Comparison of plasma levels of soluble fibrin monomer complex in patients with acute ischemic stroke before and after commencement of antithrombotic treatment

It was shown that atherothrombotic and cardioembolic subtypes of ischemic stroke in acute phase of the disease accompanied with the appearance of the high concentrated soluble fibrin monomer complexes in blood plasma. But the concentration returned to the norm one year post ischemic stroke attack. Instead the concentration, the qualitative content of the year post stroke SFMC fraction was characterized by the higher diversity in comparison with acute fraction both subtypes of ischemic stroke as well as the healthy donors. The different qualitative content of the SFMC fraction was observed for the both tested subtypes of ischemic stroke. The higher diversity of SFMC fractions was showed for the cardioembolic subtypes of ischemic stroke.

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Faculty Opinions recommendation of Door-to-needle times for tissue plasminogen activator administration and clinical outcomes in acute ischemic stroke before and after a quality improvement initiative.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718359928.793530195 ◽

2017 ◽

Author(s):

Shyam Prabhakaran

Keyword(s):

Quality Improvement ◽

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Plasminogen Activator ◽

Clinical Outcomes ◽

Tissue Plasminogen Activator ◽

Quality Improvement Initiative ◽

Tissue Plasminogen ◽

Before And After

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Treatment with Delipid Extracorporeal Lipoprotein Filter from Plasma after Intravenous Thrombolysis for Acute Ischemic Stroke: A Single-Center Experience

Cerebrovascular Diseases Extra ◽

10.1159/000511050 ◽

2020 ◽

Vol 10 (3) ◽

pp. 148-158

Author(s):

Yu Cui ◽

Zhong-He Zhou ◽

Xiao-Wen Hou ◽

Hui-Sheng Chen

Keyword(s):

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Intravenous Thrombolysis ◽

Single Center Experience ◽

Before And After ◽

Prospective Trials ◽

Symptomatic Intracranial Hemorrhage ◽

Rate Of Improvement

Introduction: The delipid extracorporeal lipoprotein filter from plasma (DELP) has been approved for the treatment of acute ischemic stroke (AIS) by the China Food and Drug Administration, but its effectiveness and mechanism are not yet fully determined. The purpose of this study was to evaluate the effect of DELP treatment on AIS patients after intravenous thrombolysis. Methods: A retrospective study was performed on AIS patients with no improvement within 24 h after intravenous thrombolysis who were subsequently treated with or without DELP. Primary outcome was the proportion with a modified Rankin scale (mRS) of 0–1 at 90 days. Secondary outcomes were changes in National Institute of Health Stroke Scale (NIHSS) score from 24 h to 14 days after thrombolysis, and the rate of improvement in stroke-associated pneumonia (SAP). The main safety outcomes were the rates of symptomatic intracranial hemorrhage and mortality. To investigate its mechanisms, serum biomarkers were measured before and after DELP. Results: A total of 252 patients were recruited, 63 in the DELP group and 189 matched patients in the NO DELP group. Compared with the NO DELP group, the DELP group showed an increase in the proportion of mRS 0–1 at 90 days (p = 0.042). More decrease in NIHSS from 24 h to 14 days (p = 0.024), a higher rate of improvement in SAP (p = 0.022), and lower mortality (p = 0.040) were shown in DELP group. Furthermore, DELP decreased levels of interleukin (IL)-1β, E-selectin, malondialdehyde, matrix metalloprotein 9, total cholesterol, low-density lipoprotein, and fibrinogen, and increased superoxide dismutase (p< 0.05). Conclusions: DELP following intravenous thrombolysis should be safe, and is associated with neurological function improvement, possibly through multiple neuroprotective mechanisms. Prospective trials are needed.

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Plasma Levels of Apolipoprotein E and Risk of Intracranial Artery Stenosis in Acute Ischemic Stroke Patients

Annals of Nutrition and Metabolism ◽

10.1159/000343789 ◽

2013 ◽

Vol 62 (1) ◽

pp. 26-31 ◽

Cited By ~ 6

Author(s):

Yong-Jae Kim ◽

Seung-Min Lee ◽

Hyun-Ji Cho ◽

Hyun Ju Do ◽

Chang Hyung Hong ◽

...

Keyword(s):

Ischemic Stroke ◽

Apolipoprotein E ◽

Acute Ischemic Stroke ◽

Plasma Levels ◽

Artery Stenosis ◽

Intracranial Artery ◽

Stroke Patients ◽

Intracranial Artery Stenosis

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KADAR FIBRIN MONOMER DAN UKURAN INFARK DI STROK ISKEMIK AKUT

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v20i3.470 ◽

2016 ◽

Vol 20 (3) ◽

pp. 171

Author(s):

Ani Kartini ◽

Mansyur Arif ◽

Hardjoeno Hardjoeno

Keyword(s):

Ischemic Stroke ◽

Infarct Size ◽

Acute Ischemic Stroke ◽

Thrombus Formation ◽

Infarct Volume ◽

Cross Sectional Study ◽

Cerebral Infarct ◽

Cross Sectional ◽

Fibrin Monomer ◽

Significant Difference

Coagulation activation and thrombosis frequently exist in ischemic stroke, thrombus formation can be detected early by the presence of fibrin monomer. The purpose of this study was to know the correlation of fibrin monomer level with cerebral infarct size in acute ischemic stroke patients. This was a cross sectional study with a total of 39 samples. The fibrin monomer level was determined by immunoturbidimetry method using STA-Compact and the measurement of the infarct size was done by CT scan of the head using Broderick formula. The results of this study showed that the median level of fibrin monomer in acute ischemic stroke with nonlacunar infarct type and lacunar infarct type were 14.46 μg/mL and 4.29 μg/mL, respectively. Mann-Whitney test showed there was a significant difference of fibrin monomer levels between nonlacunar infarct type and the lacunar type, p=0.000. The cut-off point analysis result of the fibrin monomer level was 5.96 μg/mL with a sensitivity of 88.9% and specificity of 76.4%, respectively. Spearman correlation test showed that fibrin monomer level was positively correlated with cerebral infarct volume in acute ischemic stroke (r=0.56, p=0.000). Based on this study, it can be concluded that fibrin monomer level can be used as a marker to predict the type of cerebral infarct and volume of acute ischemic stroke as well.

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Incidence of Cardioembolic Stroke Including Paradoxical Brain Embolism in Patients with Acute Ischemic Stroke before and after the Great East Japan Earthquake

Cerebrovascular Diseases ◽

10.1159/000363129 ◽

2014 ◽

Vol 37 (6) ◽

pp. 431-437 ◽

Cited By ~ 11

Author(s):

Ryo Itabashi ◽

Eisuke Furui ◽

Shoichiro Sato ◽

Yukako Yazawa ◽

Kenta Kawata ◽

...

Keyword(s):

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Great East Japan Earthquake ◽

Cardioembolic Stroke ◽

Before And After

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Abstract WP57: Utility of Flat Panel CT Perfusion for Physiologic Assessment of Acute Ischemic Stroke in the Angiography Suite

Stroke ◽

10.1161/str.44.suppl_1.awp57 ◽

2013 ◽

Vol 44 (suppl_1) ◽

Author(s):

Robert W Ryan ◽

Paula Eboli ◽

Michael J Alexander ◽

Shlee S Song ◽

Marcel M Maya ◽

...

Keyword(s):

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Perfusion Defect ◽

Ct Perfusion ◽

Endovascular Intervention ◽

Flat Panel ◽

Post Intervention ◽

Angiography Suite ◽

Before And After

Introduction The decision to perform endovascular intervention in patients with acute ischemic stroke (AIS) may be guided by physiologic imaging such as CT perfusion (CTP) demonstrating a salvageable penumbra, but such studies can delay transfer to the angiography suite. Flat Panel Detector CT (FPD-CT) allows pre, intra and post-procedural physiologic assessment using rotational images acquired on the angiography table; however these measurements have not been correlated with conventional perfusion techniques. We began a prospective, observational comparison of standard, multi-slice CTP with FPD-CT perfusion for AIS interventions, and report our initial results. Methods Patients with AIS that are candidates for endovascular intervention and have standard CTP images available were enrolled in the study after obtaining informed consent and following the IRB approved protocol. FPD-CTP images were obtained with aortic contrast injection and commercially available workstation image assessment (Siemens, Erlangen, Germany) before and after intervention, and compared with standard CT perfusion and follow up images. Results A total of 3 cases have been enrolled. All demonstrated anatomic correlations between perfusion defects in the standard CTP and the FPD-CTP. Case example: A 58 year old man developed left sided hemiplegia and standard CTP demonstrated a right MCA defect with a small core infarction (Fig 1 A). Pre-intervention FPD-CTP showed the same defect pattern (Fig 1 B), and successful mechanical thrombectomy was performed (Fig 1 C,D). Post-intervention FPD-CT showed reversal of perfusion defect outside the core infarct (Fig 1 E). The patient had good clinical recovery and only small infarct on follow up CT (Fig 1 F). Conclusions Early experience with FPD-CTP imaging shows correlation with standard CTP images and reversal of perfusion defect following successful recanalization, suggesting it may be a valuable aid for decision making in AIS intervention.

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