Effect Of Aegle Marmelos Correa On Blood Glucose Level In Normal And Alloxan- Induced Diabetic Albino Rats

10.5580/2be8 ◽  
2012 ◽  
Vol 10 (1) ◽  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Albino Rats ◽  
Aegle Marmelos

Synthesis, Characterization and in vivo Evaluation of PEGylated PPI Dendrimer for Safe and Prolonged Delivery of Insulin

2019 ◽  
Vol 9 (3) ◽  
pp. 248-263 ◽  
Author(s):  
Ashish K. Parashar ◽  
Preeti Patel ◽  
Arun K. Gupta ◽  
Neetesh K. Jain ◽  
Balak Das Kurmi
Keyword(s):  
Blood Glucose ◽  
Drug Release ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Albino Rats ◽  
Sustained Delivery ◽  
In Vivo Evaluation ◽  
Hemolytic Toxicity

Background: The present study was aimed at developing and exploring the use of PEGylated Poly (propyleneimine) dendrimers for the delivery of an anti-diabetic drug, insulin. Methods: For this study, 4.0G PPI dendrimer was synthesized by successive Michael addition and exhaustive amidation reactions, using ethylenediamine as the core and acrylonitrile as the propagating agent. Two different activated PEG moieties were employed for PEGylation of PPI dendrimers. Various physicochemical and physiological parameters UV, IR, NMR, TEM, DSC, drug entrapment, drug release, hemolytic toxicity and blood glucose level studies of both PEGylated and non- PEGylated dendritic systems were determined and compared. Results: PEGylation of PPI dendrimers caused increased solubilization of insulin in the dendritic framework as well as in PEG layers, reduced drug release and hemolytic toxicity as well as increased therapeutic efficacy with reduced side effects of insulin. These systems were found to be suitable for sustained delivery of insulin by in vitro and blood glucose-level studies in albino rats, without producing any significant hematological disturbances. Conclusion: Thus, surface modification of PPI dendrimers with PEG molecules has been found to be a suitable approach to utilize it as a safe and effective nano-carrier for drug delivery.

scholarly journals POLYHERBAL PREPARATION AND COMPARATIVE STUDIES ON DIET-INDUCED HYPERLIPIDEMIA

2019 ◽  
pp. 190-196
Author(s):  
NUZHAT QURESHI ◽  
RAGHVENDRA DUBEY ◽  
NILESH KUMAR PATHAK
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Lipid Profile ◽  
Glucose Level ◽  
Comparative Studies ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Lowering ◽  
Albino Rats ◽  
Oral Toxicity

Objective: The objective of this research article is to develop and evaluate polyherbal preparation and comparative studies on diet-induced hyperlipidemia. Methods: After the extraction, pharmacognostical and phytochemical screening was done. The lipid-lowering activity of polyherbal formulation (T1, T2, T3, T4, and T5) may be attributed to the phytoconstituents present such as alkaloids, carbohydrates, steroids, proteins, tannins, carbohydrates, flavonoids, phenols, glycosides, and triterpenes. In acute oral toxicity study, there were no behavioral changes seen up to 4 h and no mortality was observed up to the end of 24 h even at the maximum tested dose level of 2000 mg/kg per oral. It was considered maximum safe dose. Male and female albino rats weighing 150–200 g were used for the study. Hydroalcoholic extract of all plants was prepared having a dose of 2000 mg/kg. The doses were selected according to the Organisation for Economic Cooperation and Development guideline no. 425. The procedure was divided into two phases: Phase I (observation made on day 1) and Phase II (observed the animals for the next 14 days of drug administration). Animals received a single dose of 2000 mg/kg. After the administration of Healthcare Administration, food was withheld for 3–4 h. If the animal dies, conduct the main test to determine the LD50. The study was conducted by measuring various parameters, namely, daily feed intake (g), water intake (ml), body weight (g), lipid profile high-density lipoprotein (HDL), low-density lipoprotein (LDL), CHL level (mg/dl), and blood glucose level (mg/dl). Results: Results showed a significant decrease in blood glucose level and serum lipid profile such as total cholesterol, LDL, and increasing serum HDL level, so could be useful in the treatment of hypolipidemia. Conclusion: Polyherbal formulations (T1, T2, T3, T4, and T5) have hypoglycemic activity and significantly improve lipid profile levels in diet-induced experimental rats.

scholarly journals Hypoglycemic Activity of Ethanol Extract of Jasminum Grandiflorum Flowers in Vivo and Cytotoxicity of Its Chloroform Isolate in Vitro

2018 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Ethanol Extract ◽  
Diabetic Rats ◽  
Hypoglycemic Activity ◽  
Albino Rats ◽  
Chloroform Fraction ◽  
Dependent Manner ◽  
Flower Extract

Ethno pharmacological relevance: Traditionally different parts of Jasminum grandiflorum have been used to treat various ailments, including diabetes. However, antidiabetic potential of Jasminum grandiflorum on animal models of diabetes have not been evaluated. Aim of the study: The objective of this study was to determine antidiabetic potential of ethanol extract of leaves and flowers of Jasminum grandiflorum, and different fractions of the flower extract in rodent model of streptozotocin-induced diabetes. Materials and methods: Ethanol extract of both leaves and flowers of Jasminum grandiflorum were screened for the presence of various phytochemicals followed by acute and sub-acute toxicity in rats. Effect of Jasminum grandiflorum leaf and flower extracts on blood glucose level in normal albino rats, in glucose-overloaded healthy albino rats, and in streptozotocininduced diabetic rats was evaluated. Furthermore, based on preliminary results, fractionalization of the flower extract was carried out using petroleum ether, ethyl acetate, methanol, and chloroform. Different fractions were further tested for hypoglycemic activity in streptozotocin-induced diabetic rats. Results: Preliminary phytochemical evaluation suggested presence of various antidiabetic metabolites in both the extracts and were found to safe up to 5000 mg/kg dose. Flower extract (500 mg/kg, p.o.) demonstrated significant hypoglycemic effect than leaf extract (500 mg/kg, p.o.) in normal rats, glucose-overloaded rats, and streptozotocin-induced diabetic rats when compared to control. Long-term effect of different fractions of ethanol extract of Jasminum grandiflorum flowers in streptozotocin model suggested that all four fractions were able to reduce blood glucose level in a time-dependent manner at 200 mg/kg dose with chloroform fraction being highly significant (p<0.001) amongst all when compared to diabetic untreated rats. Chloroform isolate from Jasminum grandiflorum flowers demonstrated enhanced glucose uptake and dosedependent cytotoxicity in L6 cell line. Conclusion: The ethanol extract of Jasminum grandiflorum flowers as well as its various fractions have potential therapeutic value in treating diabetes, which may be due to the presence of various antidiabetic metabolites, by enhancing insulin secretion and antioxidant defense. These observations rationalize its use as ethnomedicine and hence can be considered in treating diabetes.

scholarly journals Anti-Hyperglycemic and Anti-Hyperlipidemic Potentials of Methanol Leaf Extracts of Aframomum melegueta and Piper guineense

2019 ◽  
pp. 1-8
Author(s):  
Morakinyo Adetoun Elizabeth ◽  
Oyedepo Temitope Adenike ◽  
S. O. Babarinde ◽  
J. M. Adelowo ◽  
Oyedapo Oluboade Oluokun
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Treated Group ◽  
Albino Rats ◽  
Leaf Extracts ◽  
Piper Guineense ◽  
Group I

Aim: The study investigated the anti-hyperglycemic and anti-hyperlipidemic potentials of methanol extracts of Piper guineense and Aframomum melegueta leaves with a view to utilizing the plants in the treatment and management of cardiovascular disorders. Methodology: Twenty-eight healthy albino rats were randomly divided into seven equal groups: Group I received normal saline (2 ml/kg bwt); Group II received a single dose of alloxan(150 mg/kg bwt) intraperitoneally; Group III received  alloxan (150 mg/kg bwt) + glibenclamide (5 mg/kg bwt);Group IV received alloxan (150 mg/kg bwt) +PG (200 mg/kg bwt); Group V received alloxan (150 mg/kg bwt) + PG (400 mg/kg bwt); Group VI received alloxan (150 mg/kg bwt) + AM 200 (mg/kg bwt); Group VII received alloxan (150 mg/kg bwt) + AM (400 mg/kg bwt). The blood glucose level was determined before and after treatment with the extracts. The lipid: (total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) were estimated using the Randox diagnostic kits. Results: The results revealed that alloxan was able to induce hyperglycemia at 150 mg/kg bwt and post-treatment with P. guineense and A. melegueta at 200 mg/kg and 400 mg/ kg bwt were able to significantly lower the blood glucose level which was quite apparent in AM treated groups. Also, the extracts at 200 mg/kg and 400 mg/kg were able to bring a significant (p < 0.05) reduction in TC, TG and LDL concentrations when compared to the alloxan treated group with the highest reduction in AM treated groups. Conclusion: These results revealed that the methanol extract of P. guineense and A. melegueta elicited anti-hyperglycemic and anti-hyperlipidemic potentials of the extracts with the highest effect observed in A. melegueta treated rats.

scholarly journals EVALUATION OF ANTI-DIABETIC ACTIVITY OF FICUS BENGALENSIS LINN IN ALLOXAN INDUCED RATS

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Fegade Sachin A ◽  
Siddaiah M
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Research Work ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
Albino Rats ◽  
Standard Drug ◽  
Wistar Albino Rats ◽  
Ficus Bengalensis

The present study was aimed to evaluate the anti-diabetic activity of isolated compounds from aerial parts of Ficus bengalensis in alloxan induced diabetic rats. Diabetic wistar albino rats were treated with standard drug Glibenclamide and prepared drug extract in 150 mg/kg. Hypoglycemic effect was evaluated in these rats and the efficacy of isolated compounds was administered in alloxan induced diabetic rats. At the end of study period blood glucose level were statistically analyzed based on the results. Isolated fractions produced a significant reduction in blood glucose level when compared with non-treated diabetic rats. So the present research work was confirmed that the isolated compounds possess hypoglycemic effect significantly. Keywords: Ficus begalensis, antidiabetic, allaxon induced, Diabetes mellitus.

scholarly journals Antimicrobial and antidiabetic potentials of processed finger millet (Eleusine coracana)

2018 ◽  
Vol 6 (1) ◽  
pp. 18
Author(s):  
Japhet Erasmus Aisoni ◽  
Muhammad Yusha’u ◽  
Olukayode Olugbenga Orole
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Finger Millet ◽  
Islet Cells ◽  
Salmonella Typhi ◽  
Glycaemic Index ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Methanolic Extracts

Finger millet is a food crop with energy value, phytochemical constituents, and minerals, hence its use as whole flour for traditional food preparation among traditional people. The study was designed to determine the glycaemic index and blood glucose level in albino rats, and the antimicrobial potential of processed finger millets. Finger millets were processed by fermentation and roasting, and methanolic extracts obtained used to test antimicrobial activity. Albino rats (18) divided into three groups were fed fermented, roasted, and unprocessed millet (control), and glycaemic index and blood glucose level determined. Another 25 rat were treated into 5 groups of diabetic rats without treatment, diabetic rats treated daily with Metformin, diabetic rats fed 20% millet, diabetic rats fed 40% millet, and untreated group (control). At 100% concentration, roasted and fermented millet obtained inhibition of 15mm and 14mm against Salmonella typhi, while the control drug 25mg/ml streptomycin had 17mm inhibition. While values obtained for the glycemic indexes were close though significantly different from each other (roasted - 36.83±1.23; fermented - 38.73±1.87), roasted millet brought about the highest reduction in blood glucose level 90.9 and 65.1mg/dl at 60 and 120min respectively compared with fermented millet with 125.1 and 100.2mg/dl respectively at the same time. Animals administered finger millet in Groups 3 and 4-showed regeneration of the islet cells. The millet had the capacity to bring about healing of necrotic cells while also restoring and maintaining glucose levels in blood of subjects. 

Evaluation of the Effect of Starvation on Blood Glucose Level and Body Weight of Wistar Albino Rats

2015 ◽  
Vol 8 (4) ◽  
pp. 1-8
Author(s):  
Okoro Ruth ◽  
Eze Adaora ◽  
N Victor ◽  
Onyia Felix ◽  
C Stanley ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Albino Rats ◽  
Wistar Albino Rats
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