Oxidative Damage and Reproductive Toxicity Associated with Cyromazine and Chlorpyrifos in Male Rats: The Protective Effects of Green Tea Extract

Objective: Investigating the effect of green tea extract (GTE) on the testicular damage induced by cadmium chloride CdCl2 in male rats. Design: Randomized controlled study. Animals: 40 male Wistar rats. Procedures: Rats were randomly divided into four groups: A) control group (each rat daily received pellet diet); B) GTE group each rat daily received pellet diet as well as 3 ml of 1.5 % w/v GTE, C) CdCl2 group each rat was I/P injected a single dose of 1 mg/kg CdCl2, then daily received pellet diet, and D) CdCl2+GTE group each rat was I/P injected a single dose of 1 mg/kg CdCl2 then daily received pellet diet as well as 3 ml of 1.5 % w/v GTE. After 30 days, blood samples were collected for hormonal assays (testosterone, FSH, and LH). In addition, both testes were collected; one of them was used for quantification of 17-beta hydroxysteroid dehydrogenase III (17β-HSDIII) gene expression using a real-time PCR. The other testis was used for determination of catalase and reduced glutathione; GSH, Nitric oxide (NO) and malondialdehyde (MDA) levels. Results: CdCl2 decreased serum testosterone levels and its synthesis pathway (17β-HSDIII testicular gene expression). While antioxidants catalase and GSH were reduced, oxidants MDA were enriched in the testes of CdCl2-poisoned rats. This CdCl2-promoted testicular dysfunction was corrected via the administration of GTE to male rats. Conclusion and clinical relevance: GTE could be used as a remedy for protecting against CdCl2-induced testicular damage in male rats.

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Protective effect of green tea extract against proline-induced oxidative damage in the rat kidney

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2016.08.057 ◽

2016 ◽

Vol 83 ◽

pp. 1422-1427 ◽

Cited By ~ 15

Author(s):

Débora Delwing-Dal Magro ◽

Roberto Roecker ◽

Gustavo M. Junges ◽

André F. Rodrigues ◽

Daniela Delwing-de Lima ◽

...

Keyword(s):

Oxidative Damage ◽

Protective Effect ◽

Green Tea ◽

Rat Kidney ◽

Green Tea Extract ◽

Tea Extract

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Efektivitas Ekstrak Teh Hijau (Camellia sinensis L.) terhadap Penurunan Kadar Glukosa Darah Puasa Tikus Wistar (Rattus norvegicus) yang diInduksi Aloksan

Jurnal Sehat Mandiri ◽

10.33761/jsm.v15i1.194 ◽

2020 ◽

Vol 15 (1) ◽

pp. 86-97

Author(s):

Hafshah . ◽

Kristina Simanjuntak

Keyword(s):

Green Tea ◽

Fasting Blood Glucose ◽

White Male ◽

Green Tea Extract ◽

Male Rats ◽

Test Results ◽

Male Wistar Rats ◽

Bonferroni Test ◽

Tea Extract ◽

Post Hoc

The sufferers of Diabetes Mellitus (DM) in Indonesia is the highest with fourth number in the world, with a mortality rate of 1.2 million in 2012. Because of it, DM research using antihyperglycemic green tea is needed. This study aims to determine the effectiveness of green tea extracts on decreasing fasting blood glucose (KGDP) levels in alloxan-induced white male Wistar rats. Samples were 30 male rats, aged 8-12 weeks, weight ± 200 grams. Rats were grouped into 6 groups with the first group (K1) as a control, the second group (K2) induced alloxan, the third group (K3) induced alloxan with glibenclamide, the fourth group (K4), the fifth group (K5), and the sixth group (K6) induced alloxan with green tea extract as the treatment with dose of green tea extract, 200 mg/kg, 400 mg/kg, and 800 mg/kg. The first, FBG level examination is done 3 days after induction of alloxan using a glucometer. Giving green tea extract was given for 16 days orally, then FBG level re-examined from the tail of rats. One Way ANOVA Test Results, there is the effectiveness of green tea extract on reducing FBG level (p = 0,000). The post hoc Bonferroni test showed that giving 800 mg/kg of green tea extract was the best dose in reducing KGDP close to normal (p = 0,000).

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Neuronal protective effects of high-temperature-processed green tea extract (HTP-GTE) on oxidative stress in SH-SY5Y cells

IBRO Reports ◽

10.1016/j.ibror.2019.07.1753 ◽

2019 ◽

Vol 6 ◽

pp. S557

Author(s):

A. Young Kim ◽

Hyung-Su Kim ◽

Si-Young Cho ◽

Won-Seok Park

Keyword(s):

Oxidative Stress ◽

High Temperature ◽

Green Tea ◽

Green Tea Extract ◽

Protective Effects ◽

Tea Extract

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Effect of different doses of un-fractionated green and black tea extracts on thyroid physiology

Human & Experimental Toxicology ◽

10.1177/0960327110382563 ◽

2010 ◽

Vol 30 (8) ◽

pp. 884-896 ◽

Cited By ~ 13

Author(s):

Amar K Chandra ◽

Neela De ◽

Shyamosree Roy Choudhury

Keyword(s):

Thyroid Gland ◽

Green Tea ◽

Harmful Effect ◽

Black Tea ◽

Green Tea Extract ◽

Male Rats ◽

Thyroid Peroxidase ◽

Black Tea Extract ◽

Green And Black Tea ◽

Tea Extract

Tea is a rich source of polyphenolic flavonoids including catechins, which are thought to contribute to the health benefits of it. Flavonoids have been reported to have antithyroid and goitrogenic effect. The purpose of this study was to evaluate whether high doses of green and black tea have a harmful effect on thyroid physiology. Un-fractionated green and black tea extracts were administered orally to male rats for 30 days at doses of 1.25 g%, 2.5 g% and 5.0 g%. The results showed that green tea extract at 2.5 g% and 5.0 g% doses and black tea extract only at 5.0 g% dose have the potential to alter the thyroid gland physiology and architecture, that is, enlargement of thyroid gland as well as hypertrophy and/or hyperplasia of the thyroid follicles and inhibition of the activity of thyroid peroxidase and 5′-deiodinase I with elevated thyroidal Na+, K+-ATPase activity along with significant decrease in serum T3 and T4, and a parallel increase in serum thyroid stimulating hormone (TSH). This study concludes that goitrogenic/antithyroidal potential of un-fractionated green tea extract is much more than black tea extract because of the differences in catechin contents in the tea extracts.

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