scholarly journals The relationship between magnesium and seizure control in epileptic patients

2021 ◽  
Vol 9 (6) ◽  
pp. 1532
Author(s):  
Yonathan A. Suparman ◽  
Herlyani Khosama ◽  
Corry N. Mahama
Keyword(s):  
Seizure Control ◽  
Serum Magnesium ◽  
Magnesium Level ◽  
Seizure Freedom ◽  
Serum Magnesium Level ◽  
Magnesium Intake ◽  
Dietary Magnesium ◽  
Epileptic Patients ◽  
Patients With Epilepsy ◽  
The Relationship

Background: Magnesium has a central nervous system depressant effect by inhibiting the N-methyl-D-aspartate (NMDA) receptor, an antagonist of calcium channels, and increasing the surface tension of the cell membrane. Patients with epilepsy who had seizures more than 4 times/week had lower serum magnesium levels than those with the episode of less than or equal to 1 time/week. A low dose of magnesium added to phenytoin or carbamazepine can reduce seizure frequency. We want to evaluate the relationship between serum magnesium levels and their dietary intake level with seizure control in Manado.Methods: Patients with epilepsy aged 18-65 years, from July 2019 to October 2019, were tested for dietary and serum magnesium level in the last 30 days using NutriSurvey software. Regression models were used to quantify the relationship between dietary and serum magnesium level with seizure freedom and its frequency in the last 30 days.Results: One hundred and ten epileptic patients were included in this study. The median serum magnesium level is 2 mg/dl. There was no significant relationship between serum magnesium levels and seizure freedom (p=0.423) or its frequency in the last 30 days (p=0.966). Dietary magnesium intake (OR 1.01; 95% CI 1.00-1.02, p=0.034) was associated with seizure freedom but not with its frequency (p=0.423).Conclusions: Dietary magnesium intake was associated with seizure freedom, but serum magnesium levels were not associated with seizure freedom or frequency.

The Relationship Between Maternal Serum Magnesium Level and Preterm Birth

2010 ◽  
Vol 13 (7) ◽  
pp. 335-339 ◽  
Author(s):  
S. Khani ◽  
M. Shokrzadeh ◽  
P.k Karamoddin ◽  
S. Shahmohamm
Keyword(s):  
Preterm Birth ◽  
Serum Magnesium ◽  
Maternal Serum ◽  
Magnesium Level ◽  
Serum Magnesium Level ◽  
The Relationship

scholarly journals The relationship between low serum magnesium level and intracerebral hemorrhage hematoma expansion

Medicine ◽  
2020 ◽  
Vol 99 (2) ◽  
pp. e18719
Author(s):  
Rending Zhu ◽  
Xiaolu He ◽  
Yanqun Du ◽  
Nan Chen ◽  
Wei Wang ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Serum Magnesium ◽  
Magnesium Level ◽  
Hematoma Expansion ◽  
Serum Magnesium Level ◽  
The Relationship ◽  
Low Serum

scholarly journals Association between serum magnesium levels and abdominal aorta calcification in patients with pre-dialysis chronic kidney disease stage 5

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0253592
Author(s):  
Mayumi Ito ◽  
Makoto Yamaguchi ◽  
Takayuki Katsuno ◽  
Hironobu Nobata ◽  
Shiho Iwagaitsu ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Abdominal Aorta ◽  
Serum Magnesium ◽  
Chronic Kidney Disease Stage ◽  
Magnesium Level ◽  
Disease Stage ◽  
Serum Magnesium Level ◽  
The Relationship

Background Several studies have revealed the relationship between serum magnesium levels and vascular calcification in chronic kidney disease patients. Despite excellent predictability of abdominal aorta calcification for cardiovascular disease events, the relationship between serum magnesium levels and abdominal aorta calcification, as evaluated by quantitative methods, in pre-dialysis patients remains unclear. This study aimed to determine the abdominal aorta calcification volume using computerized tomography and its association with serum magnesium levels in pre-dialysis chronic kidney disease stage 5 patients. Methods This single-center cross-sectional study included 100 consecutive patients with pre-dialysis chronic kidney disease stage 5 between January 2016 and May 2020 at Aichi Medical University Hospital, Japan. The relationships between serum magnesium levels and the abdominal aorta calcification volume were assessed using multiple linear regression models after adjusting for clinically relevant factors. We also assessed clinical factors that affect serum magnesium levels. Results The mean serum magnesium level was 2.0 mg/dL (interquartile range, 1.8 to 2.3). Multivariate analyses revealed that a higher serum magnesium level (stand. β = -0.245, p = 0.010) was significantly associated with a reduced abdominal aorta calcification volume, and that a history of cardiovascular disease (stand. β = 0.3792, p < 0.001) and older age (stand. β = 0.278, p = 0.007) were significantly associated with an increased abdominal aorta calcification volume. Moreover, multivariate analysis showed that the use of proton pump inhibitor or potassium-competitive acid blocker was significantly associated with lower serum magnesium levels (stand. β = -0.246, p = 0.019). Conclusions The present study revealed that the higher Mg level was significantly associated with lower volume of abdominal aorta calcification in pre-dialysis chronic kidney disease stage 5 patients. Further studies should be undertaken to determine the appropriate magnesium level to suppress vascular calcification.

Hair Magnesium content and its relation to Serum Magnesium level in children with Idiopathic Epilepsy

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Hamed Mahmoud Shatla ◽  
Mariam Fathy Abdel Maksoud ◽  
Raghda Mohamed Hesham Zaitoun ◽  
Alaa Rabie Abdel Baset Mahmoud
Keyword(s):  
Serum Magnesium ◽  
Serum Levels ◽  
Magnesium Content ◽  
Magnesium Level ◽  
Idiopathic Epilepsy ◽  
Age And Gender ◽  
Control Subjects ◽  
Significant Difference ◽  
And Gender ◽  
Patients With Epilepsy

Abstract Objective To measure the level of hair Mg, as well as its level in serum, in patients with epilepsy and compare them to the levels found in non-epileptic age and gender matched children, and to explore any potential correlation between either serum or hair level of magnesium and seizure characteristics in children with idiopathic epilepsy. Methods An observational cross-sectional study including 50 children with idiopathic epilepsy and 100 non-epileptic age and gender matched control subjects. Cases were subjected to full history taking, examination and measurements of serum and hair levels of magnesium, control subjects only had their serum and hair level of magnesium measured as for the cases. Results The mean serum magnesium was 29.11 ± 13.42 ug/ml for cases and 27.67 ± 7.24 ug/ml for controls and the median hair level of magnesium was 42.22 ug/g with IQR of 25.9 - 56.82 for cases and 38.6 ug/g with IQR of 25.21 - 61.25 for controls. No statistically significant difference was observed between both groups as regards either serum or hair magnesium levels. No statistically significant correlation was observed between either hair or serum levels of magnesium and seizure characteristics though the correlations were nearing statistical significance for the hair magnesium content. Conclusion Hair magnesium level may be better correlated to seizure characteristics and control than serum levels in patients with epilepsy.

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