4D Seismic Integrated to Dynamic Modeling Revealed a Late Stage Development Opportunity in the West Brae Field

Abstract Objective To determine the extent to which late stage development of new drugs relies on support from public funding. Design Cohort study. Setting All new drugs containing one or more new molecular entities approved by the US Food and Drug Administration (FDA) between January 2008 and December 2017 via the new drug application pathway. Main outcome measures Patents or drug development histories documenting late stage research contributions by a public sector research institution or a spin-off company, as well as each drug’s regulatory approval pathway and first-in-class designation. Results Over the 10 year study period, the FDA approved 248 drugs containing one or more new molecular entities. Of these drugs, 48 (19%) had origins in publicly supported research and development and 14 (6%) originated in companies spun off from a publicly supported research program. Drugs in these groups were more likely to receive expedited FDA approval (68% v 47%, P=0.005) or be designated first in class (45% v 26%, P=0.007), indicating therapeutic importance. Conclusions A review of the patents associated with new drugs approved over the past decade indicates that publicly supported research had a major role in the late stage development of at least one in four new drugs, either through direct funding of late stage research or through spin-off companies created from public sector research institutions. These findings could have implications for policy makers in determining fair prices and revenue flows for these products.

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Gemcabene, a first-in-class lipid-lowering agent in late-stage development, down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism

Molecular and Cellular Biochemistry ◽

10.1007/s11010-018-3353-5 ◽

2018 ◽

Vol 449 (1-2) ◽

pp. 167-183 ◽

Cited By ~ 9

Author(s):

Rai Ajit K. Srivastava ◽

Joseph A. Cornicelli ◽

Bruce Markham ◽

Charles L. Bisgaier

Keyword(s):

Acute Phase ◽

Late Stage ◽

Lipid Lowering ◽

C Reactive Protein ◽

Reactive Protein ◽

Stage Development ◽

Lipid Lowering Agent

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Leishmania infantum nicotinamidase is required for late-stage development in its natural sand fly vector, Phlebotomus perniciosus

International Journal for Parasitology ◽

10.1016/j.ijpara.2012.02.007 ◽

2012 ◽

Vol 42 (4) ◽

pp. 323-327 ◽

Cited By ~ 4

Author(s):

Elodie Gazanion ◽

Veronika Seblova ◽

Jan Votypka ◽

Baptiste Vergnes ◽

Déborah Garcia ◽

...

Keyword(s):

Late Stage ◽

Leishmania Infantum ◽

Sand Fly ◽

Natural Sand ◽

Phlebotomus Perniciosus ◽

Stage Development

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The Schiehallion and Loyal fields, Blocks 204/20, 204/25a, 204/25b, 205/16 and 205/21b, UK Atlantic Margin

Geological Society London Memoirs ◽

10.1144/m52-2019-27 ◽

2020 ◽

Vol 52 (1) ◽

pp. 990-1002 ◽

Cited By ~ 1

Author(s):

M. V. Ward ◽

T. Primmer ◽

E. Laws ◽

K. Macgregor ◽

T. Harpley ◽

...

Keyword(s):

Deep Water ◽

Seismic Survey ◽

The West ◽

Shetland Islands ◽

Potential Sources ◽

On Line ◽

Mature Field ◽

The Uk ◽

4D Seismic ◽

Atlantic Margin

AbstractThe Schiehallion subsea development comprises two fields, Schiehallion and Loyal, which are located approximately 200 km to the west of the Shetland Islands in the UK Continental Shelf. The Schiehallion and Loyal fields were discovered in late 1993 and 1994, respectively, with a combined oil-in-place of more than 2.3 Bbbl. The fields are developed under waterflood and were on production from 1998 to 2013. After an extended shut-in, the fields were brought back on line in 2017, through new floating production facilities.Most of the production to date has been from the Paleocene Vaila Formation deep-water turbidite, in the T31 and T34 reservoir intervals. The ongoing Quad 204 redevelopment drilling programme commenced in April 2015, has drilled and completed 21 wells to date, and is expected to continue for several more years. The campaign includes new producer–injector pairs and stand-alone wells to support existing well stock, targeting stacked turbidite reservoir intervals, including the youngest T35–T34 interval, the main T31 interval and the previously under-developed T28–T25 fairway.In addition to an active drilling programme, a 4D seismic survey was acquired and processed in 2018, and its interpretation is key to unlocking further potential sources of value in this mature field.

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A Systematic Review of Drugs in Late-Stage Development for the Treatment of Multiple Sclerosis: A Focus on Oral Synthetic Drugs

Inflammation & Allergy - Drug Targets ◽

10.2174/1871528114666150529102613 ◽

2015 ◽

Vol 13 (6) ◽

pp. 351-366 ◽

Cited By ~ 7

Author(s):

Malihe Safavi ◽

Shekoufeh Nikfar ◽

Mohammad Abdollahi

Keyword(s):

Multiple Sclerosis ◽

Systematic Review ◽

Late Stage ◽

Synthetic Drugs ◽

Stage Development

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Sentimental journey? The drifting rhythms of Tsai Ming-liang’s Journey to the West

Asian Cinema ◽

10.1386/ac_00030_1 ◽

2021 ◽

Vol 32 (1) ◽

pp. 3-18

Author(s):

Seth A. Wilder

Keyword(s):

Late Stage ◽

Early Cinema ◽

Chinese Cinema ◽

The West ◽

Making Meaning ◽

Contemporary Life ◽

Cinematic Experience ◽

Journey To The West ◽

Contemporary Chinese Cinema ◽

Contemporary Chinese

With his experimental short, Journey to the West, Tsai Ming-liang creates a cinematic experience that recalls the early ‘cinema of attractions’, but this is an attraction with a twist. As a spectacle, it is more specular than spectacular. An attraction without the attendant excitement, his is a reflection that presents a provocation. By calling out the shortened attention span of contemporary life, Tsai identifies the level of distraction that characterizes the contemporary, post-industrialized spaces of late-stage capitalism. An attempt at redemption, his film conveys a sense of what Rey Chow refers to in contemporary Chinese cinema as ‘the sentimental’. Framed by Henri Lefebvre’s and Lea Jacobs’s respective ideas concerning rhythms both extrinsic and intrinsic to the cinematic, and complemented by considerations of temporality, rather than making meaning, this article attempts to make sense of the film by locating these rhythms within it.

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