scholarly journals Antibiotic Susceptibility Evaluation of Group A Streptococcus Isolated from Children with Pharyngitis: A Study from Iran

2015 ◽  
Vol 47 (4) ◽  
pp. 225 ◽  
Author(s):  
Shirin Sayyahfar ◽  
Alireza Fahimzad ◽  
Amir Naddaf ◽  
Sara Tavassoli
Keyword(s):  
Antibiotic Susceptibility ◽  
Group A Streptococcus ◽  
Group A ◽  
Susceptibility Evaluation

scholarly journals Prevalence of asymptomatic pharyngel carriage of B-hemolytic Group A Streptococcus pyogens among school going children of age 5-12 years in Bharatpur, Nepal

2014 ◽  
Vol 2 (1) ◽  
pp. 18-20
Author(s):  
S Raza ◽  
KK Kundu ◽  
SK Dutta
Keyword(s):  
Antibiotic Susceptibility ◽  
Group A Streptococcus ◽  
Target Population ◽  
Carrier State ◽  
Diffusion Method ◽  
National Committee ◽  
Sheep Blood ◽  
Medical College ◽  
Antibiotic Susceptibility Test ◽  
Group A

Background: β- haemolytic Group A Streptococcus pyogens infection is a common cause of bacterial pharyngitis among children. Children are the target population for pharyngitis as well as other suppurative and non-suppurative infections.Objectives: The objectives of this study are to find out the rate of asymptomatic throat carriage of Streptococcus pyogens and to study antibiotic susceptibility pattern of the isolates.Methods: Total 106 randomly selected children between five to 12 years were included in this study. Throat swabs collected were inoculated on 5% sheep blood agar and incubated for 24-48 hours at 37°C. Identifi cation of Group A Streptococcus pyogens was done by β-haemolytic colony, Bacitracin sensitivity, Co-trimoxazole resistivity and catalase negativity. Antibiotic susceptibility test was performed on Muller-Hinton agar containing 5% sheep blood by modifi ed Kirby-Bauer disc diffusion method. Results were interpreted as per National Committee for the Clinical Standards Guidelines.Results: Of total 106 throat swabs Group A Streptococcus pyogens was isolated in 15 (14.15%) cases. Among the isolates seven (46.7%) were from male children whereas eight (53.3%) were from female children. Out of the 15 isolates 100% were sensitive to penicillin and its derivatives whereas 13.2%, 6.7% and 6.7% of the isolates were resistant to Erythromycin, Chloramphenicol and Ciprofl oxacin respectively. Similarly Azithromycin was found to be 100% sensitive.Conclusion: Regular screening is needed to keep the GAS infection and carrier state in check as well as to prevent from further development of complications.DOI: http://dx.doi.org/10.3126/jkmc.v2i1.10537 Journal of Kathmandu Medical College, Vol. 2, No. 1, Issue 3, Jan.-Mar., 2013: 18-20

Molecular epidemiology of nonpharyngeal group A streptococci isolates in northern Lebanon

2020 ◽  
Vol 15 (16) ◽  
pp. 1555-1569
Author(s):  
Rayane Rafei ◽  
Malaik Hawli ◽  
Marwan Osman ◽  
Simon Khelissa ◽  
Tamara Salloum ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Antibiotic Susceptibility ◽  
Group A Streptococcus ◽  
Vaccine Coverage ◽  
Virulence Gene ◽  
Gene Profiling ◽  
Group A Streptococci ◽  
Structural Variability ◽  
Group A ◽  
Resistance Rates

Aim: To characterize the epidemiology of group A Streptococcus (GAS) involved in nonpharyngeal infections sparingly addressed in Lebanon. Materials & methods: A collection of 63 nonpharyngeal GAS isolates recovered between 2010 and 2019 from northern Lebanon were analyzed through emm typing, virulence gene profiling, FCT typing and antibiotic susceptibility analysis. Results & conclusion: A total of 29 emm subtypes was detected, with emm1 being the most dominant. A great intraclonal divergence driven by the loss and gain of superantigens or by the structural variability within the FCT regions was unraveled. The resistance rates for erythromycin and tetracycline were 8 and 20.6%, respectively. The 30-valent vaccine coverage was 76%. This study evidences the complexity of the neglected GAS pathogen in Lebanon.

Etiology, clinical presentation, laboratory diagnostics, pathogenesis of impetigo and treatment methods

2020 ◽  
pp. 64-70
Author(s):  
Anastasiya Laknitskaya
Keyword(s):  
Streptococcus Pyogenes ◽  
Skin Diseases ◽  
Group A Streptococcus ◽  
Antibiotic Sensitivity ◽  
Antioxidant Defense System ◽  
Laboratory Diagnostics ◽  
Treatment Methods ◽  
Group A ◽  
The Individual

Currently, one of the priority medical and social problems is the optimization of treatment methods for pyoderma associated with Streptococcus pyogenes — group A streptococcus (GAS). To date, the proportion of pyoderma, the etiological factor of which is Streptococcus pyogenes, is about 6 % of all skin diseases and is in the range from 17.9 to 43.9 % of all dermatoses. Role of the bacterial factor in the development of streptococcal pyoderma is obvious. Traditional treatment complex includes antibacterial drugs selected individually, taking into account the antibiotic sensitivity of pathognomonic bacteria, and it is not always effective. Currently implemented immunocorrection methods often do not take into account specific immunological features of the disease, the individual, and the fact that the skin performs the function of not only a mechanical barrier, but it is also an immunocompetent organ. Such an approach makes it necessary to conduct additional studies clarifying the role of factors of innate and adaptive immunity, intercellular mediators and antioxidant defense system, that allow to optimize the treatment of this pathology.

Bilateral periorbital necrotising fasciitis associated with invasive group: a Streptococcus infection

2020 ◽  
Vol 13 (12) ◽  
pp. e236800
Author(s):  
Grace Anne McCabe ◽  
Thomas Hardy ◽  
Thomas Gordon Campbell
Keyword(s):  
Group A Streptococcus ◽  
Early Recognition ◽  
Skin Grafting ◽  
Final Diagnosis ◽  
Necrotising Fasciitis ◽  
Invasive Group ◽  
Group A ◽  
Tissue Microscopy ◽  
Periorbital Swelling ◽  
Multidisciplinary Teamwork

A previously independent 56-year-old immunocompetent woman presented with septic shock in the setting of periorbital swelling and diffuse infiltrates on chest imaging. Blood cultures were positive for growth of group A Streptococcus (GAS). Broad spectrum antimicrobials were initiated with the inclusion of the antitoxin agent clindamycin. Necrosis of periorbital tissue was noted and surgical consultation was obtained. Débridement of both eyelids with skin grafting was performed. GAS was isolated from wound cultures and also observed on periorbital tissue microscopy. The final diagnosis was bilateral periorbital necrotising fasciitis (PONF) associated with invasive GAS infection. The patient had a prolonged intensive care unit course with input from multiple specialist teams. This case demonstrates the importance of early recognition and treatment of PONF, the profound systemic morbidity caused by these infections, and illustrates successful multidisciplinary teamwork.

scholarly journals Genome‐wide analysis of in vivo CcpA binding with and without its key co‐factor HPr in the major human pathogen group A Streptococcus

2020 ◽  
Author(s):  
Sruti DebRoy ◽  
Victor Aliaga‐Tobar ◽  
Gabriel Galvez ◽  
Srishtee Arora ◽  
Xiaowen Liang ◽  
...  
Keyword(s):  
Group A Streptococcus ◽  
Human Pathogen ◽  
Genome Wide Analysis ◽  
Genome Wide ◽  
Group A
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