scholarly journals Greater Adherence to Cancer Prevention Guidelines Is Associated with Higher Circulating Concentrations of Vitamin D Metabolites in a Cross-Sectional Analysis of Pooled Participants from 2 Chemoprevention Trials

2017 ◽  
pp. jn243352 ◽  
Author(s):  
Lindsay N Kohler ◽  
Elizabeth A Hibler ◽  
Robin B Harris ◽  
Eyal Oren ◽  
Denise J Roe ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cancer Prevention ◽  
Vitamin D Metabolites ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Prevention Guidelines ◽  
Sectional Analysis

scholarly journals Association between vitamin D deficiency and exercise capacity in patients with CKD, a cross-sectional analysis

2020 ◽  
Author(s):  
Emma L Watson ◽  
Thomas J Wilkinson ◽  
Tom F O’Sullivan ◽  
Luke A Baker ◽  
Douglas W Gould ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Exercise Capacity ◽  
Muscle Mass ◽  
Ex Vivo ◽  
Muscle Size ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Sectional Analysis

AbstractEvidence is growing for a role of vitamin D in regulating skeletal muscle mass, strength and functional capacity. Given the role the kidneys play in activating total vitamin D, and the high prevalence of vitamin D deficiency in Chronic Kidney Disease (CKD), it is possible that deficiency contributes to the low levels of physical function and muscle mass in these patients. This is a secondary cross-sectional analysis of previously published interventional study, with ex vivo follow up work. 34 CKD patients at stages G3b-5 (eGFR 25.5 ± 8.3ml/min/1.73m2; age 61 ± 12 years) were recruited, with a sub-group (n=20) also donating a muscle biopsy. Vitamin D and associated metabolites were analysed in plasma by liquid chromatography tandem-mass spectroscopy and correlated to a range of physiological tests of muscle size, function, exercise capacity and body composition. The effects of 1α,25(OH)2D3 supplementation on myogenesis and myotube size was investigated in primary skeletal muscle cells from vitamin D deficient donors. In vivo, there was no association between total or active vitamin D and muscle size or strength, but a significant correlation with was seen with the total form. Ex vivo, 1α,25(OH)2D3 supplementation reduced IL-6 mRNA expression, but had no effect upon proliferation, differentiation or myotube diameter. This early preliminary work suggests that vitamin D deficiency is not a prominent factor driving the loss of muscle mass in CKD, but may play a role in reduced exercise capacity.

Dietary vitamin D intake and muscle mass in older women. Results from a cross-sectional analysis of the EPIDOS study

2012 ◽  
Vol 17 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Charlotte Dupuy ◽  
V. Lauwers-Cances ◽  
G. Abellan Van Kan ◽  
S. Gillette ◽  
A. -M. Schott ◽  
...  
Keyword(s):  
Vitamin D ◽  
Older Women ◽  
Muscle Mass ◽  
Dietary Vitamin ◽  
Cross Sectional ◽  
Vitamin D Intake ◽  
Cross Sectional Analysis ◽  
Sectional Analysis ◽  
Dietary Vitamin D

Cross-Sectional Analysis of Abnormalities of Mineral Homeostasis, Vitamin D and Parathyroid Hormone in a Cohort of Pre-Dialysis Patients

2007 ◽  
Vol 107 (3) ◽  
pp. c109-c116 ◽  
Author(s):  
Daniel Zehnder ◽  
Martin J. Landray ◽  
David C. Wheeler ◽  
William Fraser ◽  
Lisa Blackwell ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Dialysis Patients ◽  
Cross Sectional ◽  
Mineral Homeostasis ◽  
Cross Sectional Analysis ◽  
Sectional Analysis

scholarly journals How strong is the epidemiological evidence to support any potential protective role for vitamin D levels on COVID-19 infections and mortality? - A time-series analysis of European Populations

2020 ◽  
Author(s):  
Samer Singh
Keyword(s):  
Vitamin D ◽  
Time Series ◽  
Serum Vitamin ◽  
Protective Role ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Vitamin D Levels ◽  
Incidence And Mortality ◽  
Sectional Analysis

ABSTRACTA potential protective role of vitamin D serum levels on overall adverse outcomes of SARS-CoV-2 infection or COVID-19 on populations had been suggested previously based upon single-point cross-sectional analysis of 8 April 2020 data from 20 European countries assuming comparable underlying confounding variables for these populations, at an early stage of the current pandemic. Comparative time-series cross-sectional analysis of the COVID-19 data from 12 March (early pre-peak) to 26 July (late post-peak of infections) 2020 was performed to assess the strength of the assertion. The study subjects included 1,829,634 COVID-19 cases (11.11% of total worldwide) and 179,135 associated deaths (27.45 % of total worldwide) on 26 July 2012. Previously suggested cross-sectional study design and methodology could not consistently and significantly (p-value≥0.05) support the notion of the potential protective role of the mean serum vitamin D levels of the populations on COVID-19 incidence and mortality. However, the exponential correlative model, as well as alternative simple regression analysis on ln and Log10 transformed COVID-19 data for the time period indicated improved consistently negative covariation with vitamin D levels. Additionally, the later methodology increased the predictive potential for explaining the variability in data [R2 by 1.27-1.96 fold, adjusted-R2 by 1.33-2.47, p-value=0.0457-0.0035, for cases/million; R2 by 1.81-2.67, adjusted-R2 by 2.21-3.74 fold for deaths/million, p-value=0.0049-0.0228). Considering, the established role of vitamin D in immune system functioning randomized well-controlled trials may be suggested to evaluate/assess the potential protective role of vitamin D in reducing the COVID-19 impact on populations.

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