Study on Dynamic Bifurcation of the Hindmarsh-Rose Neuron under Parameters’ Changing

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.341-342.345 ◽

2011 ◽

Vol 341-342 ◽

pp. 345-349

Author(s):

Yue Ping Peng

Keyword(s):

Dynamic Characteristics ◽

Resting State ◽

General Trend ◽

Tonic Firing ◽

Bifurcation Mechanism ◽

Discharge Patterns ◽

Stimulation Current ◽

Bifurcation Process ◽

Dynamic Bifurcation ◽

Stimulation Of

In the thesis, the dynamic bifurcation characteristics of the Hindmarsh-Rose neuron are analyzed and discussed by the neurodynamic theory and methods. Under the stimulation of the current, the neuron’s discharge pattern changes from the resting state to the tonic firing, which needs the current’s amplitude reaching a certain value. Moreover the stimulation strength threshold has something to do with the parameterrof the neuron. When the stimulation current increases gradually, the general trend of the membrane potential’s ISI is the gradual decrease(The discharge frequency of the neuron increases gradually). The discharge patterns of the neuron are changed, and the neuron undergoes the process of dynamic bifurcation. This bifurcation process of the neuron has something to do with the parameterr. and different parameterrcauses different bifurcation. Under a certain current’s stimulation, the HR neuron has plenty of discharge patterns with the parameterr’s changing. From the view of neurodynamics, the discharge patterns of the HR neuron are changed, in substance, the HR neuron undergoes dynamic bifurcation process. Therefore, The HR neuron’s discharge patterns can be adjusted and controlled by the stimulation currentIand the parameterr. This investigation is helpful to know and investigate deeply the dynamic characteristics and the bifurcation mechanism of the HR neuron; and it provides a certain theory assist to investigate many neurons’ synchronization and the neural network’s synchronization.

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Study on Dynamic Characteristics of the Hippocampal Neuron under Current Stimulation

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.341-342.350 ◽

2011 ◽

Vol 341-342 ◽

pp. 350-354 ◽

Cited By ~ 5

Author(s):

Yue Ping Peng

Keyword(s):

Dynamic Characteristics ◽

Hippocampal Neuron ◽

Neuron Model ◽

Neural Excitability ◽

Hippocampal Ca1 ◽

Changing Trend ◽

Discharge Patterns ◽

Stimulation Current ◽

Neural Diseases ◽

Stimulation Amplitude

The hippocampal CA1 pyramid neuron has plenty of discharge actions. In the thesis, the dynamic characteristics of the hippocampal neuron model are analyzed and discussed by the neurodynamic theory and methods. Under the current stimulation, the hippocampal CA1 pyramid neuron has plenty of discharge patterns, and can generate many discharge patterns such as period, the chaos, and so on. Under the stimulation current amplitude unchanging, the dynamic characteristics of the hippocampal neuron have something to do with not only the current’s stimulation amplitude, but also the stimulation time’s length, which isn’t the same with common neurons such as the Hindmarsh-Rose neuron. When the stimulation amplitude increases gradually or the stimulation time prolongs, The neuron model’s ISI gradually drops off, whose changing trend approximates to an exponential function, that is to say, the discharge frequency gets quicker and quicker. In addition, the hippocampal CA1 pyramid neuron model has class II neural excitability. This investigation is helpful to know and investigate deeply the dynamic characteristics and the bifurcation mechanism of the hippocampal neuron; and it provides a certain theory assist to investigate the neural diseases such as the Alzheimer disease by neurodynamics.

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Effects of low-frequency stimulation of the superior colliculus on spontaneous and visually guided saccades

Journal of Neurophysiology ◽

10.1152/jn.1993.69.3.953 ◽

1993 ◽

Vol 69 (3) ◽

pp. 953-964 ◽

Cited By ~ 43

Author(s):

P. W. Glimcher ◽

D. L. Sparks

Keyword(s):

Superior Colliculus ◽

Time Course ◽

Low Frequency ◽

Arbitrary Point ◽

Visually Guided ◽

Spontaneous Movements ◽

Low Frequency Stimulation ◽

Frequency Stimulation ◽

Stimulation Current ◽

Stimulation Of

1. The first experiment of this study determined the effects of low-frequency stimulation of the monkey superior colliculus on spontaneous saccades in the dark. Stimulation trains, subthreshold for eliciting short-latency fixed-vector saccades, were highly effective at biasing the metrics (direction and amplitude) of spontaneous movements. During low-frequency stimulation, the distribution of saccade metrics was biased toward the direction and amplitude of movements induced by suprathreshold stimulation of the same collicular location. 2. Low-frequency stimulation biased the distribution of saccade metrics but did not initiate movements. The distribution of intervals between stimulation onset and the onset of the next saccade did not differ significantly from the distribution of intervals between an arbitrary point in time and the onset of the next saccade under unstimulated conditions. 3. Results of our second experiment indicate that low-frequency stimulation also influenced the metrics of visually guided saccades. The magnitude of the stimulation-induced bias increased as stimulation current or frequency was increased. 4. The time course of these effects was analyzed by terminating stimulation immediately before, during, or after visually guided saccades. Stimulation trains terminated at the onset of a movement were as effective as stimulation trains that continued throughout the movement. No effects were observed if stimulation ended 40–60 ms before the movement began. 5. These results show that low-frequency collicular stimulation can influence the direction and amplitude of spontaneous or visually guided saccades without initiating a movement. These data are compatible with the hypothesis that the collicular activity responsible for specifying the horizontal and vertical amplitude of a saccade differs from the type of collicular activity that initiates a saccade.

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The dynamic characteristics of dielectric barrier discharge patterns under Karman vortex on atmospheric airflow

10.1109/cieec50170.2021.9510826 ◽

2021 ◽

Author(s):

Miao Tang ◽

Jing Li ◽

Jingfeng Tang

Keyword(s):

Dielectric Barrier Discharge ◽

Dynamic Characteristics ◽

Barrier Discharge ◽

Dielectric Barrier ◽

Karman Vortex ◽

Discharge Patterns

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Study on Dynamic Characteristics of the Hippocampal Neuron under Current Conductance's Changing

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.195-196.868 ◽

2012 ◽

Vol 195-196 ◽

pp. 868-873 ◽

Cited By ~ 1

Author(s):

Yue Ping Peng ◽

Nan Zou ◽

Hai Ying Wu

Keyword(s):

Dynamic Characteristics ◽

Formation Process ◽

Hippocampal Neuron ◽

Neuron Model ◽

Discharge Process ◽

Straight Line ◽

Hippocampal Ca1 ◽

Discharge Patterns ◽

Neural Diseases ◽

Maximum Conductance

The hippocampal CA1 pyramid neuron has plenty of discharge actions. In the thesis, the dynamic characteristics of the hippocampal neuron model are analyzed and discussed by the neurodynamic theory and methods. Under a certain amplitude currents stimulation, the change of (the maximum conductance of the transient sodium channel) and (the maximum conductance of the delay rectification potassium channel) can cause different dynamic characteristics of the neuron model. The transient Na+current () caused by is indispensable in the discharges formation process of the model. The model can generate the discharge process only when reaches a certain threshold. In the discharge process of the neuron model,s changing affects little and the ISIs approximate to a straight line. The delay rectification K+current () caused by isnt indispensable in the discharges formation process of the model. Buts changing affects much in the discharge process of the neuron model. Withs changing, the neuron model undergoes different dynamic bifurcation process, and has plenty of discharge patterns such as the chaos, period, and so on. This investigation is helpful to know and investigate deeply the dynamic characteristics and the bifurcation mechanism of the hippocampal neuron; and it provides a certain theory assist to investigate the neural diseases such as the Alzheimer disease by neurodynamics.

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Effects of Electrical Stimulation of NAc Afferents on VP Neurons’ Tonic Firing

Frontiers in Cellular Neuroscience ◽

10.3389/fncel.2020.599920 ◽

2020 ◽

Vol 14 ◽

Author(s):

Martin Clark

Keyword(s):

Brain Slices ◽

Electrode Array ◽

Inhibitory Effect ◽

Pause Duration ◽

Firing Frequency ◽

Ventral Pallidum ◽

Cellular Mechanisms ◽

Tonic Firing ◽

Afferent Stimulation ◽

Stimulation Of

Afferents from the nucleus accumbens (NAc) are a major source of input into the ventral pallidum (VP). Research reveals that these afferents are GABAergic, however, stimulation of these afferents induces both excitatory and inhibitory responses within the VP. These are likely to be partially mediated by enkephalin and substance P (SP), which are also released by these afferents, and are known to modulate VP neurons. However, less is known about the potentially differential effects stimulation of these afferents has on subpopulations of neurons within the VP and the cellular mechanisms by which they exert their effects. The current study aimed to research this further using brain slices containing the VP, stimulation of the NAc afferents, and multi-electrode array (MEA) recordings of their VP targets. Stimulation of the NAc afferents induced a pause in the tonic firing in 58% of the neurons studied in the VP, while 42% were not affected. Measures used to reveal the electrophysiological difference between these groups found no significant differences in firing frequency, coefficient of variation, and spike half-width. There were however significant differences in the pause duration between neurons in the dorsal and ventral VP, with stimulation of NAc afferents producing a significantly longer pause (0.48 ± 0.06 s) in tonic firing in dorsal VP neurons, compared to neurons in the ventral VP (0.21 ± 0.09 s). Pauses in the tonic firing of VP neurons, as a result of NAc afferent stimulation, were found to be largely mediated by GABAA receptors, as the application of picrotoxin significantly reduced their duration. Opioid agonists and antagonists were found to have no significant effects on the pause in tonic activity induced by NAc afferent stimulation. However, NK-1 receptor antagonists caused significant decreases in the pause duration, suggesting that SP may contribute to the inhibitory effect of NAc afferent stimulation via activation of NK-1 receptors.

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Intrinsic discharge patterns and somatosensory inputs for neurons in raccoon primary somatosensory cortex

Journal of Neurophysiology ◽

10.1152/jn.1994.72.6.2827 ◽

1994 ◽

Vol 72 (6) ◽

pp. 2827-2839 ◽

Cited By ~ 14

Author(s):

P. J. Istvan ◽

P. Zarzecki

Keyword(s):

Somatosensory Cortex ◽

Cortical Neurons ◽

Primary Somatosensory Cortex ◽

Membrane Properties ◽

Postsynaptic Potentials ◽

Synaptic Inputs ◽

Ionic Conductances ◽

Discharge Patterns ◽

Intrinsic Membrane Properties ◽

Stimulation Of

1. Discharge patterns of neurons are regulated by synaptic inputs and by intrinsic membrane properties such as their complement of ionic conductances. Discharge patterns evoked by synaptic inputs are often used to identify the source and modality of sensory input. However, the interpretation of these discharge patterns may be complicated if different neurons respond to the same synaptic input with a variety of discharge patterns due to differences in intrinsic membrane properties. The purposes of this study were 1) to investigate intrinsic discharge patterns of neurons in primary somatosensory cortex of raccoon in vivo and 2) to use somatosensory postsynaptic potentials evoked by stimulation of forepaw digits to determine thalamocortical connectivity for the same neurons. 2. Conventional intracellular recordings with sharp electrodes were made from 121 neurons in the cortical representation of glabrous skin of digit four (d4). Intracellular injection of identical current pulses (100-120 ms in duration) elicited various patterns of discharge in different neurons. Neurons were classified on the basis of these intrinsic patterns of discharge, rates of spike adaptation, and characteristics of spike waveforms. Three main groups were identified: regular spiking (RS) neurons, intrinsic bursting (IB) neurons, and fast spiking (FS) neurons. Subclasses were identified for the RS and IB groups. 3. Neurons were tested for somatosensory inputs by stimulating electrically d3, d4, and d5. Excitatory postsynaptic potentials (EPSPs) were elicited in 100% of the neurons by electrical stimulation of d4, the "on-focus" digit. EPSPs were usually followed by inhibitory postsynaptic potentials (IPSPs). Many neurons (41%) responded with EPSP-IPSP sequences after stimulation of d3 or d5, the "off-focus" digits. 4. Latencies of somatosensory EPSPs and IPSPs were used to determine the synaptic order in the cortical circuitry of RS, IB, and FS neurons. EPSPs with monosynaptic thalamocortical latencies were recorded in RS, IB, and FS neurons. 5. We conclude that precise patterns of neural discharge in primary somatosensory cortex cannot be reliable estimates of sensory inputs reaching these neurons because patterns of discharge are so strongly influenced by intrinsic membrane properties. Ionic conductances governing patterns of neuronal discharge seem almost identical in intact cortex of raccoon, rat, and cat, and in slices of rodent cortex, because similar patterns of discharge are found. The consistency of patterns of discharge across species and types of preparation suggests that these intrinsic membrane properties are a general property of cerebral cortical neurons and should be considered when evaluation sensory coding by these neurons.

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Vestibular implantation and longitudinal electrical stimulation of the semicircular canal afferents in human subjects

Journal of Neurophysiology ◽

10.1152/jn.00171.2013 ◽

2015 ◽

Vol 113 (10) ◽

pp. 3866-3892 ◽

Cited By ~ 35

Author(s):

James O. Phillips ◽

Leo Ling ◽

Kaibao Nie ◽

Elyse Jameyson ◽

Christopher M. Phillips ◽

...

Keyword(s):

Electrical Stimulation ◽

Eye Movements ◽

Human Subjects ◽

Vestibular Function ◽

Slow Phase ◽

Vestibular Loss ◽

Stimulation Current ◽

Eye Velocity ◽

Over Time ◽

Stimulation Of

Animal experiments and limited data in humans suggest that electrical stimulation of the vestibular end organs could be used to treat loss of vestibular function. In this paper we demonstrate that canal-specific two-dimensionally (2D) measured eye velocities are elicited from intermittent brief 2 s biphasic pulse electrical stimulation in four human subjects implanted with a vestibular prosthesis. The 2D measured direction of the slow phase eye movements changed with the canal stimulated. Increasing pulse current over a 0–400 μA range typically produced a monotonic increase in slow phase eye velocity. The responses decremented or in some cases fluctuated over time in most implanted canals but could be partially restored by changing the return path of the stimulation current. Implantation of the device in Meniere's patients produced hearing and vestibular loss in the implanted ear. Electrical stimulation was well tolerated, producing no sensation of pain, nausea, or auditory percept with stimulation that elicited robust eye movements. There were changes in slow phase eye velocity with current and over time, and changes in electrically evoked compound action potentials produced by stimulation and recorded with the implanted device. Perceived rotation in subjects was consistent with the slow phase eye movements in direction and scaled with stimulation current in magnitude. These results suggest that electrical stimulation of the vestibular end organ in human subjects provided controlled vestibular inputs over time, but in Meniere's patients this apparently came at the cost of hearing and vestibular function in the implanted ear.

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