Synthesis, Characterization and Antitumor Activities of Cis-gallic acid[(1R,2R)-1,2-cyclohexanediamine] Platinum(II)

2012 ◽  
Vol 554-556 ◽  
pp. 1645-1649 ◽  
Author(s):  
Qing Kun Wang ◽  
Shao Ping Pu ◽  
Yong Nian Li ◽  
Jian He ◽  
Li Min Zhou ◽  
...  
Keyword(s):  
Gallic Acid ◽  
Title Compound ◽  
Complex Structure ◽  
Platinum Complex ◽  
Tumor Cell Lines ◽  
Antitumor Activities ◽  
Mtt Method ◽  
Potassium Tetrachloroplatinate ◽  
Growth Of Tumor

Abstract. In order to obtain a gallic acid platinum complex, the title compound was synthesed from potassium tetrachloroplatinate by the reaction potassium iodide, (1R,2R)-1,2-cyclohexanediamine, silver nitrate and gallic acid respectively. The complex structure and component were characterized by elemental analysis, ESI-MS, 1H-NMR and IR and the anticancer activity was measured by MTT method. The result showed that its structure was consistent with the title compound and had inhibiting effect on the growth of tumor cell lines in vitro.

Synthesis, Characterization and Antitumor Activities of Cis-Ammine Gallic Acid(cyclohexylamine)Platinum(II)

2012 ◽  
Vol 581-582 ◽  
pp. 210-213
Author(s):  
Qing Kun Wang ◽  
Shao Ping Pu ◽  
Yong Nian Li ◽  
Jian He ◽  
Li Min Zhou ◽  
...  
Keyword(s):  
Gallic Acid ◽  
Title Compound ◽  
Complex Structure ◽  
Platinum Complex ◽  
Tumor Cell Lines ◽  
Antitumor Activities ◽  
Inhibiting Effect ◽  
Mtt Method ◽  
Growth Of Tumor

In order to obtain a gallic acid platinum complex, the title compound was synthesed from cis-[Pt(Cyclohexylamine)]2I2 by the reaction with NH3, silver nitrate and gallic acid respectively. The complex structure and component were characterized by elemental analysis, ESI-MS, 1H-NMR and IR and the anticancer activity was measured by MTT method. The result showed that its structure was consistent with the title compound and had inhibiting effect on the growth of tumor cell lines in vitro.

Synthesis, Characterization and Antitumor Activities of Cis-Chlorogenic Acid[(1R,2R)-1,2-Cyclohexanediamine] Platinum(II)

2014 ◽  
Vol 884-885 ◽  
pp. 593-597
Author(s):  
Jian He ◽  
Qing Kun Wang ◽  
Xue Jie Li ◽  
Shao Ping Pu
Keyword(s):  
Chlorogenic Acid ◽  
Exchange Resin ◽  
Anion Exchange Resin ◽  
Complex Structure ◽  
Platinum Complex ◽  
Butyl Alcohol ◽  
Antitumor Activities ◽  
Mtt Method ◽  
Growth Of Tumor

Abstract. In order to obtain a chlorogenic acid platinum complex, The intermediate Pt(C6H14N2)(H2O)2(NO3)2 solution was synthesized from Pt(C6H14N2)I2 and AgNO3, and it was treated with the anion exchange resin to give the key intermediate Pt(C6H14N2)(OH)2. The key intermediate was subsequently reacted with chlorogenic acid in butyl alcohol. The complex structure and component were characterized by elemental analysis, ESI-MS, 1H-NMR and IR and the anticancer activity was measured by MTT method. The result showed that its structure was consistent with the title compound and had inhibiting effect on the growth of tumor cell lines in vitro.

Synthesis, Characterization and Antitumor Activities of Platinum(II) Complexes

2013 ◽  
Vol 803 ◽  
pp. 145-148 ◽  
Author(s):  
Qing Kun Wang ◽  
Shao Ping Pu ◽  
Yong Nian Li ◽  
Jian He ◽  
Jie Jin ◽  
...  
Keyword(s):  
Oxalic Acid ◽  
Platinum Complexes ◽  
Tumor Cell Lines ◽  
Potassium Oxalate ◽  
Antitumor Activities ◽  
Inhibiting Effect ◽  
Mtt Method ◽  
Leaving Groups ◽  
Growth Of Tumor

In order to obtain the mixed isobutylamine /cyclopentylamine platinum complexes with chloride and oxalic acid ions as leaving groups. The title compounds were synthetised from potassiumtetrachloroplatinate(II) by the reaction with potassium iodide, cyclopentylamine, isobutylamine, silver nitrate, potassium chloride, potassium oxalate monohydrate. The complexes structure and component were characterized by elemental analysis, ESI-MS, 1H-NMR and IR and the anticancer activity were measured by MTT method. The results showed that its structure was consistent with the title compound and had inhibiting effect on the growth of tumor cell lines in vitro.

Synthesis, Characterization and anti-HIV and Antitumor Activities of New Coumarin Derivatives

2008 ◽  
Vol 63 (1) ◽  
pp. 83-89 ◽  
Author(s):  
Yaseen A. Al-Soud ◽  
Haitham H. Al-Sa’doni ◽  
Houssain A. S. Amajaour ◽  
Kifah S. M. Salih ◽  
Mohammad S. Mubarakb ◽  
...  
Keyword(s):  
T Cells ◽  
In Vitro Cytotoxicity ◽  
Tumor Cell Lines ◽  
Coumarin Derivatives ◽  
Antitumor Activities ◽  
Reverse Transcriptase Inhibitors ◽  
Human T Cells ◽  
Anti Hiv ◽  
Hiv 1

A new series of coumarin and benzofuran derivatives were synthesized as potential non-nucleoside reverse transcriptase inhibitors (NNRTIs) by reacting, separately, 4-bromomethylcoumarins, their sulphonyl chlorides, and ethyl 3-(bromomethyl)-6-methoxy-1-benzofuran-2-carboxylate with different imidazoles and their benzo analogs. The antiviral (HIV-1, HIV-2) properties of the newly synthesized compounds were investigated in vitro and all compounds were found to be inactive, except 10 which showed inhibition of HIV-2 with EC50 > 0.51 μgmL−1. The in vitro cytotoxicity of 17 and 19 was assayed against a panel of tumor cell lines consisting of CD4 human T-cells.

Bimetallic DppfM(II) (M = Pt and Pd) dithiocarbamate complexes: Synthesis, characterization, and anticancer activity

2019 ◽  
Vol 43 (9-10) ◽  
pp. 437-442 ◽  
Author(s):  
Shou De Xu ◽  
Xiang Hua Wu
Keyword(s):  
Antitumor Activity ◽  
Platinum Complex ◽  
Spectroscopic Methods ◽  
X Ray Diffraction ◽  
Antitumor Activities ◽  
High Potency ◽  
Promising Candidate ◽  
X Ray ◽  
Mtt Assays

A series of bimetallic dppfM(II) (dppf = 1,1’-bis (diphenyphosphino) ferrocene; M = Pt and Pd) dithiocarbamate complexes is synthesized and characterized by spectroscopic methods and single-crystal X-ray diffraction. Their antitumor activities in vitro are investigated by MTT assays against four cancer cell lines. The anticancer studies indicate most of the complexes display good to excellent antitumor activity. Remarkably, the platinum complex with a pyrrolidinyl substituent (3b) was identified as the most promising candidate due to its high potency and broad spectrum of activity.

scholarly journals Synthesis and biological evaluation of novel benzo[b]xanthone derivatives as potential antitumor agents

2013 ◽  
Vol 78 (9) ◽  
pp. 1301-1308 ◽  
Author(s):  
Lin Luo ◽  
Jiang-Ke Qin ◽  
Zhi-Kai Dai ◽  
Shi-Hua Gao
Keyword(s):  
Cell Lines ◽  
Antitumor Agents ◽  
Biological Evaluation ◽  
Structural Factors ◽  
Anticancer Activities ◽  
Antitumor Activities ◽  
Mtt Method ◽  
Human Solid Tumor ◽  
Synthesis And Biological Evaluation

Nine novel aminoalkoxy substituted benzoxanthones (3a-3i) were synthesized. Their antitumor activities were evaluated in five human solid tumor cell lines including Hep-G2, BEL-7402, HeLa, MGC-803 and CNE by MTT method. The results showed that most of the compounds displayed moderate to good inhibitory activities on the tested cancer cell lines in vitro, among them compounds 3a and 3h showed higher antitumor activity than other tested compounds against most cell lines. The influence of two kinds of structural factors including the terminal amino group and length of carbon spacers on the anticancer activities were explored to discuss the preliminary structure-activity relationships.

scholarly journals New Triterpene Glycosides from Camptosorus Sibiricus

2010 ◽  
Vol 5 (10) ◽  
pp. 1934578X1000501
Author(s):  
Ning Li ◽  
Wan Xiao ◽  
Bailing Hou ◽  
Xian Li
Keyword(s):  
Human Tumor ◽  
2D Nmr ◽  
Spectroscopic Methods ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines ◽  
Mtt Method ◽  
Cycloartane Glycosides ◽  
New Compounds

Two new cycloartane glycosides were isolated from the whole herbs of Camptosorus sibiricus Rupr. By means of chemical and spectroscopic methods (1D and 2D NMR, HRMS, ESIMS), the structures were established as (24 R)-3β,7β,24,25,30-pentahydroxycycloartane-30- O-coumaroyl-3- O-β-D-glucopyranosyl-24- O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (1) and (24 R)-3β,7β,24,25,30-pentahydroxy-1-ene-cycloartane 24- O-β-D-glucopyranoside (2). The two new compounds were inactive in vitro against A375-S2 and Hela human tumor cell lines using the MTT method.

scholarly journals New Cycloartane Glycosides from Camptosorus Sibiricus Rupr

2008 ◽  
Vol 3 (6) ◽  
pp. 1934578X0800300
Author(s):  
Peng Zhang ◽  
Yiyu Cheng ◽  
Zhongjun Ma
Keyword(s):  
Human Tumor ◽  
2D Nmr ◽  
Spectroscopic Methods ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines ◽  
Mtt Method ◽  
Cycloartane Glycosides ◽  
New Compounds

Two new cycloartane glycosides were isolated from the whole herbs of Camptosorus sibiricus Rupr.. By means of chemical and spectroscopic methods (IR, 1D- and 2D- NMR, HRMS, ESI-MS), the structures were established as (24 R)-3β,7β,24,25,30-pentahydroxycycloartane 3- O-β-D-glucopyranosyl-24- O-β-D-glucopyranosyl-30- O-β-D-glucopyranoside (1), and (24 R)-3β,7β,24,25,30-pentahydroxycycloartane 3- O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-24- O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside (2). The two new compounds were tested for their cytotoxicity in vitro against human tumor cell lines (A375-S2, Hela) using the MTT method, but both compounds were inactive.

Bimetallic Catalyzed N-arylation Used in Synthesis of Novel β-carbolines Derivatives

2020 ◽  
Vol 17 (5) ◽  
pp. 520-525
Author(s):  
Rui Cai ◽  
Li Zhu ◽  
Pengfei Wang ◽  
Yu Zhao
Keyword(s):  
Antitumor Activity ◽  
Tumor Cell ◽  
13C Nmr ◽  
Antiproliferative Activity ◽  
Pyridine Ring ◽  
Catalyst System ◽  
Tumor Cell Lines ◽  
Antitumor Activities ◽  
Acid Condition

Background: Natural occurring β-Carbolines alkaloids are abundant in the plant kingdom or other organisms, and they were found to possess good antitumor activity through multiple mechanisms. Based on previous summarized SARs of β-carboline derivatives, the modification on pyridine ring would have a great impact on their antitumor activities. Therefore, we plan to synthesized arylated β-carboline-3-amides to find more valuable β-Carbolines derivatives. Methods: A novel bimetallic Pd(OAc)2/AgOAc catalyst system was developed for the amidation of aryl iodides under acid condition. A series of N-arylated β-carbolines derivatives were synthesized using this method. The structures of these compounds were confirmed by 1H NMR, 13C NMR and HRMS, and their in vitro antiproliferative activity was investigated against HepG2 and Hela tumor cell lines by MTT assay. Results: Eleven N-arylated β-carboline-3-amides were synthesized using this bimetallic catalyzed method in 58-98% yields. These synthesized N-arylated compounds showed no antiproliferative activity at 20 μM. Conclusion: We have discovered an efficient and bimetallic catalytic system allowing the Narylation of secondary acyclic amides. This is the first report that N-arylation of aliphatic secondary acyclic amides under acid condition.

Design, Syntheses and Biological Evaluation of 3-Arylurea-5-Fluoroindolin-2-One Derivatives

2013 ◽  
Vol 634-638 ◽  
pp. 922-925
Author(s):  
Zhao Yang ◽  
Zhi Xiang Wang ◽  
Zheng Fang ◽  
Kai Guo
Keyword(s):  
Drug Discovery ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Biological Evaluation ◽  
Antitumor Activities ◽  
Mtt Method ◽  
Antitumor Bioactivity ◽  
Better Than ◽  
Fragment Based Drug Discovery

Sixteen 3-arylurea-5-fluoroindolin-2-one derivatives were designed according to the principle of fragment based drug discovery and synthesized with 5-fluoroisatin as the starting material. The obtained structures were identified by 1H NMR, MS and elemental analysis. In vitro evaluation of antitumor bioactivity was performed by MTT method. Most of synthesized compounds showed antitumor activities, especially, activities of 6a, 6h, and 6j in tumor inhibition were better than others.

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