Growth Hormone Deficiency in Children and Adolescents with Cerebral Palsy: Relation to Gross Motor Function and Degree of Spasticity

2011 ◽  
Vol 14 (7) ◽  
pp. 433-440 ◽  
Author(s):  
Rasha T. Hamza ◽  
Mona A. Ismail ◽  
Amira I. Hamed
Keyword(s):  
Growth Hormone ◽  
Cerebral Palsy ◽  
Children And Adolescents ◽  
Growth Hormone Deficiency ◽  
Motor Function ◽  
Hormone Deficiency ◽  
Gross Motor ◽  
Gross Motor Function

scholarly journals Acute Response to One Bout of Dynamic Standing Exercise on Blood Glucose and Blood Lactate Among Children and Adolescents With Cerebral Palsy Who are Nonambulant

2021 ◽  
pp. 1-6
Author(s):  
Åsa Andersson ◽  
Petra Lundström ◽  
Katarina Lauruschkus ◽  
Åsa B. Tornberg
Keyword(s):  
Cerebral Palsy ◽  
Blood Glucose ◽  
Children And Adolescents ◽  
Blood Lactate ◽  
Motor Function ◽  
System Level ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Lactate Levels ◽  
Blood Lactate Levels

Purpose: To investigate the acute exercise effects of dynamic standing exercise on blood glucose and blood lactate among children and adolescents with cerebral palsy who are nonambulant. Methods: Twenty-four participants with cerebral palsy who are nonambulant performed 30 minutes of dynamic standing exercise using a motorized device enabling assisted passive movements in an upright weight-bearing position. Capillary blood samples were taken from the fingertip for measurement of blood glucose and blood lactate at rest and at the end of exercise. Results: At rest, the participants had hyperlactatemia that was unaffected after exercise, presented as median and interquartile range at rest 1.8 (1.3:2.7) mmol/L, and after exercise 2.0 (1.1:2.5) mmol/L. Children and adolescents with Gross Motor Function Classification System, level V, had higher lactate levels at rest (2.5 [1.8:2.9] vs 1.4 [1.0:2.0]; P = .030) and after exercise (2.3 [2.0:2.6] vs 1.2 [0.9:2.2]; P = .032) compared with children and adolescents with Gross Motor Function Classification System, level IV, respectively. A statistically significant larger decrease in blood lactate levels after exercise was observed in children and adolescents with higher resting blood lactate levels (ρ = .56; P = .004). There were no statistically significant changes in blood glucose. Conclusions: Forty percentage of the participants had mild hyperlactatemia at rest and participants with the highest blood lactate levels at rest had the greatest decrease in blood lactate levels after one bout of exercise. Children and adolescents who were classified with the highest level of the Gross Motor Function Classification Scale had higher blood lactate levels. More studies are needed on how to prevent chronically high resting levels of lactate with exercise in children with cerebral palsy who are nonambulant.

scholarly journals Pain in children and adolescents with cerebral palsy – a cross-sectional register study of 3545 individuals

BMC Neurology ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Elsa Eriksson ◽  
Gunnar Hägglund ◽  
Ann I. Alriksson-Schmidt
Keyword(s):  
Cerebral Palsy ◽  
Pain Intensity ◽  
Children And Adolescents ◽  
Motor Function ◽  
Daily Activities ◽  
Cross Sectional ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Disturbed Sleep ◽  
Prevalence Of Pain

Abstract Background Pain is a common problem for individuals with cerebral palsy (CP). In Sweden, 95% of children and adolescents with CP are followed in a national follow-up programme (CPUP), which includes data on pain. The purpose of this study was to investigate the prevalence of pain based on age, sex, gross motor function and source of report (self or proxy). Pain intensity, pain site, and how much pain disturbed sleep and daily activities were also studied. Methods This was a cross-sectional register study based on all participants in CPUP, 4–18-years of age, with data reported in 2017–2018. Gross motor function was classified using the Gross Motor Function Classification System (GMFCS). Logistic regression was used to analyse prevalence of pain and how much pain had disturbed sleep and daily activities in the last four weeks. Results In total, 3545 participants (2065 boys) were included. The overall prevalence of pain was 44%. Older age and female sex were associated with higher risk of pain with odds ratios of 1.07 (95% confidence interval (CI) 1.06–1.09) and 1.28 (CI 1.12–1.47), respectively. Pain was most common in the lower extremities. There was no statistically significant difference in prevalence of pain related to source of report. Pain intensity was higher at older ages and higher GMFCS-levels. Hip/thigh pain and abdominal pain were associated with the most intense pain. Of those who reported pain, pain disturbed sleep for 36% and daily activities for 61%. Conclusions Both pain frequency and pain intensity were higher at higher age. Pain intensity increased with increasing GMFCS-level. Two-thirds of all children and adolescents with CP reported that their pain disturbed their daily activities, and one-third reported that pain disturbed their sleep.

scholarly journals Gender Differences in Treatments and Interventions Received for Children and Adolescents with Cerebral Palsy

2019 ◽  
Author(s):  
Annika Lundkvist Josenby ◽  
Tomasz Czuba ◽  
Ann I Alriksson Schmidt
Keyword(s):  
Gender Differences ◽  
Cerebral Palsy ◽  
Children And Adolescents ◽  
Motor Function ◽  
Classification System ◽  
Place Of Birth ◽  
Gross Motor ◽  
Gross Motor Function ◽  
National Quality ◽  
Manual Ability Classification System

Abstract Background In the Swedish population-based follow-up program and national quality registry for individuals with cerebral palsy (CPUP), physiotherapy (PT) and occupational therapy (OT) treatments are regularly recorded along with functional status. By Swedish law, all citizens irrespective of personal characteristics or socioeconomic status have the right to receive medical treatments as applicable. Previous studies have shown gender differences in terms of certain treatments and interventions received among children with CP. The purpose of this study was to examine differences in PT and OT treatments and interventions by gender and place of birth in children and adolescents participating in CPUP. Methods This was a cross-sectional study. Data from the latest PT form (n = 2695) and OT form (n = 3480) measures were extracted for individuals aged 0-17 years in CPUP. Logistic regressions were used to assess the relationships between the outcome variables and gender and place of birth (including an interaction term gender x place of birth), adjusted for age, Gross Motor Function Classification System (GMFCS) levels and spasticity scores for PT interventions, and Manual Ability Classification System (MACS) for OT interventions. Results are presented as odds ratios [95% confidence intervals] and p-values. Girls were more likely to have spinal braces than boys; 1.544 [1.073, 2.223] p<0.05, a significant interaction with place of birth indicated less spinal braces prescribed to children born outside Scandinavia; 0.204 [0.0792, 0.525] p<0.001. Boys were more likely to have undergone selective dorsal rhizotomy (SDR); 0.485 [0.251, 0.939] p<0.05. Individuals born outside Scandinavia, were less likely to have received intrathecal baclofen (ITB) 0.269 [0.0737, 0.980] p<0.05. Conclusions Of the treatments prescribed, gender differences were observed for spinal braces and having undergone SDR. A statistically significant difference based on place of birth was seen for spinal brace and having received ITB treatment. Other PT and OT treatments were associated with age, levels of spasticity, and functional severity classified with the Gross Motor Function Classification System and the Manual Ability Classification System. Increased awareness of differences based on gender and where a child is born, could be obtained by inter- and intraprofessional discussions.

Prevalence of Speech Problems and the Use of Augmentative and Alternative Communication in Children With Cerebral Palsy: A Registry-Based Study in Norway

2010 ◽  
Vol 19 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Guro Andersen ◽  
Tone R. Mjøen ◽  
Torstein Vik
Keyword(s):  
Cerebral Palsy ◽  
Motor Function ◽  
Gestational Age ◽  
Augmentative And Alternative Communication ◽  
Alternative Communication ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Children With Cerebral Palsy ◽  
Communicative Abilities ◽  
Normal Speech

Abstract This study describes the prevalence of speech problems and the use of augmentative and alternative communication (AAC) in children with cerebral palsy (CP) in Norway. Information on the communicative abilities of 564 children with CP born 1996–2003, recorded in the Norwegian CP Registry, was collected. A total of 270 children (48%) had normal speech, 90 (16%) had slightly indistinct speech, 52 (9%) had indistinct speech, 35 (6%) had very indistinct speech, 110 children (19%) had no speech, and 7 (1%) were unknown. Speech problems were most common in children with dyskinetic CP (92 %), in children with the most severe gross motor function impairments and among children being totally dependent on assistance in feeding or tube-fed children. A higher proportion of children born at term had speech problems when compared with children born before 32 weeks of gestational age 32 (p > 0.001). Among the 197 children with speech problems only, 106 (54%) used AAC in some form. Approximately 20% of children had no verbal speech, whereas ~15% had significant speech problems. Among children with either significant speech problems or no speech, only 54% used AAC in any form.

Ankle contractures are frequent among children with cerebral palsy and associated with lower gross motor function and degree of spasticity

2021 ◽  
Author(s):  
Lærke Hartvig Krarup ◽  
Pia Kjær Kristensen ◽  
Louise Strand ◽  
Sofie Langbo Bredtoft ◽  
Inger Mechlenburg ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Motor Function ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Children With Cerebral Palsy

scholarly journals Motor learning-based activities may improve functional ability in adults with severe cerebral palsy: A controlled pilot study

2021 ◽  
pp. 1-11
Author(s):  
Helle Hüche Larsen ◽  
Rasmus Feld Frisk ◽  
Maria Willerslev-Olsen ◽  
Jens Bo Nielsen
Keyword(s):  
Cerebral Palsy ◽  
Motor Learning ◽  
Motor Function ◽  
Functional Ability ◽  
Active Group ◽  
Control Group ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Learning Principles

BACKGROUND: Cerebral palsy (CP) is a neurodevelopmental disturbance characterized by impaired control of movement. Function often decreases and 15% of adults are classified as severely affected (Gross Motor Function Classification Scale III-V). Little is known about interventions that aim to improve functional abilities in this population. OBJECTIVE: To evaluate a 12-week intervention based on motor learning principles on functional ability in adults with severe CP. METHODS: 16 adults (36±10 years, GMFCS III-V) were enrolled and divided into an intervention group (Active group) and a standard care group (Control group). Primary outcome measure was Gross Motor Function Measure (GMFM-88). Secondary measures were neurological status. The Active group were measured at baseline, after the intervention and at one-month follow-up. The Control group were measured at baseline and after one month. RESULTS: Analysis showed statistically significant improvement in GMFM-88 for the Active group from baseline to post assessment compared with the Control group (group difference: 5 points, SE 14.5, p = 0.008, CI: 1.2 to 8.7). Improvements were maintained at follow-up. Results from the neurological screening showed no clear tendencies. CONCLUSIONS: The study provides support that activities based on motor learning principles may improve gross motor function in adults with severe CP.

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