Synthesis of Methyl 2-Cyano-(1,2-dimethylcyclohepta[b]pyrrol-6-ylidene)acetate. A Steric Effect to Accelerate the Geometrical Isomerism of the Exocyclic C=C Bond of Heterocycle-fused Heptafulvenes

Heterocycles ◽  
1993 ◽  
Vol 36 (8) ◽  
pp. 1725 ◽  
Author(s):  
Hitoshi Takeshita ◽  
Yukari Ikeda ◽  
Bing Zhu Yin ◽  
Nobuo Kato ◽  
Akira Mori
Keyword(s):  
Steric Effect ◽  
Geometrical Isomerism

scholarly journals Differential steric effects in the inelastic scattering of NO(X) + Ar: spin–orbit changing transitions

2019 ◽  
Vol 21 (26) ◽  
pp. 14173-14185 ◽  
Author(s):  
M. Brouard ◽  
S. D. S. Gordon ◽  
B. Nichols ◽  
V. Walpole ◽  
F. J. Aoiz ◽  
...  
Keyword(s):  
Inelastic Scattering ◽  
Steric Effect ◽  
Steric Effects ◽  
Spin Orbit ◽  
First Time

The differential steric effect for spin–orbit changing collisions of NO with Ar is determined for the first time.

Carbamoylphosphonate MMP inhibitors. Part 4: The influence of chirality and geometrical isomerism on the potency and selectivity of inhibition

2004 ◽  
Vol 15 (15) ◽  
pp. 2415-2420 ◽  
Author(s):  
Eli Breuer ◽  
Yiffat Katz ◽  
Rivka Hadar ◽  
Reuven Reich
Keyword(s):  
Mmp Inhibitors ◽  
Geometrical Isomerism

scholarly journals Spatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Feng Li ◽  
Wenting Yu ◽  
Jiaojiao Zhang ◽  
Yuhang Dong ◽  
Xiaohui Ding ◽  
...  
Keyword(s):  
Steric Effect ◽  
Sirna Delivery ◽  
Dna Nanotechnology ◽  
Hybridization Chain Reaction ◽  
Dna Nanostructures ◽  
Chain Reaction ◽  
Dna Hairpins ◽  
In Vivo Experiments ◽  
Dna And Rna

AbstractDNA nanostructures have been demonstrated as promising carriers for gene delivery. In the carrier design, spatiotemporally programmable assembly of DNA under nanoconfinement is important but has proven highly challenging due to the complexity–scalability–error of DNA. Herein, a DNA nanotechnology-based strategy via the cascade hybridization chain reaction (HCR) of DNA hairpins in polymeric nanoframework has been developed to achieve spatiotemporally programmable assembly of DNA under nanoconfinement for precise siRNA delivery. The nanoframework is prepared via precipitation polymerization with Acrydite-DNA as cross-linker. The potential energy stored in the loops of DNA hairpins can overcome the steric effect in the nanoframework, which can help initiate cascade HCR of DNA hairpins and achieve efficient siRNA loading. The designer tethering sequence between DNA and RNA guarantees a triphosadenine triggered siRNA release specifically in cellular cytoplasm. Nanoframework provides stability and ease of functionalization, which helps address the complexity–scalability–error of DNA. It is exemplified that the phenylboronate installation on nanoframework enhanced cellular uptake and smoothed the lysosomal escape. Cellular results show that the siRNA loaded nanoframework down-regulated the levels of relevant mRNA and protein. In vivo experiments show significant therapeutic efficacy of using siPLK1 loaded nanoframework to suppress tumor growth.

scholarly journals Steric Effect in Base-catalyzed Ring-opening Reactions of Epoxides

1963 ◽  
Vol 66 (3) ◽  
pp. 355-357 ◽  
Author(s):  
Shizuyoshi Sakai ◽  
Tatsuo Sugiyama ◽  
Yoshio Ishii
Keyword(s):  
Ring Opening ◽  
Steric Effect ◽  
Ring Opening Reactions

The steric effect in lysogenization by bacteriophage lambda

Virology ◽  
1965 ◽  
Vol 27 (3) ◽  
pp. 340-345 ◽  
Author(s):  
Allan Campbell
Keyword(s):  
Steric Effect ◽  
Bacteriophage Lambda

The nature of the steric effect in the general-acid-catalyzed hydrolyses of benzaldehyde acetals

1983 ◽  
Vol 48 (23) ◽  
pp. 4175-4179 ◽  
Author(s):  
James L. Jensen ◽  
Anna B. Martinez ◽  
Cheryl L. Shimazu
Keyword(s):  
Steric Effect ◽  
General Acid ◽  
Acid Catalyzed
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