Research on Measurement System of Biological Tissue Parameters Based on Optical Coherence Tomography

2013 ◽  
Vol 333-335 ◽  
pp. 135-139
Author(s):  
Hai Ye ◽  
Ying Jun Gao
Keyword(s):  
Optical Coherence Tomography ◽  
Refractive Index ◽  
Measurement System ◽  
Biological Tissue ◽  
Scattering Coefficient ◽  
Optical Parameters ◽  
Optical Coherence ◽  
Tissue Samples ◽  
Non Invasive ◽  
Experimental Values

In order to measure the optical parameters of biological tissue accurately and non-invasive, the measurement system based on optical coherence tomography was analyzed and designed from two aspects of hardware and software. The refractive index was calibrated by standard refractive index solutions, experiments were preformed to obtain refractive index of tissue samples and scattering coefficient of IntralipidTMsolution with different concentrations. Results show that the experimental values of refractive index agree with the standard values roughly and scattering coefficient linear relate with concentration in IntralipidTMsolution. The measurement system designed in our experiment is accurate and reliable, simple and feasible.

Estimation of Refractive Index for Biological Tissue Using Micro-Optical Coherence Tomography

2019 ◽  
Vol 66 (6) ◽  
pp. 1803-1809 ◽  
Author(s):  
Hongying Tang ◽  
Xinyu Liu ◽  
Si Chen ◽  
Xiaojun Yu ◽  
Yuemei Luo ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Refractive Index ◽  
Biological Tissue ◽  
Optical Coherence

EFFICIENT FITTING RANGE FOR GLUCOSE MEASUREMENT WITH OPTICAL COHERENCE TOMOGRAPHY

2009 ◽  
Vol 02 (01) ◽  
pp. 107-115
Author(s):  
SHU FENG ◽  
KEHONG YUAN ◽  
DATIAN YE
Keyword(s):  
Optical Coherence Tomography ◽  
Monte Carlo ◽  
Biological Tissues ◽  
Scattering Coefficient ◽  
Glucose Measurement ◽  
Optical Coherence ◽  
Non Invasive ◽  
Tissue Simulating Phantoms

Studies of non-invasive glucose measurement with optical coherence tomography (OCT) in tissue-simulating phantoms and biological tissues show that glucose has an effect on the OCT signal slope. Choosing an efficient fitting range to calculate the OCT signal slope is important because it helps to improve the precision of glucose measurement. In this paper, we study the problem in two ways: (1) scattering-induced change of OCT signal slope versus depth in intralipid suspensions with different concentrations based on Monte Carlo (MC) simulations and experiments and (2) efficient fitting range for glucose measurement in 3% and 10% intralipid. The results show that the OCT signal slope expresses a contrary change with scattering coefficient below a certain depth in high intralipid concentrations, so that there is an effective fitting depth. With an efficient fitting range from 100 μm to the effective fitting depth, the precision of glucose measurement can be 4.4 mM for 10% intralipid and 2.2 mM for 3% intralipid.

scholarly journals Non-invasive three-dimensional thickness analysis of oral epithelium based on optical coherence tomography—development and diagnostic performance

Heliyon ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. e06645
Author(s):  
Charlotte Theresa Trebing ◽  
Sinan Sen ◽  
Stefan Rues ◽  
Christopher Herpel ◽  
Maria Schöllhorn ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diagnostic Performance ◽  
Three Dimensional ◽  
Oral Epithelium ◽  
Optical Coherence ◽  
Non Invasive

Label-free non-invasive classification of rice seeds using optical coherence tomography assisted with deep neural network

2021 ◽  
Vol 137 ◽  
pp. 106861
Author(s):  
Deepa Joshi ◽  
Ankit Butola ◽  
Sheetal Raosaheb Kanade ◽  
Dilip K. Prasad ◽  
S.V. Amitha Mithra ◽  
...  
Keyword(s):  
Neural Network ◽  
Optical Coherence Tomography ◽  
Deep Neural Network ◽  
Optical Coherence ◽  
Label Free ◽  
Non Invasive ◽  
Rice Seeds

scholarly journals Monitoring New Long-Lasting Intravitreal Formulation for Glaucoma with Vitreous Images Using Optical Coherence Tomography

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 217
Author(s):  
Maria Jesus Rodrigo ◽  
Amaya Pérez del Palomar ◽  
Alberto Montolío ◽  
Silvia Mendez-Martinez ◽  
Manuel Subias ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Relative Intensity ◽  
Therapeutic Option ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Aggregate Size ◽  
Daily Practice ◽  
Optical Coherence ◽  
Non Invasive ◽  
Invasive Method

Intravitreal injection is the gold standard therapeutic option for posterior segment pathologies, and long-lasting release is necessary to avoid reinjections. There is no effective intravitreal treatment for glaucoma or other optic neuropathies in daily practice, nor is there a non-invasive method to monitor drug levels in the vitreous. Here we show that a glaucoma treatment combining a hypotensive and neuroprotective intravitreal formulation (IF) of brimonidine–Laponite (BRI/LAP) can be monitored non-invasively using vitreoretinal interface imaging captured with optical coherence tomography (OCT) over 24 weeks of follow-up. Qualitative and quantitative characterisation was achieved by analysing the changes in vitreous (VIT) signal intensity, expressed as a ratio of retinal pigment epithelium (RPE) intensity. Vitreous hyperreflective aggregates mixed in the vitreous and tended to settle on the retinal surface. Relative intensity and aggregate size progressively decreased over 24 weeks in treated rat eyes as the BRI/LAP IF degraded. VIT/RPE relative intensity and total aggregate area correlated with brimonidine levels measured in the eye. The OCT-derived VIT/RPE relative intensity may be a useful and objective marker for non-invasive monitoring of BRI/LAP IF.

Line‐field confocal optical coherence tomography for non‐invasive diagnosis of lichenoid dermatoses of the childhood: A case series

2021 ◽  
Author(s):  
Linda Tognetti ◽  
Andrea. Carraro ◽  
Elisa Cinotti ◽  
Mariano Suppa ◽  
Veronique Marmol ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Case Series ◽  
Optical Coherence ◽  
Line Field ◽  
Non Invasive

Results of the project «Optimization of the process of obtaining the service OCT “ (project implementation period 20.06.2019–08.10.2019)

2021 ◽  
pp. 29-37
Author(s):  
Irina Aleksandrovna Rakitina ◽  
Alfiya Gumyarovna Iskhakova ◽  
Evgeny Andreevich Zamytsky ◽  
Marina Vladimirovna Makolina ◽  
Farida Sagitovna Goleeva ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Anterior Segment ◽  
Contact Method ◽  
Optical Coherence ◽  
Non Invasive ◽  
Risk Of Injury ◽  
Eye Tissues ◽  
Implementation Period ◽  
Project Optimization ◽  
Theoretical Foundations

Optical Coherence Tomography (OCT) is a modern, highly accurate, non-invasive study of various eye structures. OCT is a non-contact method that allows a specialist to visualize eye tissue with a very high resolution (1–15 microns), the accuracy of which is comparable to microscopic examination. The theoretical foundations of the OCT method were developed in 1995 by the American ophthalmologist K. Pulafito, and already in 1996–1997 Carl Zeiss Meditec introduced the first device for optical coherence tomography into clinical practice. Today, OCT devices are used to diagnose various diseases of the fundus and anterior segment of the eye. Due to the maximum accuracy, the method of light scanning greatly simplifies the diagnosis of pathologies of the organs of vision, regardless of the cause of their occurrence and the stage of the course. In terms of information content, the technique is not inferior to histology, but the advantage of OCT is the absence of the risk of injury to the eye tissues [1, 2].

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