Synthesis and Characterization of Novel Degradable Responsive Polyurethane Microsphere

2013 ◽  
Vol 750-752 ◽  
pp. 1271-1275 ◽  
Author(s):  
Lian Hai Shan ◽  
Yuan Yuan Cui ◽  
Shuai Huang ◽  
Zhi Bin Zhang
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Chemical Structure ◽  
Solvent Polarity ◽  
Toluene Diisocyanate ◽  
Synthesis And Characterization ◽  
The Novel ◽  
Swelling Ratio ◽  
Swelling Properties

The present study describes degradable polyurethane (PU) microspheres fabricated using toluene diisocyanate, polycaprolactone, polyethylene glycol, 2, 2-hydroxymethyl-2-propionic acid and triethylamine for drug delivery. The novel microspheres were synthesized using self-emulsion and condensed phase separation method. Fourier-Transform Infrared Spectrum analysis (FTIR) was performed revealing the chemical structure of polyurethane microspheres with special chains changing. Swelling properties influenced by solvent polarity, PEG content, PEG molecular weight, were evaluated, suggesting that the swelling ratio (SR) of PU microspheres increased with the increase in solvent polarity, PEG content and PEG molecular weight respectively.

Synthesis and Characterization of Poly (ε-caprolactone)/ TiO2 Nanocomposites Obtained by In Situ Polymerization

2011 ◽  
Vol 328-330 ◽  
pp. 1533-1536
Author(s):  
Guang Shuo Wang ◽  
Zhi Yong Wei ◽  
Lian Liu ◽  
Pei Wang ◽  
Min Qi
Keyword(s):  
Thermal Stability ◽  
Molecular Weight ◽  
Crystalline Structure ◽  
Synthesis And Characterization ◽  
The Novel ◽  
Biodegradable Poly ◽  
Thermal Stability Of ◽  
Nucleating Effect

The novel biodegradable poly (ε-caprolactone)/TiO2 nanocomposites were prepared by in situ polymerization of ε-caprolactone in the presence of modified-TiO2 nanoparticles as initiator. The molecular weight of poly (ε-caprolactone) (PCL) matrix was dependent on the amount of the TiO2 fillers. The incorporation of TiO2 did not significantly affect the crystalline structure of PCL. An astounding nucleating effect of TiO2 on PCL crystallization was observed. The enhanced thermal stability of PCL nanocomposites was observed. The novel biodegradable poly (ε-caprolactone)/TiO2 nanocomposites were prepared by in situ polymerization of ε-caprolactone in the presence of modified-TiO2 nanoparticles as initiator. The molecular weight of poly (ε-caprolactone) (PCL) matrix was dependent on the amount of the TiO2 fillers. The incorporation of TiO2 did not significantly affect the crystalline structure of PCL. An astounding nucleating effect of TiO2 on PCL crystallization was observed. The enhanced thermal stability of PCL nanocomposites was observed.

scholarly journals SYNTHESIS AND CHARACTERIZATION OF BOC-PROTECTED THIO-1,3,4-OXADIAZOL-2-YL DERIVATIVES

2021 ◽  
pp. 5-10
Author(s):  
S. SYED SHAFI ◽  
R. RAJESH ◽  
S. SENTHILKUMAR
Keyword(s):  
Photoluminescence Spectrum ◽  
Chemical Structure ◽  
Phenylacetic Acid ◽  
Industrial Applications ◽  
Powder Xrd ◽  
Synthesis And Characterization ◽  
The Novel ◽  
Structural And Optical Properties ◽  
Good Thermal Stability

Objective: The objective of this work is to synthesis thio-1,3,4-oxadiazol-2-yl derivatives for industrial applications. Methods: The synthesis was done by the reaction of (S)-2-amino-2-phenylacetic acid with ethanol-derived ethyl (S)-2-amino-2-phenylacetate. The reaction of ethyl (S)-2-amino-2-phenylacetate with Boc anhydride and hydrazine produces ethyl (S)-2-((tert-butoxycarbonyl)amino)-2-phenylacetate. The intermediate 5-alkyl amino-1,3,4-oxadiazole-2-thiols have been isolated as stable compounds. Results: To study the characteristics of these compounds, they are subjected to 1HNMR, 13CNMR, and IR. These studies examine the chemical structure of synthesized compounds. The mass of the novel compounds was established with the help of the LCMS test. The structural and optical properties were examined by the powder XRD and photoluminescence spectrum respectively. Conclusion: The sharp intense peak in the powder XRD indicates the crystal nature of the sample. The values obtained from the LCMS test indicate that the compounds have good thermal stability. The absorption peak at 358 nm in the PL spectrum indicates that the sample can be used in photoelectronic devices.

Synthesis and Characterization of Poly(butylenes succinate) with Control Different End-Group

2012 ◽  
Vol 430-432 ◽  
pp. 497-500 ◽  
Author(s):  
Chun Na Cui ◽  
Ji Tao Huang
Keyword(s):  
Mechanical Properties ◽  
Molecular Weight ◽  
Thermal Properties ◽  
Acid Ester ◽  
Chemical Structure ◽  
Starting Material ◽  
Synthesis And Characterization ◽  
End Group

Poly (butylenes succinate) (PBS) was synthesized by using1, 4-butanediol and succinate as starting material, titanic acid ester and acetate as catalyst, and tried to improve PBS by changing end-group to carboxyl, hydroxyl and chlorine. The results of GPC showed, molecular weight of four kinds of polymer was all beyond seventy thousand; chemical structure of the polymer was measured by FTIR and nitrogen/sulfur/chlorine elementary analyzer; PBS controlled end-group had better thermal properties by DSC and TG; different end-group had influenced mechanical properties; and biodegradability experiment results showed biodegradable speed of PBS can be controlled by changing their end-group.

Synthesis and Characterization of Novel Degradable and Temperature/Ionic-Strength Responsive Polyurethane Microsphere

2014 ◽  
Vol 1033-1034 ◽  
pp. 1077-1081
Author(s):  
Ke Wei Yu ◽  
Yang Quan Deng ◽  
Shu Wen Yu ◽  
Wei Min Zhang
Keyword(s):  
Drug Delivery ◽  
Ionic Strength ◽  
Toluene Diisocyanate ◽  
Synthesis And Characterization ◽  
Swelling Kinetics ◽  
Temperature Sensitive ◽  
In Vitro Degradation ◽  
Good Ability

The present study describes degradable and temperature/ionic-strength responsive polyurethane (PU) microspheres fabricated using toluene diisocyanate, polycaprolactone, polyethylene glycol, 2, 2-hydroxymethyl-2-propionic acid and triethylamine for drug delivery.[1]We studied the properties of Temperature-sensitive, Ionic strength effects on SR, Swelling-deswelling reversibility, In vitro degradation, the result showed that: when the increase in temperature between 20°C and 50°C, as well as the ionic strength at certain temperature tended to decrease SR. The swelling kinetics was also investigated showing the presence of good ability to change reversibly at different temperature. The degradable studies using phosphate buffer solvent revealing polymeric matrix easily be tuned by varying polycaprolactam (PCL) composition, thus matching specific requirements.

Synthesis and Characterization of PLA-Based Aliphatic-Aromatic Copolyesters: Effect of Diols

2008 ◽  
Vol 55-57 ◽  
pp. 785-788
Author(s):  
M. Namkajorn ◽  
Atitsa Petchsuk ◽  
Mantana Opaprakasit ◽  
Pakorn Opaprakasit
Keyword(s):  
Mechanical Properties ◽  
Molecular Weight ◽  
Lactic Acid ◽  
Chemical Structure ◽  
Molar Ratio ◽  
Synthesis And Characterization ◽  
Polycondensation Reaction ◽  
Dimethyl Terephthalate ◽  
Aromatic Species

PLA-based aliphatic aromatic copolyesters have been synthesized and characterized in order to incorporate the degradability of PLA and good mechanical properties of aromatic species. Synthesis of the copolymers was conducted by polycondensation of lactic acid with dimethyl terephthalate (DMT) and various diols using stannous(II) octoate as a catalyst. Three types of diols with different methylene lengths were employed, i.e., ethylene glycol (EG), propylene glycol (PG) and 1, 4-butanediol (BD). Effects of diols and comonomer molar ratio on the extent of polycondensation reaction and molecular weight of the resulting copolymers were investigated. Diacids and diol ratios of L-lactic acid (LLA), dimethyl terephthalate (DMT) and diol of 1/1/2, 1/2/4 and 2/1/2 were employed. Characterization of chemical structure, molecular weight and thermal and physical properties of the resulting copolymers were conducted by FTIR, NMR, and DSC.

Synthesis and Characterization of Poly(N-Arylenebenzimidazole Ketone)

2012 ◽  
Vol 204-208 ◽  
pp. 4211-4214 ◽  
Author(s):  
Ye Wei Xu ◽  
Jie Tang ◽  
Guan Jun Chang ◽  
Fang Hua Zhu ◽  
Lin Zhang
Keyword(s):  
Weight Loss ◽  
Chemical Structure ◽  
Synthesis And Characterization ◽  
The Novel ◽  
Displacement Reaction ◽  
Good Solubility ◽  
Nucleophilic Displacement ◽  
Ft Ir ◽  
Good Agreement

Using 1,4-bis(2-benzimidazolyl) benzene (BBIB) and 4,4'-difluorobenzophenone as the monomers, poly(N-arylenebenzimidazole ketone) (PNABIK) has been prepared via the aromatic nucleophilic displacement reaction. The chemical structure of PNABIK was confirmed by FT-IR, elemental analysis and 1H NMR. The results show a good agreement with the proposed structures. The polymer was obtained in quantitative yields with Mn value 12500 and Mw value 28600, respectively. DSC and TGA measurements show that the glass transition temperature (Tg) is 202 °C and 5% weight loss temperature is 550°C in nitrogen and 571 °C in air, respectively. In addition, the novel polymer exhibit good solubility.

Synthesis and Characterization of PCL/TiO2 Nanocomposites Obtained by In Situ Polymerization

2012 ◽  
Vol 182-183 ◽  
pp. 194-197
Author(s):  
Lian Liu ◽  
Yuan Liu ◽  
Teng Yu ◽  
Li Na Heng ◽  
Pei Wang
Keyword(s):  
Molecular Weight ◽  
Nanocomposite Materials ◽  
Synthesis And Characterization ◽  
The Novel ◽  
Biodegradable Poly

The novel biodegradable poly(ε-caprolactone)/TiO2nanocomposite materials were successfully prepared via in situ in the presence of modified-TiO2initiator and Sn(Oct)2 catalyst. The relationships between morphology, molecular weight, and properties were investigated by means of SEM, TGA, DSC and GPC. A tendency of the nanoparticles to form aggregates was observed, especially at higher fillers contents. The molecular weight of PCL matrix was dependent on the amount of the TiO2fillers

scholarly journals Synthesis and characterization of different soybean oil-based polyols with fatty alcohol and aromatic alcohol

e-Polymers ◽  
2021 ◽  
Vol 21 (1) ◽  
pp. 491-499
Author(s):  
Fukai Yang ◽  
Hao Yu ◽  
Yuyuan Deng ◽  
Xinyu Xu
Keyword(s):  
Molecular Weight ◽  
Soybean Oil ◽  
Retention Time ◽  
Ring Opening ◽  
Isoamyl Alcohol ◽  
Synthesis And Characterization ◽  
Intermolecular Force ◽  
H Nmr ◽  
Epoxy Groups

Abstract In this article, five kinds of soybean oil-based polyols (polyol-E, polyol-P, polyol-I, polyol-B, and polyol-M) were prepared by ring-opening the epoxy groups in epoxidized soybean oil (ESO) with ethyl alcohol, 1-pentanol, isoamyl alcohol, p-tert-butylphenol, and 4-methoxyphenol in the presence of tetrafluoroboric acid as the catalyst. The SOPs were characterized by FTIR, 1H NMR, GPC, viscosity, and hydroxyl numbers. Compared with ESO, the retention time of SOPs is shortened, indicating that the molecular weight of SOPs is increased. The structure of different monomers can significantly affect the hydroxyl numbers of SOPs. Due to the large steric hindrance of isoamyl alcohol, p-hydroxyanisole, and p-tert-butylphenol, SOPs prepared by these three monomers often undergo further dehydration to ether reactions, which consumes the hydroxyl of polyols, thus forming dimers and multimers; therefore, the hydroxyl numbers are much lower than polyol-E and polyol-P. The viscosity of polyol-E and polyol-P is much lower than that of polyol-I, polyol-B, and polyol-M. A longer distance between the molecules and the smaller intermolecular force makes the SOPs dehydrate to ether again. This generates dimer or polymers and makes the viscosity of these SOPs larger, and the molecular weight greatly increases.

scholarly journals Synthesis and characterization of novel protein nanodots as drug delivery carriers with an enhanced biological efficacy of melatonin in breast cancer cells

RSC Advances ◽  
2021 ◽  
Vol 11 (16) ◽  
pp. 9076-9085
Author(s):  
Kanchan Yadav ◽  
Megha Das ◽  
Nurul Hassan ◽  
Archana Mishra ◽  
Jayeeta Lahiri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Live Cell Imaging ◽  
Biomedical Applications ◽  
Breast Cancer Cells ◽  
Cell Imaging ◽  
Synthesis And Characterization ◽  
Novel Protein

A novel nanodot-using protein has been synthesized for the live cell imaging and drug delivery of melatonin in breast cancer cells. Its unique properties hold potential for various biomedical applications in the field of bioimaging and drug delivery.

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