in rodent model of streptozotocin-induced diabetes. Materials and methods: Ethanol extract of both leaves and flowers of Jasminum grandiflorum were screened for the presence of various phytochemicals followed by acute and sub-acute toxicity in rats. Effect of Jasminum grandiflorum leaf and flower extracts on blood glucose level in normal albino rats, in glucose-overloaded healthy albino rats, and in streptozotocininduced diabetic rats was evaluated. Furthermore, based on preliminary results, fractionalization of the flower extract was carried out using petroleum ether, ethyl acetate, methanol, and chloroform. Different fractions were further tested for hypoglycemic activity in streptozotocin-induced diabetic rats. Results: Preliminary phytochemical evaluation suggested presence of various antidiabetic metabolites in both the extracts and were found to safe up to 5000 mg/kg dose. Flower extract (500 mg/kg, p.o.) demonstrated significant hypoglycemic effect than leaf extract (500 mg/kg, p.o.) in normal rats, glucose-overloaded rats, and streptozotocin-induced diabetic rats when compared to control. Long-term effect of different fractions of ethanol extract of Jasminum grandiflorum flowers in streptozotocin model suggested that all four fractions were able to reduce blood glucose level in a time-dependent manner at 200 mg/kg dose with chloroform fraction being highly significant (p<0.001) amongst all when compared to diabetic untreated rats. Chloroform isolate from Jasminum grandiflorum flowers demonstrated enhanced glucose uptake and dosedependent cytotoxicity in L6 cell line. Conclusion: The ethanol extract of Jasminum grandiflorum flowers as well as its various fractions have potential therapeutic value in treating diabetes, which may be due to the presence of various antidiabetic metabolites, by enhancing insulin secretion and antioxidant defense. These observations rationalize its use as ethnomedicine and hence can be considered in treating diabetes.

scholarly journals EVALUATION OF ANTI-DIABETIC ACTIVITY OF FICUS BENGALENSIS LINN IN ALLOXAN INDUCED RATS

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Fegade Sachin A ◽  
Siddaiah M
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Research Work ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
Albino Rats ◽  
Standard Drug ◽  
Wistar Albino Rats ◽  
Ficus Bengalensis

The present study was aimed to evaluate the anti-diabetic activity of isolated compounds from aerial parts of Ficus bengalensis in alloxan induced diabetic rats. Diabetic wistar albino rats were treated with standard drug Glibenclamide and prepared drug extract in 150 mg/kg. Hypoglycemic effect was evaluated in these rats and the efficacy of isolated compounds was administered in alloxan induced diabetic rats. At the end of study period blood glucose level were statistically analyzed based on the results. Isolated fractions produced a significant reduction in blood glucose level when compared with non-treated diabetic rats. So the present research work was confirmed that the isolated compounds possess hypoglycemic effect significantly. Keywords: Ficus begalensis, antidiabetic, allaxon induced, Diabetes mellitus.

Evaluation of the Effect of Starvation on Blood Glucose Level and Body Weight of Wistar Albino Rats

2015 ◽  
Vol 8 (4) ◽  
pp. 1-8
Author(s):  
Okoro Ruth ◽  
Eze Adaora ◽  
N Victor ◽  
Onyia Felix ◽  
C Stanley ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Albino Rats ◽  
Wistar Albino Rats

scholarly journals Study of the oral hypoglycemic activity of Moringaoleifera leaves alone and in combination with Glibenclamide in streptozotocin induced diabetic albino rats

2017 ◽  
Vol 6 (10) ◽  
pp. 2470
Author(s):  
Sushma V. Naidu ◽  
Suresha R. N. ◽  
Jayanthi M. K. ◽  
Satish A. M. ◽  
Kalabharathi H. L. ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Control ◽  
Hypoglycemic Activity ◽  
Control Group ◽  
Albino Rats ◽  
Standard Group ◽  
Gum Acacia ◽  
Diabetic Control Group

Background: Oringaoleifera is a widely used plant with high medicinal value, well known for its pharmacological actions and is used in various conditions. It has been reported to have many biological properties like anti-inflammatory, antimicrobial, antispasmodic, antitumour including antidiabetic activity.Methods: The study was carried out in Wistar albino rats with body weight 150-250gms. Diabetes was induced by injecting Streptozotocin intraperitoneally- dose 55 mg/kg BW. Animals were divided into 5 groups with 6 animals in each group. First group (Control) was given 2% gum acacia. Other 4 groups were induced diabetes by giving Streptozotocin. Diabetic control group received gum acacia (0.5 ml), Standard group received Glibenclamide (0.5mg/kg BW), Test group received Moringaoleifera extract (300mg/kg) and Test+ Standard group receiving combination of Moringaoleifera and glibenclamide at half the above doses. All drugs were given orally for 28 days and blood glucose levels analyzed using Glucometer on Day 0 before drug and on D1, D3, D7, D14, D21, and D28. Data were statistically analyzed by ANOVA and Tukey‘s Post Hoc test.Results: Hypoglycemia produced by Moringaoleifera extract was significant (p<0.001) when compared to diabetic control group from day 7 to day 28. The percent reduction of blood glucose level was 52.9% as compared to Glibenclamide group 61.3%. The combination group also showed significant hypoglycemic activity the percentage reduction being 56.44%.Conclusions: Thus, Moringaoleifera decreased blood glucose level efficaciously as compared to diabetic control group and similar to standard group at p<0.001.

scholarly journals Effects of Moringa oleifera Leaves Methanolic Extract on Alloxan- Induced Diabetic Albino Rats

2019 ◽  
pp. 1-8
Author(s):  
C. Udeogu ◽  
C. C. Ejiofor ◽  
A. Nwakulite
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Moringa Oleifera ◽  
Albino Rats ◽  
High Blood Glucose ◽  
Before And After ◽  
Moringa Oleifera Leaves ◽  
Group 2 ◽  
Wistar Albino Rats

Moringa oleifera, popularly known as “miracle tree” belongs to the family, Moringaceae. It is a medicinal plant in which the leaves are the most nutritious part, being a significant source of vitamins and protein among others. This study was conceived and designed based on the gaps in the research that has been performed and what is known about the plant. In this study, the effect of Moringa oleifera leaves extract on alloxan induced diabetes in Wistar albino rats was investigated. A total of forty five (45) rats were acclimatized for a period of two weeks, then randomly divided into five (5) groups (1, 2, 3, 4, and 5) of  nine (9) rats each and fed with standard feed and water. Group 1 which is the control was fed with just water and standard feed while Hyperglycemia was induced in groups 2, 3, 4, & 5 intra-peritoneally after an over-night fasting using alloxan at a concentration of 130 mg/kg b.w. and allowed for 48hours which resulted in a high blood glucose level between 300 mg/dl and 600 mg/dl. Group 2 was not given any treatment while Groups 3, 4, & 5 were treated with doses 100 mg/kg b.w., 200 mg/kg bw, and 400 mg/kgbw of Moringa oleifera leaf extract respectively for a period of four weeks. A glucometer was used to check the blood glucose level of the animals before and after treatment. The results of Groups 3, 4, & 5 (172.0±4.75 mg/dl, 142.9±47.25 mg/dl, 70.6±24.46 mg/dl respectively) showed a significant decrease (p< 0.05) in blood glucose level of the induced rats when compared with Group 2 (316±47.17 mg/dl) which was induced only alloxan. It can therefore be concluded that this study has shown that the extract of Moringa oleifera leaves offers an anti-diabetic effect in Wistar albino rats.

Synthesis, Characterization and in vivo Evaluation of PEGylated PPI Dendrimer for Safe and Prolonged Delivery of Insulin

2019 ◽  
Vol 9 (3) ◽  
pp. 248-263 ◽  
Author(s):  
Ashish K. Parashar ◽  
Preeti Patel ◽  
Arun K. Gupta ◽  
Neetesh K. Jain ◽  
Balak Das Kurmi
Keyword(s):  
Blood Glucose ◽  
Drug Release ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Albino Rats ◽  
Sustained Delivery ◽  
In Vivo Evaluation ◽  
Hemolytic Toxicity

Background: The present study was aimed at developing and exploring the use of PEGylated Poly (propyleneimine) dendrimers for the delivery of an anti-diabetic drug, insulin. Methods: For this study, 4.0G PPI dendrimer was synthesized by successive Michael addition and exhaustive amidation reactions, using ethylenediamine as the core and acrylonitrile as the propagating agent. Two different activated PEG moieties were employed for PEGylation of PPI dendrimers. Various physicochemical and physiological parameters UV, IR, NMR, TEM, DSC, drug entrapment, drug release, hemolytic toxicity and blood glucose level studies of both PEGylated and non- PEGylated dendritic systems were determined and compared. Results: PEGylation of PPI dendrimers caused increased solubilization of insulin in the dendritic framework as well as in PEG layers, reduced drug release and hemolytic toxicity as well as increased therapeutic efficacy with reduced side effects of insulin. These systems were found to be suitable for sustained delivery of insulin by in vitro and blood glucose-level studies in albino rats, without producing any significant hematological disturbances. Conclusion: Thus, surface modification of PPI dendrimers with PEG molecules has been found to be a suitable approach to utilize it as a safe and effective nano-carrier for drug delivery.

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