The relationship between low serum magnesium level and intracerebral hemorrhage hematoma expansion

Background: Magnesium has a central nervous system depressant effect by inhibiting the N-methyl-D-aspartate (NMDA) receptor, an antagonist of calcium channels, and increasing the surface tension of the cell membrane. Patients with epilepsy who had seizures more than 4 times/week had lower serum magnesium levels than those with the episode of less than or equal to 1 time/week. A low dose of magnesium added to phenytoin or carbamazepine can reduce seizure frequency. We want to evaluate the relationship between serum magnesium levels and their dietary intake level with seizure control in Manado.Methods: Patients with epilepsy aged 18-65 years, from July 2019 to October 2019, were tested for dietary and serum magnesium level in the last 30 days using NutriSurvey software. Regression models were used to quantify the relationship between dietary and serum magnesium level with seizure freedom and its frequency in the last 30 days.Results: One hundred and ten epileptic patients were included in this study. The median serum magnesium level is 2 mg/dl. There was no significant relationship between serum magnesium levels and seizure freedom (p=0.423) or its frequency in the last 30 days (p=0.966). Dietary magnesium intake (OR 1.01; 95% CI 1.00-1.02, p=0.034) was associated with seizure freedom but not with its frequency (p=0.423).Conclusions: Dietary magnesium intake was associated with seizure freedom, but serum magnesium levels were not associated with seizure freedom or frequency.

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The relationship between low serum calcium level and intracerebral hemorrhage hematoma expansion

Medicine ◽

10.1097/md.0000000000018844 ◽

2020 ◽

Vol 99 (3) ◽

pp. e18844

Author(s):

Jian Sun ◽

Wanjun Liu ◽

Rending Zhu ◽

Yao Wu ◽

Liqi Yang

Keyword(s):

Intracerebral Hemorrhage ◽

Serum Calcium ◽

Calcium Level ◽

Serum Calcium Level ◽

Hematoma Expansion ◽

The Relationship ◽

Low Serum

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Hypomagnesaemia in Pregnancy: A predictor of Preterm Labour

Journal of Dhaka Medical College ◽

10.3329/jdmc.v19i1.6253 ◽

1970 ◽

Vol 19 (1) ◽

pp. 51-57 ◽

Cited By ~ 1

Author(s):

AR Shahid ◽

AU Hosna ◽

HZ Tahmina

Keyword(s):

Preterm Labour ◽

Serum Magnesium ◽

Magnesium Level ◽

The Body ◽

Health Concern ◽

Magnesium Concentration ◽

Serum Magnesium Level ◽

Term Labour ◽

In Pregnancy ◽

Low Serum

Preterm birth is a major health concern. It is the leading cause of perinatal mortality and morbidity. Besides varied etiology, it may be due to alteration in basic biochemical function of the body at cellular level stating emphasis to trace elements of which magnesium, being one of them. Pregnancy is marked by a state of hypomagnesaemia and varied hypomagnesaemia is observed in preterm labour cases. The study is conducted to find out the relationship between low serum magnesium concentrations with preterm labour, with a view to ascertain it as one of the predictor of preterm labour. This study has been designed as cross sectional case control study. 100 pregnant women with preterm labour were taken as case and 100 women with term labour as control. It is found that mean level of serum magnesium was lower in preterm labour as compared with term labour. The study shows that there is significant decrease in magnesium in maternal body in case of preterm labour. The study also shows that the relative risk of preterm labour was 3.18 times more in patients with serum magnesium level less than 1.9 mg/ dl in comparison to those who had the level of 1.9 mg/dl or more. Low level of serum magnesium significantly correlated with the preterm labour. Moreover different studies also shows that the decreased serum magnesium level has an association with the uterine irritability leads to the preterm labour. As such, it is assumed that the low serum magnesium concentration in pregnancy has a role in pathophysiology of preterm labour and may be used as a predictor of preterm labour. Key words: Hypomagnesaemia; predictor; preterm labour. DOI: 10.3329/jdmc.v19i1.6253 J Dhaka Med Coll. 2010; 19(1) : 51-57

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Association between serum magnesium levels and abdominal aorta calcification in patients with pre-dialysis chronic kidney disease stage 5

PLoS ONE ◽

10.1371/journal.pone.0253592 ◽

2021 ◽

Vol 16 (6) ◽

pp. e0253592

Author(s):

Mayumi Ito ◽

Makoto Yamaguchi ◽

Takayuki Katsuno ◽

Hironobu Nobata ◽

Shiho Iwagaitsu ◽

...

Keyword(s):

Cardiovascular Disease ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Abdominal Aorta ◽

Serum Magnesium ◽

Chronic Kidney Disease Stage ◽

Magnesium Level ◽

Disease Stage ◽

Serum Magnesium Level ◽

The Relationship

Background Several studies have revealed the relationship between serum magnesium levels and vascular calcification in chronic kidney disease patients. Despite excellent predictability of abdominal aorta calcification for cardiovascular disease events, the relationship between serum magnesium levels and abdominal aorta calcification, as evaluated by quantitative methods, in pre-dialysis patients remains unclear. This study aimed to determine the abdominal aorta calcification volume using computerized tomography and its association with serum magnesium levels in pre-dialysis chronic kidney disease stage 5 patients. Methods This single-center cross-sectional study included 100 consecutive patients with pre-dialysis chronic kidney disease stage 5 between January 2016 and May 2020 at Aichi Medical University Hospital, Japan. The relationships between serum magnesium levels and the abdominal aorta calcification volume were assessed using multiple linear regression models after adjusting for clinically relevant factors. We also assessed clinical factors that affect serum magnesium levels. Results The mean serum magnesium level was 2.0 mg/dL (interquartile range, 1.8 to 2.3). Multivariate analyses revealed that a higher serum magnesium level (stand. β = -0.245, p = 0.010) was significantly associated with a reduced abdominal aorta calcification volume, and that a history of cardiovascular disease (stand. β = 0.3792, p < 0.001) and older age (stand. β = 0.278, p = 0.007) were significantly associated with an increased abdominal aorta calcification volume. Moreover, multivariate analysis showed that the use of proton pump inhibitor or potassium-competitive acid blocker was significantly associated with lower serum magnesium levels (stand. β = -0.246, p = 0.019). Conclusions The present study revealed that the higher Mg level was significantly associated with lower volume of abdominal aorta calcification in pre-dialysis chronic kidney disease stage 5 patients. Further studies should be undertaken to determine the appropriate magnesium level to suppress vascular calcification.

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