The Relationship Between Maternal Serum Magnesium Level and Preterm Birth

Background: Hypertensive disorders are major factors responsible for morbidity and mortality in pregnancy and pre-eclampsia is the leading cause. The etiopathology of pre-eclampsia is not known even after significant research done on it. A strong strategy in its management is to try to reduce the incidence and severity by predicting its occurrence. In this study, the effect of serum calcium and serum magnesium levels is being investigated with occurrence pre-eclampsia.Methods: Total 120 pregnant patients attending Tirath Ram Shah Hospital were included in the study. They were divided into two groups namely normotensive and hypertensive of 60 each. The serum calcium and serum magnesium levels were estimated and the correlation of these levels was studied with the pre-eclampsia related factors. The data was analysed by application of statistical test of significance.Results: Mean serum calcium level in the normotensive group was 10.119±1.27 mg/dl while mean serum calcium level in the hypertensive group was 9.461±1.164. Mean serum magnesium level in the normotensive women in the study was 1.979±0.405 mg/dl. In the hypertensive women, mean serum magnesium level was 1.723±0.414 mg/dl.Conclusions: This study shows that low levels of calcium and magnesium are found in serum of pre-eclampsia patients as compared to normotensive cases of the study population. The severity of pre-eclampsia is inversely proportional to the levels of serum calcium and magnesium.

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The relationship between magnesium and seizure control in epileptic patients

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20212218 ◽

2021 ◽

Vol 9 (6) ◽

pp. 1532

Author(s):

Yonathan A. Suparman ◽

Herlyani Khosama ◽

Corry N. Mahama

Keyword(s):

Seizure Control ◽

Serum Magnesium ◽

Magnesium Level ◽

Seizure Freedom ◽

Serum Magnesium Level ◽

Magnesium Intake ◽

Dietary Magnesium ◽

Epileptic Patients ◽

Patients With Epilepsy ◽

The Relationship

Background: Magnesium has a central nervous system depressant effect by inhibiting the N-methyl-D-aspartate (NMDA) receptor, an antagonist of calcium channels, and increasing the surface tension of the cell membrane. Patients with epilepsy who had seizures more than 4 times/week had lower serum magnesium levels than those with the episode of less than or equal to 1 time/week. A low dose of magnesium added to phenytoin or carbamazepine can reduce seizure frequency. We want to evaluate the relationship between serum magnesium levels and their dietary intake level with seizure control in Manado.Methods: Patients with epilepsy aged 18-65 years, from July 2019 to October 2019, were tested for dietary and serum magnesium level in the last 30 days using NutriSurvey software. Regression models were used to quantify the relationship between dietary and serum magnesium level with seizure freedom and its frequency in the last 30 days.Results: One hundred and ten epileptic patients were included in this study. The median serum magnesium level is 2 mg/dl. There was no significant relationship between serum magnesium levels and seizure freedom (p=0.423) or its frequency in the last 30 days (p=0.966). Dietary magnesium intake (OR 1.01; 95% CI 1.00-1.02, p=0.034) was associated with seizure freedom but not with its frequency (p=0.423).Conclusions: Dietary magnesium intake was associated with seizure freedom, but serum magnesium levels were not associated with seizure freedom or frequency.

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The relationship between low serum magnesium level and intracerebral hemorrhage hematoma expansion

Medicine ◽

10.1097/md.0000000000018719 ◽

2020 ◽

Vol 99 (2) ◽

pp. e18719

Author(s):

Rending Zhu ◽

Xiaolu He ◽

Yanqun Du ◽

Nan Chen ◽

Wei Wang ◽

...

Keyword(s):

Intracerebral Hemorrhage ◽

Serum Magnesium ◽

Magnesium Level ◽

Hematoma Expansion ◽

Serum Magnesium Level ◽

The Relationship ◽

Low Serum

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Association between serum magnesium levels and abdominal aorta calcification in patients with pre-dialysis chronic kidney disease stage 5

PLoS ONE ◽

10.1371/journal.pone.0253592 ◽

2021 ◽

Vol 16 (6) ◽

pp. e0253592

Author(s):

Mayumi Ito ◽

Makoto Yamaguchi ◽

Takayuki Katsuno ◽

Hironobu Nobata ◽

Shiho Iwagaitsu ◽

...

Keyword(s):

Cardiovascular Disease ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Abdominal Aorta ◽

Serum Magnesium ◽

Chronic Kidney Disease Stage ◽

Magnesium Level ◽

Disease Stage ◽

Serum Magnesium Level ◽

The Relationship

Background Several studies have revealed the relationship between serum magnesium levels and vascular calcification in chronic kidney disease patients. Despite excellent predictability of abdominal aorta calcification for cardiovascular disease events, the relationship between serum magnesium levels and abdominal aorta calcification, as evaluated by quantitative methods, in pre-dialysis patients remains unclear. This study aimed to determine the abdominal aorta calcification volume using computerized tomography and its association with serum magnesium levels in pre-dialysis chronic kidney disease stage 5 patients. Methods This single-center cross-sectional study included 100 consecutive patients with pre-dialysis chronic kidney disease stage 5 between January 2016 and May 2020 at Aichi Medical University Hospital, Japan. The relationships between serum magnesium levels and the abdominal aorta calcification volume were assessed using multiple linear regression models after adjusting for clinically relevant factors. We also assessed clinical factors that affect serum magnesium levels. Results The mean serum magnesium level was 2.0 mg/dL (interquartile range, 1.8 to 2.3). Multivariate analyses revealed that a higher serum magnesium level (stand. β = -0.245, p = 0.010) was significantly associated with a reduced abdominal aorta calcification volume, and that a history of cardiovascular disease (stand. β = 0.3792, p < 0.001) and older age (stand. β = 0.278, p = 0.007) were significantly associated with an increased abdominal aorta calcification volume. Moreover, multivariate analysis showed that the use of proton pump inhibitor or potassium-competitive acid blocker was significantly associated with lower serum magnesium levels (stand. β = -0.246, p = 0.019). Conclusions The present study revealed that the higher Mg level was significantly associated with lower volume of abdominal aorta calcification in pre-dialysis chronic kidney disease stage 5 patients. Further studies should be undertaken to determine the appropriate magnesium level to suppress vascular calcification.

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The study of association between maternal serum magnesium levels and preterm labour in a tertiary care hospital

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20193773 ◽

2019 ◽

Vol 8 (9) ◽

pp. 3543

Author(s):

Shifali Anand ◽

Jyoti Hak ◽

Niveditaa Prashar ◽

Nikita Gandotra ◽

Rohini Jaggi

Keyword(s):

Pregnant Women ◽

Preterm Labour ◽

Serum Magnesium ◽

Maternal Serum ◽

Magnesium Level ◽

Cervical Dilatation ◽

Care Hospital ◽

Serum Magnesium Level ◽

Group A ◽

Low Serum

Background: Serum magnesium level in pregnancy is a valuable tool to find out preterm onset of labour. In the asymptomatic group, greater surveillance and administration of steroids, tocolytics and transfer to a higher centre wherever necessary has to be done with mothers with low serum magnesium level. The objective of the study is to find association between serum magnesium levels and women with preterm labour, and to compare these values with those patients who have a term delivery.Methods: The subjects included 100 pregnant women with preterm labour (cases) between 28 and 37 weeks gestation (Group A) and similar number of pregnant women with term labour (controls) between 37 and 40 weeks (Group B). Inclusion criteria for cases was singleton pregnancy, painful uterine contractions more than two in 30 minutes, intact fetal membranes, cervical dilatation (at least 1 cm) and effacement (80%). Serum magnesium levels were done in both the groups. Patients were followed until delivery. Routine antenatal investigations were done. Serum levels of magnesium were estimated by Erba’s semi auto-analyser.Results: 62% patients in Group A were from rural areas. More patients in Group A (70%) were from low socioeconomic class. More women in Group A were anaemic (44%). Mean value of hemoglobin in Group A was 9.93gm/dL. More patients in Group A had muscle cramps (89%). VLBW (<1500gm) neonates were more in Group A (21%). Also, LBW (1500-2499gm) neonates were more in Group A (60%). Mean neonatal birth weight in Group A (1907.3gm) was less. Neonatal morbidity and mortality was observed significantly more in Group A. Mean serum magnesium was less in Group A. Mean serum magnesium levels in primi and multigravida patients were less in Group A. Moreover, mean serum magnesium levels were less in urban and rural patients in Group A. Mean serum magnesium levels were less in normal and overweight patients in Group A. Also, mean serum magnesium levels were less in patients with cervical dilatation <3cm and >3cm in Group A.Conclusions: Low maternal serum magnesium level is associated with preterm labour. Patients with preterm labour have significantly low serum magnesium level when compared with labour at term.

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