Bimetallic DppfM(II) (M = Pt and Pd) dithiocarbamate complexes: Synthesis, characterization, and anticancer activity

2019 ◽  
Vol 43 (9-10) ◽  
pp. 437-442 ◽  
Author(s):  
Shou De Xu ◽  
Xiang Hua Wu
Keyword(s):  
Antitumor Activity ◽  
Platinum Complex ◽  
Spectroscopic Methods ◽  
X Ray Diffraction ◽  
Antitumor Activities ◽  
High Potency ◽  
Promising Candidate ◽  
X Ray ◽  
Mtt Assays

A series of bimetallic dppfM(II) (dppf = 1,1’-bis (diphenyphosphino) ferrocene; M = Pt and Pd) dithiocarbamate complexes is synthesized and characterized by spectroscopic methods and single-crystal X-ray diffraction. Their antitumor activities in vitro are investigated by MTT assays against four cancer cell lines. The anticancer studies indicate most of the complexes display good to excellent antitumor activity. Remarkably, the platinum complex with a pyrrolidinyl substituent (3b) was identified as the most promising candidate due to its high potency and broad spectrum of activity.

Synthesis, X-ray Diffraction Structures, Spectroscopic Properties, and in vitro Antitumor Activity of Isomeric (1H-1,2,4-Triazole)Ru(III) Complexes

2003 ◽  
Vol 42 (19) ◽  
pp. 6024-6031 ◽  
Author(s):  
Vladimir B. Arion ◽  
Erwin Reisner ◽  
Madeleine Fremuth ◽  
Michael A. Jakupec ◽  
Bernhard K. Keppler ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Spectroscopic Properties ◽  
X Ray Diffraction ◽  
X Ray

Synthesis and Antitumor Activity Assay of Epoxy Bicyclo[4.2.2]deca-2,4,7,(9)- tri(tetra)enes and Tricyclo[9.4.2.02,10]heptadeca-2,12,14,16-tetraene

2019 ◽  
Vol 23 (10) ◽  
pp. 1158-1165
Author(s):  
Vladimir A. D'yakonov ◽  
Gulnara N. Kadikova ◽  
Guzel F. Gazizullina ◽  
Lilya U. Dzhemileva ◽  
Artur R. Tulyabaev ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Tumor Cell ◽  
Tumor Cell Lines ◽  
Activity Assay ◽  
X Ray Diffraction ◽  
X Ray ◽  
High Antitumor Activity ◽  
High Yields ◽  
First Time

Triepoxides were synthesized for the first time in high yields (80-85%) by oxidation of substituted bicyclo[4.2.2]deca-2,4,7,9-tetraenes, bicyclo[4.2.2]deca-2,4,7-trienes, and tricyclo[9.4.2.02,10]heptadeca-2,12,14,16-tetraene with an excess of m-chloroperbenzoic acid. The structures of the epoxy derivatives were reliably proved using modern spectral methods and X-ray diffraction analysis. A high antitumor activity in vitro was found for triepoxides against the Jurkat, K562, U937 tumor cell lines and normal fibroblasts.

scholarly journals Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Zou Xun-Zhong ◽  
Feng An-Sheng ◽  
Zeng Fu-Ran ◽  
Lai Min-Cheng ◽  
Liao Yan-Zhi ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Metal Salts ◽  
X Ray Diffraction ◽  
Antitumor Activities ◽  
Thiazole Derivatives ◽  
Monoclinic System ◽  
Bioactive Materials ◽  
X Ray ◽  
Microplate Reader

Two pyridine thiazole derivatives, namely, 4-(pyridin-2-yl)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)thiazole (L1) and 4-(pyridin-3-yl)-2-(2-(pyridin-4-ylmethylene)hydrazinyl)thiazole (L2), were afforded by a cyclization reaction between α-haloketone and thioamide, and their Zn(II) complexes were prepared by the reaction of ligands and corresponding metal salts, respectively, and characterized by X-ray diffraction and elemental analysis. Both crystals were obtained by ether diffusion and crystallized in a monoclinic system. The in vitro antimicrobial activity of the Zn(II) complexes and ligands was screened using the microplate reader method, and in vitro antitumor activities of the complexes were evaluated by MTT, with a view to developing new improved bioactive materials with novel properties. The biological activity studies of the compounds showed that the metal complexes were more active than the free ligands, and some compounds had absolute specificity for certain bacteria or cancer cell lines.

scholarly journals Cotton Cellulose-CdTe Quantum Dots Composite Films with Inhibition of Biofilm-Forming S. aureus

Fibers ◽  
2019 ◽  
Vol 7 (6) ◽  
pp. 57 ◽  
Author(s):  
Rohan S. Dassanayake ◽  
Poorna T. Wansapura ◽  
Phat Tran ◽  
Abdul Hamood ◽  
Noureddine Abidi
Keyword(s):  
Quantum Dots ◽  
Composite Film ◽  
Biofilm Formation ◽  
Biomedical Applications ◽  
Composite Films ◽  
X Ray Diffraction ◽  
Promising Candidate ◽  
X Ray ◽  
Cdte Qds

A cellulose-cadmium (Cd)-tellurium (TE) quantum dots (QDs) composite film was successfully synthesized by incorporating CdTe QDs onto a cellulose matrix derived from waste cotton linters. Cellulose-CdTe QDs composite film was characterized by field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray (EDX) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), and X-ray diffraction (XRD). The antibacterial activity of the prepared composite film was investigated using the multidrug-resistance (MTR) Staphylococcus aureus bacteria. In vitro antibacterial assays demonstrated that CdTe QDs composite film can efficiently inhibit biofilm formation. Our results showed that the cellulose-CdTe QDs composite film is a promising candidate for biomedical applications including wound dressing, medical instruments, burn treatments, implants, and other biotechnology fields.

scholarly journals Photoprotective Activity of Lichen Extracts and Isolated Compounds in Parmotrema Tinctorum

2021 ◽  
Vol 11 (5) ◽  
pp. 12653-12661
Keyword(s):  
Spectroscopic Methods ◽  
X Ray Diffraction ◽  
X Ray ◽  
First Time ◽  
Excellent Source ◽  
Parmotrema Tinctorum

Lichens are an excellent source for the discovery and development of new photoprotective compounds. However, investigation on their bioactivities remains limited, especially in Vietnam. In this study, six lichen extracts (Parmotrema poolii, P. sancti-angelii, P. tinctorum, Usnea baileyi, U. pulvinulata, U. undulata) and five isolated compounds from commonly distributed species P. tinctorum (methyl β-orcinol carboxylate (1), atranorin (2), lecanorol (3), salazinic acid (4), 1β-acetoxyhopan-3β,22-diol (5)) have been screened in vitro for their photoprotective activity. The photoprotective potential was investigated by determination of their absolute (UV-PF, c, UVA-PF) and relative indexes (SUI, ISP). The structures of isolated compounds were elucidated by spectroscopic methods and confirmed by X-ray diffraction. The results showed that P. poolii, P. sancti-angelii, P. tinctorum, U. baileyi, U. undulata, and compounds of methyl β-orcinol carboxylate (1) and salazinic acid (4) acted as strict UVB filters, and their photoprotective activities are comparable to that of the commercial UVB filter (4-methylbenzylidene camphor). Meanwhile, U. pulvinulata acted as a UVA booster. Compound (3) presented characteristics of a UVA filter, (2) protected well from both UVA and UVB while (5) exhibited a weak photoprotective activity. For the first time, this work successfully extracted several highly potential solar photoprotective compounds from Vietnam's lichens.

Synthesis and Antitumor Activity Evaluation of New Phenanthrene-Based Tylophorine Derivatives

2019 ◽  
Vol 16 (6) ◽  
pp. 462-467
Author(s):  
Songtao Li ◽  
Hongling Zhao ◽  
Zhifeng Yin ◽  
Shuhua Deng ◽  
Yang Gao ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Cell Lines ◽  
Antitumor Activities ◽  
Human Carcinoma ◽  
Carcinoma Cell Lines ◽  
Structure Activity ◽  
Human Carcinoma Cell ◽  
Ic50 Values ◽  
Relationship Of

A series of new phenanthrene-based tylophorine derivatives (PBTs) were synthesized in good yield and their structures were characterized by 1H-NMR spectroscopy and ESI MS. In vitro antitumor activity of these compounds against five human carcinoma cell lines, including HCT116 (colorectal), BGC-823 (gastric), HepG-2 (hepatic), Hela (cervical) and H460 (lung) cells, was evaluated by MTT assay. Among these PBTs, compound 6b showed the highest antitumor activities against HCT116 and HepG-2 cell lines with IC50 values of 6.1 and 6.4 μM, respectively, which were comparable to that of adriamycin hydrochloride. The structure-activity relationship of these compounds was also discussed based on the results of their antitumor activity.

Bis(μ-carboxylato)dienerhodium(I) Complexes - Synthesis, Characterization and Catalytic Activity

2008 ◽  
Vol 73 (8-9) ◽  
pp. 1205-1221 ◽  
Author(s):  
Jiří Zedník ◽  
Jan Sedláček ◽  
Jan Svoboda ◽  
Jiří Vohlídal ◽  
Dmitrij Bondarev ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Diffraction Analysis ◽  
Spectroscopic Methods ◽  
X Ray Diffraction ◽  
X Ray

Dinuclear rhodium(I) η2:η2-cycloocta-1,5-diene (series a) and η2:η2-norborna-2,5-diene (series b) complexes with μ-RCOO- ligands, where R is linear C21H43 (complexes 1a, 1b), CH2CMe3 (2a, 2b), 1-adamantyl (3a, 3b) and benzyl (4a, 4b), have been prepared and characterized by spectroscopic methods. Structures of complexes 2b, 3a and 4a were determined by X-ray diffraction analysis. Complexes prepared show low to moderate catalytic activity in polymerization of phenylacetylene in THF giving high-cis-transoid polymers, but they show only oligomerization activity in dichloromethane.

scholarly journals New Haloterpenes from the Marine Red Alga Laurencia papillosa: Structure Elucidation and Biological Activity

Marine Drugs ◽  
2021 ◽  
Vol 19 (1) ◽  
pp. 35
Author(s):  
Mohamed Shaaban ◽  
Ghada S. E. Abou-El-Wafa ◽  
Christopher Golz ◽  
Hartmut Laatsch
Keyword(s):  
Biological Activity ◽  
Crude Extract ◽  
Structure Elucidation ◽  
Antimicrobial Activities ◽  
Red Alga ◽  
Spectroscopic Methods ◽  
X Ray Diffraction ◽  
X Ray ◽  
Chemical Structures ◽  
Terpene Derivatives

Analysis of the air-dried marine red alga Laurencia papillosa, collected near Ras-Bakr at the Suez gulf (Red Sea) in Egypt delivered five new halogenated terpene derivatives: aplysiolic acid (1), 7-acetyl-aplysiol (2), aplysiol-7-one (3), 11,14-dihydroaplysia-5,11,14,15-tetrol (5a), and a new maneonene derivative 6, named 5-epi-maneolactone. The chemical structures of these metabolites were characterized employing spectroscopic methods, and the relative and absolute configurations were determined by comparison of experimental and ab initio-calculated NMR, NOE, ECD, and ORD data, and by X-ray diffraction of 2 and 6. The antimicrobial activities of the crude extract and compounds 1–3, 5a and 6 were studied.

A study on using expanded perlite with hydroxyapatite: Reinforced bio-composites

2021 ◽  
pp. 095441192199656
Author(s):  
Erdoğan Karip ◽  
Mehtap Muratoğlu
Keyword(s):  
Body Fluid ◽  
Xrd Analysis ◽  
Cold Isostatic Pressing ◽  
Expanded Perlite ◽  
X Ray Diffraction ◽  
Pressing Method ◽  
X Ray ◽  
Infra Red ◽  
Ft Ir

People are exposed to different kinds of diseases or various accidents in life. Hydroxyapatite (HA) has been widely employed for bone treatment applications. In this study, HA was extracted from sheep bones. Bio-composites were doped with 1, 5, and 10 wt.% of expanded perlite and 5 wt.% of ZrO2–MgO-P2O5. The bio-composites were prepared by the cold isostatic pressing method (250 MPa) and sintered at 900°C for 1 h. In order to evaluate the characteristics of the bio-composites, microhardness, density, X-ray diffraction (XRD), Fourier transform infra-red spectroscopy (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) analyses were carried out on them. Additionally, the specimens whose characteristics were determined were kept in synthetic body fluid (SBF), and their in vitro behavior was examined. As a result, it was observed that microhardness increased as both the weight and the grain size of the expanded perlite were increased. Calcium silicate, tri-calcium phosphate, and hydroxyapatite were observed in the XRD analysis of all samples, and the formation of apatite structures was increased by addition of ZrO2–MgO–P2O5.

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