Synthesis and Characterization of Novel Degradable and Temperature/Ionic-Strength Responsive Polyurethane Microsphere

2014 ◽  
Vol 1033-1034 ◽  
pp. 1077-1081
Author(s):  
Ke Wei Yu ◽  
Yang Quan Deng ◽  
Shu Wen Yu ◽  
Wei Min Zhang
Keyword(s):  
Drug Delivery ◽  
Ionic Strength ◽  
Toluene Diisocyanate ◽  
Synthesis And Characterization ◽  
Swelling Kinetics ◽  
Temperature Sensitive ◽  
In Vitro Degradation ◽  
Good Ability

The present study describes degradable and temperature/ionic-strength responsive polyurethane (PU) microspheres fabricated using toluene diisocyanate, polycaprolactone, polyethylene glycol, 2, 2-hydroxymethyl-2-propionic acid and triethylamine for drug delivery.[1]We studied the properties of Temperature-sensitive, Ionic strength effects on SR, Swelling-deswelling reversibility, In vitro degradation, the result showed that: when the increase in temperature between 20°C and 50°C, as well as the ionic strength at certain temperature tended to decrease SR. The swelling kinetics was also investigated showing the presence of good ability to change reversibly at different temperature. The degradable studies using phosphate buffer solvent revealing polymeric matrix easily be tuned by varying polycaprolactam (PCL) composition, thus matching specific requirements.

Synthesis and Characterization of Novel Degradable Responsive Polyurethane Microsphere

2013 ◽  
Vol 750-752 ◽  
pp. 1271-1275 ◽  
Author(s):  
Lian Hai Shan ◽  
Yuan Yuan Cui ◽  
Shuai Huang ◽  
Zhi Bin Zhang
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Chemical Structure ◽  
Solvent Polarity ◽  
Toluene Diisocyanate ◽  
Synthesis And Characterization ◽  
The Novel ◽  
Swelling Ratio ◽  
Swelling Properties

The present study describes degradable polyurethane (PU) microspheres fabricated using toluene diisocyanate, polycaprolactone, polyethylene glycol, 2, 2-hydroxymethyl-2-propionic acid and triethylamine for drug delivery. The novel microspheres were synthesized using self-emulsion and condensed phase separation method. Fourier-Transform Infrared Spectrum analysis (FTIR) was performed revealing the chemical structure of polyurethane microspheres with special chains changing. Swelling properties influenced by solvent polarity, PEG content, PEG molecular weight, were evaluated, suggesting that the swelling ratio (SR) of PU microspheres increased with the increase in solvent polarity, PEG content and PEG molecular weight respectively.

Dual-drug delivery based charge-conversional polymeric micelles for enhanced cellular uptake and combination therapy

2019 ◽  
Vol 10 (43) ◽  
pp. 5879-5893 ◽  
Author(s):  
Jianhong Liao ◽  
Yajing Song ◽  
Can Liu ◽  
Dan Li ◽  
Hua Zheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Combination Therapy ◽  
Synergistic Effect ◽  
Polymeric Micelles ◽  
The Self ◽  
Synthesis And Characterization ◽  
A Charge ◽  
Dual Drug

We herein report on the synthesis and characterization of a dual-drug conjugated prodrug, and the self-assembled micelles showed a charge-conversion behavior and synergistic effect in vitro.

scholarly journals Synthesis and characterization of novel protein nanodots as drug delivery carriers with an enhanced biological efficacy of melatonin in breast cancer cells

RSC Advances ◽  
2021 ◽  
Vol 11 (16) ◽  
pp. 9076-9085
Author(s):  
Kanchan Yadav ◽  
Megha Das ◽  
Nurul Hassan ◽  
Archana Mishra ◽  
Jayeeta Lahiri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Live Cell Imaging ◽  
Biomedical Applications ◽  
Breast Cancer Cells ◽  
Cell Imaging ◽  
Synthesis And Characterization ◽  
Novel Protein

A novel nanodot-using protein has been synthesized for the live cell imaging and drug delivery of melatonin in breast cancer cells. Its unique properties hold potential for various biomedical applications in the field of bioimaging and drug delivery.

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