The selection of nanofillers and compatibilizing agents, and their size and concentration, are always considered to be crucial in the design of durable nanobiocomposites with maximized mechanical properties (i.e., fracture strength (FS), yield strength (YS), Young’s modulus (YM), etc). Therefore, the statistical optimization of the key design factors has become extremely important to minimize the experimental runs and the cost involved. In this study, both statistical (i.e., analysis of variance (ANOVA) and response surface methodology (RSM)) and machine learning techniques (i.e., artificial intelligence-based techniques (i.e., artificial neural network (ANN) and genetic algorithm (GA)) were used to optimize the concentrations of nanofillers and compatibilizing agents of the injection-molded HDPE nanocomposites. Initially, through ANOVA, the concentrations of TiO2 and cellulose nanocrystals (CNCs) and their combinations were found to be the major factors in improving the durability of the HDPE nanocomposites. Further, the data were modeled and predicted using RSM, ANN, and their combination with a genetic algorithm (i.e., RSM-GA and ANN-GA). Later, to minimize the risk of local optimization, an ANN-GA hybrid technique was implemented in this study to optimize multiple responses, to develop the nonlinear relationship between the factors (i.e., the concentration of TiO2 and CNCs) and responses (i.e., FS, YS, and YM), with minimum error and with regression values above 95%.
Leveraging Artificial Intelligence and Big Data to Optimize COVID-19 Clinical Public Health and Vaccination Roll-Out Strategies in Africa
